Catalog Number: 2168
Chemical Name: Benzyloxycarbonyl-Asp(OMe)-Gln-Met-Asp(OMe)-fluoromethylketone
Biological Activity
Caspase-3 inhibitor. Inhibits MG 132-induced small cell lung cancer cell death in vitro.
Technical Data
  • M.Wt:
  • Formula:
  • Sequence:

    (Modifications: Asp-1 = Z-Asp(OMe), Asp-4 = (OMe)-fluoromethylketone)

  • Solubility:
    Soluble to 13.71 mg/ml in DMSO
  • Storage:
    Desiccate at -20°C
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis. All Tocris products are intended for laboratory research use only.
Background References
  1. Characterization of NF-κB expression in Hodgkin's disease: inhibition of constitutively expressed NF-κB results in spontaneous caspase-independent apoptosis in Hodgkin and Reed-Sternberg cells.
    Izban et al.
    Mod.Pathol., 2001;14:297
  2. Alterations in protein kinase C activity and processing during zinc deficiency-induced cell death.
    Chou et al.
    Biochem.J., 2004;383:63
  3. Differential response to MG132 cytotoxicity against small cell lung cancer cells to changes in cellular GSH contents.
    Bang et al.
    Biochem.Pharmacol., 2004;68:659

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