Human CCL13/MCP‑4 Biotinylated Antibody
Human CCL13/MCP‑4 Biotinylated Antibody Summary
Gln24-Thr98
Accession # Q99616
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Applications
Human CCL13/MCP-4 Sandwich Immunoassay
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CCL13/MCP-4
Human CCL13 is a CC chemokine recently cloned from a human fetal and a human heart cDNA library. Human CCL13 cDNA encodes a 98 amino acid residue precursor protein with a 23 amino acid residue hydrophobic signal peptide that is cleaved to yield an 8 kDa, 75 aa mature CCL13. Mature CCL13 lacks any potential N-glycosylation sites and shares a pyroglutamate proline motif with other human MCP proteins. Human CCL13 is most homologous to MCP-1, -3, and Eotaxin, exhibiting approximately 65-66% amino acid sequence identity. CCL13 mRNA is expressed by a number of activated cell types, including endothelial cells, macrophages, bronchial epithelium and type II alveolar cells, and perhaps lymphocytes. CCL13 is a chemoattractant for monocytes and eosinophils, and activates basophils. In addition, it has been reported to be chemotactic for CD4+ and CD8+ T cells, with an activity almost equivalent to that of MCP-3. The bioactivities of CCL13 is most likely mediated by the CC chemokine receptors CCR2 and CCR3, both of which have been shown to bind CCL13.
- Garcia-Zepeda, E.A. et al. (1996) J. Immunol. 157:5613.
- Uguccioni, M. et al. (1996) J. Exp. Med. 183:2379.
- Godisha, R. et al. (1997) J. Leukoc, Biol. 61:353.
- Stellato, C. et al. (1997) J. Clin. Invest. 99:926.
- Heath, H. et al. (1997) J. Clin. Invest. 99:178.
- Charo, I.F. et al. (1994) Proc. Natl. Acad. Sci. USA 91:2752.
- Daugherty, B.L. et al. (1996) J. Exp. Med. 183:2349.
- Combadiere, C. et al. (1995) J. Biol. Chem. 270:16491.
Product Datasheets
Citation for Human CCL13/MCP‑4 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
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Increased expression of Th2-associated chemokines in bullous pemphigoid disease. Role of eosinophils in the production and release of these chemokines.
Authors: Gounni Abdelilah S, Wellemans V, Agouli M, Guenounou M, Hamid Q, Beck LA, Lamkhioued B
Clin. Immunol., 2006;120(2):220-31.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Development
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