6 results for "Group II mGluR Antagonists Small Molecules and Peptides" in Products
Group II mGluR Antagonists Small Molecules and Peptides
Metabotropic Glutamate (mGlu) group II receptors are members of the metabotropic class of glutamate receptors, which also includes mGlu group I and mGlu group III receptors. Group II receptors are divided into two subtypes, mGlu2 and mGlu3. mGlu group II receptors are coupled to Gi/o, which inhibits adenylyl cyclase, decreasing the formation of cAMP. These receptors are involved in presynaptic inhibition and do not appear to affect postsynaptic membrane potential by themselves. The human genes for mGlu2 and mGlu3 receptors have been localized to chromosomes 3 (p21.1) and 7 (7q21.1-q21.2) respectively.
Highly potent and selective group II mGlu antagonist
| Chemical Name: | (2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid |
| Purity: | ≥98% |
Non-selective mGlu antagonist; active isomer of (RS)-MCPG (Cat. No. 0336)
| Chemical Name: | (S)-α-Methyl-4-carboxyphenylglycine |
| Purity: | ≥98% |
Potent and selective group II mGlu antagonist; disodium salt of LY 341495 (Cat. No. 1209)
| Chemical Name: | (2S)-2-Amino-2-[(1S,2S)-2-carboxycycloprop-1-yl]-3-(xanth-9-yl) propanoic acid disodium salt |
| Purity: | ≥97% |
Non-selective mGlu antagonist; disodium salt of (RS)-MCPG (Cat. No. 0336)
| Chemical Name: | (RS)-α-Methyl-4-carboxyphenylglycine disodium salt |
| Purity: | ≥98% |
Non-selective mGlu antagonist
| Chemical Name: | (RS)-α-Methyl-4-carboxyphenylglycine |
| Purity: | ≥98% |
Selective, non-competitive mGlu2 antagonist
| Chemical Name: | (Z)-1-[2-Cycloheptyloxy-2-(2,6-dichlorophenyl)ethenyl]-1H-1,2,4-triazole |
| Purity: | ≥98% |
