Z-DQMD-FMK
Chemical Name: Benzyloxycarbonyl-Asp(OMe)-Gln-Met-Asp(OMe)-fluoromethylketone
Biological Activity
Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.Technical Data
(Modifications: Asp-1 = Z-Asp(OMe), Asp-4 = (OMe)-fluoromethylketone)
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Characterization of NF-κB expression in Hodgkin's disease: inhibition of constitutively expressed NF-κB results in spontaneous caspase-independent apoptosis in Hodgkin and Reed-Sternberg cells.
Izban et al.
Mod.Pathol., 2001;14:297 -
Differential response to MG132 cytotoxicity against small cell lung cancer cells to changes in cellular GSH contents.
Bang et al.
Biochem.Pharmacol., 2004;68:659 -
Alterations in protein kinase C activity and processing during zinc deficiency-induced cell death.
Chou et al.
Biochem.J., 2004;383:63
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Citation for Z-DQMD-FMK
The citations listed below are publications that use Tocris products. Selected citations for Z-DQMD-FMK include:
1 Citation: Showing 1 - 1
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HIV induces production of IL-18 from intestinal epithelial cells that increases intestinal permeability and microbial translocation.
Authors: Allam Et al.
PLoS One 2018;13:e0194185
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