Chemical Name: [(3-Chlorophenyl)methylene]hydrazone-3-chlorobenzaldehyde
Biological ActivityAllosteric ligand for the metabotropic glutamate receptor mGlu5; displays neutral modulation. Does not affect agonist-stimulated mGlu5 responses, but blocks regulation of the receptor by other allosteric modulators such as DFB (Cat. No. 1625) and DMeOB (Cat. No. 1953).
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Tocris products are intended for laboratory research use only, unless stated otherwise.
A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.
O'Brien et al.
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