Allosteric ligand for the metabotropic glutamate receptor mGlu5
; displays neutral modulation. Does not affect agonist-stimulated mGlu5
responses, but blocks regulation of the receptor by other allosteric modulators such as DFB
(Cat. No. 1625) and DMeOB
(Cat. No. 1953).
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All Tocris products are intended for laboratory research use only.
A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.
O'Brien et al.