GSK-3 alpha Antibody (S07-3A2)

Name: GSK-3 alpha Antibody (S07-3A2)
Brand: Novus Biologicals
SKU: NBP3-15036
Price: 479 USD
Availability: InStock

Novus Biologicals | Catalog # NBP3-15036

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Product Documents

Recombinant Monoclonal Antibody

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S07-3A2 expressed in HEK293

View all GSK-3 alpha Primary Antibodies »

Product Specifications

Immunogen

A synthetic peptide of human GSK-3 alpha (Uniprot#: P49840)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

51 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for GSK-3 alpha Antibody (S07-3A2)

Western Blot: GSK-3 alpha Antibody (S07-3A2) [NBP3-15036]

Western Blot: GSK-3 alpha Antibody (S07-3A2) [NBP3-15036] - Western blot detection of GSK-3 alpha in K562, Rat Brain, Hela cell lysates using GSK-3 alpha Rabbit mAb (1:1000 diluted). Predicted band size: 51kDa. Observed band size: 51kDa.

Applications for GSK-3 alpha Antibody (S07-3A2)

Application

Recommended Usage

Western Blot

1/2000

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: GSK-3 alpha

Glycogen synthases kinase 3 alpha (GSK3-alpha) is a multifunctional Serine/Threonine protein kinase, one of two isoforms of GSK3 (1). Originally identified as a regulator of glycogen synthase, it has been shown to be involved in the hormonal control of several regulatory factors and transcription factors. GSK3-alpha activity is down regulated by phosphorylation on Serine 21 by PKB, or activated by phosphorylation on Tyrosine 279 (2). Insulin inactivates GSK3-alpha by rapid phosphorylation which leads to activation of Glycogen Synthase in the cells (3). GSK3-alpha activitiy has been linked to a pathogenic mechanism in Alzheimer's disease (4).

Long Name

Glycogen Synthase Kinase 3 alpha

Alternate Names

GSK3 alpha, GSK3A

Gene Symbol

GSK3A

Additional GSK-3 alpha Products

Product Documents for GSK-3 alpha Antibody (S07-3A2)

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Certificate of Analysis

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Product Specific Notices for GSK-3 alpha Antibody (S07-3A2)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.