DCB

Catalog # Availability Size / Price Qty
1952/10
1952/50
DCB | CAS No. 6971-97-7 | Group I mGluR Modulators
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Description: Allosteric modulator of mGlu5 receptors
Alternative Names: 3,3'-Dichlorobenzaldazine

Chemical Name: [(3-Chlorophenyl)methylene]hydrazone-3-chlorobenzaldehyde

Purity: ≥98%

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Biological Activity

Allosteric ligand for the metabotropic glutamate receptor mGlu5; displays neutral modulation. Does not affect agonist-stimulated mGlu5 responses, but blocks regulation of the receptor by other allosteric modulators such as DFB (Cat. No. 1625) and DMeOB (Cat. No. 1953).

Technical Data

M.Wt:
277.15
Formula:
C14H10Cl2N2
Solubility:
Soluble to 100 mM in ethanol with gentle warming and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at RT
CAS No:
6971-97-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5.
    O'Brien et al.
    Mol.Pharmacol., 2003;64:731

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