Z-LR-AMC Fluorogenic Peptide Substrate
Z-LR-AMC Fluorogenic Peptide Substrate Summary
Z-Leu-Arg-AMC. Z: N-carbobenzyloxy; 7-Amino-4-methylcoumarin.
CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.
In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.
|Formulation||Supplied as a stock solution in dimethyl sulfoxide (DMSO) with a concentration of 20 mg/mL or 32 mM.|
|Shipping||The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.|
|Stability & Storage:||Samples are stable for up to twelve months from date of receipt at -20° C to -70° C. The substrate can be aliquoted and stored -20° C to -70° C in a manual defrost freezer for six months. Avoid repeated freeze-thaw cycles. Protect from exposure to direct light.|
Citations for Z-LR-AMC Fluorogenic Peptide Substrate
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 8
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Role of engineered metal oxide nanoparticle agglomeration in reactive oxygen species generation and cathepsin B release in NLRP3 inflammasome activation and pulmonary toxicity
Authors: Tina M Sager
Inhal Toxicol, 2016-12-05;28(14):686-697.
Sample Types: Complex Sample Type
Redundancy between Cysteine Cathepsins in Murine Experimental Autoimmune Encephalomyelitis.
Authors: Allan E, Yates R
PLoS ONE, 2015-06-15;10(6):e0128945.
Sample Types: Recombinant Protein
Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage.
Authors: Zhao L, Hua T, Crowley C, Ru H, Ni X, Shaw N, Jiao L, Ding W, Qu L, Hung L, Huang W, Liu L, Ye K, Ouyang S, Cheng G, Liu Z
Cell Res, 2014-01-10;24(3):344-58.
Sample Types: Protein
The cystatin M/E-cathepsin L balance is essential for tissue homeostasis in epidermis, hair follicles, and cornea.
Authors: Zeeuwen PL, van Vlijmen-Willems IM, Cheng T
FASEB J., 2010-05-21;24(10):3744-55.
Sample Types: Tissue Homogenates
Applications: Enzyme Assay Substrate
Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification.
Authors: Cheng T, Hitomi K, van Vlijmen-Willems IM, de Jongh GJ, Yamamoto K, Nishi K, Watts C, Reinheckel T, Schalkwijk J, Zeeuwen PL
J. Biol. Chem., 2006-03-24;281(23):15893-9.
Sample Types: Recombinant Protein
Applications: Enzyme Assay
Mannan-binding lectin-associated serine protease 3 cleaves synthetic peptides and insulin-like growth factor-binding protein 5.
Authors: Cortesio CL, Jiang W
Arch. Biochem. Biophys., 2006-03-03;449(1):164-70.
Distinct roles for cysteine cathepsin genes in multistage tumorigenesis.
Authors: Gocheva V, Zeng W, Ke D, Klimstra D, Reinheckel T, Peters C, Hanahan D, Joyce JA
Genes Dev., 2006-02-15;20(5):543-56.
Sample Types: Buffer
Characterization of cathepsin L secreted by Sf21 insect cells.
Authors: Johnson GD, Jiang W
Arch. Biochem. Biophys., 2005-10-21;444(1):7-14.
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