Casein Kinase 1 alpha Antibody - BSA Free

A: The CK1a gene has two sites of alternate splicing which may or may not insert two sequences called L (long, 28 amino acids) and S (short, 12 amino acids). So there are four possible and actual expressed forms, CK1a, CK1aL, CK1aS and CK1aLS. With collaboration, the lab showed that the L peptide contained a nuclear localization sequence and, using GFP fusions, CK1a forms with L go into the nucleus and those without do not. These are the isoforms mentioned. However, cross reactivity with other isoforms of Casein Kinase 1 such as beta, gamma, delta, or epsilon has not been determined, and so we cannot say for sure whether cross reactivity will occur.