10 results for "KOR Small Molecules and Peptides" in Products
KOR Small Molecules and Peptides
Kappa Opioid Receptor (KOR) is a 45 kDa 7TM opioid receptor that is primarily expressed in the central nervous system and peripheral visceral pain sensory nerves. Following ligation by dynorphin peptides, KOR signaling induces analgesia, dysphoria, diuresis, and increased feeding desire. KOR also exerts neuroprotective and anti-inflammatory effects. Human KOR shares 94% amino acid sequence identity with mouse and rat KOR.
Selective and irreversible κ antagonist
| Chemical Name: | 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-(3-isothiocyanatophenyl)-2-(1-pyrrolidinyl)ethyl]acetamide hydrochloride |
| Purity: | ≥98% |
Selective κ agonist
| Chemical Name: | trans-(±)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride |
| Purity: | ≥99% |
Activator of κ-opioid DREADD (KORD)
| Chemical Name: | (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester |
| Purity: | ≥98% |
Selective κ agonist; less active enantiomer of (±)-U-50488 (Cat. No. 0495)
| Chemical Name: | trans-(+)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)-cyclohexyl]benzeneacetamide hydrochloride |
| Purity: | ≥99% |
Selective κ agonist; more active enantiomer of (±)-U-50488 (Cat. No. 0495)
| Chemical Name: | trans-(-)-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide hydrochloride |
| Purity: | ≥99% |
Opioid receptor antagonist
| Chemical Name: | (5α)-17-(Cyclopropylmethyl)-4,5-epoxy-6-methylenemorphinan-3,14-diol hydrochloride |
| Purity: | ≥98% |
κ agonist, acts peripherally
| Chemical Name: | (RS)-[3-[1-[[(3,4-Dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]acetic acid hydrochloride |
| Purity: | ≥98% |
Subtype-selective κ agonist
| Chemical Name: | 4-[(3,4-Dichlorophenyl)acetyl]-3-(1-pyrrolidinylmethyl)-1-piperazinecarboxylic acid methyl ester fumarate |
| Purity: | ≥99% |
Endogenous κ agonist
| Purity: | ≥95% |
Selective κ opioid receptor antagonist
| Chemical Name: | N-[3-[4-(4-Methoxyphenyl)-1-piperazinyl]propyl]-1-methyl-6-oxopyrido[2,3-e]pyrrolo[1,2-a]pyrazine-5(6H)-acetamide |
| Purity: | ≥98% |
