Endoglin/CD105 [Unconjugated]

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Background: Endoglin/CD105

Endoglin (CD105) is a transmembrane type III receptor for TGF-beta superfamily ligands and plays an important role in smooth muscle differentiation, angiogenesis, and neovascularization. It is highly expressed on proliferating vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. Human Endoglin haploinsufficiency can a cause the vascular disorder, hereditary hemorrhagic telangiectasia type I. Elevated levels of anti-angiogenic soluble Endoglin contribute to pathogenicity in preeclampsia. Endoglin associates with the receptors TGF-beta RII, Activin RIIA or RIIB, BMPR-IA/ALK-3, or BMPR-IB/ALK6 and enhance binding of Activin A, BMP-2, -7, -9, TGF-beta 1, or TGF-beta 3. Endoglin can either enhance or inhibit signaling through these receptor complexes.

Related Research Areas

• Adipose-derived Stem Cell Markers
• Cancer Biomarkers
• Cancer Stem Cell Markers
• Endothelial Cell Markers
• Hemangioblasts
• Hematopoietic Stem Cell Markers
• Immune Regulatory Molecules on Endothelial Cells
• Mesenchymal Stem Cell Markers
• Monocyte Markers
• Preeclampsia
• TGF-beta Family
• TGF-beta Superfamily