Human ASAHL/N-acylethanolamine-hydrolyzing Acid A Antibody
Human ASAHL/N-acylethanolamine-hydrolyzing Acid A Antibody Summary
Accession # Q02083
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Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: ASAHL/N-acylethanolamine-hydrolyzing Acid Amidase
ASAHL (N-acylsphingosine-amidohydrolase-like; N acylethanolamine hydrolyzine acid amidase; also acid ceramidase like protein) is a 30 kDa member of the acid ceramidase family. It is a secreted lysosomal glycoprotein that cleaves fatty acid amides such as palmitoylethanolamine. Human ASAHL is synthesized as a 359 amino acid (aa) preproprecursor that contains a 28 aa signal sequence, a 96 aa prosegment, and a 30 31 kDa, 235 aa mature region that begins at Cys125. Multiple isoforms likely exist. One isoform shows a deletion of aa 324 359, while another has a two aa substitution for aa 198 359. The human proform (aa 29 359) is 78% aa identical to mouse ASAHL proform.
Citation for Human ASAHL/N-acylethanolamine-hydrolyzing Acid A Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
Ulcerative colitis impairs the acylethanolamide-based anti-inflammatory system reversal by 5-aminosalicylic acid and glucocorticoids.
Authors: Suarez J, Romero-Zerbo Y, Marquez L, Rivera P, Iglesias M, Bermudez-Silva FJ, Andreu M, Rodriguez de Fonseca F
PLoS ONE, 2012;7(5):e37729.
Sample Types: Tissue Homogenates
Applications: Western Blot
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