Human CCR7 Biotinylated Antibody
Human CCR7 Biotinylated Antibody Summary
Met1-Pro378
Accession # AAA58615
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of CCR7 in Human PBMCs by Flow Cytomtetry. Human peripheral blood mononuclear cells (PBMCs) were stained with PE-conjugated Mouse anti-Human CD4 Monoclonal Antibody (Catalog # FAB3791P) and either (A) Mouse anti-Human CCR7 Biotinylated Monoclonal Antibody (Catalog # FAB197B) or (B) Mouse IgG2A isotype control antibody (Catalog # IC003B) followed by APC-conjugated Streptavidin (Catalog # F0040). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: CCR7
CCR7 (Chemokine Receptor 7; also CD197) is a 7 transmembrane (7TM) G protein-coupled chemokine receptor for the homeostatic chemokines CCL19/MIP-3 beta and CCL21/6Ckine. CCL19 and CCL21 are constitutively expressed by high endothelial venule epithelial cells or fibroblastic reticular cells in secondary lymphoid organs. CCR7 is upregulated on dendritic cells, naïve and memory T cells, Treg, NK cells, and B cells following inflammatory stimulation. Its expression enables the function of immune cell trafficking to and retention in regional lymph nodes for expansion of the adaptive immune response. Human CCR7 shares 87% amino acid sequence identity with mouse CCR7.
Product Datasheets
Citation for Human CCR7 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
1 Citation: Showing 1 - 1
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Interleukin-15 response signature predicts RhCMV/SIV vaccine efficacy
Authors: F Barrenäs, SG Hansen, L Law, C Driscoll, RR Green, E Smith, J Chang, I Golez, T Urion, X Peng, L Whitmore, D Newhouse, CM Hughes, D Morrow, KT Randall, AN Selseth, JC Ford, RM Gilbride, BE Randall, E Ainslie, K Oswald, R Shoemaker, R Fast, WJ Bosche, MK Axthelm, Y Fukazawa, GN Pavlakis, BK Felber, S Fourati, RP Sekaly, JD Lifson, J Komorowski, E Kosmider, D Shao, W Song, PT Edlefsen, LJ Picker, M Gale
PloS Pathogens, 2021;17(7):e1009278.
Species: Rhesus Macaque
Sample Types: Whole Cells
Applications: Flow Cytometry
FAQs
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