10 results for "Histone Deacetylase 8/HDAC8 Small Molecules and Peptides" in Products
Histone Deacetylase 8/HDAC8 Small Molecules and Peptides
Human Histone Deacetylase 8 (HDAC8) is a member of the class I histone Deacetylases (HDACs). Expression of HDAC8 is restricted to cells showing smooth muscle differentiation in normal human tissue and is a novel marker of smooth muscle differentiation. Like other class I and II HDAC members, the activity of HDAC8 is sensitive to HDAC inhibitor trichostatin A.
Sirtuin 2, is a member of the class III histone deacetylases (HDACs) and has been implicated in many cellular processes that include histone deacetylation, gene silencing, chromosomal stability, and aging (3 - 4). The enzymatic activity of class III HDACs is nicotinamide adenine dinucleotide (NAD) dependent and insensitive to HDAC inhibitor trichostatin A
Potent and selective HDAC8 inhibitor
| Chemical Name: | N-Hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide |
| Purity: | ≥98% |
Potent class I and IIb HDAC inhibitor
| Chemical Name: | 5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide |
| Purity: | ≥98% |
Dual histone deacetylase (HDAC) 6/8 inhibitor
| Chemical Name: | N1-Hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide |
| Purity: | ≥98% |
Histone deacetylase inhibitor
| Alternate Names: | VPA,Sodium Valproate |
| Chemical Name: | Sodium 2-propylpentanoate |
Class I and II HDAC inhibitor
| Alternate Names: | Vorinostat |
| Chemical Name: | N-Hydroxy-N'-phenyloctanediamide |
| Purity: | ≥98% |
Histone deacetylase inhibitor
| Alternate Names: | 4-PB,Sodium phenylbutyrate |
| Chemical Name: | 4-Phenylbutyric acid, sodium salt |
| Purity: | ≥98% |
Pan-histone deacetylase inhibitor
| Chemical Name: | (2E)-N-Hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2-propenamide |
| Purity: | ≥98% |
HDAC (Class I) inhibitor
| Alternate Names: | entinostat,SNDX 275 |
| Chemical Name: | (Pyridin-3-yl)methyl 4-(2-aminophenylcarbamoyl)benzylcarbamate |
| Purity: | ≥98% |
Potent and selective class IIa HDAC inhibitor; brain penetrant
| Chemical Name: | 2-(2-Fluorophenyl)-N-hydroxy-2-(4-(5-(trifluoromethyl)pyrimidin-2-yl)phenyl)acetamide |
| Purity: | ≥98% |
Selective HDAC3 inhibitor; also myelination inducer
| Chemical Name: | N-(2-Aminophenyl)-5-[(phenylmethyl)amino]-2-pyrazinecarboxamide dihydrochloride |
| Purity: | ≥98% |
