8 results for "mGluR1" in Products
mGluR1 Products
Metabotropic glutamate receptor 1 (mGluR1) is a 130 kDa, 7-transmembrane glycoprotein that belongs to group I of the C-family of G-protein coupled receptors. On neurons, mGluR1 is postsynaptic, associates with Gq-like proteins, mobilizes intracellular Ca++, and influences ion channel activity. Mature mGluR1 is 1176 amino acids (aa) in length and contains a 574 aa N-terminal extracellular domain (ECD) (aa 19-592). The ECD binds glutamate and forms either a covalent homodimer or heterodimer with CaSR. There is one alternative splice form for human mGluR1 that shows a 20 aa substitution for the C-terminal 308 amino acids. Over aa 33-522, human mGluR1 shares more that 98% aa identity with mouse, rat and canine mGluR1.
Potent and selective group I mGlu antagonist
| Alternate Names: | UPF 523 |
| Chemical Name: | (RS)-1-Aminoindan-1,5-dicarboxylic acid |
| Purity: | ≥98% |
Selective non-competitive mGlu1 antagonist
| Chemical Name: | 7-(Hydroxyimino)cyclopropa[b]chromen-1a-carboxylate ethyl ester |
| Purity: | ≥98% |
Highly potent, mGlu1-selective non-competitive antagonist
| Chemical Name: | (3,4-Dihydro-2H-pyrano[2,3-b]quinolin-7-yl)-(cis-4-methoxycyclohexyl)-methanone |
| Purity: | ≥98% |
Selective mGlu1a antagonist
| Chemical Name: | (S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid |
| Purity: | ≥98% |
Group I mGlu antagonist
| Chemical Name: | N-tricyclo[3.3.1.13,7]dec-1-yl-2-quinoxalinecarboxamide |
| Purity: | ≥98% |
Potent group I mGlu antagonist
| Chemical Name: | N-Phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide |
| Purity: | ≥98% |
Selective mGlu1 antagonist
| Alternate Names: | MPMQ hydrochloride |
| Chemical Name: | 6-Methoxy-N-(4-methoxyphenyl)-4-quinazolinamine hydrochloride |
| Purity: | ≥98% |
Potent and selective mGlu5 antagonist; brain penetrant
| Chemical Name: | 3-Fluoro-5-[3-(5-fluoro-2-pyridinyl)-1,2,4-oxadiazol-5-yl]benzonitrile |
| Purity: | ≥98% |
