8 results for "RAR beta/NR1B2 Small Molecules and Peptides" in Products
RAR beta/NR1B2 Small Molecules and Peptides
Retinoids can reverse various premalignant lesions as well as prevent some second primary tumors. The effects of retinoids are regulated by retinoic acid receptors (RAR) and retinoid X receptors, which act as ligand-activated transcription factors. Ligand-dependent transcriptional activation of RARs is a multistep process that ends with the formation of a multimeric co-activator complex on regulated promoters (1,2). Loss of RAR-beta expression and the accumulation of p53 and Ki67 proteins may help in the early identification of esophageal cancer in high-risk populations (3).
Retinoic acid analog; RARα agonist
| Chemical Name: | 4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carboxamido]benzoic acid |
| Purity: | ≥98% |
High affinity pan-RAR antagonist
| Chemical Name: | 4-[2-[5,6-Dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthalenyl]ethynyl]benzoic acid |
| Purity: | ≥98% |
Selective RARβ/γ antagonist
| Chemical Name: | 4-[6-[(2-Methoxyethoxy)methoxy]-7-tricyclo[3.3.1.13,7]dec-1-yl-2-naphthalenyl)benzoic acid |
| Purity: | ≥98% |
RARβ2 agonist
| Chemical Name: | 4-[4-(2-Butoxyethoxy-)-5-methyl-2-thiazolyl]-2-fluorobenzoic acid |
| Purity: | ≥98% |
Potent RAR agonist
| Chemical Name: | 4-[(1E)-3-[3,5-bis(1,1-Dimethylethyl)phenyl]-3-oxo-1-propenyl]benzoic acid |
| Purity: | ≥98% |
Selective RARβ agonist
| Chemical Name: | 5-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-anthracenyl)-3-thiophenecarboxylic acid |
| Purity: | ≥98% |
Synthetic retinoid; induces differentiation of stem cells
| Chemical Name: | 4-[2-(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)ethynyl)-benzoic acid |
| Purity: | ≥99% |
Blocks retinoic acid metabolism
| Alternate Names: | R-75251 |
| Chemical Name: | 5-[(3-Chlorophenyl)-1H-imidazol-1-ylmethyl]-1H-benzimidazole dihydrochloride |
| Purity: | ≥98% |
