Extracellular Matrix and Fibrosis Products

R&D Systems supports ECM research with a full line of recombinant proteins and antibodies as well as Tocris Bioscience peptides and small molecules. Our immunoassay selection includes Quantikine^® and DuoSet^® ELISA kits, ELISpot kits, Luminex^® assays, and Proteome Profiler^™ antibody arrays. We also provide stem cell and cell culture products to support your research. Learn More.

Recombinant Proteins

ADAM and ADAMTS Family

TGF-beta

Thrombospondins

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Quantikine^® and DuoSet^® ELISA Kits

FGF Proteins and Receptors

MMPs, TIMPs, and Complexes

PDGF Proteins and Receptors

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Antibodies

Hyaluronan and Binding Proteins

Proteoglycans

Serpin Family

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Multi-analyte Assays

Luminex^® High Performance Assays

Proteome Profiler^® Protease/Protease Inhibitor Array

Simple Plex Assays

 

Small Molecule Agonists and Antagonists

PDGF Receptor Inhibitors

Synthetic MMP Inhibitors

TGF-beta Receptor Inhibitors

Search all Small Molecules and Peptides

Cardiovascular Diagnostics

BiosPacific^™ IVD Assay Development

Cliniqa^® Chemistry Controls

 

Extracellular Matrix Literature and Resources

 

Brochures and Product Guides

Cardiovascular Research Product Guide

Products for Chemokine Research

Products for Glycobiology Research

Signal Transduction Antibody Reference Guide

 

Posters

Atherosclerosis Disease Progression

Microenvironmental Regulation of Tumor Growth & Metastasis

Periodic Table of Cytokine and Chemokine Families

The Complex Biology of Macrophages

 

References and Troubleshooting Guides

Articular Cartilage Extracellular Matrix Interactive Pathway

Chemokine Superfamily Pathway: Human/Mouse Ligand-Receptor Interactions

IHC/ICC Protocol Guide

Protocols/Troubleshooting Guides From Novus Biologicals^®

Protocols/Troubleshooting Guides From R&D Systems^®

TGF-beta Signaling Interactive Pathway

Background

The extracellular matrix (ECM) surrounding blood and lymphatic vessels provides a physical support for the vessels and serves as a reservoir for chemotactic and growth factors. It is composed of fibrous proteins such as Collagens, Fibronectin, and Laminins as well as matricellular molecules such as Fibulins and Matrilins. Increased deposition of matrix components during disease and wound healing can lead to their abnormal accumulation and fibrosis.