CD117/c-kit Antibody - BSA Free

Name: CD117/c-kit Antibody - BSA Free
Brand: Novus Biologicals
SKU: NBP1-85593
Price: 269 USD
Availability: InStock

Novus Biologicals | Catalog # NBP1-85593

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

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Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: VGDEIRLLCTDPGFVKWTFEILDETNENKQNEWITEKAEATNTGKYTCTNKHGLSNSIYVFVRDPAKLFLVDRSLYGKEDNDTLVRCPLTDPEVTNYSLKGCQGKPLPKDLRFIPDPKAGIMIKSVKRAYHRLCLHCSVDQ

Marker

Hematopoietic Stem Cell Marker

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CD117/c-kit Antibody - BSA Free

Immunohistochemistry-Paraffin: CD117/c-kit Antibody [NBP1-85593]

Immunohistochemistry-Paraffin: CD117/c-kit Antibody [NBP1-85593] - Staining of human cerebellum shows moderate membranous and cytoplasmic positivity in Purkinje cells.

Immunohistochemistry-Paraffin: CD117/c-kit Antibody - BSA Free [NBP1-85593]

Staining of human liver shows no positivity in hepatocytes as expected.

Immunohistochemistry-Paraffin: CD117/c-kit Antibody - BSA Free [NBP1-85593]

Staining of human skin shows moderate membranous and cytoplasmic positivity in squamous epithelial cells.

Immunohistochemistry-Paraffin: CD117/c-kit Antibody - BSA Free [NBP1-85593]

Staining of human breast shows strong membranous and cytoplasmic positivity in glandular cells.

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Applications for CD117/c-kit Antibody - BSA Free

Application

Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Application Notes

For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CD117/c-kit

CD117 is a 145 kD immunoglobulin superfamily member, also known as c-Kit and stem cell factor receptor (SCFR). It is a transmembrane tyrosine-kinase receptor that binds the c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia (AML) cells. CD117 interaction with it's ligand is critical for the development of hematopoietic stem cells. The 2B8 antibody does not block c-Kit activity.

Long Name

Stem Cell Factor Receptor

Alternate Names

c-kit, CD117, ckit, KIT, PBT, SCF R, SCFR

Gene Symbol

KIT

Additional CD117/c-kit Products

Product Documents for CD117/c-kit Antibody - BSA Free

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Certificate of Analysis

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Product Specific Notices for CD117/c-kit Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.