CRBN Small Molecules and Peptides

Thalidomide

Catalog #: 0652

Binds cereblon; also TNF-α synthesis inhibitor

Chemical Name:	N-(2,6-dioxo-3-piperidinyl)phthalimide
Purity:	≥98%

dTAG-13-NEG

Catalog #: 6916

Citations (2)

Product Documents

Negative control for dTAG-13 (Cat. No. 6605)

Chemical Name:	1-[(2S)-1-Oxo-2-(3,4,5-trimethoxyphenyl)butyl]-(2S)-2-piperidinecarboxylate (1R)-3-(3,4-dimethoxyphenyl)-1-[2-[2-[[6-[[2-(1-methyl-2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]hexyl]amino]-2-oxoethoxy]phenyl]propyl ester
Purity:	≥97%

Lenalidomide

Catalog #: 6305

(1)

Citations (8)

Product Documents

Cereblon binder; induces ubiquitination and degradation of CK1α by E3 ubiquitin ligase

Chemical Name:	3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione
Purity:	≥98%

ZNL 02-096

Catalog #: 7240

Citations (2)

Product Documents

Potent and selective Wee1 Degrader (PROTAC®)

Chemical Name:	4-((3-(4-(4-((2-Allyl-1-(6-(2-hydroxypropan-2-yl)pyridin-2-yl)-3-oxo-2,3-dihydro-1H-pyrazolo[3,4-d]pyrimidin-6-yl)amino)phenyl)piperazin-1-yl)propyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
Purity:	≥98%

CRBN-6-5-5-VHL

Catalog #: 6948

Product Documents

Potent and selective cereblon Degrader (PROTAC®); cell-permeable

Chemical Name:	(2S,4R)-1-((2S)-2-(5-((5-((6-((2-(2,6-Dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)hexyl)oxy)pentyl)oxy)pentanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
Purity:	≥96%

Pomalidomide 4'-alkylC3-acid

Catalog #: 7096

Product Documents

Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Chemical Name:	4-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]butanoic acid
Purity:	≥95%

Pomalidomide 4'-PEG2-acid

Catalog #: 7212

Product Documents

Cereblon ligand with PEG linker and terminal acid for onward chemistry

Chemical Name:	3-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]ethoxy]ethoxy]propanoic acid
Purity:	≥95%

Pomalidomide 4'-PEG1-azide

Catalog #: 7434

Product Documents

Cereblon ligand with PEG linker and terminal azide for onward chemistry

Chemical Name:	4-[[2-(2-Azidoethoxy)ethyl]amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity:	≥95%

Pomalidomide 4'-alkylC2-azide

Catalog #: 7439

Product Documents

Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Chemical Name:	4-[(2-Azidoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity:	≥95%

Lenalidomide 5'-piperazine-4-methylpiperidine

Catalog #: 7473

Product Documents

Cereblon ligand with terminal piperidine for onward chemistry

Chemical Name:	3-[1,3-Dihydro-1-oxo-5-[4-(4-piperidinylmethyl)-1-piperazinyl]-2H-isoindol-2-yl]-2,6-piperidinedione dihydrochloride
Purity:	≥94%

Thalidomide 4'-oxyacetamide-alkylC4-azide

Catalog #: 6300

Product Documents

Cereblon ligand with alkyl linker and terminal azide for onward chemistry

Alternate Names:	Azido-Thalidomide
Chemical Name:	N-(4-Azidobutyl)-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide
Purity:	≥98%

Thalidomide-4-hydroxyacetate

Catalog #: 6466

Product Documents

Carboxylic acid-functionalized Thalidomide; cereblon ligand for PROTACs

Chemical Name:	2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid
Purity:	≥98%

Thalidomide 4'-oxyacetamide-PEG3-amine

Catalog #: 6467

(1)

Product Documents

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Alternate Names:	Thalidomide - linker 1
Chemical Name:	N-[2-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]ethyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride
Purity:	≥95%

Thalidomide 4'-ether-alkylC6-amine

Catalog #: 6627

(1)

Product Documents

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:	Thalidomide - linker 4
Chemical Name:	4-[(6-Aminohexyl)oxy]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Purity:	≥95%

Pomalidomide 4'-PEG2-amine

Catalog #: 6637

(1)

Product Documents

Cereblon ligand with PEG linker and terminal amine for onward chemistry

Alternate Names:	Pomalidomide - linker 1
Chemical Name:	4-[[2-[2-(2-Aminoethoxy)ethoxy]ethyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
Purity:	≥95%

Pomalidomide 4'-alkylC5-acid

Catalog #: 6682

Product Documents

Cereblon ligand with alkyl linker and terminal acid for onward chemistry

Alternate Names:	Pomalidomide - linker 3
Chemical Name:	6-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]hexanoic acid
Purity:	≥95%

Thalidomide, propargyl

Catalog #: 6685

Product Documents

Alkyne-functionalized Thalidomide; 'click' cereblon ligand for PROTACs

Chemical Name:	2-(2,6-Dioxo-3-piperidinyl)-4-(2-propyn-1-yloxy)-1H-isoindole-1,3(2H)-dione
Purity:	≥95%

Thalidomide 4'-ether-PEG2-alkyne

Catalog #: 6686

Product Documents

Cereblon ligand with PEG linker and terminal alkyne for onward chemistry

Alternate Names:	Thalidomide - linker 5
Chemical Name:	2-(2,6-Dioxo-3-piperidinyl)-4-[2-[2-(2-propyn-1-yloxy)oxy]ethoxy]-1H-isoindole-1,3(2H)dione
Purity:	≥95%

Pomalidomide 4'-alkylC5-amine

Catalog #: 6716

Product Documents

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:	Pomalidomide - linker 4
Chemical Name:	4-[(5-Aminopentyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Purity:	≥95%

Thalidomide 4'-ether-alkylC2-amine

Catalog #: 6850

Citations (10)

Product Documents

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:	Thalidomide - linker 6
Chemical Name:	4-(2-Aminoethoxy)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Purity:	≥95%

Pomalidomide 4'-alkylC2-amine

Catalog #: 6851

Product Documents

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:	Pomalidomide - linker 7
Chemical Name:	4-[(2-Aminoethyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Purity:	≥95%

Thalidomide 4'-oxyacetamide-alkylC1-PEG3-alkylC3-amine

Catalog #: 6913

Product Documents

Cereblon ligand with alkyl-PEG-alkyl linker and terminal amine for onward chemistry

Chemical Name:	N-[3-[2-[2-(3-Aminopropoxy)ethoxy]ethoxy]propyl]-2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetamide hydrochloride
Purity:	≥95%

Thalidomide 4'-ether-alkylC4-amine

Catalog #: 6917

Product Documents

Cereblon ligand with alkyl linker and terminal amine for onward chemistry

Alternate Names:	Thalidomide - linker 9
Chemical Name:	4-(4-Aminobutoxy)-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Purity:	≥95%