R&D Systems offers biosimilar antibodies for research use only. Our biosimilar antibodies are designed to be used as controls with our anti-idiotype antibodies. We offer many biosimilar antibodies that are conjugated or unconjugated to fit your needs. Biosimilar antibodies are expressed recombinantly using the same sequence as the original therapeutic antibody.
The biosimilar antibody is used in a bridging assay with anti-idiotype antibodies. In figure 1b, Anti-Rituximab (Anti-Idiotype) Antibody is coated to a plate to capture Rituximab Biosimilar. Then, biotinylated Anti-Rituximab (Anti-Idiotype) Antibody is used to detect Rituximab Biosimilar followed by streptavidin-HRP.
Fig. 1a Diagram of Bridging Assay
Fig. 1b Rituximab Biosimilar used in a Bridging Assay
R&D Systems also offers many anti-idiotype antibodies to be used with our biosimilar antibodies.