P2RY13 belongs to the family of G protein-coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. P2RY13 is strongly expressed in the spleen and adult brain. It is expressed at lower levels in the placenta, lung, liver, spinal cord, thymus, small intestine, uterus, stomach, testis, fetal brain, and adrenal gland. P2RY13 is activated by ADP and may play a role in hematopoiesis and the immune system.