9 results for "HIF-1 alpha/HIF1A Small Molecules and Peptides" in Products
HIF-1 alpha/HIF1A Small Molecules and Peptides
The hypoxia-inducible transcription factor 1 alpha (HIF-1 alpha/HIF1A) is the regulated member of the transcription factor heterodimer HIF-1 alpha/beta. HIF-1 alpha/HIF1A binds to hypoxia-response elements (HREs) in the promoters of many genes involved in the adaptation to an environment of insufficient oxygen or hypoxia. Hypoxic tissue environment...
Thioredoxin-1 inhibitor
| Alternate Names: | IV-2 |
| Chemical Name: | 2-[(1-Methylpropyl)dithio]-1H-imidazole |
| Purity: | ≥98% |
HIF-1α inhibitor; down-regulates HIF-1α protein synthesis
| Chemical Name: | N,N'-(Dithiodi-2,1-ethanediyl)bis[2,5-dichlorobenzenesulfonamide |
| Purity: | ≥98% |
HIF α-subunit inhibitor
| Chemical Name: | 2-Oxo-2-(p-tolyl)ethyl 3-(2,4-dinitrobenzamido)benzoate |
| Purity: | ≥98% |
Potent, selective HIF-1α prolyl hydroxylase-2 (PHD2) inhibitor
| Chemical Name: | N-[[1,2-Dihydro-4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]carbonyl]glycine |
| Purity: | ≥98% |
Potent HIF-1α inhibitor
| Chemical Name: | N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine |
| Purity: | ≥98% |
Malate dehydrogenase-2 (MDH2) inhibitor; also inhibits HIF-1α
| Alternate Names: | CAY 10585 |
| Chemical Name: | Methyl 4-hydroxy-3-[[2-(4-tricyclo[3.3.1.13,7]dec-1-ylphenoxy)acetyl]amino]benzoate |
| Purity: | ≥98% |
Prolyl hydroxylase inhibitor
| Chemical Name: | N-(2-Methoxy-2-oxoacetyl)glycine methyl ester |
| Purity: | ≥97% |
Highly potent and selective HIF-1α inhibitor
| Alternate Names: | Quinomycin A |
| Chemical Name: | N-(2-Quinoxalinylcarbonyl)-O-[N-(2-quinoxalinylcarbonyl)-D-seryl-L-alanyl-3-mercapto-N,S-dimethylcysteinyl-N-methyl-L-valyl]-D-seryl-L-alanyl-N-methylcysteinyl-N-methyl-L-valine-(81)-lactone-cyclic (37)-thioether |
| Purity: | ≥98% |
Inhibitor of VHL; blocks interaction of VHL and HIF-α
| Chemical Name: | (2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide |
| Purity: | ≥98% |
