Human CD44v4/5 Antibody
Human CD44v4/5 Antibody Summary
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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CD44 in Human PBMCs. CD44 was detected in immersion fixed human peripheral blood mononuclear cells (PBMCs) using 8 µg/mL Mouse Anti-Human CD44 v4/5 Monoclonal Antibody (Catalog # BBA25) for 3 hours at room temperature. Cells were stained (red) and counterstained (green). View our protocol for Fluorescent ICC Staining of Non-adherent Cells.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: CD44
CD44 is a ubiquitously expressed protein that is the major receptor for hyaluronan and exerts control over cell growth and migration (1‑3). Human CD44 has a 20 amino acid (aa) signal sequence, an extracellular domain (ECD) with a 100 aa hyaluronan-binding disulfide-stabilized link region and a 325‑530 aa stem region, a 21 aa transmembrane domain, and a 72 aa cytoplasmic domain. Within the stem, ten variably spliced exons (v1‑10, exons 6‑15) produce multiple protein isoforms
(1‑3). The standard or hematopoietic form, CD44H, does not include the variable segments (1‑3). Cancer aggressiveness and T cell activation have been correlated with expression of specific isoforms (1, 3). With variable N- and O-glycosylation and splicing within the stalk, CD44 can range from 80 to 200 kDa (1). Within the
N‑terminal invariant portion of the ECD (aa 21‑220), human CD44 shares 76%, 76%, 86%, 83% and 79% identity with corresponding mouse, rat, equine, canine and bovine CD44, respectively. The many reported functions of CD44 fall within three categories (1). First, CD44 binds hyaluronan and other ligands within the extracellular matrix and can function as a “platform” for growth factors and metalloproteinases. Second, CD44 can function as a co-receptor that modifies activity of receptors including MET and the ERBB family of tyrosine kinases. Third, the CD44 intracellular domain links the plasma membrane to the actin cytoskeleton via the ERM proteins, ezrin, radixin and moesin. CD44 can be synthesized in a soluble form (4) or may be cleaved at multiple sites by either membrane-type matrix metalloproteinases, or ADAM proteases to produce soluble ectodomains (5, 6). The cellular portion may then undergo gamma secretase-dependent intramembrane cleavage to form an A beta -like transmembrane portion and a cytoplasmic signaling portion that affects gene expression (7, 8). These cleavage events are thought to promote metastasis by enhancing tumor cell motility and growth (1, 5).
- Ponta, H. et al. (2003) Nat. Rev. Mol. Cell Biol. 4:33.
- Screaton, G.R. et al. (1992) Proc. Natl. Acad. Sci. USA 89:12160.
- Lynch, K.W. (2004) Nat. Rev. Immunol. 4:931.
- Yu, Q. and B.P. Toole (1996) J. Biol. Chem. 271:20603.
- Nagano, O. and H. Saya (2004) Cancer Sci. 95:930.
- Nakamura, H. et al. (2004) Cancer Res. 64:876.
- Murakami, D. et al. (2003) Oncogene 22:1511.
- Lammich, S. et al. (2002) J. Biol. Chem. 277:44754.
- Fox, S.B. et al. (1994) Cancer Res. 54:4539.
Product Datasheets
Citations for Human CD44v4/5 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Peptidoglycan from Bacillus anthracis Inhibits Human Macrophage Efferocytosis in Part by Reducing Cell Surface Expression of MERTK and TIM-3
Authors: JS Mytych, Z Pan, C Lopez-Davi, N Redinger, C Lawrence, J Ziegler, N Popescu, JA James, AD Farris
bioRxiv : the preprint server for biology, 2023-05-10;0(0):.
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sFlt-1-enriched exosomes induced endothelial cell dysfunction and a preeclampsia-like phenotype in mice
Authors: X Huang, L Jia, Y Jia, X Xu, R Wang, M Wei, H Li, H Peng, Y Wei, Q He, K Wang
Cytokine, 2023-04-14;166(0):156190.
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ITK signaling regulates a switch between T helper 17 and T regulatory cell lineages via a calcium-mediated pathway
Authors: O Anannya, W Huang, A August
bioRxiv : the preprint server for biology, 2023-04-03;0(0):.
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Single cell analysis in head and neck cancer reveals potential immune evasion mechanisms during early metastasis
Authors: HS Quah, EY Cao, L Suteja, CH Li, HS Leong, FT Chong, S Gupta, C Arcinas, JF Ouyang, V Ang, T Celhar, Y Zhao, HC Tay, J Chan, T Takahashi, DSW Tan, SK Biswas, OJL Rackham, NG Iyer
Nature Communications, 2023-03-27;14(1):1680.
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Development of Electrochemical Immunosensors for HER-1 and HER-2 Analysis in Serum for Breast Cancer Patients
Authors: S Wignarajah, I Chianella, IE Tothill
Biosensors, 2023-03-07;13(3):.
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UCHL1, besides leptin and fibronectin, also could be a sensitive marker of the relapsing-remitting type of multiple sclerosis
Authors: E Górska, M Tylicka, A Hermanowic, E Matuszczak, A Sankiewicz, E Gorodkiewi, J Hermanowic, E Karpi?ska, K Socha, J Kochanowic, M Jakoniuk, J Kami?ska, E Homšak, OM Koper-Lenk
Scientific Reports, 2023-02-28;13(1):3423.
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Metabolic Reprogramming of Macrophages upon In Vitro Incubation with Aluminum-Based Adjuvant
Authors: R Danielsson, N Ferey, I Mile, H Eriksson
International Journal of Molecular Sciences, 2023-02-23;24(5):.
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Selective inhibition of HDAC6 promotes bladder cancer radiosensitization and mitigates the radiation-induced CXCL1 signalling
Authors: YC Tsai, TY Wang, CL Hsu, WC Lin, JY Chen, JH Li, YS Pu, AL Cheng, JC Cheng, SF Su
British Journal of Cancer, 2023-02-21;0(0):.
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Identification of cell-biologic mechanisms of coronary artery spasm and its ex vivo diagnosis using peripheral blood-derived iPSCs
Authors: HM Yang, JE Lee, JY Kim, J You, J Kim, HS Lee, HM Yoo, MG Kong, JK Han, HJ Cho, KW Park, HJ Kang, BK Koo, YB Park, HS Kim
Biomaterials research, 2023-02-18;27(1):16.
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Platelet-instructed SPP1+ macrophages drive myofibroblast activation in fibrosis in a CXCL4-dependent manner
Authors: K Hoeft, GJL Schaefer, H Kim, D Schumacher, T Bleckwehl, Q Long, BM Klinkhamme, F Peisker, L Koch, J Nagai, M Halder, S Ziegler, E Liehn, C Kuppe, J Kranz, S Menzel, I Costa, A Wahida, P Boor, RK Schneider, S Hayat, R Kramann
Cell Reports, 2023-02-17;42(2):112131.
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Oral squamous cell carcinoma cell-derived GM-CSF regulates PD-L1 expression in tumor-associated macrophages through the JAK2/STAT3 signaling pathway
Authors: P Wang, L Tao, Y Yu, Q Wang, P Ye, Y Sun, J Zhou
American journal of cancer research, 2023-02-15;13(2):589-601.
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Memory Precursors and Short-Lived Effector T cell Subsets Have Different Sensitivities to TGFbeta
Authors: JA O'Sullivan, FJ Kohlhapp, A Zloza, L Plaza-Roja, B Burke, NO Dulin, JA Guevara-Pa
International Journal of Molecular Sciences, 2023-02-15;24(4):.
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Exosome-Based Delivery of Super-Repressor IkappaBalpha Alleviates Alcohol-Associated Liver Injury in Mice
Authors: HH Kim, YR Shim, SE Choi, TE Falana, JK Yoo, SH Ahn, M Park, H Seo, C Choi, WI Jeong
Pharmaceutics, 2023-02-14;15(2):.
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Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cells
Authors: F Parween, SP Singh, HH Zhang, N Kathuria, FA Otaizo-Car, A Shamsaddin, PJ Gardina, S Ganesan, J Kabat, HA Lorenzi, TG Myers, JM Farber
bioRxiv : the preprint server for biology, 2023-02-13;0(0):.
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Downregulation of miR-137 Facilitates CD4+ T Cell Pyroptosis in Systemic Lupus Erythematosus via Stimulating AMPK Pathway
Authors: A Gong, L Mi, F Wei, Y Zhuang, Y Song, C Pan, X Zhang, G Lin, Z Wu, Y Liu
Journal of Immunology Research, 2023-02-09;2023(0):1241774.
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Elevated fatty acid beta-oxidation by leptin contributes to the proinflammatory characteristics of fibroblast-like synoviocytes from RA patients via LKB1-AMPK pathway
Authors: J Wei, X Huang, X Zhang, G Chen, C Zhang, X Zhou, J Qi, Y Zhang, X Li
Cell Death & Disease, 2023-02-09;14(2):97.
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Myeloid cells protect corneal nerves against sterile injury through negative-feedback regulation of TLR2-IL-6 axis
Authors: HJ Lee, HJ Kim, JH Ko, JY Oh
Journal of Neuroinflammation, 2023-02-07;20(1):27.
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Co-Treatment with Human Leukocyte Extract and Albendazole Stimulates Drug's Efficacy and Th1 Biased Immune Response in Mesocestoides vogae (Cestoda) Infection via Modulation of Transcription Factors, Macrophage Polarization, and Cytokine Profiles
Authors: G Hr?ková, T Ma?ak Kuba, D Mudro?ová, Z Jur?acková, D Ciglanová
Pharmaceutics, 2023-02-06;15(2):.
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Heparin is essential for optimal cell signaling by FGF21 and for regulation of betaKlotho cellular stability
Authors: SJ An, J Mohanty, F Tome, Y Suzuki, I Lax, J Schlessing
Proceedings of the National Academy of Sciences of the United States of America, 2023-02-06;120(7):e2219128120.
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Conjugated Bile Acids Promote Lymphangiogenesis by Modulation of the Reactive Oxygen Species-p90RSK-Vascular Endothelial Growth Factor Receptor 3 Pathway
Authors: P Banerjee, S Kumaravel, S Roy, N Gaddam, J Odeh, KJ Bayless, S Glaser, S Chakrabort
Cells, 2023-02-06;12(4):.
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Cancer stem cell-derived extracellular vesicles preferentially target MHC-II-macrophages and PD1+ T cells in the tumor microenvironment
Authors: P Gonzalez-C, Z Guo, T Ziglari, NM Claudio, KH Nguyen, N Oshimori, J Seras-Fran, F Pucci
PLoS ONE, 2023-02-03;18(2):e0279400.
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Redox-dependent Igfbp2 signaling controls Brca1 DNA damage response to govern neural stem cell fate
Authors: WS Shahin, SO Ebed, SR Tyler, B Miljkovic, SH Choi, Y Zhang, W Zhou, IA Evans, C Yeaman, JF Engelhardt
Nature Communications, 2023-01-27;14(1):444.
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Tissue CD14+CD8+ T cells reprogrammed by myeloid cells and modulated by LPS
Authors: LJ Pallett, L Swadling, M Diniz, AA Maini, M Schwabenla, AD Gasull, J Davies, S Kucykowicz, JK Skelton, N Thomas, NM Schmidt, OE Amin, US Gill, KA Stegmann, AR Burton, E Stephenson, G Reynolds, M Whelan, J Sanchez, R de Maeyer, C Thakker, K Suveizdyte, I Uddin, AM Ortega-Pri, C Grant, F Froghi, G Fusai, S Lens, S Pérez-Del-, W Al-Akkad, G Mazza, M Noursadegh, A Akbar, PTF Kennedy, BR Davidson, M Prinz, BM Chain, M Haniffa, DW Gilroy, M Dorner, B Bengsch, A Schurich, MK Maini
Nature, 2023-01-25;614(7947):334-342.
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Polyamine metabolism impacts T cell dysfunction in the oral mucosa of people living with HIV
Authors: SS Mahalingam, S Jayaraman, N Bhaskaran, E Schneider, F Faddoul, A Paes da Si, MM Lederman, R Asaad, K Adkins-Tra, LP Shriver, P Pandiyan
Nature Communications, 2023-01-25;14(1):399.
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Endogenous inflammatory mediators produced by injury activate TRPV1 and TRPA1 nociceptors to induce sexually dimorphic cold pain that is dependent on TRPM8 and GFRalpha3
Authors: C Yang, S Yamaki, T Jung, B Kim, R Huyhn, DD McKemy
bioRxiv : the preprint server for biology, 2023-01-23;0(0):.
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Autofluorescence lifetime imaging classifies human lymphocyte activation and subtype
Authors: RL Schmitz, KE Tweed, P Rehani, K Samimi, J Riendeau, I Jones, EM Maly, EC Guzman, MH Forsberg, A Shahi, CM Capitini, AJ Walsh, MC Skala
bioRxiv : the preprint server for biology, 2023-01-23;0(0):.
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Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function
Authors: Z Su, J Brooks, J Pelker, T Andreyeva, H Sobon, R Gifford, M Powers, J Wang, C Dower, M Hegen, D Messing, AD Sheehan, JJ Brennan
PLoS ONE, 2023-01-20;18(1):e0280590.
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Sensory nerve niche regulates mesenchymal stem cell homeostasis via FGF/mTOR/autophagy axis
Authors: F Pei, L Ma, J Jing, J Feng, Y Yuan, T Guo, X Han, TV Ho, J Lei, J He, M Zhang, JF Chen, Y Chai
Nature Communications, 2023-01-20;14(1):344.
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Mammalian Glycosylation Patterns Protect Citrullinated Chemokine MCP-1/CCL2 from Partial Degradation
Authors: O Korchynsky, K Yoshida, N Korchynska, J Czarnik-Kw, PP Tak, GJM Pruijn, T Isozaki, JH Ruth, PL Campbell, MA Amin, AE Koch
International Journal of Molecular Sciences, 2023-01-18;24(3):.
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Conventional Type I Migratory CD103+ Dendritic Cells are Required for Corneal Allograft Survival
Authors: T Blanco, R Bir Singh, H Nakagawa, Y Taketani, TH Dohlman, Y Chen, SK Chauhan, J Yin, R Danan
Mucosal Immunology, 2023-01-13;0(0):.
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DR5 Up-Regulation Induced by Dichloroacetate Sensitizes Tumor Cells to Lipid Nanoparticles Decorated with TRAIL
Authors: J Marco-Brua, D de Miguel, L Martínez-L, A Anel
Journal of Clinical Medicine, 2023-01-12;12(2):.
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DNA dioxygenases Tet2/3 regulate gene promoter accessibility and chromatin topology in lineage-specific loci to control epithelial differentiation
Authors: GD Chen, I Fatima, Q Xu, E Rozhkova, MY Fessing, AN Mardaryev, AA Sharov, GL Xu, VA Botchkarev
Science Advances, 2023-01-11;9(2):eabo7605.
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Culture impact on the transcriptomic programs of primary and iPSC-derived human alveolar type 2 cells
Authors: KD Alysandrat, C Garcia-de-, C Yao, P Pessina, J Huang, C Villacorta, OT Hix, K Minakin, CL Burgess, P Bawa, A Murthy, B Konda, MF Beers, BR Stripp, CF Kim, DN Kotton
JCI Insight, 2023-01-10;0(0):.
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Arachidin-1, a Prenylated Stilbenoid from Peanut, Enhances the Anticancer Effects of Paclitaxel in Triple-Negative Breast Cancer Cells
Authors: S Mohammadho, A Weaver, M Sudhakaran, LC Ho, T Le, AI Doseff, F Medina-Bol
Cancers, 2023-01-07;15(2):.
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PD-L2 Blockade Exacerbates Liver Lesion in Mice Infected with Capillaria hepatica through Reducing Alternatively Activated Macrophages
Authors: M Huang, X Li, X Zheng, F Wang, Y Zou, L Wang
Tropical medicine and infectious disease, 2023-01-06;8(1):.
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Heat Shock Protein 27 Is Involved in the Bioactive Glass Induced Osteogenic Response of Human Mesenchymal Stem Cells
Authors: L Hyväri, S Vanhatupa, M Ojansivu, M Kelloniemi, TK Pakarinen, L Hupa, S Miettinen
Cells, 2023-01-05;12(2):.
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Studies with neutralizing antibodies suggest CXCL8-mediated neutrophil activation is independent of C-C motif chemokine receptor-like 2 (CCRL2) ligand binding function
Authors: Z Su, J Brooks, J Pelker, T Andreyeva, H Sobon, R Gifford, M Powers, J Wang, C Dower, M Hegen, D Messing, AD Sheehan, JJ Brennan
PLoS ONE, 2023;18(1):e0280590.
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Arachidin-1, a Prenylated Stilbenoid from Peanut, Enhances the Anticancer Effects of Paclitaxel in Triple-Negative Breast Cancer Cells
Authors: S Mohammadho, A Weaver, M Sudhakaran, LC Ho, T Le, AI Doseff, F Medina-Bol
Cancers, 2023;15(2):.
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Oral squamous cell carcinoma cell-derived GM-CSF regulates PD-L1 expression in tumor-associated macrophages through the JAK2/STAT3 signaling pathway
Authors: P Wang, L Tao, Y Yu, Q Wang, P Ye, Y Sun, J Zhou
American journal of cancer research, 2023;13(2):589-601.
-
Identification of cell-biologic mechanisms of coronary artery spasm and its ex vivo diagnosis using peripheral blood-derived iPSCs
Authors: HM Yang, JE Lee, JY Kim, J You, J Kim, HS Lee, HM Yoo, MG Kong, JK Han, HJ Cho, KW Park, HJ Kang, BK Koo, YB Park, HS Kim
Biomaterials research, 2023;27(1):16.
-
Exosome-Based Delivery of Super-Repressor IkappaBalpha Alleviates Alcohol-Associated Liver Injury in Mice
Authors: HH Kim, YR Shim, SE Choi, TE Falana, JK Yoo, SH Ahn, M Park, H Seo, C Choi, WI Jeong
Pharmaceutics, 2023;15(2):.
-
Conventional Type I Migratory CD103+ Dendritic Cells are Required for Corneal Allograft Survival
Authors: T Blanco, R Bir Singh, H Nakagawa, Y Taketani, TH Dohlman, Y Chen, SK Chauhan, J Yin, R Danan
Mucosal Immunology, 2023;0(0):.
-
DR5 Up-Regulation Induced by Dichloroacetate Sensitizes Tumor Cells to Lipid Nanoparticles Decorated with TRAIL
Authors: J Marco-Brua, D de Miguel, L Martínez-L, A Anel
Journal of Clinical Medicine, 2023;12(2):.
-
Myeloid cells protect corneal nerves against sterile injury through negative-feedback regulation of TLR2-IL-6 axis
Authors: HJ Lee, HJ Kim, JH Ko, JY Oh
Journal of Neuroinflammation, 2023;20(1):27.
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A culture model to analyze the acute biomaterial-dependent reaction of human primary neutrophils in vitro
Authors: MA Wesdorp, A Schwab, EI Bektas, R Narcisi, D Eglin, MJ Stoddart, GJVM Van Osch, M D'Este
Oncogene, 2023;20(0):627-637.
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Conjugated Bile Acids Promote Lymphangiogenesis by Modulation of the Reactive Oxygen Species-p90RSK-Vascular Endothelial Growth Factor Receptor 3 Pathway
Authors: P Banerjee, S Kumaravel, S Roy, N Gaddam, J Odeh, KJ Bayless, S Glaser, S Chakrabort
Cells, 2023;12(4):.
-
Co-Treatment with Human Leukocyte Extract and Albendazole Stimulates Drug's Efficacy and Th1 Biased Immune Response in Mesocestoides vogae (Cestoda) Infection via Modulation of Transcription Factors, Macrophage Polarization, and Cytokine Profiles
Authors: G Hr?ková, T Ma?ak Kuba, D Mudro?ová, Z Jur?acková, D Ciglanová
Pharmaceutics, 2023;15(2):.
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Progranulin from different gliocytes in the nucleus accumbens exerts distinct roles in FTD- and neuroinflammation-induced depression-like behaviors
Authors: J Wang, S Lai, T Zhou, Z Xia, W Li, W Sha, J Liu, Y Chen
Journal of Neuroinflammation, 2022-12-29;19(1):318.
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Role of intracortical neuropil growth in the gyrification of the primate cerebral cortex
Authors: BG Rash, JI Arellano, A Duque, P Rakic
Proceedings of the National Academy of Sciences of the United States of America, 2022-12-27;120(1):e2210967120.
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RNF213 Loss-of-Function Promotes Angiogenesis of Cerebral Microvascular Endothelial Cells in a Cellular State Dependent Manner
Authors: V Roy, A Brodeur, L Touzel Des, N Dupré, F Gros-Louis
Cells, 2022-12-24;12(1):.
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Eosinophil-derived IL-4 is necessary to establish the inflammatory structure in innate inflammation
Authors: A Kolbinger, TJ Schäufele, H Steigerwal, J Friedel, S Pierre, G Geisslinge, K Scholich
Embo Molecular Medicine, 2022-12-21;0(0):e16796.
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Engineering of immunoinstructive extracellular matrices for enhanced osteoinductivity
Authors: A García-Gar, S Pigeot, I Martin
Bioactive materials, 2022-12-21;24(0):174-184.
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The Influence of Severity and Disease Duration on TNF Receptors' Redistribution in Asthma and Rheumatoid Arthritis
Authors: A Alshevskay, J Lopatnikov, J Zhukova, O Chumasova, N Shkaruba, A Sizikov, I Evsegneeva, D Demina, V Nepomniash, A Karaulov, S Sennikov
Cells, 2022-12-20;12(1):.
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Deteriorative Effects of Radiation Injury Combined with Skin Wounding in a Mouse Model
Authors: L Wang, B Lin, M Zhai, W Cui, L Hull, A Zizzo, X Li, JG Kiang, M Xiao
Toxics, 2022-12-14;10(12):.
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Direct thrombin inhibitors as alternatives to heparin to preserve lung growth and function in a murine model of compensatory lung growth
Authors: ST Tsikis, TI Hirsch, SC Fligor, A Pan, MM Joiner, A Devietro, PD Mitchell, H Kishikawa, KM Gura, M Puder
Scientific Reports, 2022-12-07;12(1):21117.
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Mitochondrial PARP1 regulates NAD+-dependent poly ADP-ribosylation of mitochondrial nucleoids
Authors: JH Lee, M Hussain, EW Kim, SJ Cheng, AKL Leung, NB Fakouri, DL Croteau, VA Bohr
Experimental & Molecular Medicine, 2022-12-06;0(0):.
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Effect of exogenous IL-37 on immune cells from a patient carrying a potential IL37 loss-of-function variant: A case study
Authors: LU Teufel, CI van der Ma, V Klück, A Simons, A Hoischen, V Vernimmen, LAB Joosten, RJW Arts
Cytokine, 2022-12-05;162(0):156102.
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AXL and MET Tyrosine Kinase Receptors Co-Expression as a Potential Therapeutic Target in Malignant Pleural Mesothelioma
Authors: F Zito Marin, CM Della Cort, V Ciaramella, S Erra, A Ronchi, A Fiorelli, G Vicidomini, M Santini, G Scognamigl, F Morgillo, F Ciardiello, R Franco, M Accardo
Journal of personalized medicine, 2022-12-02;12(12):.
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Ras drives malignancy through stem cell crosstalk with the microenvironment
Authors: S Yuan, KS Stewart, Y Yang, MD Abdusselam, SM Parigi, TY Feinberg, K Tumaneng, H Yang, JM Levorse, L Polak, D Ng, E Fuchs
Nature, 2022-11-30;0(0):.
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Cell Type-Specific Metabolic Response to Amino Acid Starvation Dictates the Role of Sestrin2 in Regulation of mTORC1
Authors: B Blagojevic, F Almouhanna, G Poschet, S Wölfl
Cells, 2022-11-30;11(23):.
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CLEC-1 is a death sensor that limits antigen cross-presentation by dendritic cells and represents a target for cancer immunotherapy
Authors: M Drouin, J Saenz, V Gauttier, B Evrard, G Teppaz, S Pengam, C Mary, A Desselle, V Thepenier, E Wilhelm, E Merieau, C Ligeron, I Girault, MD Lopez, C Fourgeux, D Sinha, I Baccelli, A Moreau, C Louvet, R Josien, J Poschmann, N Poirier, E Chiffoleau
Science Advances, 2022-11-18;8(46):eabo7621.
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Cbln1 regulates axon growth and guidance in multiple neural regions
Authors: P Han, Y She, Z Yang, M Zhuang, Q Wang, X Luo, C Yin, J Zhu, SR Jaffrey, SJ Ji
PloS Biology, 2022-11-17;20(11):e3001853.
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Medin co-aggregates with vascular amyloid-beta in Alzheimer's disease
Authors: J Wagner, K Degenhardt, M Veit, N Louros, K Konstantou, A Skodras, K Wild, P Liu, U Obermüller, V Bansal, A Dalmia, LM Häsler, M Lambert, M De Vleesch, HA Davies, J Madine, D Kronenberg, R Feederle, D Del Turco, KPR Nilsson, T Lashley, T Deller, M Gearing, LC Walker, P Heutink, F Rousseau, J Schymkowit, M Jucker, JJ Neher
Nature, 2022-11-16;0(0):.
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CD206<sup>+</sup>CD68<sup>+</sup> mono-macrophages and serum soluble CD206 level are increased in antineutrophil cytoplasmic antibodies associated glomerulonephritis
Authors: XN An, ZN Wei, YY Xie, J Xu, Y Shen, LY Ni, H Shi, PY Shen, W Zhang, YX Chen
BMC immunology, 2022-11-15;23(1):55.
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IL-33 Induces an Antiviral Signature in Mast Cells but Enhances Their Permissiveness for Human Rhinovirus Infection
Authors: C Akoto, A Willis, CF Banas, JA Bell, D Bryant, C Blume, DE Davies, EJ Swindle
Viruses, 2022-11-01;14(11):.
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A Novel P53 Nanomedicine Reduces Immunosuppression and Augments Anti-PD-1 Therapy for Non-Small Cell Lung Cancer in Syngeneic Mouse Models
Authors: SS Kim, JB Harford, M Moghe, C Doherty, EH Chang
Cells, 2022-10-31;11(21):.
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Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity
Authors: AG Yates, E Kislitsyna, C Alfonso Ma, J Zhang, AL Sewell, A Goikolea-V, V Cai, LF Alkhader, A Skaland, B Hammond, R Dimitrova, D Batalle, C Fernandes, AD Edwards, P Gressens, C Thornton, HB Stolp
Journal of Neuroinflammation, 2022-10-29;19(1):265.
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Osteopontin Exacerbates High-Fat Diet-Induced Metabolic Disorders in a Microbiome-Dependent Manner
Authors: J Chen, P Zeng, L Gong, X Zhang, Z Ling, K Bi, F Shi, K Wang, Q Zhang, J Jiang, Y Zhang, T Uede, EM El-Omar, H Diao
MBio, 2022-10-27;0(0):e0253122.
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Evasion of cGAS and TRIM5 defines pandemic HIV
Authors: L Zuliani-Al, ML Govasli, J Rasaiyaah, C Monit, SO Perry, RP Sumner, S McAlpine-S, C Dickson, KM Rifat Fays, L Hilditch, RJ Miles, F Bibollet-R, BH Hahn, T Boecking, N Pinotsis, LC James, DA Jacques, GJ Towers
Nature Microbiology, 2022-10-26;7(11):1762-1776.
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The Vi Capsular Polysaccharide of Salmonella Typhi Promotes Macrophage Phagocytosis by Binding the Human C-Type Lectin DC-SIGN
Authors: LF Zhang, B Lepenies, S Nakamae, BM Young, RL Santos, M Raffatellu, BA Cobb, H Hiyoshi, AJ Bäumler
MBio, 2022-10-26;0(0):e0273322.
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S100A8-mediated metabolic adaptation controls HIV-1 persistence in macrophages in vivo
Authors: F Real, A Zhu, B Huang, A Belmellat, A Sennepin, T Vogl, C Ransy, M Revol, R Arrigucci, A Lombès, J Roth, ML Gennaro, F Bouillaud, S Cristofari, M Bomsel
Nature Communications, 2022-10-11;13(1):5956.
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Development of the Novel Bifunctional Fusion Protein BR102 That Simultaneously Targets PD-L1 and TGF-beta for Anticancer Immunotherapy
Authors: ZH Wu, N Li, ZZ Gao, G Chen, L Nie, YQ Zhou, MZ Jiang, Y Chen, J Chen, XF Mei, F Hu, HB Wang
Cancers, 2022-10-10;14(19):.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Capture -
M1 macrophages evoke an increase in polymeric immunoglobulin receptor (PIGR) expression in MDA-MB468 breast cancer cells through secretion of interleukin-1beta
Authors: W Asanprakit, DN Lobo, O Eremin, AJ Bennett
Scientific Reports, 2022-10-07;12(1):16842.
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Dual-Function Semaphorin 4D Released by Platelets: Suppression of Osteoblastogenesis and Promotion of Osteoclastogenesis
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International Journal of Molecular Sciences, 2022-03-09;23(6):.
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MicroRNA-129-1-3p Represses the Progression of Triple-Negative Breast Cancer by Targeting the GRIN2D Gene
Authors: Q Li, Z Gu, Q Tan, L Ren, S Chen
BioMed Research International, 2022-03-07;2022(0):1549357.
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Transitional premonocytes emerge in the periphery for host defense against bacterial infections
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Science Advances, 2022-03-04;8(9):eabj4641.
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Dickkopf-1 Promotes Angiogenesis and is a Biomarker for Hepatic Stem Cell-like Hepatocellular Carcinoma
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International Journal of Molecular Sciences, 2022-03-03;23(5):.
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Immunoregulatory effects of Lactococcus lactis-derived extracellular vesicles in allergic asthma
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Clinical and translational allergy, 2022-03-01;12(3):e12138.
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Cloning of the Human MORG1 Promoter: Differential Regulation by Hypoxia and Prolyl-Hydroxylase Inhibitors
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Fatty acids secreted from head and neck cancer induce M2-like Macrophages
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Journal of leukocyte biology, 2022-02-25;0(0):.
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The Platelet Collagen Receptor GPVI Is Cleaved by Tspan15/ADAM10 and Tspan33/ADAM10 Molecular Scissors
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Vitamin D3 Stimulates Proliferation Capacity, Expression of Pluripotency Markers, and Osteogenesis of Human Bone Marrow Mesenchymal Stromal/Stem Cells, Partly through SIRT1 Signaling
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Biomolecules, 2022-02-18;12(2):.
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Antibody-Drug Conjugate Targeting c-Kit for the Treatment of Small Cell Lung Cancer
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International Journal of Molecular Sciences, 2022-02-18;23(4):.
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The Modulatory Effects of DMF on Microglia in Aged Mice Are Sex-Specific
Authors: V Mela, A Sayd Gaban, E O'Neill, S Bechet, A Walsh, MA Lynch
Cells, 2022-02-18;11(4):.
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Kidney Injury in COVID-19: Epidemiology, Molecular Mechanisms and Potential Therapeutic Targets
Authors: JP Teixeira, S Barone, K Zahedi, M Soleimani
International Journal of Molecular Sciences, 2022-02-17;23(4):.
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Molecular Mechanisms Underlying the Cellular Entry and Host Range Restriction of Lujo Virus
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MBio, 2022-02-15;0(0):e0306021.
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Chemokine (C-C Motif) Ligand 8 and Tubulo-Interstitial Injury in Chronic Kidney Disease
Authors: J Lee, Y Lee, KH Kim, DK Kim, KW Joo, SJ Shin, YS Kim, SH Yang
Cells, 2022-02-14;11(4):.
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Interleukin 33-mediated inhibition of A-type K+ channels induces sensory neuronal hyperexcitability and nociceptive behaviors in mice
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Theranostics, 2022-02-14;12(5):2232-2247.
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The Nephrotoxin Puromycin Aminonucleoside Induces Injury in Kidney Organoids Differentiated from Induced Pluripotent Stem Cells
Authors: L Nguyen, W Wruck, L Erichsen, N Graffmann, J Adjaye
Cells, 2022-02-11;11(4):.
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Pulmonary vascular inflammation with fatal coronavirus disease 2019 (COVID-19): possible role for the NLRP3 inflammasome
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Respiratory Research, 2022-02-10;23(1):25.
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ADAM8 signaling drives neutrophil migration and ARDS severity
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JCI Insight, 2022-02-08;7(3):.
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Modeling axonal regeneration by changing cytoskeletal dynamics in stem cell-derived motor nerve organoids
Authors: WM Seo, J Yoon, JH Lee, Y Lee, H Lee, D Geum, W Sun, MR Song
Scientific Reports, 2022-02-08;12(1):2082.
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Gas6 induces inflammation and reduces plaque burden but worsens behavior in a sex-dependent manner in the APP/PS1 model of Alzheimer's disease
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Journal of Neuroinflammation, 2022-02-07;19(1):38.
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Induction of osteogenesis by bone-targeted Notch activation
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Elife, 2022-02-04;11(0):.
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Anti-Inflammatory Activity of Orally Administered Monostroma nitidum Rhamnan Sulfate against Lipopolysaccharide-Induced Damage to Mouse Organs and Vascular Endothelium
Authors: M Terasawa, K Hiramoto, R Uchida, K Suzuki
Marine Drugs, 2022-02-03;20(2):.
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Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-beta/Wnt3a Is Mediated by GLI2 Upregulation
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Cells, 2022-02-03;11(3):.
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Inflammation Promotes Oxidative and Nitrosative Stress in Chronic Myelogenous Leukemia
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Biomolecules, 2022-02-03;12(2):.
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Human olfactory mesenchymal stromal cell transplantation ameliorates experimental autoimmune encephalomyelitis revealing an inhibitory role for IL16 on myelination
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Acta neuropathologica communications, 2022-01-29;10(1):12.
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Impact of Adalimumab Treatment on Interleukin-17 and Interleukin-17 Receptor Expression in Skin and Synovium of Psoriatic Arthritis Patients with Mild Psoriasis
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Biomedicines, 2022-01-29;10(2):.
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Novel patient-derived models of DSRCT enable validation of ERBB signaling as a potential therapeutic vulnerability
Authors: RS Smith, I Odintsov, Z Liu, AJ Lui, T Hayashi, M Vojnic, Y Suehara, L Delasos, MS Mattar, J Hmeljak, HA Ramirez, M Shaw, G Bui, AB Hartono, E Gladstone, S Kunte, H Magnan, I Khodos, E De Stanchi, MP La Quaglia, J Yao, M Laé, SB Lee, L Spraggon, CA Pratilas, M Ladanyi, R Somwar
Disease Models & Mechanisms, 2022-01-27;0(0):.
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Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1beta to downregulate PPARalpha and FOXO3
Authors: Y Li, Y Zhu, S Feng, Y Ishida, TP Chiu, T Saito, S Wang, DK Ann, JJ Ou
Cell Reports, 2022-01-25;38(4):110284.
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Neuropilin-1 mediates lung tissue-specific control of ILC2 function in type 2 immunity
Authors: J Zhang, J Qiu, W Zhou, J Cao, X Hu, W Mi, B Su, B He, J Qiu, L Shen
Nature Immunology, 2022-01-24;0(0):.
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LncCDH5-3:3 Regulates Apoptosis, Proliferation, and Aggressiveness in Human Lung Cancer Cells
Authors: K Kwa?niak, J Czarnik-Kw, K Malysheva, K Pogoda, O Korchynsky, P Rybojad, B Karczmarek, J Tabarkiewi
Cells, 2022-01-23;11(3):.
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Arachidin-1, a Prenylated Stilbenoid from Peanut, Induces Apoptosis in Triple-Negative Breast Cancer Cells
Authors: S Mohammadho, LC Ho, L Fang, J Xu, F Medina-Bol
International Journal of Molecular Sciences, 2022-01-20;23(3):.
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Regulation of the Receptor Tyrosine Kinase AXL in Response to Therapy and Its Role in Therapy Resistance in Glioblastoma
Authors: L Scherschin, M Prem, I Kremenetsk, I Tinhofer, P Vajkoczy, AG Karbe, JS Onken
International Journal of Molecular Sciences, 2022-01-17;23(2):.
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TNF-alpha Activating Osteoclasts in Patients with Psoriatic Arthritis Enhances the Recruitment of Osteoclast Precursors: A Plausible Role of WNT5A-MCP-1 in Osteoclast Engagement in Psoriatic Arthritis
Authors: SH Lin, JC Ho, SC Li, YW Cheng, CY Hsu, WY Chou, CC Hsiao, CH Lee
International Journal of Molecular Sciences, 2022-01-15;23(2):.
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Sialyltransferase ST6GAL-1 mediates resistance to chemoradiation in rectal cancer
Authors: M Smithson, R Irwin, G Williams, KL Alexander, LE Smythies, M Nearing, MC McLeod, S Al Diffalh, SL Bellis, KM Hardiman
The Journal of Biological Chemistry, 2022-01-15;0(0):101594.
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Kinase inhibitor-induced cardiotoxicity assessed in vitro with human pluripotent stem cell derived cardiomyocytes
Authors: HQ Xian, C Blanco, K Bonham, HR Snodgrass
Toxicology and Applied Pharmacology, 2022-01-15;437(0):115886.
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Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction
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Nature Communications, 2022-01-10;13(1):81.
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Early Reconstitution of Antibody Secreting Cells after Allogeneic Stem Cell Transplantation
Authors: M Hinterleit, C Hinterleit, E Malenke, B Federmann, U Holzer, M Müller, WA Bethge, S Wirths
Journal of Clinical Medicine, 2022-01-05;11(1):.
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Comprehensive Molecular Landscape of Cetuximab Resistance in Head and Neck Cancer Cell Lines
Authors: INF Gomes, RJ da Silva-O, LS da Silva, O Martinho, AF Evangelist, A van Helvoo, LF Leal, VAO Silva, SP Dos Santos, FC Nascimento, A Lopes Carv, RM Reis
Cells, 2022-01-04;11(1):.
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Protective immunity induced by oral vaccination with a recombinant Lactococcus lactis vaccine against H5Nx in chickens
Authors: Y Ren, X Lu, Z Yang, H Lei
Bmc Veterinary Research, 2022-01-03;18(1):3.
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HIF1alpha/HIF2alpha induces glioma cell dedifferentiation into cancer stem cells through Sox2 under hypoxic conditions
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Journal of Cancer, 2022-01-01;13(1):1-14.
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Adipose-Derived Mesenchymal Stromal/Stem Cell Line Prevents Hepatic Ischemia/Reperfusion Injury in Rats by Inhibiting Inflammasome Activation
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Cell Transplantation, 2022-01-01;31(0):9636897221089.
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3, 3'- diindolylmethane hinders IL-17A/IL-17RA interaction and mitigates imiquimod-induced psoriasiform in mice
Authors: M Srikanth, M Rasool
International immunopharmacology, 2022;109(0):108795.
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Human Basal and Suprabasal Keratinocytes Are Both Able to Generate and Maintain Dermo-Epidermal Skin Substitutes in Long-Term In Vivo Experiments
Authors: L Pontiggia, AK Ahuja, HK Yosef, D Rütsche, E Reichmann, U Moehrlen, T Biedermann
Cells, 2022;11(14):.
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Role of Periostin and Nuclear Factor-kappaB Interplay in the Development of Diabetic Nephropathy
Authors: L Abbad, N Prakoura, A Michon, R Chalghoumi, S Reichelt-W, MC Banas, C Chatzianto
Cells, 2022;11(14):.
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Efficient transdermal delivery of functional protein cargoes by a hydrophobic peptide MTD�1067
Authors: HJ Shin, SU Bak, HN La, JS Kang, HH Lee, HJ Eom, BK Lee, HA Kang
Oncogene, 2022;12(1):10853.
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Functional Profiling of In Vitro Reactivated Memory B Cells Following Natural SARS-CoV-2 Infection and Gam-COVID-Vac Vaccination
Authors: EA Astakhova, MG Byazrova, GM Yusubaliev, SV Kulemzin, NA Kruglova, AG Prilipov, VP Baklaushev, AA Gorchakov, AV Taranin, AV Filatov
Cells, 2022;11(13):.
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Lipopolysaccharide-induced murine lung injury results in long-term pulmonary changes and downregulation of angiogenic pathways
Authors: ST Tsikis, SC Fligor, TI Hirsch, A Pan, LJ Yu, H Kishikawa, MM Joiner, PD Mitchell, M Puder
Oncogene, 2022;12(1):10245.
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Peroxiredoxin IV plays a critical role in cancer cell growth and radioresistance through the activation of the Akt/GSK3 signaling pathways
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The Journal of Biological Chemistry, 2022;0(0):102123.
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Collagen?binding vascular endothelial growth factor (CBD?VEGF) promotes liver regeneration in murine partial hepatectomy
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Molecular Medicine Reports, 2022;26(5):.
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A RORgammat+ cell instructs gut microbiota-specific Treg cell differentiation
Authors: R Kedmi, TA Najar, KR Mesa, A Grayson, L Kroehling, Y Hao, S Hao, M Pokrovskii, M Xu, J Talbot, J Wang, J Germino, CA Lareau, AT Satpathy, MS Anderson, TM Laufer, I Aifantis, JM Bartleson, PM Allen, H Paidassi, JM Gardner, M Stoeckius, DR Littman
Nature, 2022;0(0):.
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Cytoplasmic LMO2-LDB1 Complex Activates STAT3 Signaling through Interaction with gp130-JAK in Glioma Stem Cells
Authors: CG Park, SH Choi, SY Lee, K Eun, MG Park, J Jang, HJ Jeong, SJ Kim, S Jeong, K Lee, H Kim
Cells, 2022;11(13):.
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HydrAd: A Helper-Dependent Adenovirus Targeting Multiple Immune Pathways for Cancer Immunotherapy
Authors: A Rosewell S, C Porter, G Biegert, L Jatta, M Suzuki
Oncogene, 2022;14(11):.
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ADSCs stimulated by resistin promote breast cancer cell malignancy via CXCL5 in a breast cancer coculture model
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Scientific Reports, 2022;12(1):15437.
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FASN inhibition targets multiple drivers of NASH by reducing steatosis, inflammation and fibrosis in preclinical models
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Scientific Reports, 2022;12(1):15661.
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Blocking TIGIT/CD155 signalling reverses CD8+ T cell exhaustion and enhances the antitumor activity in cervical cancer
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Oncogene, 2022;20(1):280.
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Ultra-Sensitive and Semi-Quantitative Vertical Flow Assay for the Rapid Detection of Interleukin-6 in Inflammatory Diseases
Authors: R Lei, H Arain, M Obaid, N Sabhnani, C Mohan
Biosensors, 2022;12(9):.
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Transcriptional Profiling of Insulin-like Growth Factor Signaling Components in Embryonic Lung Development and Idiopathic Pulmonary Fibrosis
Authors: V Kheirollah, A Khadim, G Kiliaris, M Korfei, MM Barroso, I Alexopoulo, AI Vazquez-Ar, M Wygrecka, C Ruppert, A Guenther, W Seeger, S Herold, E El Agha
Cells, 2022;11(12):.
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Ibrutinib Does Not Impact CCR7-Mediated Homeostatic Migration in T-Cells from Chronic Lymphocytic Leukemia Patients
Authors: T Mateu-Albe, A Marcos-Jim, S Wissmann, J Loscertale, F Terrón, JV Stein, C Muñoz-Call, C Cuesta-Mat
Cancers, 2022;14(11):.
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Viral and Cellular Factors Contributing to the Hematogenous Dissemination of Human Cytomegalovirus via Polymorphonuclear Leukocytes
Authors: B Braun, K Laib Sampa, AK Kuderna, M Widmann, C Sinzger
Viruses, 2022;14(7):.
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Lipocalin 2 Deficiency Alters Prostaglandin Biosynthesis and mTOR Signaling Regulation of Thermogenesis and Lipid Metabolism in Adipocytes
Authors: J Deis, TY Lin, T Bushman, X Chen
Cells, 2022;11(9):.
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A Novel P53 Nanomedicine Reduces Immunosuppression and Augments Anti-PD-1 Therapy for Non-Small Cell Lung Cancer in Syngeneic Mouse Models
Authors: SS Kim, JB Harford, M Moghe, C Doherty, EH Chang
Cells, 2022;11(21):.
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Montelukast reduces grey matter abnormalities and functional deficits in a mouse model of inflammation-induced encephalopathy of prematurity
Authors: AG Yates, E Kislitsyna, C Alfonso Ma, J Zhang, AL Sewell, A Goikolea-V, V Cai, LF Alkhader, A Skaland, B Hammond, R Dimitrova, D Batalle, C Fernandes, AD Edwards, P Gressens, C Thornton, HB Stolp
Journal of Neuroinflammation, 2022;19(1):265.
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Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis
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Cell Death & Disease, 2022;13(5):512.
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Effect of SPARC Suppression in Mice, Perfused Human Anterior Segments, and Trabecular Meshwork Cells
Authors: WW MacDonald, SS Swaminatha, JY Heo, A Castillejo, J Hsueh, BJ Liu, D Jo, A Du, H Lee, MH Kang, DJ Rhee
Investigative Ophthalmology & Visual Science, 2022;63(6):8.
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The ASIC3-M-CSF-M2 macrophage-positive feedback loop modulates fibroblast-to-myofibroblast differentiation in skin fibrosis pathogenesis
Authors: JJ Wu, ZL Sun, SY Liu, ZH Chen, ZD Yuan, ML Zou, YY Teng, YY Li, DY Guo, FL Yuan
Cell Death & Disease, 2022;13(6):527.
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CD206<sup>+</sup>CD68<sup>+</sup> mono-macrophages and serum soluble CD206 level are increased in antineutrophil cytoplasmic antibodies associated glomerulonephritis
Authors: XN An, ZN Wei, YY Xie, J Xu, Y Shen, LY Ni, H Shi, PY Shen, W Zhang, YX Chen
BMC immunology, 2022;23(1):55.
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The Therapeutic Treatment with the GAG-Binding Chemokine Fragment CXCL9(74-103) Attenuates Neutrophilic Inflammation and Lung Dysfunction during Klebsiella pneumoniae Infection in Mice
Authors: D Boff, RC Russo, H Crijns, VLS de Oliveir, MS Mattos, PE Marques, GB Menezes, AT Vieira, MM Teixeira, P Proost, FA Amaral
International Journal of Molecular Sciences, 2022;23(11):.
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Immunomodulatory Effects of IFNalpha on T and NK Cells in Chronic Myeloid Leukemia Patients in Deep Molecular Response Preparing for Treatment Discontinuation
Authors: MC Puzzolo, M Breccia, P Mariglia, G Colafigli, S Pepe, E Scalzulli, E Mariggiò, R Latagliata, A Guarini, R Foà
Journal of Clinical Medicine, 2022;11(19):.
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Interleukin-8 produced from cancer-associated fibroblasts suppresses proliferation of the OCUCh-LM1 cancer cell line
Authors: R Tanaka, K Kimura, S Eguchi, G Ohira, S Tanaka, R Amano, H Tanaka, M Yashiro, M Ohira, S Kubo
BMC Cancer, 2022;22(1):748.
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Interleukin-19 Promotes Retinal Neovascularization in a Mouse Model of Oxygen-Induced Retinopathy
Authors: J Zou, W Tan, B Li, Z Wang, Y Li, J Zeng, B Jiang, S Yoshida, Y Zhou
Investigative Ophthalmology & Visual Science, 2022;63(8):9.
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Exercised accelerated the production of muscle-derived kynurenic acid in skeletal muscle and alleviated the postmenopausal osteoporosis through the Gpr35/NFkappaB p65 pathway
Authors: T Shi, Y Shi, H Gao, Y Ma, Q Wang, S Shen, X Shao, W Gong, X Chen, J Qin, J Wu, Q Jiang, B Xue
Journal of Orthopaedic Translation, 2022;35(0):1-12.
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Targeting Microtubule-Associated Protein Tau in Chemotherapy-Resistant Models of High-Grade Serous Ovarian Carcinoma
Authors: MV Barbolina
Cancers, 2022;14(18):.
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Progranulin from different gliocytes in the nucleus accumbens exerts distinct roles in FTD- and neuroinflammation-induced depression-like behaviors
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Journal of Neuroinflammation, 2022;19(1):318.
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Culture impact on the transcriptomic programs of primary and iPSC-derived human alveolar type 2 cells
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JCI Insight, 2022;0(0):.
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Transplantation of Human Induced Pluripotent Stem Cell-Derived Neural Progenitor Cells Promotes Forelimb Functional Recovery after Cervical Spinal Cord Injury
Authors: Y Zheng, CM Gallegos, H Xue, S Li, DH Kim, H Zhou, X Xia, Y Liu, Q Cao
Cells, 2022;11(17):.
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Inflammation and Oxidative Stress Induce NGF Secretion by Pulmonary Arterial Cells through a TGF-beta1-Dependent Mechanism
Authors: C Bouchet, G Cardouat, M Douard, F Coste, P Robillard, F Delcambre, T Ducret, JF Quignard, P Vacher, I Baudrimont, R Marthan, P Berger, C Guibert, V Freund-Mic
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IL-33 Induces an Antiviral Signature in Mast Cells but Enhances Their Permissiveness for Human Rhinovirus Infection
Authors: C Akoto, A Willis, CF Banas, JA Bell, D Bryant, C Blume, DE Davies, EJ Swindle
Viruses, 2022;14(11):.
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Cell Type-Specific Metabolic Response to Amino Acid Starvation Dictates the Role of Sestrin2 in Regulation of mTORC1
Authors: B Blagojevic, F Almouhanna, G Poschet, S Wölfl
Cells, 2022;11(23):.
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Context-dependent function of TSLP and IL-1beta in skin allergic sensitization and atopic march
Authors: J Segaud, W Yao, P Marschall, F Daubeuf, C Lehalle, B German, P Meyer, P Hener, C Hugel, E Flatter, M Guivarch, L Clauss, SF Martin, M Oulad-Abde, M Li
Nature Communications, 2022;13(1):4703.
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Osteopontin Exacerbates High-Fat Diet-Induced Metabolic Disorders in a Microbiome-Dependent Manner
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MBio, 2022;0(0):e0253122.
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Integrated Antitumor Activities of Cellular Immunotherapy with CIK Lymphocytes and Interferons against KIT/PDGFRA Wild Type GIST
Authors: E Fiorino, A Merlini, L D'Ambrosio, I Cerviere, E Berrino, C Marchiò, L Giraudo, M Basiricò, A Massa, C Donini, V Leuci, R Rotolo, F Galvagno, L Vitali, A Proment, S Ferrone, A Pisacane, Y Pignochino, M Aglietta, G Grignani, G Mesiano, D Sangiolo
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The Vi Capsular Polysaccharide of Salmonella Typhi Promotes Macrophage Phagocytosis by Binding the Human C-Type Lectin DC-SIGN
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S100A8-mediated metabolic adaptation controls HIV-1 persistence in macrophages in vivo
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Enhanced half-life and antitumor activity of Interleukin-15 through genetic fusion of a serum albumin-specific protein binder
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International journal of pharmaceutics, 2022;625(0):122059.
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Chronic Binge Alcohol and Ovarian Hormone Loss Dysregulate Circulating Immune Cell SIV Co-Receptor Expression and Mitochondrial Homeostasis in SIV-Infected Rhesus Macaques
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Direct thrombin inhibitors as alternatives to heparin to preserve lung growth and function in a murine model of compensatory lung growth
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The NLRP3 Activation in Infiltrating Macrophages Contributes to Corneal Fibrosis by Inducing TGF-beta1 Expression in the Corneal Epithelium
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Development of the Novel Bifunctional Fusion Protein BR102 That Simultaneously Targets PD-L1 and TGF-beta for Anticancer Immunotherapy
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Species: Human
Sample Types: Cell Culture Supernates
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Establishment of a humanized animal model of systemic sclerosis in which T helper-17 cells from patients with systemic sclerosis infiltrate and cause fibrosis in the lungs and skin
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CLEC-1 is a death sensor that limits antigen cross-presentation by dendritic cells and represents a target for cancer immunotherapy
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Vitamin D3 Stimulates Proliferation Capacity, Expression of Pluripotency Markers, and Osteogenesis of Human Bone Marrow Mesenchymal Stromal/Stem Cells, Partly through SIRT1 Signaling
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Bone morphogenetic protein 1.3 inhibition decreases scar formation and supports cardiomyocyte survival after myocardial infarction
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TLR induced IL-27 plays host-protective role against B16BL6 melanoma in C57BL/6 mice
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TNF-alpha Activating Osteoclasts in Patients with Psoriatic Arthritis Enhances the Recruitment of Osteoclast Precursors: A Plausible Role of WNT5A-MCP-1 in Osteoclast Engagement in Psoriatic Arthritis
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The Modulatory Effects of DMF on Microglia in Aged Mice Are Sex-Specific
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Human olfactory mesenchymal stromal cell transplantation ameliorates experimental autoimmune encephalomyelitis revealing an inhibitory role for IL16 on myelination
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Cloning of the Human MORG1 Promoter: Differential Regulation by Hypoxia and Prolyl-Hydroxylase Inhibitors
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Fatty acids secreted from head and neck cancer induce M2-like Macrophages
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Loss of myeloid lipoprotein lipase exacerbates adipose tissue fibrosis with collagen VI deposition and hyperlipidemia in leptin-deficient obese mice
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Impaired myocellular Ca2+ cycling in protein phosphatase PP2A-B56alpha knockout mice is normalized by beta-adrenergic stimulation
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Human Wharton's Jelly Mesenchymal Stem Cells Secretome Inhibits Human SARS-CoV-2 and Avian Infectious Bronchitis Coronaviruses
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CDK6-PI3K signaling axis is an efficient target for attenuating ABCB1/P-gp mediated multi-drug resistance (MDR) in cancer cells
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SARS-CoV-2 Infects Human ACE2-Negative Endothelial Cells through an alphavbeta3 Integrin-Mediated Endocytosis Even in the Presence of Vaccine-Elicited Neutralizing Antibodies
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Elevated ATP via enhanced miRNA-30b, 30c, and 30e downregulates the expression of CD73 in CD8+ T cells of HIV-infected individuals
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PloS Pathogens, 2022;18(3):e1010378.
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Induction of Pro-Fibrotic CLIC4 in Dermal Fibroblasts by TGF-beta/Wnt3a Is Mediated by GLI2 Upregulation
Authors: CW Wasson, B Caballero-, J Gillespie, E Derrett-Sm, J Mankouri, CP Denton, G Canettieri, NA Riobo-Del, F Del Galdo
Cells, 2022;11(3):.
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Dickkopf-1 Promotes Angiogenesis and is a Biomarker for Hepatic Stem Cell-like Hepatocellular Carcinoma
Authors: T Suda, T Yamashita, H Sunagozaka, H Okada, K Nio, Y Sakai, T Yamashita, E Mizukoshi, M Honda, S Kaneko
International Journal of Molecular Sciences, 2022;23(5):.
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BAP1 shapes the bone marrow niche for lymphopoiesis by fine-tuning epigenetic profiles in endosteal mesenchymal stromal cells
Authors: J Jeong, I Jung, JH Kim, S Jeon, DY Hyeon, H Min, B Kang, J Nah, D Hwang, SJ Um, M Ko, RH Seong
Cell Death and Differentiation, 2022;0(0):.
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Neuropilin-1 mediates lung tissue-specific control of ILC2 function in type 2 immunity
Authors: J Zhang, J Qiu, W Zhou, J Cao, X Hu, W Mi, B Su, B He, J Qiu, L Shen
Nature Immunology, 2022;0(0):.
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Stromal reprogramming through dual PDGFRalpha/beta blockade boosts the efficacy of anti-PD-1 immunotherapy in fibrotic tumors
Authors: T Akiyama, T Yasuda, T Uchihara, N Yasuda-Yos, BJY Tan, A Yonemura, T Semba, J Yamasaki, Y Komohara, K Ohnishi, F Wei, L Fu, J Zhang, F Kitamura, K Yamashita, K Eto, S Iwagami, H Tsukamoto, T Umemoto, M Masuda, O Nagano, Y Satou, H Saya, P Tan, H Baba, T Ishimoto
Cancer Research, 2022;0(0):.
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Cyclo(Val-Pro) and Cyclo(Leu-Hydroxy-Pro) from Pseudomonas sp. (ABS-36) alleviates acute and chronic renal injury under in vitro and in vivo models (Ischemic reperfusion and unilateral ureter obstruction)
Authors: K Hira, P Sharma, A Mahale, O Prakash Ku, A Sajeli Beg
International immunopharmacology, 2021-12-29;103(0):108494.
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Kaposi's sarcoma herpesvirus activates the hypoxia response to usurp HIF2alpha-dependent translation initiation for replication and oncogenesis
Authors: O Méndez-Sol, M Bendjennat, J Naipauer, PR Theodoridi, JJD Ho, RE Verdun, JM Hare, E Cesarman, S Lee, EA Mesri
Cell Reports, 2021-12-28;37(13):110144.
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Novel Combinations of Human Immunomodulatory mAbs Lacking Cardiotoxic Effects for Therapy of TNBC
Authors: C Vetrei, M Passariell, G Froechlich, R Rapuano Le, E Sasso, N Zambrano, C De Lorenzo
Cancers, 2021-12-27;14(1):.
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Increased MFG-E8 at neuromuscular junctions is an exacerbating factor for sarcopenia-associated denervation
Authors: M Ikemoto-Ue, H Zhou, T Kurosawa, Y Yoshimoto, M Toyoda, N Kanazawa, T Nakazawa, M Morita, K Tsuchida, A Uezumi
Aging Cell, 2021-12-24;0(0):e13536.
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Lucanthone, Autophagy Inhibitor, Enhances the Apoptotic Effects of TRAIL through miR-216a-5p-Mediated DR5 Upregulation and DUB3-Mediated Mcl-1 Downregulation
Authors: JY Yoon, SM Woo, SU Seo, SR Song, SG Lee, TK Kwon
International Journal of Molecular Sciences, 2021-12-21;23(1):.
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Targeting AURKA in treatment of peritoneal tumor dissemination in gastrointestinal cancer
Authors: H Ozawa, H Imazeki, Y Ogiwara, H Kawakubo, K Fukuda, Y Kitagawa, C Kudo-Saito
Translational Oncology, 2021-12-10;16(0):101307.
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Dissection of the NKG2C NK cell response against Puumala Orthohantavirus
Authors: H Vietzen, S Hartenberg, SW Aberle, E Puchhammer
PloS Neglected Tropical Diseases, 2021-12-06;15(12):e0010006.
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Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model
Authors: T Fukasawa, A Yoshizaki, S Ebata, A Yoshizaki-, Y Asano, A Enomoto, K Miyagawa, Y Kazoe, K Mawatari, T Kitamori, S Sato
Elife, 2021-12-02;10(0):.
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Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation
Authors: J Heil, V Olsavszky, K Busch, K Klapproth, C de la Torr, C Sticht, K Sandorski, J Hoffmann, H Schönhaber, J Zierow, M Winkler, CD Schmid, T Staniczek, DE Daniels, J Frayne, G Metzgeroth, D Nowak, S Schneider, M Neumaier, V Weyer, C Groden, HJ Gröne, K Richter, C Mogler, MM Taketo, K Schledzews, C Géraud, S Goerdt, PS Koch
Nature Communications, 2021-11-29;12(1):6963.
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Insulin Downregulated the Infection of Uropathogenic Escherichia coli (UPEC) in Bladder Cells in a High-Glucose Environment through JAK/STAT Signaling Pathway
Authors: CH Ho, SP Liu, CK Fan, KY Tzou, CC Wu, PC Cheng
Microorganisms, 2021-11-24;9(12):.
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Combination of IDO1high and CCL19low expression in the tumor tissue reduces survival in HPV positive cervical cancer
Authors: H Jayakumar, A Seetharama, S Sunder Sin, H Dhandapani, J Subramani, S Ganeshraja, R Thangaraja, P Ramanathan
Journal of reproductive immunology, 2021-11-23;149(0):103454.
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ML218 HCl Is More Efficient Than Capsaicin in Inhibiting Bacterial Antigen-Induced Cal 27 Oral Cancer Cell Proliferation
Authors: R Chakrabort, H Hu, C Darido, K Vickery, S Ranganatha
International Journal of Molecular Sciences, 2021-11-22;22(22):.
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Proliferin-1 Ameliorates Cardiotoxin-Related Skeletal Muscle Repair in Mice
Authors: H Goto, A Inoue, L Piao, L Hu, Z Huang, X Meng, Y Suzuki, H Umegaki, M Kuzuya, XW Cheng
Stem Cells International, 2021-11-20;2021(0):9202990.
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TGFbeta1 Secreted by Cancer-Associated Fibroblasts as an Inductor of Resistance to Photodynamic Therapy in Squamous Cell Carcinoma Cells
Authors: M Gallego-Re, M Gutiérrez-, M Fernández-, M Mascaraque, M Portillo-E, Y Gilaberte, E Carrasco, Á Juarranz
Cancers, 2021-11-10;13(22):.
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Chemical inducer of regucalcin attenuates lipopolysaccharide-induced inflammatory responses in pancreatic MIN6 beta-cells and RAW264.7 macrophages
Authors: T Murata, K Hashimoto, S Kohno, C Takahashi, M Yamaguchi, C Ito, M Itoigawa, R Kojima, K Hikita, N Kaneda
FEBS Open Bio, 2021-11-09;0(0):.
Species: Mouse
Sample Types: Cell Culture Media
Applications: ELISA -
Conversion of Osteoclasts into Bone-Protective, Tumor-Suppressing Cells
Authors: KX Li, X Sun, BY Li, H Yokota
Cancers, 2021-11-09;13(22):.
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Macrophage-mediated RON signaling supports breast cancer growth and progression through modulation of IL-35
Authors: SJ Ruiz-Torre, JR Bourn, NM Benight, BG Hunt, C Lester, SE Waltz
Oncogene, 2021-11-06;0(0):.
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Lipoprotein(a), an Opsonin, Enhances the Phagocytosis of Nontypeable Haemophilus influenzae by Macrophages
Authors: Z Liu, Y Li, Y Wang, Z Liu, Y Su, Q Ma, R Han
Journal of Immunology Research, 2021-11-02;2021(0):2185568.
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The IL-6R and Bmi-1 axis controls self-renewal and chemoresistance of head and neck cancer stem cells
Authors: AE Herzog, KA Warner, Z Zhang, E Bellile, MA Bhagat, RM Castilho, GT Wolf, PJ Polverini, AT Pearson, JE Nör
Cell Death & Disease, 2021-10-23;12(11):988.
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Gomisin M2 alleviates psoriasis?like skin inflammation by inhibiting inflammatory signaling pathways
Authors: N Kim, S Lee, J Kang, TK Kwon, D Khang, SH Kim
Molecular Medicine Reports, 2021-10-19;24(6):.
Species: Human, Mouse
Sample Types: Cell Lysates
Applications: Flow Cytometry, Western Blot -
In Vitro Cellular and Molecular Interplay between Human Foreskin-Derived Mesenchymal Stromal/Stem Cells and the Th17 Cell Pathway
Authors: M Najar, M Merimi, WH Faour, CA Lombard, D Moussa Agh, Y Ouhaddi, EM Sokal, L Lagneaux, H Fahmi
Pharmaceutics, 2021-10-19;13(10):.
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Chorionic villus-derived mesenchymal stem cell-mediated autophagy promotes the proliferation and invasiveness of trophoblasts under hypoxia by activating the JAK2/STAT3 signalling pathway
Authors: Y Chu, C Zhu, C Yue, W Peng, W Chen, G He, C Liu, Y Lv, G Gao, K Yao, R Han, X Hu, Y Zhang, Y Ye
Cell & bioscience, 2021-10-13;11(1):182.
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Inactivation of HIV-1 in Polarized Infant Tonsil Epithelial Cells by Human Beta-Defensins 2 and 3 Tagged with the Protein Transduction Domain of HIV-1 Tat
Authors: R Herrera, K Rosbe, SM Tugizov
Viruses, 2021-10-11;13(10):.
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Surfactant protein C is associated with perineuronal nets and shows age-dependent changes of brain content and hippocampal deposits in wildtype and 3xTg mice
Authors: S Schob, J Puchta, K Winter, D Michalski, B Mages, H Martens, A Emmer, KT Hoffmann, F Gaunitz, A Meinicke, M Krause, W Härtig
Journal of chemical neuroanatomy, 2021-10-07;0(0):102036.
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IL-6 promotes drug resistance through formation of polyploid giant cancer cells and stromal fibroblast reprogramming
Authors: N Niu, J Yao, RC Bast, AK Sood, J Liu
Oncogenesis, 2021-09-29;10(9):65.
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CX3CL1(+) Microparticles-Induced MFG-E8 Enhances Apoptotic Cell Clearance by Alveolar Macrophages
Authors: WH Tsai, SC Chang, YC Lin, HC Hsu
Cells, 2021-09-28;10(10):.
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Spatial immunophenotypes predict response to anti-PD1 treatment and capture distinct paths of T cell evasion in triple negative breast cancer
Authors: D Hammerl, JWM Martens, M Timmermans, M Smid, AM Trapman-Ja, R Foekens, OI Isaeva, L Voorwerk, HE Balcioglu, R Wijers, I Nederlof, R Salgado, H Horlings, M Kok, R Debets
Nature Communications, 2021-09-27;12(1):5668.
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Circulating cytokines present in multiple myeloma patients inhibit the osteoblastic differentiation of adipose stem cells
Authors: L Kobari, M Auclair, O Piau, N Ferrand, M Zaoui, F Delhommeau, B Fève, M Sabbah, L Garderet
Leukemia, 2021-09-23;0(0):.
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Endothelial-Derived Extracellular Vesicles Induce Cerebrovascular Dysfunction in Inflammation
Authors: D Roig-Carle, E Willms, RD Fontijn, S Martinez-P, I Mäger, HE de Vries, M Hirst, B Sharrack, DK Male, CA Hawkes, IA Romero
Pharmaceutics, 2021-09-21;13(9):.
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The intracellular milieu of Parkinson's disease patient brain cells modulates alpha-synuclein protein aggregation
Authors: N Gustavsson, E Savchenko, O Klementiev, L Roybon
Acta neuropathologica communications, 2021-09-16;9(1):153.
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Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cells
Authors: D Chanda, M Rehan, SR Smith, KG Dsouza, Y Wang, K Bernard, D Kurundkar, V Memula, K Kojima, JA Mobley, GA Benavides, V Darley-Usm, YI Kim, JW Zmijewski, JS Deshane, S De Langhe, VJ Thannickal
Elife, 2021-09-16;10(0):.
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IL-18 binding protein suppresses IL-17-induced osteoclastogenesis and rectifies type 17 helper T cell / regulatory T cell imbalance in rheumatoid arthritis
Authors: HK Min, S Kim, JY Lee, KW Kim, SH Lee, HR Kim
Journal of Translational Medicine, 2021-09-16;19(1):392.
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Visualization of individual cell division history in complex tissues using iCOUNT
Authors: A Denoth-Lip, BN Jaeger, T Liang, LN Royall, SE Chie, K Buthey, D Machado, VI Korobeynyk, M Kruse, CM Munz, A Gerbaulet, BD Simons, S Jessberger
Cell Stem Cell, 2021-09-14;0(0):.
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TNF-alpha Increases IP-10 Expression in MCF-7 Breast Cancer Cells via Activation of the JNK/c-Jun Pathways
Authors: S Kochumon, A Al-Sayyar, T Jacob, A Hasan, F Al-Mulla, S Sindhu, R Ahmad
Biomolecules, 2021-09-13;11(9):.
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Expression of IL-20 Receptor Subunit beta Is Linked to EAE Neuropathology and CNS Neuroinflammation
Authors: JR Dayton, Y Yuan, LP Pacumio, BG Dorflinger, SC Yoo, MJ Olson, SI Hernández-, MM McMahon, L Cruz-Oreng
Frontiers in Cellular Neuroscience, 2021-09-07;15(0):683687.
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Immunomodulatory effect of NEDD8-activating enzyme inhibition in Multiple Myeloma: upregulation of NKG2D ligands and sensitization to Natural Killer cell recognition
Authors: S Petillo, C Capuano, R Molfetta, C Fionda, A Mekhloufi, C Pighi, F Antonangel, A Zingoni, A Soriani, MT Petrucci, R Galandrini, R Paolini, A Santoni, M Cippitelli
Cell Death & Disease, 2021-09-04;12(9):836.
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Distinct systemic and mucosal immune responses during acute SARS-CoV-2 infection
Authors: N Smith, P Goncalves, B Charbit, L Grzelak, M Beretta, C Planchais, T Bruel, V Rouilly, V Bondet, J Hadjadj, N Yatim, H Pere, SH Merkling, A Ghozlane, S Kernéis, F Rieux-Lauc, B Terrier, O Schwartz, H Mouquet, D Duffy, JP Di Santo
Nature Immunology, 2021-09-01;0(0):.
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Apamin Enhances Neurite Outgrowth and Regeneration after Laceration Injury in Cortical Neurons
Authors: H Kim, JY Hong, J Lee, WJ Jeon, IH Ha
Toxins, 2021-08-28;13(9):.
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In�vitro effects of conditioned medium from bioreactor cultured human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) on skin-derived cell lines
Authors: YM Park, M Lee, S Jeon, D Hr?zová
Regenerative Therapy, 2021-08-24;18(0):281-291.
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(-)-Carveol Prevents Gastric Ulcers via Cytoprotective, Antioxidant, Antisecretory and Immunoregulatory Mechanisms in Animal Models
Authors: CAL Serafim, MEC Araruna, EB Alves Júni, LMO Silva, AO Silva, MS da Silva, AF Alves, AA Araújo, LM Batista
Frontiers in Pharmacology, 2021-08-23;12(0):736829.
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Single-cell RNA-seq reveals a critical role of novel pro-inflammatory EndMT in mediating adverse remodeling in coronary artery-on-a-chip
Authors: P Zhao, Q Yao, PJ Zhang, E The, Y Zhai, L Ao, MJ Jarrett, CA Dinarello, DA Fullerton, X Meng
Science Advances, 2021-08-20;7(34):.
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Neutrophils promote T-cell activation through the regulated release of CD44-bound Galectin-9 from the cell surface during HIV infection
Authors: G Dunsmore, EP Rosero, S Shahbaz, DM Santer, J Jovel, P Lacy, S Houston, S Elahi
PloS Biology, 2021-08-19;19(8):e3001387.
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Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery
Authors: S Di Franco, P Bianca, DS Sardina, A Turdo, M Gaggianesi, V Veschi, A Nicotra, LR Mangiapane, M Lo Iacono, I Pillitteri, S van Hooff, F Martorana, G Motta, E Gulotta, VL Lentini, E Martorana, ME Fiori, S Vieni, MR Bongiorno, G Giannone, D Giuffrida, L Memeo, L Colarossi, M Mare, P Vigneri, M Todaro, R De Maria, JP Medema, G Stassi
Nature Communications, 2021-08-18;12(1):5006.
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Lysosome purinergic receptor P2X4 regulates neoangiogenesis induced by microvesicles from sarcoma patients
Authors: W Palinski, M Monti, R Camerlingo, I Iacobucci, S Bocella, F Pinto, C Iannuzzi, G Mansueto, S Pignatiell, F Fazioli, M Gallo, L Marra, F Cozzolino, A De Chiara, P Pucci, A Bilancio, F de Nigris
Cell Death & Disease, 2021-08-17;12(9):797.
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Bacterial Antigens Reduced the Inhibition Effect of Capsaicin on Cal 27 Oral Cancer Cell Proliferation
Authors: R Chakrabort, K Vickery, C Darido, S Ranganatha, H Hu
International Journal of Molecular Sciences, 2021-08-12;22(16):.
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PGC1alpha is required for the renoprotective effect of lncRNA Tug1 in�vivo and links Tug1 with urea cycle metabolites
Authors: L Li, J Long, K Mise, DL Galvan, PA Overbeek, L Tan, SV Kumar, WK Chan, PL Lorenzi, BH Chang, FR Danesh
Cell Reports, 2021-08-10;36(6):109510.
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Recombinant antibodies recognize conformation-dependent epitopes of the leucine zipper of misfolding-prone myocilin
Authors: AC Patterson-, AN Qerqez, LR Azouz, MT Ma, SE Hill, Y Ku, LA Schildmeye, JA Maynard, RL Lieberman
The Journal of Biological Chemistry, 2021-08-09;0(0):101067.
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A non-neutralizing antibody broadly protects against influenza virus infection by engaging effector cells
Authors: YA Ko, YH Yu, YF Wu, YC Tseng, CL Chen, KS Goh, HY Liao, TH Chen, TR Cheng, AS Yang, CH Wong, C Ma, KI Lin
PloS Pathogens, 2021-08-05;17(8):e1009724.
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Deficient inflammasome activation permits an exaggerated asthma phenotype in rhinovirus C-infected immature mice
Authors: M Han, T Ishikawa, CC Stroupe, HA Breckenrid, JK Bentley, MB Hershenson
Mucosal Immunology, 2021-08-05;0(0):.
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Bacitracin and Rutin Regulate Tissue Factor Production in Inflammatory Monocytes and Acute Myeloid Leukemia Blasts
Authors: L Beckmann, CC Rolling, M Voigtlände, J Mäder, F Klingler, A Schulenkor, C Lehr, C Bokemeyer, W Ruf, F Langer
Cancers, 2021-08-04;13(16):.
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Synergistic effects of silver nanoparticles and cisplatin in combating inflammation and hyperplasia of airway stents
Authors: Z Li, C Tian, D Jiao, J Li, Y Li, X Zhou, H Zhao, Y Zhao, X Han
Bioactive materials, 2021-07-29;9(0):266-280.
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Monocyte-dependent co-stimulation of cytokine induction in human gammadelta T cells by TLR8 RNA ligands
Authors: R Serrano, C Coch, C Peters, G Hartmann, D Wesch, D Kabelitz
Scientific Reports, 2021-07-27;11(1):15231.
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Infectious titer determination of lentiviral vectors using a temporal immunological real-time imaging approach
Authors: JJ Labisch, GP Wiese, K Barnes, F Bollmann, K Pflanz
PLoS ONE, 2021-07-15;16(7):e0254739.
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PAR2-Induced Tissue Factor Synthesis by Primary Cultures of Human Kidney Tubular Epithelial Cells Is Modified by Glucose Availability
Authors: TLR Humphries, K Shen, A Iyer, DW Johnson, GC Gobe, D Nikolic-Pa, DP Fairlie, DA Vesey
International Journal of Molecular Sciences, 2021-07-14;22(14):.
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Mechanical forces regulate endothelial-to-mesenchymal transition and atherosclerosis via an Alk5-Shc mechanotransduction pathway
Authors: V Mehta, KL Pang, CS Givens, Z Chen, J Huang, DT Sweet, H Jo, JS Reader, E Tzima
Science Advances, 2021-07-09;7(28):.
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An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer
Authors: P Voabil, M de Bruijn, LM Roelofsen, SH Hendriks, S Brokamp, M van den Br, A Broeks, J Sanders, P Herzig, A Zippelius, CU Blank, KJ Hartemink, K Monkhorst, JBAG Haanen, TN Schumacher, DS Thommen
Nature Medicine, 2021-07-08;27(7):1250-1261.
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Interleukin-36gamma aggravates macrophage foam cell formation and atherosclerosis progression in ApoE knockout mice
Authors: M Zhang, J Liu, R Gao, Y Hu, L Lu, C Liu, L Ai, J Pan, L Tian, J Fan
Cytokine, 2021-07-07;146(0):155630.
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Evidence That Tumor Microenvironment Initiates Epithelial-To-Mesenchymal Transition and Calebin A can Suppress it in Colorectal Cancer Cells
Authors: C Buhrmann, A Brockmuell, C Harsha, AB Kunnumakka, P Kubatka, BB Aggarwal, M Shakibaei
Frontiers in Pharmacology, 2021-07-02;12(0):699842.
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Influence of a High-Impact Multidimensional Rehabilitation Program on the Gut Microbiota of Patients with Multiple Sclerosis
Authors: M Barone, L Mendozzi, F D'Amico, M Saresella, S Rampelli, F Piancone, F La Rosa, I Marventano, M Clerici, A d'Arma, L Pugnetti, V Rossi, M Candela, P Brigidi, S Turroni
International Journal of Molecular Sciences, 2021-07-02;22(13):.
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TNF-alpha augments CXCL10/CXCR3 axis activity to induce Epithelial-Mesenchymal Transition in colon cancer cell
Authors: Z Wang, X Ao, Z Shen, L Ao, X Wu, C Pu, W Guo, W Xing, M He, H Yuan, J Yu, L Li, X Xu
International journal of biological sciences, 2021-06-26;17(11):2683-2702.
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Apoptotic mesenchymal stromal cells support osteoclastogenesis while inhibiting multinucleated giant cells formation in vitro
Authors: P Humbert, MÁ Brennan, J De Lima, R Brion, A Adrait, C Charrier, B Brulin, V Trichet, Y Couté, F Blanchard, P Layrolle
Scientific Reports, 2021-06-09;11(1):12144.
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Immunomodulatory mAbs as Tools to Investigate on Cis-Interaction of PD-1/PD-L1 on Tumor Cells and to Set Up Methods for Early Screening of Safe and Potent Combinatorial Treatments
Authors: C Vetrei, M Passariell, G Froechlich, R Rapuano Le, N Zambrano, C De Lorenzo
Cancers, 2021-06-08;13(12):.
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ADAM10 and ADAM17 regulate EGFR, c-Met and TNF RI signalling in liver regeneration and fibrosis
Authors: O Zbodakova, K Chalupsky, L Sarnova, P Kasparek, M Jirouskova, M Gregor, R Sedlacek
Scientific Reports, 2021-06-01;11(1):11414.
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Inflammation and enhanced atherogenesis in the carotid artery with altered blood flow in an atherosclerosis-resistant mouse strain
Authors: J Zhao, C Huangfu, Z Chang, W Zhou, AT Grainger, Z Liu, W Shi
Physiological Reports, 2021-06-01;9(11):e14829.
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MFG-E8 Regulates Vascular Smooth Muscle Cell Migration Through Dose-Dependent Mediation of Actin Polymerization
Authors: HY Chiang, PH Chu, SC Chen, TH Lee
Journal of the American Heart Association, 2021-05-27;10(11):e020870.
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Colorectal cancer cell intrinsic fibroblast activation protein alpha binds to Enolase1 and activates NF-&kappaB pathway to promote metastasis
Authors: Z Yuan, H Hu, Y Zhu, W Zhang, Q Fang, T Qiao, T Ma, M Wang, R Huang, Q Tang, F Gao, C Zou, X Gao, G Wang, X Wang
Cell Death & Disease, 2021-05-25;12(6):543.
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Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and &beta-amyloid pathology
Authors: S Da Mesquit, J Herz, M Wall, T Dykstra, KA de Lima, GT Norris, N Dabhi, T Kennedy, W Baker, J Kipnis
Science Advances, 2021-05-21;7(21):.
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A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo expansion of CD8 and NK cells
Authors: KE Harris, KJ Lorentsen, HK Malik-Chau, K Loughlin, HM Basappa, S Hartstein, G Ahmil, NS Allen, BC Avanzino, A Balasubram, AA Boudreau, K Chang, MC Cuturi, LM Davison, DM Ho, S Iyer, US Rangaswamy, P Sankaran, U Schellenbe, R Buelow, ND Trinklein
Scientific Reports, 2021-05-19;11(1):10592.
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Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents
Authors: AT Kwok, NS Mohamed, JF Plate, RR Yammani, S Rosas, TA Bateman, E Livingston, JE Moore, BA Kerr, J Lee, CM Furdui, L Tan, ML Bouxsein, VL Ferguson, LS Stodieck, DC Zawieja, MD Delp, XW Mao, JS Willey
Scientific Reports, 2021-05-18;11(1):10469.
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Anti-Vascular Endothelial Growth Factor C Antibodies Efficiently Inhibit the Growth of Experimental Clear Cell Renal Cell Carcinomas
Authors: A Dumond, C Montemagno, V Vial, R Grépin, G Pagès
Cells, 2021-05-17;10(5):.
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IL-13R&alpha2 Regulates the IL-13/IFN-&gamma Balance during Innate Lymphoid Cell and Dendritic Cell Responses to Pox Viral Vector-Based Vaccination
Authors: Z Li, S Roy, C Ranasinghe
Vaccines, 2021-05-01;9(5):.
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Meningeal lymphatics affect microglia responses and anti-A&beta immunotherapy
Authors: S Da Mesquit, Z Papadopoul, T Dykstra, L Brase, FG Farias, M Wall, H Jiang, CD Kodira, KA de Lima, J Herz, A Louveau, DH Goldman, AF Salvador, S Onengut-Gu, E Farber, N Dabhi, T Kennedy, MG Milam, W Baker, I Smirnov, SS Rich, Dominantly, BA Benitez, CM Karch, RJ Perrin, M Farlow, JP Chhatwal, DM Holtzman, C Cruchaga, O Harari, J Kipnis
Nature, 2021-04-28;0(0):.
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Light-induced dynamic RGD pattern for sequential modulation of macrophage phenotypes
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Bioactive materials, 2021-04-21;6(11):4065-4072.
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Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1
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Nature Chemical Biology, 2021-04-15;0(0):.
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Deconvoluting global cytokine signaling networks in natural killer cells
Authors: GM Wiedemann, EK Santosa, S Grassmann, S Sheppard, JB Le Luduec, NM Adams, C Dang, KC Hsu, JC Sun, CM Lau
Nature Immunology, 2021-04-15;0(0):.
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Orthopedic surgery-induced cognitive dysfunction is mediated by CX3CL1/R1 signaling
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Journal of Neuroinflammation, 2021-04-15;18(1):93.
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Capturing human trophoblast development with naive pluripotent stem cells in�vitro
Authors: S Io, M Kabata, Y Iemura, K Semi, N Morone, A Minagawa, B Wang, I Okamoto, T Nakamura, Y Kojima, C Iwatani, H Tsuchiya, B Kaswandy, E Kondoh, S Kaneko, K Woltjen, M Saitou, T Yamamoto, M Mandai, Y Takashima
Cell Stem Cell, 2021-04-07;28(6):1023-1039.e13.
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CAR directs T cell adaptation to bile acids in the small intestine
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Nature, 2021-04-07;0(0):.
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Agonist anti-ChemR23 mAb reduces tissue neutrophil accumulation and triggers chronic inflammation resolution
Authors: C Trilleaud, V Gauttier, K Biteau, I Girault, L Belarif, C Mary, S Pengam, G Teppaz, V Thepenier, R Danger, G Robert-Sie, M Néel, S Bruneau, A Glémain, A Néel, A Poupon, JF Mosnier, G Chêne, M Dubourdeau, G Blancho, B Vanhove, N Poirier
Science Advances, 2021-04-02;7(14):.
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TGF-&beta2 Promotes Oxidative Stress in Human Trabecular Meshwork Cells by Selectively Enhancing NADPH Oxidase 4 Expression
Authors: VR Rao, EB Stubbs
Investigative Ophthalmology & Visual Science, 2021-04-01;62(4):4.
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Glycan Epitopes on 201B7 Human-Induced Pluripotent Stem Cells Using R-10G and R-17F Marker Antibodies
Authors: Y Nagai, H Nakao, A Kojima, Y Komatsubar, Y Ohta, N Kawasaki, N Kawasaki, H Toyoda, T Kawasaki
Biomolecules, 2021-03-29;11(4):.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Probiotic-Derived Polyphosphate Accelerates Intestinal Epithelia Wound Healing through Inducing Platelet-Derived Mediators
Authors: S Isozaki, H Konishi, M Fujiya, H Tanaka, Y Murakami, S Kashima, K Ando, N Ueno, K Moriichi, T Okumura
Mediators of Inflammation, 2021-03-29;2021(0):5582943.
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P-selectin axis plays a key role in microglia immunophenotype and glioblastoma progression
Authors: E Yeini, P Ofek, S Pozzi, N Albeck, D Ben-Shusha, G Tiram, S Golan, R Kleiner, R Sheinin, S Israeli Da, S Reich-Zeli, R Grossman, Z Ram, H Brem, TM Hyde, P Magod, D Friedmann-, A Madi, R Satchi-Fai
Nature Communications, 2021-03-26;12(1):1912.
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Traditional Thai Massage Promoted Immunity in the Elderly via Attenuation of Senescent CD4+ T Cell Subsets: A Randomized Crossover Study
Authors: K Sornkayasi, A Jumnainson, W Phoksawat, W Eungpinich, C Leelayuwat
International Journal of Environmental Research and Public Health, 2021-03-19;18(6):.
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Intratumor Regulatory Noncytotoxic NK Cells in Patients with Hepatocellular Carcinoma
Authors: A Zecca, V Barili, D Rizzo, A Olivani, E Biasini, D Laccabue, R Dalla Vall, C Ferrari, E Cariani, G Missale
Cells, 2021-03-10;10(3):.
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Ceramide Synthase 2 Null Mice Are Protected from Ovalbumin-Induced Asthma with Higher T Cell Receptor Signal Strength in CD4+ T Cells
Authors: SH Shin, KA Cho, HS Yoon, SY Kim, HY Kim, Y Pewzner-Ju, SA Jung, WJ Park, AH Futerman, JW Park
International Journal of Molecular Sciences, 2021-03-08;22(5):.
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Early Colorectal Responses to HIV-1 and Modulation by Antiretroviral Drugs
Authors: C Herrera, MD McRaven, KG Laing, J Dennis, TJ Hope, RJ Shattock
Vaccines, 2021-03-08;9(3):.
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Small Immunomodulatory Molecules as Potential Therapeutics in Experimental Murine Models of Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS)
Authors: D Shah, P Das, S Acharya, B Agarwal, DJ Christense, SM Robertson, V Bhandari
International Journal of Molecular Sciences, 2021-03-04;22(5):.
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Siglec-6 is a target for chimeric antigen receptor T-cell treatment of chronic lymphocytic leukemia
Authors: D Kovalovsky, JH Yoon, MG Cyr, S Simon, E Voynova, C Rader, A Wiestner, J Alejo, S Pittaluga, RE Gress
Leukemia, 2021-02-25;0(0):.
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Heparan sulfate is essential for thymus growth
Authors: HP Hsu, YT Chen, YY Chen, CY Lin, PY Chen, SY Liao, CCY Lim, Y Yamaguchi, CL Hsu, IL Dzhagalov
The Journal of Biological Chemistry, 2021-02-15;0(0):100419.
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Initial Identification of UDP-Glucose Dehydrogenase as a Prognostic Marker in Breast Cancer Patients, Which Facilitates Epirubicin Resistance and Regulates Hyaluronan Synthesis in MDA-MB-231 Cells
Authors: DL Vitale, I Caon, A Parnigoni, I Sevic, FM Spinelli, A Icardi, A Passi, D Vigetti, L Alaniz
Biomolecules, 2021-02-09;11(2):.
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Study of fucoidans as natural biomolecules for therapeutical applications in osteoarthritis
Authors: C Vaamonde-G, N Flórez-Fer, MD Torres, MJ Lamas-Vázq, FJ Blanco, H Domínguez, R Meijide-Fa
Carbohydrate polymers, 2021-01-26;258(0):117692.
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Perlecan in the Natural and Cell Therapy Repair of Human Adult Articular Cartilage: Can Modifications in This Proteoglycan Be a Novel Therapeutic Approach?
Authors: J Garcia, HS McCarthy, JH Kuiper, J Melrose, S Roberts
Biomolecules, 2021-01-13;11(1):.
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FOLFOX Therapy Induces Feedback Upregulation of CD44v6 through YB-1 to Maintain Stemness in Colon Initiating Cells
Authors: S Ghatak, VC Hascall, RR Markwald, S Misra
International Journal of Molecular Sciences, 2021-01-13;22(2):.
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High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors: A Kumar, K Sundaram, J Mu, GW Dryden, MK Sriwastva, C Lei, L Zhang, X Qiu, F Xu, J Yan, X Zhang, JW Park, ML Merchant, HCL Bohler, B Wang, S Zhang, C Qin, Z Xu, X Han, CJ McClain, Y Teng, HG Zhang
Nature Communications, 2021-01-11;12(1):213.
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Psoralidin, a major component of Psoraleae Fructus, induces inflammasome activation and idiosyncratic liver injury
Authors: Y Wang, G Xu, Z Wang, R Li, X Zhan, H Liu, Q Qin, W Li, X Wang, M Zhang, J Tang, Z Bai, X Xiao
International immunopharmacology, 2021-01-07;92(0):107352.
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Gut-licensed IFN&gamma+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes
Authors: LM Sanmarco, MA Wheeler, C Gutiérrez-, CM Polonio, M Linnerbaue, FA Pinho-Ribe, Z Li, F Giovannoni, KV Batterman, G Scalisi, SEJ Zandee, ES Heck, M Alsuwailm, DL Rosene, B Becher, IM Chiu, A Prat, FJ Quintana
Nature, 2021-01-06;0(0):.
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Senescence-Associated Secretory Phenotype Suppression Mediated by Small-Sized Mesenchymal Stem Cells Delays Cellular Senescence through TLR2 and TLR5 Signaling
Authors: JH Kwon, M Kim, S Um, HJ Lee, YK Bae, SJ Choi, HH Hwang, W Oh, HJ Jin
Cells, 2021-01-03;10(1):.
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(-)-Carveol Prevents Gastric Ulcers via Cytoprotective, Antioxidant, Antisecretory and Immunoregulatory Mechanisms in Animal Models
Authors: CAL Serafim, MEC Araruna, EB Alves Júni, LMO Silva, AO Silva, MS da Silva, AF Alves, AA Araújo, LM Batista
Frontiers in Pharmacology, 2021;12(0):736829.
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Insulin Downregulated the Infection of Uropathogenic Escherichia coli (UPEC) in Bladder Cells in a High-Glucose Environment through JAK/STAT Signaling Pathway
Authors: CH Ho, SP Liu, CK Fan, KY Tzou, CC Wu, PC Cheng
Microorganisms, 2021;9(12):.
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Targeting AURKA in treatment of peritoneal tumor dissemination in gastrointestinal cancer
Authors: H Ozawa, H Imazeki, Y Ogiwara, H Kawakubo, K Fukuda, Y Kitagawa, C Kudo-Saito
Translational Oncology, 2021;16(0):101307.
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Meningeal lymphatics affect microglia responses and anti-A&beta immunotherapy
Authors: S Da Mesquit, Z Papadopoul, T Dykstra, L Brase, FG Farias, M Wall, H Jiang, CD Kodira, KA de Lima, J Herz, A Louveau, DH Goldman, AF Salvador, S Onengut-Gu, E Farber, N Dabhi, T Kennedy, MG Milam, W Baker, I Smirnov, SS Rich, Dominantly, BA Benitez, CM Karch, RJ Perrin, M Farlow, JP Chhatwal, DM Holtzman, C Cruchaga, O Harari, J Kipnis
Nature, 2021;0(0):.
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TNF-alpha Increases IP-10 Expression in MCF-7 Breast Cancer Cells via Activation of the JNK/c-Jun Pathways
Authors: S Kochumon, A Al-Sayyar, T Jacob, A Hasan, F Al-Mulla, S Sindhu, R Ahmad
Biomolecules, 2021;11(9):.
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Proliferin-1 Ameliorates Cardiotoxin-Related Skeletal Muscle Repair in Mice
Authors: H Goto, A Inoue, L Piao, L Hu, Z Huang, X Meng, Y Suzuki, H Umegaki, M Kuzuya, XW Cheng
Stem Cells International, 2021;2021(0):9202990.
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Combination of IDO1high and CCL19low expression in the tumor tissue reduces survival in HPV positive cervical cancer
Authors: H Jayakumar, A Seetharama, S Sunder Sin, H Dhandapani, J Subramani, S Ganeshraja, R Thangaraja, P Ramanathan
Journal of reproductive immunology, 2021;149(0):103454.
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Increased MFG-E8 at neuromuscular junctions is an exacerbating factor for sarcopenia-associated denervation
Authors: M Ikemoto-Ue, H Zhou, T Kurosawa, Y Yoshimoto, M Toyoda, N Kanazawa, T Nakazawa, M Morita, K Tsuchida, A Uezumi
Aging Cell, 2021;0(0):e13536.
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Senescence-Associated Secretory Phenotype Suppression Mediated by Small-Sized Mesenchymal Stem Cells Delays Cellular Senescence through TLR2 and TLR5 Signaling
Authors: JH Kwon, M Kim, S Um, HJ Lee, YK Bae, SJ Choi, HH Hwang, W Oh, HJ Jin
Cells, 2021;10(1):.
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Gut-licensed IFN&gamma+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes
Authors: LM Sanmarco, MA Wheeler, C Gutiérrez-, CM Polonio, M Linnerbaue, FA Pinho-Ribe, Z Li, F Giovannoni, KV Batterman, G Scalisi, SEJ Zandee, ES Heck, M Alsuwailm, DL Rosene, B Becher, IM Chiu, A Prat, FJ Quintana
Nature, 2021;0(0):.
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Expression of IL-20 Receptor Subunit beta Is Linked to EAE Neuropathology and CNS Neuroinflammation
Authors: JR Dayton, Y Yuan, LP Pacumio, BG Dorflinger, SC Yoo, MJ Olson, SI Hernández-, MM McMahon, L Cruz-Oreng
Frontiers in Cellular Neuroscience, 2021;15(0):683687.
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Chemical inducer of regucalcin attenuates lipopolysaccharide-induced inflammatory responses in pancreatic MIN6 beta-cells and RAW264.7 macrophages
Authors: T Murata, K Hashimoto, S Kohno, C Takahashi, M Yamaguchi, C Ito, M Itoigawa, R Kojima, K Hikita, N Kaneda
FEBS Open Bio, 2021;0(0):.
Species: Mouse
Sample Types: Cell Culture Media
Applications: ELISA -
Single-cell-level protein analysis revealing the roles of autoantigen-reactive B lymphocytes in autoimmune disease and the murine model
Authors: T Fukasawa, A Yoshizaki, S Ebata, A Yoshizaki-, Y Asano, A Enomoto, K Miyagawa, Y Kazoe, K Mawatari, T Kitamori, S Sato
Elife, 2021;10(0):.
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Light-induced dynamic RGD pattern for sequential modulation of macrophage phenotypes
Authors: Y Luo, X Zheng, P Yuan, X Ye, L Ma
Bioactive materials, 2021;6(11):4065-4072.
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Aging-associated deficit in CCR7 is linked to worsened glymphatic function, cognition, neuroinflammation, and &beta-amyloid pathology
Authors: S Da Mesquit, J Herz, M Wall, T Dykstra, KA de Lima, GT Norris, N Dabhi, T Kennedy, W Baker, J Kipnis
Science Advances, 2021;7(21):.
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Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery
Authors: S Di Franco, P Bianca, DS Sardina, A Turdo, M Gaggianesi, V Veschi, A Nicotra, LR Mangiapane, M Lo Iacono, I Pillitteri, S van Hooff, F Martorana, G Motta, E Gulotta, VL Lentini, E Martorana, ME Fiori, S Vieni, MR Bongiorno, G Giannone, D Giuffrida, L Memeo, L Colarossi, M Mare, P Vigneri, M Todaro, R De Maria, JP Medema, G Stassi
Nature Communications, 2021;12(1):5006.
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Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation
Authors: J Heil, V Olsavszky, K Busch, K Klapproth, C de la Torr, C Sticht, K Sandorski, J Hoffmann, H Schönhaber, J Zierow, M Winkler, CD Schmid, T Staniczek, DE Daniels, J Frayne, G Metzgeroth, D Nowak, S Schneider, M Neumaier, V Weyer, C Groden, HJ Gröne, K Richter, C Mogler, MM Taketo, K Schledzews, C Géraud, S Goerdt, PS Koch
Nature Communications, 2021;12(1):6963.
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Study of fucoidans as natural biomolecules for therapeutical applications in osteoarthritis
Authors: C Vaamonde-G, N Flórez-Fer, MD Torres, MJ Lamas-Vázq, FJ Blanco, H Domínguez, R Meijide-Fa
Carbohydrate polymers, 2021;258(0):117692.
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In�vitro effects of conditioned medium from bioreactor cultured human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) on skin-derived cell lines
Authors: YM Park, M Lee, S Jeon, D Hr?zová
Regenerative Therapy, 2021;18(0):281-291.
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A non-neutralizing antibody broadly protects against influenza virus infection by engaging effector cells
Authors: YA Ko, YH Yu, YF Wu, YC Tseng, CL Chen, KS Goh, HY Liao, TH Chen, TR Cheng, AS Yang, CH Wong, C Ma, KI Lin
PloS Pathogens, 2021;17(8):e1009724.
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Novel Combinations of Human Immunomodulatory mAbs Lacking Cardiotoxic Effects for Therapy of TNBC
Authors: C Vetrei, M Passariell, G Froechlich, R Rapuano Le, E Sasso, N Zambrano, C De Lorenzo
Cancers, 2021;14(1):.
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The IL-6R and Bmi-1 axis controls self-renewal and chemoresistance of head and neck cancer stem cells
Authors: AE Herzog, KA Warner, Z Zhang, E Bellile, MA Bhagat, RM Castilho, GT Wolf, PJ Polverini, AT Pearson, JE Nör
Cell Death & Disease, 2021;12(11):988.
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Spaceflight and hind limb unloading induces an arthritic phenotype in knee articular cartilage and menisci of rodents
Authors: AT Kwok, NS Mohamed, JF Plate, RR Yammani, S Rosas, TA Bateman, E Livingston, JE Moore, BA Kerr, J Lee, CM Furdui, L Tan, ML Bouxsein, VL Ferguson, LS Stodieck, DC Zawieja, MD Delp, XW Mao, JS Willey
Scientific Reports, 2021;11(1):10469.
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Lucanthone, Autophagy Inhibitor, Enhances the Apoptotic Effects of TRAIL through miR-216a-5p-Mediated DR5 Upregulation and DUB3-Mediated Mcl-1 Downregulation
Authors: JY Yoon, SM Woo, SU Seo, SR Song, SG Lee, TK Kwon
International Journal of Molecular Sciences, 2021;23(1):.
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Deficient inflammasome activation permits an exaggerated asthma phenotype in rhinovirus C-infected immature mice
Authors: M Han, T Ishikawa, CC Stroupe, HA Breckenrid, JK Bentley, MB Hershenson
Mucosal Immunology, 2021;0(0):.
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ML218 HCl Is More Efficient Than Capsaicin in Inhibiting Bacterial Antigen-Induced Cal 27 Oral Cancer Cell Proliferation
Authors: R Chakrabort, H Hu, C Darido, K Vickery, S Ranganatha
International Journal of Molecular Sciences, 2021;22(22):.
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An ex vivo tumor fragment platform to dissect response to PD-1 blockade in cancer
Authors: P Voabil, M de Bruijn, LM Roelofsen, SH Hendriks, S Brokamp, M van den Br, A Broeks, J Sanders, P Herzig, A Zippelius, CU Blank, KJ Hartemink, K Monkhorst, JBAG Haanen, TN Schumacher, DS Thommen
Nature Medicine, 2021;27(7):1250-1261.
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Lipoprotein(a), an Opsonin, Enhances the Phagocytosis of Nontypeable Haemophilus influenzae by Macrophages
Authors: Z Liu, Y Li, Y Wang, Z Liu, Y Su, Q Ma, R Han
Journal of Immunology Research, 2021;2021(0):2185568.
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Kaposi's sarcoma herpesvirus activates the hypoxia response to usurp HIF2alpha-dependent translation initiation for replication and oncogenesis
Authors: O Méndez-Sol, M Bendjennat, J Naipauer, PR Theodoridi, JJD Ho, RE Verdun, JM Hare, E Cesarman, S Lee, EA Mesri
Cell Reports, 2021;37(13):110144.
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Novel patient-derived models of DSRCT enable validation of ERBB signaling as a potential therapeutic vulnerability
Authors: RS Smith, I Odintsov, Z Liu, AJ Lui, T Hayashi, M Vojnic, Y Suehara, L Delasos, MS Mattar, J Hmeljak, HA Ramirez, M Shaw, G Bui, AB Hartono, E Gladstone, S Kunte, H Magnan, I Khodos, E De Stanchi, MP La Quaglia, J Yao, M Laé, SB Lee, L Spraggon, CA Pratilas, M Ladanyi, R Somwar
Disease Models & Mechanisms, 2021;0(0):.
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High-fat diet-induced upregulation of exosomal phosphatidylcholine contributes to insulin resistance
Authors: A Kumar, K Sundaram, J Mu, GW Dryden, MK Sriwastva, C Lei, L Zhang, X Qiu, F Xu, J Yan, X Zhang, JW Park, ML Merchant, HCL Bohler, B Wang, S Zhang, C Qin, Z Xu, X Han, CJ McClain, Y Teng, HG Zhang
Nature Communications, 2021;12(1):213.
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Surfactant protein C is associated with perineuronal nets and shows age-dependent changes of brain content and hippocampal deposits in wildtype and 3xTg mice
Authors: S Schob, J Puchta, K Winter, D Michalski, B Mages, H Martens, A Emmer, KT Hoffmann, F Gaunitz, A Meinicke, M Krause, W Härtig
Journal of chemical neuroanatomy, 2021;0(0):102036.
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Cyclo(Val-Pro) and Cyclo(Leu-Hydroxy-Pro) from Pseudomonas sp. (ABS-36) alleviates acute and chronic renal injury under in vitro and in vivo models (Ischemic reperfusion and unilateral ureter obstruction)
Authors: K Hira, P Sharma, A Mahale, O Prakash Ku, A Sajeli Beg
International immunopharmacology, 2021;103(0):108494.
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TGFbeta1 Secreted by Cancer-Associated Fibroblasts as an Inductor of Resistance to Photodynamic Therapy in Squamous Cell Carcinoma Cells
Authors: M Gallego-Re, M Gutiérrez-, M Fernández-, M Mascaraque, M Portillo-E, Y Gilaberte, E Carrasco, Á Juarranz
Cancers, 2021;13(22):.
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Conversion of Osteoclasts into Bone-Protective, Tumor-Suppressing Cells
Authors: KX Li, X Sun, BY Li, H Yokota
Cancers, 2021;13(22):.
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Dissection of the NKG2C NK cell response against Puumala Orthohantavirus
Authors: H Vietzen, S Hartenberg, SW Aberle, E Puchhammer
PloS Neglected Tropical Diseases, 2021;15(12):e0010006.
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Inactivation of HIV-1 in Polarized Infant Tonsil Epithelial Cells by Human Beta-Defensins 2 and 3 Tagged with the Protein Transduction Domain of HIV-1 Tat
Authors: R Herrera, K Rosbe, SM Tugizov
Viruses, 2021;13(10):.
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Macrophage-mediated RON signaling supports breast cancer growth and progression through modulation of IL-35
Authors: SJ Ruiz-Torre, JR Bourn, NM Benight, BG Hunt, C Lester, SE Waltz
Oncogene, 2021;0(0):.
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Endothelial-Derived Extracellular Vesicles Induce Cerebrovascular Dysfunction in Inflammation
Authors: D Roig-Carle, E Willms, RD Fontijn, S Martinez-P, I Mäger, HE de Vries, M Hirst, B Sharrack, DK Male, CA Hawkes, IA Romero
Pharmaceutics, 2021;13(9):.
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Gomisin M2 alleviates psoriasis?like skin inflammation by inhibiting inflammatory signaling pathways
Authors: N Kim, S Lee, J Kang, TK Kwon, D Khang, SH Kim
Molecular Medicine Reports, 2021;24(6):.
Species: Human
Sample Types: Cell Lysates
Applications: Western Blot -
Spatial immunophenotypes predict response to anti-PD1 treatment and capture distinct paths of T cell evasion in triple negative breast cancer
Authors: D Hammerl, JWM Martens, M Timmermans, M Smid, AM Trapman-Ja, R Foekens, OI Isaeva, L Voorwerk, HE Balcioglu, R Wijers, I Nederlof, R Salgado, H Horlings, M Kok, R Debets
Nature Communications, 2021;12(1):5668.
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Small Immunomodulatory Molecules as Potential Therapeutics in Experimental Murine Models of Acute Lung Injury (ALI)/Acute Respiratory Distress Syndrome (ARDS)
Authors: D Shah, P Das, S Acharya, B Agarwal, DJ Christense, SM Robertson, V Bhandari
International Journal of Molecular Sciences, 2021;22(5):.
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Interleukin-36gamma aggravates macrophage foam cell formation and atherosclerosis progression in ApoE knockout mice
Authors: M Zhang, J Liu, R Gao, Y Hu, L Lu, C Liu, L Ai, J Pan, L Tian, J Fan
Cytokine, 2021;146(0):155630.
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MFG-E8 Regulates Vascular Smooth Muscle Cell Migration Through Dose-Dependent Mediation of Actin Polymerization
Authors: HY Chiang, PH Chu, SC Chen, TH Lee
Journal of the American Heart Association, 2021;10(11):e020870.
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Immunomodulatory mAbs as Tools to Investigate on Cis-Interaction of PD-1/PD-L1 on Tumor Cells and to Set Up Methods for Early Screening of Safe and Potent Combinatorial Treatments
Authors: C Vetrei, M Passariell, G Froechlich, R Rapuano Le, N Zambrano, C De Lorenzo
Cancers, 2021;13(12):.
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Evidence That Tumor Microenvironment Initiates Epithelial-To-Mesenchymal Transition and Calebin A can Suppress it in Colorectal Cancer Cells
Authors: C Buhrmann, A Brockmuell, C Harsha, AB Kunnumakka, P Kubatka, BB Aggarwal, M Shakibaei
Frontiers in Pharmacology, 2021;12(0):699842.
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PAR2-Induced Tissue Factor Synthesis by Primary Cultures of Human Kidney Tubular Epithelial Cells Is Modified by Glucose Availability
Authors: TLR Humphries, K Shen, A Iyer, DW Johnson, GC Gobe, D Nikolic-Pa, DP Fairlie, DA Vesey
International Journal of Molecular Sciences, 2021;22(14):.
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Influence of a High-Impact Multidimensional Rehabilitation Program on the Gut Microbiota of Patients with Multiple Sclerosis
Authors: M Barone, L Mendozzi, F D'Amico, M Saresella, S Rampelli, F Piancone, F La Rosa, I Marventano, M Clerici, A d'Arma, L Pugnetti, V Rossi, M Candela, P Brigidi, S Turroni
International Journal of Molecular Sciences, 2021;22(13):.
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Mesenchymal stromal cell aging impairs the self-organizing capacity of lung alveolar epithelial stem cells
Authors: D Chanda, M Rehan, SR Smith, KG Dsouza, Y Wang, K Bernard, D Kurundkar, V Memula, K Kojima, JA Mobley, GA Benavides, V Darley-Usm, YI Kim, JW Zmijewski, JS Deshane, S De Langhe, VJ Thannickal
Elife, 2021;10(0):.
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A bispecific antibody agonist of the IL-2 heterodimeric receptor preferentially promotes in vivo expansion of CD8 and NK cells
Authors: KE Harris, KJ Lorentsen, HK Malik-Chau, K Loughlin, HM Basappa, S Hartstein, G Ahmil, NS Allen, BC Avanzino, A Balasubram, AA Boudreau, K Chang, MC Cuturi, LM Davison, DM Ho, S Iyer, US Rangaswamy, P Sankaran, U Schellenbe, R Buelow, ND Trinklein
Scientific Reports, 2021;11(1):10592.
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Orthopedic surgery-induced cognitive dysfunction is mediated by CX3CL1/R1 signaling
Authors: I Cho, JM Kim, EJ Kim, SY Kim, EH Kam, E Cheong, M Suh, BN Koo
Journal of Neuroinflammation, 2021;18(1):93.
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Traditional Thai Massage Promoted Immunity in the Elderly via Attenuation of Senescent CD4+ T Cell Subsets: A Randomized Crossover Study
Authors: K Sornkayasi, A Jumnainson, W Phoksawat, W Eungpinich, C Leelayuwat
International Journal of Environmental Research and Public Health, 2021;18(6):.
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Capturing human trophoblast development with naive pluripotent stem cells in�vitro
Authors: S Io, M Kabata, Y Iemura, K Semi, N Morone, A Minagawa, B Wang, I Okamoto, T Nakamura, Y Kojima, C Iwatani, H Tsuchiya, B Kaswandy, E Kondoh, S Kaneko, K Woltjen, M Saitou, T Yamamoto, M Mandai, Y Takashima
Cell Stem Cell, 2021;28(6):1023-1039.e13.
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Psoralidin, a major component of Psoraleae Fructus, induces inflammasome activation and idiosyncratic liver injury
Authors: Y Wang, G Xu, Z Wang, R Li, X Zhan, H Liu, Q Qin, W Li, X Wang, M Zhang, J Tang, Z Bai, X Xiao
International immunopharmacology, 2021;92(0):107352.
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TGF-&beta2 Promotes Oxidative Stress in Human Trabecular Meshwork Cells by Selectively Enhancing NADPH Oxidase 4 Expression
Authors: VR Rao, EB Stubbs
Investigative Ophthalmology & Visual Science, 2021;62(4):4.
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Probiotic-Derived Polyphosphate Accelerates Intestinal Epithelia Wound Healing through Inducing Platelet-Derived Mediators
Authors: S Isozaki, H Konishi, M Fujiya, H Tanaka, Y Murakami, S Kashima, K Ando, N Ueno, K Moriichi, T Okumura
Mediators of Inflammation, 2021;2021(0):5582943.
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Ceramide Synthase 2 Null Mice Are Protected from Ovalbumin-Induced Asthma with Higher T Cell Receptor Signal Strength in CD4+ T Cells
Authors: SH Shin, KA Cho, HS Yoon, SY Kim, HY Kim, Y Pewzner-Ju, SA Jung, WJ Park, AH Futerman, JW Park
International Journal of Molecular Sciences, 2021;22(5):.
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Mechanical forces regulate endothelial-to-mesenchymal transition and atherosclerosis via an Alk5-Shc mechanotransduction pathway
Authors: V Mehta, KL Pang, CS Givens, Z Chen, J Huang, DT Sweet, H Jo, JS Reader, E Tzima
Science Advances, 2021;7(28):.
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Deconvoluting global cytokine signaling networks in natural killer cells
Authors: GM Wiedemann, EK Santosa, S Grassmann, S Sheppard, JB Le Luduec, NM Adams, C Dang, KC Hsu, JC Sun, CM Lau
Nature Immunology, 2021;0(0):.
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Agonist anti-ChemR23 mAb reduces tissue neutrophil accumulation and triggers chronic inflammation resolution
Authors: C Trilleaud, V Gauttier, K Biteau, I Girault, L Belarif, C Mary, S Pengam, G Teppaz, V Thepenier, R Danger, G Robert-Sie, M Néel, S Bruneau, A Glémain, A Néel, A Poupon, JF Mosnier, G Chêne, M Dubourdeau, G Blancho, B Vanhove, N Poirier
Science Advances, 2021;7(14):.
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Substrate-biased activity-based probes identify proteases that cleave receptor CDCP1
Authors: T Kryza, T Khan, S Lovell, BS Harrington, J Yin, S Porazinski, M Pajic, H Koistinen, JK Rantala, T Dreyer, V Magdolen, U Reuning, Y He, EW Tate, JD Hooper
Nature Chemical Biology, 2021;0(0):.
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Initial Identification of UDP-Glucose Dehydrogenase as a Prognostic Marker in Breast Cancer Patients, Which Facilitates Epirubicin Resistance and Regulates Hyaluronan Synthesis in MDA-MB-231 Cells
Authors: DL Vitale, I Caon, A Parnigoni, I Sevic, FM Spinelli, A Icardi, A Passi, D Vigetti, L Alaniz
Biomolecules, 2021;11(2):.
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Siglec-6 is a target for chimeric antigen receptor T-cell treatment of chronic lymphocytic leukemia
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Autophagy regulates fatty acid availability for oxidative phosphorylation through mitochondria-endoplasmic reticulum contact sites
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Nat Commun, 2020-08-13;11(1):4056.
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Forward genetics identifies a novel sleep mutant with sleep state inertia and REM sleep deficits
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Sci Adv, 2020-08-12;6(33):eabb3567.
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Evaluation of a new live recombinant vaccine against cutaneous leishmaniasis in BALB/c mice
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Parasit Vectors, 2020-08-12;13(1):415.
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Uniaxial Static Strain Promotes Osteoblast Proliferation and Bone Matrix Formation in Distraction Osteogenesis In Vitro
Authors: Z Li, J Zheng, D Wan, X Yang
Biomed Res Int, 2020-08-12;2020(0):3906426.
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Matrix metalloproteinases activation in Toxocara canis induced pulmonary pathogenesis
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J Microbiol Immunol Infect, 2020-08-11;0(0):.
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The IL1beta-IL1R signaling is involved in the stimulatory effects triggered by hypoxia in breast cancer cells and cancer-associated fibroblasts (CAFs)
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J. Exp. Clin. Cancer Res., 2020-08-10;39(1):153.
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Myeloid-derived suppressor cell depletion therapy targets IL-17A-expressing mammary carcinomas
Authors: B Dawod, J Liu, S Gebremeske, C Yan, A Sappong, B Johnston, DW Hoskin, JS Marshall, J Wang
Sci Rep, 2020-08-07;10(1):13343.
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Lipopolysaccharide administration for a mouse model of cerebellar ataxia with neuroinflammation
Authors: J Hong, D Yoon, Y Nam, D Seo, JH Kim, MS Kim, TY Lee, KS Kim, PW Ko, HW Lee, K Suk, SR Kim
Sci Rep, 2020-08-07;10(1):13337.
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Modulation of glycosyltransferase ST6Gal-I in gastric cancer-derived organoids disrupts homeostatic epithelial cell turnover
Authors: KL Alexander, CA Serrano, A Chakrabort, M Nearing, LN Council, A Riquelme, M Garrido, SL Bellis, LE Smythies, PD Smith
J. Biol. Chem., 2020-08-06;0(0):.
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Isolation of Two Novel Human Anti-CTLA-4 mAbs with Intriguing Biological Properties on Tumor and NK Cells
Authors: M Passariell, C Vetrei, E Sasso, G Froechlich, C Gentile, AM D'Alise, N Zambrano, E Scarselli, A Nicosia, C De Lorenzo
Cancers (Basel), 2020-08-06;12(8):.
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Frequency Shift of a SH-SAW Biosensor with Glutaraldehyde and 3-Aminopropyltriethoxysilane Functionalized Films for Detection of Epidermal Growth Factor
Authors: XC Lo, JY Li, MT Lee, DJ Yao
Biosensors (Basel), 2020-08-05;10(8):.
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Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain Barrier
Authors: M Clé, C Desmetz, J Barthelemy, MF Martin, O Constant, G Maarifi, V Foulongne, K Bolloré, Y Glasson, F De Bock, M Blaquiere, L Dehouck, N Pirot, E Tuaillon, S Nisole, F Najioullah, P Van de Per, A Cabié, N Marchi, F Gosselet, Y Simonin, S Salinas
MBio, 2020-08-04;11(4):.
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Tousled-Like Kinases Suppress Innate Immune Signaling Triggered by Alternative Lengthening of Telomeres
Authors: S Segura-Bay, M Villamor-P, CS Attolini, LM Koenig, M Sanchiz-Ca, SJ Boulton, TH Stracker
Cell Rep, 2020-08-04;32(5):107983.
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In situ neutrophil efferocytosis shapes T cell immunity to influenza infection
Authors: K Lim, TH Kim, A Trzeciak, AM Amitrano, EC Reilly, H Prizant, DJ Fowell, DJ Topham, M Kim
Nat. Immunol., 2020-08-03;0(0):.
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CD154 inhibits death of T cells via a Cis interaction with the alpha5beta1 integrin
Authors: M Bachsais, S Salti, K Zaoui, GS Hassan, F Aoudjit, W Mourad
PLoS ONE, 2020-08-03;15(8):e0235753.
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Interleukin 16 contributes to gammaherpesvirus pathogenesis by inhibiting viral reactivation
Authors: S Liu, Z Lei, J Li, L Wang, R Jia, Z Liu, C Jiang, Y Gao, M Liu, L Kuang, Z Qian, D Zhou, SH Speck, X Liang
PLoS Pathog., 2020-07-31;16(7):e1008701.
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NLRP3 Inflammasome Activation in Lung Vascular Endothelial Cells Contributes to Intestinal Ischemia/Reperfusion-Induced Acute Lung Injury
Authors: H Ito, H Kimura, T Karasawa, S Hisata, A Sadatomo, Y Inoue, N Yamada, E Aizawa, E Hishida, R Kamata, T Komada, S Watanabe, T Kasahara, T Suzuki, H Horie, J Kitayama, N Sata, K Yamaji-Keg, M Takahashi
J. Immunol., 2020-07-29;0(0):.
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Overexpression of pigment epithelium-derived factor in placenta-derived mesenchymal stem cells promotes mitochondrial biogenesis in retinal cells
Authors: JY Kim, S Park, SH Park, D Lee, GH Kim, JE Noh, KJ Lee, GJ Kim
Lab. Invest., 2020-07-28;0(0):.
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Expansion of Human iPSC-Derived Ureteric Bud Organoids with Repeated Branching Potential
Authors: SI Mae, M Ryosaka, S Sakamoto, K Matsuse, A Nozaki, M Igami, R Kabai, A Watanabe, K Osafune
Cell Rep, 2020-07-28;32(4):107963.
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Pathophysiological mechanisms underlying a rat model of triple whammy acute kidney injury
Authors: L Prieto-Gar, L Vicente-Vi, V Blanco-Goz, O Hidalgo-Th, MC García-Mac, A Kurtz, AT Layton, AB Sanz, AI Morales, C Martínez-S, M Pericacho, SM Sancho-Mar, FJ López-Hern
Lab. Invest., 2020-07-27;0(0):.
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Hepatic protein-tyrosine phosphatase 1B disruption and pharmacological inhibition attenuate ethanol-induced oxidative stress and ameliorate alcoholic liver disease in mice
Authors: MF Hsu, S Koike, A Mello, LE Nagy, FG Haj
Redox Biol, 2020-07-24;36(0):101658.
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Wogonin Induces Apoptosis and Reverses Sunitinib Resistance of Renal Cell Carcinoma Cells via Inhibiting CDK4-RB Pathway
Authors: Y Wang, S Chen, S Sun, G Liu, L Chen, Y Xia, J Cui, W Wang, X Jiang, L Zhang, Y Zhu, Y Zou, B Shi
Front Pharmacol, 2020-07-24;11(0):1152.
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IGSF3 mutation identified in patient with severe COPD alters cell function and motility
Authors: KS Schweitzer, N Jinawath, R Yonescu, K Ni, N Rush, V Charoensaw, I Bronova, E Berdyshev, SM Leach, LA Gillenwate, RP Bowler, DB Pearse, CA Griffin, I Petrache
JCI Insight, 2020-07-23;0(0):.
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An evaluation of the tumour endothelial marker CLEC14A as a therapeutic target in solid tumours
Authors: J Robinson, K Whitworth, E Jinks, Z Nagy, R Bicknell, SP Lee
J Pathol Clin Res, 2020-07-21;0(0):.
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Effect of IFN-gamma on the kynurenine/tryptophan ratio in monolayer-cultured keratinocytes and a 3D reconstructed human epidermis model
Authors: A Gustafsson, Z Prgomet, S Jankovskaj, T Ruzgas, J Engblom, L Ohlsson, A Gjörloff W
J. Dermatol. Sci., 2020-07-17;0(0):.
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Mechanisms Mediating High Molecular Weight Hyaluronan Induced Anti-hyperalgesia
Authors: IJM Bonet, D Araldi, EV Khomula, O Bogen, PG Green, JD Levine
J. Neurosci., 2020-07-14;0(0):.
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Cellular senescence promotes skin carcinogenesis through p38MAPK and p44/p42MAPK signaling
Authors: F Alimirah, T Pulido, A Valdovinos, S Alptekin, E Chang, E Jones, DA Diaz, J Flores, MC Velarde, M Demaria, AR Davalos, CD Wiley, C Limbad, PY Desprez, J Campisi
Cancer Res., 2020-07-08;0(0):.
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Interleukin-22 deficiency alleviates doxorubicin-induced oxidative stress and cardiac injury via the p38 MAPK/macrophage/Fizz3 axis in mice
Authors: J Ye, Y Wang, Y Xu, Z Wang, L Liu, M Wang, D Ye, J Zhang, Z Yang, Y Lin, Q Ji, J Wan
Redox Biol, 2020-07-07;36(0):101636.
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Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling
Authors: G Dolgormaa, N Harimoto, N Ishii, T Yamanaka, K Hagiwara, M Tsukagoshi, T Igarashi, A Watanabe, N Kubo, K Araki, T Handa, T Yokobori, T Oyama, H Kuwano, K Shirabe
Br. J. Cancer, 2020-07-06;0(0):.
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Assessment and Comparison of the Efficacy of Methotrexate, Prednisolone, Adalimumab, and Tocilizumab on Multipotency of Mesenchymal Stem Cells
Authors: S Liu, T Kiyoi, M Ishida, M Mogi
Front Pharmacol, 2020-07-03;11(0):1004.
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LncRNA SNHG6 regulating Hedgehog signaling pathway and affecting the biological function of gallbladder carcinoma cells through targeting miR-26b-5p
Authors: XF Liu, K Wang, HC Du
Eur Rev Med Pharmacol Sci, 2020-07-01;24(14):7598-7611.
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TREM-1 and TREM-2 Expression on Blood Monocytes Could Help Predict Survival in High-Grade Glioma Patients
Authors: K Kluckova, J Kozak, K Szaboova, B Rychly, M Svajdler, M Suchankova, E Tibenska, B Filova, J Steno, V Matejcik, M Homolova, M Bucova
Mediators Inflamm., 2020-07-01;2020(0):1798147.
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Programmed cell death-ligand 2: A neglected but important target in the immune response to cancer?
Authors: C Solinas, M Aiello, E Rozali, M Lambertini, K Willard-Ga, E Migliori
Transl Oncol, 2020-07-01;13(10):100811.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Heterogenous Nuclear Ribonucleoprotein H1 Promotes Colorectal Cancer Progression through the Stabilization of mRNA of Sphingosine-1-Phosphate Lyase 1
Authors: K Takahashi, M Fujiya, H Konishi, Y Murakami, T Iwama, T Sasaki, T Kunogi, A Sakatani, K Ando, N Ueno, S Kashima, K Moriichi, H Tanabe, T Okumura
Int J Mol Sci, 2020-06-25;21(12):.
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IL-18BP is a secreted immune checkpoint and barrier to IL-18 immunotherapy
Authors: T Zhou, W Damsky, OE Weizman, MK McGeary, KP Hartmann, CE Rosen, S Fischer, R Jackson, RA Flavell, J Wang, MF Sanmamed, MW Bosenberg, AM Ring
Nature, 2020-06-24;0(0):.
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Clinical relevance of B7H3 expression in retinoblastoma
Authors: B Ganesan, S Parameswar, A Sharma, S Krishnakum
Sci Rep, 2020-06-23;10(1):10185.
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Mitochondrial alterations triggered by repeated exposure to fine (PM2.5-0.18) and quasi-ultrafine (PM0.18) fractions of ambient particulate matter
Authors: J Sotty, J Kluza, C De Sousa, M Tardivel, S Anthérieu, LY Alleman, L Canivet, E Perdrix, A Loyens, P Marchetti, JM Lo Guidice, G Garçon
Environ Int, 2020-06-22;142(0):105830.
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Mechanisms of Epstein-Barr virus nuclear antigen 1 favor Tregs accumulation in nasopharyngeal carcinoma
Authors: J Wang, Y Luo, P Bi, J Lu, F Wang, X Liu, B Zhang, X Li
Cancer Med, 2020-06-22;0(0):.
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Nifedipine Exacerbates Lipogenesis in the Kidney via KIM-1, CD36, and SREBP Upregulation: Implications from an Animal Model for Human Study
Authors: YC Lin, JC Wang, MS Wu, YF Lin, CR Chen, CY Chen, KC Chen, CC Peng
Int J Mol Sci, 2020-06-19;21(12):.
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Innate Lymphocyte Th1 and Th17 Responses in Elderly Hospitalised Patients with Infection and Sepsis
Authors: JD Coakley, EP Breen, A Moreno-Oli, AI Al-Harbi, AM Melo, B O'Connell, R McManus, DG Doherty, T Ryan
Vaccines (Basel), 2020-06-17;8(2):.
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Delayed treatment with an autophagy inhibitor 3-MA alleviates the progression of hyperuricemic nephropathy
Authors: Y Shi, M Tao, X Ma, Y Hu, G Huang, A Qiu, S Zhuang, N Liu
Cell Death Dis, 2020-06-17;11(6):467.
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IL-6 Deficiency Exacerbates Allergic Asthma and Abrogates the Protective Effect of Allergic Inflammation against Streptococcus pneumoniae Pathogenesis
Authors: T Schmit, S Ghosh, RK Mathur, T Barnhardt, G Ambigapath, M Wu, C Combs, MN Khan
J. Immunol., 2020-06-15;0(0):.
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The L1 cell adhesion molecule affects protein kinase D1 activity in the cerebral cortex in a mouse model of Alzheimer's disease
Authors: S Chen, Q Jiang, P Huang, C Hu, H Shen, M Schachner, W Zhao
Brain Res. Bull., 2020-06-12;162(0):141-150.
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Distinct Functional Requirements for Podocalyxin in Immature and Mature Podocytes Reveal Mechanisms of Human Kidney Disease
Authors: I Refaeli, MR Hughes, AK Wong, MLZ Bissonnett, CD Roskelley, A Wayne Vogl, SJ Barbour, BS Freedman, KM McNagny
Sci Rep, 2020-06-10;10(1):9419.
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Development of immortalized human hepatocyte-like hybrid cells by fusion of multi-lineage progenitor cells with primary hepatocytes
Authors: DP Collins, JH Hapke, RN Aravalli, CJ Steer
PLoS ONE, 2020-06-04;15(6):e0234002.
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Early Reperfusion Following Ischemic Stroke Provides Beneficial Effects, Even After Lethal Ischemia with Mature Neural Cell Death
Authors: Y Tanaka, N Nakagomi, N Doe, A Nakano-Doi, T Sawano, T Takagi, T Matsuyama, S Yoshimura, T Nakagomi
Cells, 2020-06-01;9(6):.
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Bacteriophage K1F targets Escherichia coli K1 in cerebral endothelial cells and influences the barrier function
Authors: C Møller-Ols, T Ross, KN Leppard, V Foisor, C Smith, DK Grammatopo, AP Sagona
Sci Rep, 2020-06-01;10(1):8903.
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miR-23a-3p is a Key Regulator of IL-17C-Induced Tumor Angiogenesis in Colorectal Cancer
Authors: Y Lee, SJ Kim, J Choo, G Heo, JW Yoo, Y Jung, SH Rhee, E Im
Cells, 2020-06-01;9(6):.
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M1 Macrophages Promote TRAIL Expression in Adipose Tissue-Derived Stem Cells, Which Suppresses Colitis-Associated Colon Cancer by Increasing Apoptosis of CD133+ Cancer Stem Cells and Decreasing M2 Macrophage Population
Authors: YW Eom, R Akter, W Li, S Lee, S Hwang, J Kim, MY Cho
Int J Mol Sci, 2020-05-29;21(11):.
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Microbiota-driven interleukin-17 production provides immune protection against invasive candidiasis
Authors: M Li, C Li, X Wu, T Chen, L Ren, B Xu, J Cao
Crit Care, 2020-05-27;24(1):268.
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SIX2 Regulates Human &beta Cell Differentiation from Stem Cells and Functional Maturation In�Vitro
Authors: L Velazco-Cr, MM Goedegebuu, KG Maxwell, P Augsornwor, NJ Hogrebe, JR Millman
Cell Rep, 2020-05-26;31(8):107687.
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Reversal of prolonged obesity-associated cerebrovascular dysfunction by inhibiting microglial Tak1
Authors: Q Shen, Z Chen, F Zhao, S Pan, T Zhang, X Cheng, L Zhang, S Zhang, J Qi, J Li, D Cai, G Zhang
Nat. Neurosci., 2020-05-25;0(0):.
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Paraquat increases Interleukin-1&beta in hippocampal dentate gyrus to impair hippocampal neurogenesis in adult mice
Authors: Q Li, H Xiao, Y Shao, X Chang, Y Zhang, Z Zhou
Ecotoxicol. Environ. Saf., 2020-05-22;200(0):110733.
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Persistent DNA damage-induced NLRP12 improves hematopoietic stem cell function
Authors: Q Lin, L Wu, Z Ma, FA Chowdhury, HH Mazumder, W Du
JCI Insight, 2020-05-21;5(10):.
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Bone marrow is the preferred site of memory CD4+ T cell proliferation during recovery from sepsis
Authors: T Skirecki, P Swacha, G Hoser, J Golab, D Nowis, E Koz?owska
JCI Insight, 2020-05-21;5(10):.
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Overexpression of MIG-6 in the cartilage induces an osteoarthritis-like phenotype in mice
Authors: M Bellini, MA Pest, M Miranda-Ro, L Qin, JW Jeong, F Beier
Arthritis Res. Ther., 2020-05-19;22(1):119.
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CNTF-STAT3-IL-6 Axis Mediates Neuroinflammatory Cascade across Schwann Cell-Neuron-Microglia
Authors: Z Hu, N Deng, K Liu, N Zhou, Y Sun, W Zeng
Cell Rep, 2020-05-19;31(7):107657.
Species: Mouse
Sample Types:
Applications: In Vivo -
Remodeling of light and dark zone follicular dendritic cells governs germinal center responses
Authors: NB Pikor, U Mörbe, M Lütge, C Gil-Cruz, C Perez-Shib, M Novkovic, HW Cheng, C Nombela-Ar, T Nagasawa, MA Linterman, L Onder, B Ludewig
Nat. Immunol., 2020-05-18;21(6):649-659.
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Anti-IL-20 antibody improved motor function and reduced glial scar formation after traumatic spinal cord injury in rats
Authors: JS Lee, YH Hsu, YS Chiu, IM Jou, MS Chang
J Neuroinflammation, 2020-05-14;17(1):156.
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Redox Modulation and Induction of Ferroptosis as a New Therapeutic Strategy in Hepatocellular Carcinoma
Authors: J Lippmann, K Petri, S Fulda, J Liese
Transl Oncol, 2020-05-13;13(8):100785.
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Metformin, an AMPK Activator, Inhibits Activation of FLSs but Promotes HAPLN1 Secretion
Authors: Y Chen, F Qiu, B Yu, Y Chen, F Zuo, X Zhu, KS Nandakumar, C Xiao
Mol Ther Methods Clin Dev, 2020-05-13;17(0):1202-1214.
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Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration
Authors: RE James, R Schalks, E Browne, I Eleftheria, CP Munoz, ND Mazarakis, R Reynolds
Acta Neuropathol Commun, 2020-05-12;8(1):66.
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ADAPT identifies an ESCRT complex composition that discriminates VCaP from LNCaP prostate cancer cell exosomes
Authors: T Hornung, HA O'Neill, SC Logie, KM Fowler, JE Duncan, M Rosenow, AS Bondre, T Tinder, V Maher, J Zarkovic, Z Zhong, MN Richards, X Wei, MR Miglarese, G Mayer, M Famulok, D Spetzler
Nucleic Acids Res., 2020-05-07;0(0):.
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Lipoprotein(a) Cellular Uptake Ex�Vivo and Hepatic Capture In�Vivo Is Insensitive to PCSK9 Inhibition With Alirocumab
Authors: K Chemello, S Beeské, TT Trang Tran, V Blanchard, EF Villard, B Poirier, JC Le Bail, G Dargazanli, S Ho-Van-Gui, D Boulay, O Bergis, MP Pruniaux, M Croyal, P Janiak, E Guillot, G Lambert
JACC Basic Transl Sci, 2020-05-06;5(6):549-557.
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Local microvascular leakage promotes trafficking of activated neutrophils to remote organs
Authors: C Owen-Woods, R Joulia, A Barkaway, L Rolas, B Ma, AF Nottebaum, KP Arkill, M Stein, T Girbl, M Golding, DO Bates, D Vestweber, MB Voisin, S Nourshargh
J. Clin. Invest., 2020-05-01;0(0):.
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Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells
Authors: DM Santer, GES Minty, DP Golec, J Lu, J May, A Namdar, J Shah, S Elahi, D Proud, M Joyce, DL Tyrrell, M Houghton
PLoS Pathog., 2020-04-30;16(4):e1008515.
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Lipocalin2 Induced by Bacterial Flagellin Protects Mice against Cyclophosphamide Mediated Neutropenic Sepsis
Authors: D Lim, HK Kim, JH Jeong, YS Jung, SE Lee, HC Jang, SI Jung, HS Choi, JH Rhee, SG Lee, C Park, M Song, HE Choy
Microorganisms, 2020-04-29;8(5):.
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LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development
Authors: NK Vinckier, NA Patel, RJ Geusz, A Wang, J Wang, I Matta, AR Harrington, M Wortham, N Wetton, J Wang, US Jhala, MG Rosenfeld, CW Benner, HP Shih, M Sander
Nat Commun, 2020-04-29;11(1):2082.
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Anti-HER2 induced myeloid cell alterations correspond with increasing vascular maturation in a murine model of HER2+ breast cancer
Authors: MJ Bloom, AM Jarrett, TA Triplett, AK Syed, T Davis, TE Yankeelov, AG Sorace
BMC Cancer, 2020-04-28;20(1):359.
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Notch signalling drives synovial fibroblast identity and arthritis pathology
Authors: K Wei, I Korsunsky, JL Marshall, A Gao, GFM Watts, T Major, AP Croft, J Watts, PE Blazar, JK Lange, TS Thornhill, A Filer, K Raza, LT Donlin, CW Siebel, CD Buckley, S Raychaudhu, MB Brenner
Nature, 2020-04-22;582(7811):259-264.
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Combined IMIG and Immune Ig Attenuate Allergic Responses in Beagle Dogs
Authors: RM Gorczynski, T Maqbool, G Hoffmann
J Immunol Res, 2020-04-21;2020(0):2061609.
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Retinal phototoxicity and the evaluation of the blue light hazard of a new solid-state lighting technology
Authors: I Jaadane, G Villalpand, P Boulenguez, S Carré, I Dassieni, C Lebon, S Chahory, F Behar-Cohe, C Martinsons, A Torriglia
Sci Rep, 2020-04-21;10(1):6733.
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Myeloid cell-derived TGF-beta signaling regulates ECM deposition in mammary carcinoma via adenosine-dependent mechanisms
Authors: G Vasiukov, T Novitskaya, A Zijlstra, P Owens, F Ye, Z Zhao, HL Moses, T Blackwell, I Feoktistov, SV Novitskiy
Cancer Res., 2020-04-20;0(0):.
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Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21
Authors: L Mercurio, D Lulli, F Mascia, E Dellambra, C Scarponi, M Morelli, C Valente, ML Carbone, S Pallotta, G Girolomoni, C Albanesi, S Pastore, S Madonna
Aging (Albany NY), 2020-04-17;12(8):6823-6851.
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Developmental IL-6 Exposure Favors Production of PDGF-Responsive Multipotential Progenitors at the Expense of Neural Stem Cells and Other Progenitors
Authors: E Kumari, FJ Velloso, A Nasuhidehn, A Somasundar, VH Savanur, KD Buono, SW Levison
Stem Cell Reports, 2020-04-16;0(0):.
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Preclinical immunotherapy with Cytokine-Induced Killer lymphocytes against epithelial ovarian cancer
Authors: S Capellero, J Erriquez, C Melano, G Mesiano, S Genta, A Pisacane, G Mittica, E Ghisoni, M Olivero, MF Di Renzo, M Aglietta, D Sangiolo, G Valabrega
Sci Rep, 2020-04-15;10(1):6478.
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Enhanced myostatin expression and signalling promote tubulointerstitial inflammation in diabetic nephropathy
Authors: D Verzola, S Milanesi, F Viazzi, F Ansaldo, M Saio, S Garibaldi, A Carta, F Costigliol, G Salvidio, C Barisione, P Esposito, G Garibotto, D Picciotto
Sci Rep, 2020-04-14;10(1):6343.
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Transplantation of Endothelial Progenitor Cells in Obese Diabetic Rats Following Myocardial Infarction: Role of Thymosin Beta-4
Authors: KK Poh, PSS Lee, AH Djohan, MJ Galupo, GG Songco, TC Yeo, HC Tan, AM Richards, L Ye
Cells, 2020-04-12;9(4):.
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Independent and inter-dependent immunoregulatory effects of NCF1 and NOS2 in experimental autoimmune encephalomyelitis
Authors: J Zhong, ACY Yau, R Holmdahl
J Neuroinflammation, 2020-04-11;17(1):113.
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Synthesis and Cytotoxic Activity Evaluation of New Cu(I) Complexes of Bis(pyrazol-1-yl) Acetate Ligands Functionalized with an NMDA Receptor Antagonist
Authors: M Pellei, L Bagnarelli, L Luciani, F Del Bello, G Giorgioni, A Piergentil, W Quaglia, M De Franco, V Gandin, C Marzano, C Santini
Int J Mol Sci, 2020-04-09;21(7):.
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Liraglutide Attenuates Non-Alcoholic Fatty Liver Disease in Mice by Regulating the Local Renin-Angiotensin System
Authors: M Yang, X Ma, X Xuan, H Deng, Q Chen, L Yuan
Front Pharmacol, 2020-04-08;11(0):432.
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Familial hypercholesterolemia class II low density lipoprotein-receptor response to statin treatment
Authors: L Omer, L Hindi, G Militello, KB Stivers, KC Tien, NL Boyd
Dis Model Mech, 2020-04-06;0(0):.
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Cell body shape and directional movement stability in human-induced pluripotent stem cell-derived dopaminergic neurons
Authors: Y Arioka, E Shishido, I Kushima, D Mori, N Ozaki
Sci Rep, 2020-04-02;10(1):5820.
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Identification of the Neuroinvasive Pathogen Host Target, LamR, as an Endothelial Receptor for the Treponema pallidum Adhesin Tp0751
Authors: KV Lithgow, B Church, A Gomez, E Tsao, S Houston, LA Swayne, CE Cameron
mSphere, 2020-04-01;5(2):.
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Hypoxia-induced complement dysregulation is associated with microvascular impairments in mouse tracheal transplants
Authors: MA Khan, T Shamma, S Kazmi, A Altuhami, HA Ahmed, AM Assiri, DC Broering
J Transl Med, 2020-03-31;18(1):147.
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Helicobacter pylori Avoids the Critical Activation of NLRP3 Inflammasome-Mediated Production of Oncogenic Mature IL-1&beta in Human Immune Cells
Authors: SK Pachathund, N Blaser, H Bruns, S Backert
Cancers (Basel), 2020-03-27;12(4):.
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Development and implementation of large-scale quality control for the European bank for induced Pluripotent Stem Cells
Authors: O O'Shea, R Steeg, C Chapman, P Mackintosh, GN Stacey
Stem Cell Res, 2020-03-20;45(0):101773.
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Evidence for a pathogenic role of extrafollicular, IL-10-producing CCR6+B helper T cells in systemic lupus erythematosus
Authors: F Facciotti, P Larghi, R Bosotti, C Vasco, N Gagliani, C Cordiglier, S Mazzara, V Ranzani, E Rottoli, S Curti, A Penatti, B Karnani, Y Kobayashi, M Crosti, M Bombaci, JP van Hambur, G Rossetti, R Gualtierot, M Gerosa, S Gatti, S Torretta, L Pignataro, SW Tas, S Abrignani, M Pagani, F Grassi, PL Meroni, RA Flavell, J Geginat
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Pathogens, 2020;9(1):.
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Grape Seed Waste Counteracts Aflatoxin B1 Toxicity in Piglet Mesenteric Lymph Nodes
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Characterization of Human NK Cell-Derived Exosomes: Role of DNAM1 Receptor In Exosome-Mediated Cytotoxicity Against Tumor
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Combined Dendritic and Axonal Deterioration Are Responsible for Motoneuronopathy in Patient-Derived Neuronal Cell Models of Chorea-Acanthocytosis
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TGF&beta1 Suppressed Matrix Mineralization of Osteoblasts Differentiation by Regulating SMURF1-C/EBP&beta-DKK1 Axis
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Concurrent Targeting of Potential Cancer Stem Cells Regulating Pathways Sensitizes Lung Adenocarcinoma to Standard Chemotherapy
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Transplantation of Neural Precursors Derived from Induced Pluripotent Cells Preserve Perineuronal Nets and Stimulate Neural Plasticity in ALS Rats
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Synthesis and Cytotoxic Activity Evaluation of New Cu(I) Complexes of Bis(pyrazol-1-yl) Acetate Ligands Functionalized with an NMDA Receptor Antagonist
Authors: M Pellei, L Bagnarelli, L Luciani, F Del Bello, G Giorgioni, A Piergentil, W Quaglia, M De Franco, V Gandin, C Marzano, C Santini
Int J Mol Sci, 2020;21(7):.
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CNTF-STAT3-IL-6 Axis Mediates Neuroinflammatory Cascade across Schwann Cell-Neuron-Microglia
Authors: Z Hu, N Deng, K Liu, N Zhou, Y Sun, W Zeng
Cell Rep, 2020;31(7):107657.
Species: Mouse
Sample Types:
Applications: In Vivo -
Microbiota-driven interleukin-17 production provides immune protection against invasive candidiasis
Authors: M Li, C Li, X Wu, T Chen, L Ren, B Xu, J Cao
Crit Care, 2020;24(1):268.
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Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells
Authors: DM Santer, GES Minty, DP Golec, J Lu, J May, A Namdar, J Shah, S Elahi, D Proud, M Joyce, DL Tyrrell, M Houghton
PLoS Pathog., 2020;16(4):e1008515.
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Helicobacter pylori Avoids the Critical Activation of NLRP3 Inflammasome-Mediated Production of Oncogenic Mature IL-1&beta in Human Immune Cells
Authors: SK Pachathund, N Blaser, H Bruns, S Backert
Cancers (Basel), 2020;12(4):.
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SIX2 Regulates Human &beta Cell Differentiation from Stem Cells and Functional Maturation In�Vitro
Authors: L Velazco-Cr, MM Goedegebuu, KG Maxwell, P Augsornwor, NJ Hogrebe, JR Millman
Cell Rep, 2020;31(8):107687.
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Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration
Authors: RE James, R Schalks, E Browne, I Eleftheria, CP Munoz, ND Mazarakis, R Reynolds
Acta Neuropathol Commun, 2020;8(1):66.
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Bone marrow is the preferred site of memory CD4+ T cell proliferation during recovery from sepsis
Authors: T Skirecki, P Swacha, G Hoser, J Golab, D Nowis, E Koz?owska
JCI Insight, 2020;5(10):.
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Anti-IL-20 antibody improved motor function and reduced glial scar formation after traumatic spinal cord injury in rats
Authors: JS Lee, YH Hsu, YS Chiu, IM Jou, MS Chang
J Neuroinflammation, 2020;17(1):156.
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Intracellular Insulin-like growth factor binding protein 2 (IGFBP2) contributes to the senescence of keratinocytes in psoriasis by stabilizing cytoplasmic p21
Authors: L Mercurio, D Lulli, F Mascia, E Dellambra, C Scarponi, M Morelli, C Valente, ML Carbone, S Pallotta, G Girolomoni, C Albanesi, S Pastore, S Madonna
Aging (Albany NY), 2020;12(8):6823-6851.
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Remodeling of light and dark zone follicular dendritic cells governs germinal center responses
Authors: NB Pikor, U Mörbe, M Lütge, C Gil-Cruz, C Perez-Shib, M Novkovic, HW Cheng, C Nombela-Ar, T Nagasawa, MA Linterman, L Onder, B Ludewig
Nat. Immunol., 2020;21(6):649-659.
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Lipocalin2 Induced by Bacterial Flagellin Protects Mice against Cyclophosphamide Mediated Neutropenic Sepsis
Authors: D Lim, HK Kim, JH Jeong, YS Jung, SE Lee, HC Jang, SI Jung, HS Choi, JH Rhee, SG Lee, C Park, M Song, HE Choy
Microorganisms, 2020;8(5):.
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Overexpression of MIG-6 in the cartilage induces an osteoarthritis-like phenotype in mice
Authors: M Bellini, MA Pest, M Miranda-Ro, L Qin, JW Jeong, F Beier
Arthritis Res. Ther., 2020;22(1):119.
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Combined IMIG and Immune Ig Attenuate Allergic Responses in Beagle Dogs
Authors: RM Gorczynski, T Maqbool, G Hoffmann
J Immunol Res, 2020;2020(0):2061609.
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Redox Modulation and Induction of Ferroptosis as a New Therapeutic Strategy in Hepatocellular Carcinoma
Authors: J Lippmann, K Petri, S Fulda, J Liese
Transl Oncol, 2020;13(8):100785.
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Local microvascular leakage promotes trafficking of activated neutrophils to remote organs
Authors: C Owen-Woods, R Joulia, A Barkaway, L Rolas, B Ma, AF Nottebaum, KP Arkill, M Stein, T Girbl, M Golding, DO Bates, D Vestweber, MB Voisin, S Nourshargh
J. Clin. Invest., 2020;0(0):.
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Multivariate patterning of human pluripotent cells under perfusion reveals critical roles of induced paracrine factors in kidney organoid development
Authors: NR Glass, M Takasako, PX Er, DM Titmarsh, A Hidalgo, EJ Wolvetang, MH Little, JJ Cooper-Whi
Sci Adv, 2020;6(2):eaaw2746.
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The PI3K subunits, P110&alpha and P110&beta are potential targets for overcoming P-gp and BCRP-mediated MDR in cancer
Authors: L Zhang, Y Li, Q Wang, Z Chen, X Li, Z Wu, C Hu, D Liao, W Zhang, ZS Chen
Mol. Cancer, 2020;19(1):10.
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Compartmentalized profiling of amniotic fluid cytokines in women with preterm labor
Authors: G Bhatti, R Romero, GE Rice, W Fitzgerald, P Pacora, N Gomez-Lope, M Kavdia, AL Tarca, L Margolis
PLoS ONE, 2020;15(1):e0227881.
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CD44 mediates stem cell mobilization to damaged lung via its novel transcriptional targets, Cortactin and Survivin
Authors: A Ouhtit, R Thouta, H Zayed, RL Gaur, A Fernando, M Rahman, DA Welsh
Int J Med Sci, 2020;17(1):103-111.
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Reversal of prolonged obesity-associated cerebrovascular dysfunction by inhibiting microglial Tak1
Authors: Q Shen, Z Chen, F Zhao, S Pan, T Zhang, X Cheng, L Zhang, S Zhang, J Qi, J Li, D Cai, G Zhang
Nat. Neurosci., 2020;0(0):.
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Anti-HER2 induced myeloid cell alterations correspond with increasing vascular maturation in a murine model of HER2+ breast cancer
Authors: MJ Bloom, AM Jarrett, TA Triplett, AK Syed, T Davis, TE Yankeelov, AG Sorace
BMC Cancer, 2020;20(1):359.
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Mechanisms Mediating High Molecular Weight Hyaluronan Induced Anti-hyperalgesia
Authors: IJM Bonet, D Araldi, EV Khomula, O Bogen, PG Green, JD Levine
J. Neurosci., 2020;0(0):.
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LSD1-mediated enhancer silencing attenuates retinoic acid signalling during pancreatic endocrine cell development
Authors: NK Vinckier, NA Patel, RJ Geusz, A Wang, J Wang, I Matta, AR Harrington, M Wortham, N Wetton, J Wang, US Jhala, MG Rosenfeld, CW Benner, HP Shih, M Sander
Nat Commun, 2020;11(1):2082.
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Pathophysiological mechanisms underlying a rat model of triple whammy acute kidney injury
Authors: L Prieto-Gar, L Vicente-Vi, V Blanco-Goz, O Hidalgo-Th, MC García-Mac, A Kurtz, AT Layton, AB Sanz, AI Morales, C Martínez-S, M Pericacho, SM Sancho-Mar, FJ López-Hern
Lab. Invest., 2020;0(0):.
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Mac-2-binding protein glycan isomer enhances the aggressiveness of hepatocellular carcinoma by activating mTOR signaling
Authors: G Dolgormaa, N Harimoto, N Ishii, T Yamanaka, K Hagiwara, M Tsukagoshi, T Igarashi, A Watanabe, N Kubo, K Araki, T Handa, T Yokobori, T Oyama, H Kuwano, K Shirabe
Br. J. Cancer, 2020;0(0):.
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Assessment and Comparison of the Efficacy of Methotrexate, Prednisolone, Adalimumab, and Tocilizumab on Multipotency of Mesenchymal Stem Cells
Authors: S Liu, T Kiyoi, M Ishida, M Mogi
Front Pharmacol, 2020;11(0):1004.
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Overexpression of pigment epithelium-derived factor in placenta-derived mesenchymal stem cells promotes mitochondrial biogenesis in retinal cells
Authors: JY Kim, S Park, SH Park, D Lee, GH Kim, JE Noh, KJ Lee, GJ Kim
Lab. Invest., 2020;0(0):.
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Programmed cell death-ligand 2: A neglected but important target in the immune response to cancer?
Authors: C Solinas, M Aiello, E Rozali, M Lambertini, K Willard-Ga, E Migliori
Transl Oncol, 2020;13(10):100811.
Species: Human
Sample Types: Whole Tissue
Applications: IHC -
Blood Monocyte Phenotype Fingerprint of Stable Coronary Artery Disease: A Cross-Sectional Substudy of SMARTool Clinical Trial
Authors: S Sbrana, J Campolo, A Clemente, L Bastiani, A Cecchettin, E Ceccherini, C Caselli, D Neglia, O Parodi, D Chiappino, JM Smit, AJ Scholte, G Pelosi, S Rocchiccio
Biomed Res Int, 2020;2020(0):8748934.
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An evaluation of the tumour endothelial marker CLEC14A as a therapeutic target in solid tumours
Authors: J Robinson, K Whitworth, E Jinks, Z Nagy, R Bicknell, SP Lee
J Pathol Clin Res, 2020;0(0):.
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Genetic and pharmacological targeting of A2a receptor improves function of anti-mesothelin CAR T cells
Authors: E Masoumi, L Jafarzadeh, HR Mirzaei, K Alishah, K Fallah-Meh, H Rostamian, M Khakpoor-K, R Meshkani, F Noorbakhsh, J Hadjati
J. Exp. Clin. Cancer Res., 2020;39(1):49.
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Leukemia-induced dysfunctional TIM-3+CD4+ bone marrow T cells increase risk of relapse in pediatric B-precursor ALL patients
Authors: F Blaeschke, S Willier, D Stenger, M Lepenies, MA Horstmann, G Escherich, M Zimmermann, F Rojas Ring, S Canzar, T Kaeuferle, M Rohlfs, V Binder, C Klein, T Feuchtinge
Leukemia, 2020;0(0):.
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Myeloid cell-derived TGF-beta signaling regulates ECM deposition in mammary carcinoma via adenosine-dependent mechanisms
Authors: G Vasiukov, T Novitskaya, A Zijlstra, P Owens, F Ye, Z Zhao, HL Moses, T Blackwell, I Feoktistov, SV Novitskiy
Cancer Res., 2020;0(0):.
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Retinal phototoxicity and the evaluation of the blue light hazard of a new solid-state lighting technology
Authors: I Jaadane, G Villalpand, P Boulenguez, S Carré, I Dassieni, C Lebon, S Chahory, F Behar-Cohe, C Martinsons, A Torriglia
Sci Rep, 2020;10(1):6733.
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Independent and inter-dependent immunoregulatory effects of NCF1 and NOS2 in experimental autoimmune encephalomyelitis
Authors: J Zhong, ACY Yau, R Holmdahl
J Neuroinflammation, 2020;17(1):113.
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Transplantation of Endothelial Progenitor Cells in Obese Diabetic Rats Following Myocardial Infarction: Role of Thymosin Beta-4
Authors: KK Poh, PSS Lee, AH Djohan, MJ Galupo, GG Songco, TC Yeo, HC Tan, AM Richards, L Ye
Cells, 2020;9(4):.
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Developmental IL-6 Exposure Favors Production of PDGF-Responsive Multipotential Progenitors at the Expense of Neural Stem Cells and Other Progenitors
Authors: E Kumari, FJ Velloso, A Nasuhidehn, A Somasundar, VH Savanur, KD Buono, SW Levison
Stem Cell Reports, 2020;0(0):.
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Identification of the Neuroinvasive Pathogen Host Target, LamR, as an Endothelial Receptor for the Treponema pallidum Adhesin Tp0751
Authors: KV Lithgow, B Church, A Gomez, E Tsao, S Houston, LA Swayne, CE Cameron
mSphere, 2020;5(2):.
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Hypoxia-induced complement dysregulation is associated with microvascular impairments in mouse tracheal transplants
Authors: MA Khan, T Shamma, S Kazmi, A Altuhami, HA Ahmed, AM Assiri, DC Broering
J Transl Med, 2020;18(1):147.
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Preclinical immunotherapy with Cytokine-Induced Killer lymphocytes against epithelial ovarian cancer
Authors: S Capellero, J Erriquez, C Melano, G Mesiano, S Genta, A Pisacane, G Mittica, E Ghisoni, M Olivero, MF Di Renzo, M Aglietta, D Sangiolo, G Valabrega
Sci Rep, 2020;10(1):6478.
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Cell body shape and directional movement stability in human-induced pluripotent stem cell-derived dopaminergic neurons
Authors: Y Arioka, E Shishido, I Kushima, D Mori, N Ozaki
Sci Rep, 2020;10(1):5820.
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Development and implementation of large-scale quality control for the European bank for induced Pluripotent Stem Cells
Authors: O O'Shea, R Steeg, C Chapman, P Mackintosh, GN Stacey
Stem Cell Res, 2020;45(0):101773.
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Enhanced myostatin expression and signalling promote tubulointerstitial inflammation in diabetic nephropathy
Authors: D Verzola, S Milanesi, F Viazzi, F Ansaldo, M Saio, S Garibaldi, A Carta, F Costigliol, G Salvidio, C Barisione, P Esposito, G Garibotto, D Picciotto
Sci Rep, 2020;10(1):6343.
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Chlamydia pneumoniae infection-induced endoplasmic reticulum stress causes fatty acid-binding protein 4 secretion in murine adipocytes
Authors: NF Walenna, Y Kurihara, B Chou, K Ishii, T Soejima, K Hiromatsu
J. Biol. Chem., 2020;0(0):.
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Interleukin-25-mediated resistance against intestinal trematodes does not depend on the generation of Th2 responses
Authors: M Álvarez-Iz, M Pérez-Cres, JG Esteban, C Muñoz-Anto, R Toledo
Parasites & vectors, 2020;13(1):608.
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TREM-1 and TREM-2 Expression on Blood Monocytes Could Help Predict Survival in High-Grade Glioma Patients
Authors: K Kluckova, J Kozak, K Szaboova, B Rychly, M Svajdler, M Suchankova, E Tibenska, B Filova, J Steno, V Matejcik, M Homolova, M Bucova
Mediators Inflamm., 2020;2020(0):1798147.
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Bacteriophage K1F targets Escherichia coli K1 in cerebral endothelial cells and influences the barrier function
Authors: C Møller-Ols, T Ross, KN Leppard, V Foisor, C Smith, DK Grammatopo, AP Sagona
Sci Rep, 2020;10(1):8903.
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Inhibition of bone morphogenetic protein 6 receptors ameliorates Sj�gren's syndrome in mice
Authors: H Yin, L Kalra, Z Lai, MC Guimaro, L Aber, BM Warner, D Michael, N Zhang, J Cabrera-Pe, A Karim, WD Swaim, S Afione, A Voigt, CQ Nguyen, PB Yu, DB Bloch, JA Chiorini
Sci Rep, 2020;10(1):2967.
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Interleukin 16 contributes to gammaherpesvirus pathogenesis by inhibiting viral reactivation
Authors: S Liu, Z Lei, J Li, L Wang, R Jia, Z Liu, C Jiang, Y Gao, M Liu, L Kuang, Z Qian, D Zhou, SH Speck, X Liang
PLoS Pathog., 2020;16(7):e1008701.
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Lipopolysaccharide administration for a mouse model of cerebellar ataxia with neuroinflammation
Authors: J Hong, D Yoon, Y Nam, D Seo, JH Kim, MS Kim, TY Lee, KS Kim, PW Ko, HW Lee, K Suk, SR Kim
Sci Rep, 2020;10(1):13337.
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IGSF3 mutation identified in patient with severe COPD alters cell function and motility
Authors: KS Schweitzer, N Jinawath, R Yonescu, K Ni, N Rush, V Charoensaw, I Bronova, E Berdyshev, SM Leach, LA Gillenwate, RP Bowler, DB Pearse, CA Griffin, I Petrache
JCI Insight, 2020;0(0):.
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The IL1beta-IL1R signaling is involved in the stimulatory effects triggered by hypoxia in breast cancer cells and cancer-associated fibroblasts (CAFs)
Authors: R Lappano, M Talia, F Cirillo, DC Rigiraccio, D Scordamagl, R Guzzi, AM Miglietta, EM De Frances, A Belfiore, AH Sims, M Maggiolini
J. Exp. Clin. Cancer Res., 2020;39(1):153.
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Lipoprotein(a) Cellular Uptake Ex�Vivo and Hepatic Capture In�Vivo Is Insensitive to PCSK9 Inhibition With Alirocumab
Authors: K Chemello, S Beeské, TT Trang Tran, V Blanchard, EF Villard, B Poirier, JC Le Bail, G Dargazanli, S Ho-Van-Gui, D Boulay, O Bergis, MP Pruniaux, M Croyal, P Janiak, E Guillot, G Lambert
JACC Basic Transl Sci, 2020;5(6):549-557.
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Uniaxial Static Strain Promotes Osteoblast Proliferation and Bone Matrix Formation in Distraction Osteogenesis In Vitro
Authors: Z Li, J Zheng, D Wan, X Yang
Biomed Res Int, 2020;2020(0):3906426.
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NLRP3 Inflammasome Activation in Lung Vascular Endothelial Cells Contributes to Intestinal Ischemia/Reperfusion-Induced Acute Lung Injury
Authors: H Ito, H Kimura, T Karasawa, S Hisata, A Sadatomo, Y Inoue, N Yamada, E Aizawa, E Hishida, R Kamata, T Komada, S Watanabe, T Kasahara, T Suzuki, H Horie, J Kitayama, N Sata, K Yamaji-Keg, M Takahashi
J. Immunol., 2020;0(0):.
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Evidence for a pathogenic role of extrafollicular, IL-10-producing CCR6+B helper T cells in systemic lupus erythematosus
Authors: F Facciotti, P Larghi, R Bosotti, C Vasco, N Gagliani, C Cordiglier, S Mazzara, V Ranzani, E Rottoli, S Curti, A Penatti, B Karnani, Y Kobayashi, M Crosti, M Bombaci, JP van Hambur, G Rossetti, R Gualtierot, M Gerosa, S Gatti, S Torretta, L Pignataro, SW Tas, S Abrignani, M Pagani, F Grassi, PL Meroni, RA Flavell, J Geginat
Proc. Natl. Acad. Sci. U.S.A., 2020;117(13):7305-7316.
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Circular RNA VMA21 ameliorates sepsis-associated acute kidney injury by regulating miR-9-3p/SMG1/inflammation axis and oxidative stress
Authors: Y Shi, CF Sun, WH Ge, YP Du, NB Hu
J. Cell. Mol. Med., 2020;0(0):.
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IL-6 Deficiency Exacerbates Allergic Asthma and Abrogates the Protective Effect of Allergic Inflammation against Streptococcus pneumoniae Pathogenesis
Authors: T Schmit, S Ghosh, RK Mathur, T Barnhardt, G Ambigapath, M Wu, C Combs, MN Khan
J. Immunol., 2020;0(0):.
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LncRNA SNHG6 regulating Hedgehog signaling pathway and affecting the biological function of gallbladder carcinoma cells through targeting miR-26b-5p
Authors: XF Liu, K Wang, HC Du
Eur Rev Med Pharmacol Sci, 2020;24(14):7598-7611.
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Distinct Functional Requirements for Podocalyxin in Immature and Mature Podocytes Reveal Mechanisms of Human Kidney Disease
Authors: I Refaeli, MR Hughes, AK Wong, MLZ Bissonnett, CD Roskelley, A Wayne Vogl, SJ Barbour, BS Freedman, KM McNagny
Sci Rep, 2020;10(1):9419.
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Modulation of glycosyltransferase ST6Gal-I in gastric cancer-derived organoids disrupts homeostatic epithelial cell turnover
Authors: KL Alexander, CA Serrano, A Chakrabort, M Nearing, LN Council, A Riquelme, M Garrido, SL Bellis, LE Smythies, PD Smith
J. Biol. Chem., 2020;0(0):.
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4-Phenylbutyrate ameliorates apoptotic neural cell death in Down syndrome by reducing protein aggregates
Authors: K Hirata, T Nambara, K Kawatani, N Nawa, H Yoshimatsu, H Kusakabe, K Banno, K Nishimura, M Ohtaka, M Nakanishi, H Taniguchi, H Arahori, K Wada, K Ozono, Y Kitabatake
Sci Rep, 2020;10(1):14047.
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Clinical relevance of B7H3 expression in retinoblastoma
Authors: B Ganesan, S Parameswar, A Sharma, S Krishnakum
Sci Rep, 2020;10(1):10185.
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Blockade of beta-Catenin-Induced CCL28 Suppresses Gastric Cancer Progression via Inhibition of Treg Cell Infiltration
Authors: L Ji, W Qian, L Gui, Z Ji, P Yin, GN Lin, Y Wang, B Ma, WQ Gao
Cancer Res., 2020;80(10):2004-2016.
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Nifedipine Exacerbates Lipogenesis in the Kidney via KIM-1, CD36, and SREBP Upregulation: Implications from an Animal Model for Human Study
Authors: YC Lin, JC Wang, MS Wu, YF Lin, CR Chen, CY Chen, KC Chen, CC Peng
Int J Mol Sci, 2020;21(12):.
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Interleukin-22 deficiency alleviates doxorubicin-induced oxidative stress and cardiac injury via the p38 MAPK/macrophage/Fizz3 axis in mice
Authors: J Ye, Y Wang, Y Xu, Z Wang, L Liu, M Wang, D Ye, J Zhang, Z Yang, Y Lin, Q Ji, J Wan
Redox Biol, 2020;36(0):101636.
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Zika Virus Infection Promotes Local Inflammation, Cell Adhesion Molecule Upregulation, and Leukocyte Recruitment at the Blood-Brain Barrier
Authors: M Clé, C Desmetz, J Barthelemy, MF Martin, O Constant, G Maarifi, V Foulongne, K Bolloré, Y Glasson, F De Bock, M Blaquiere, L Dehouck, N Pirot, E Tuaillon, S Nisole, F Najioullah, P Van de Per, A Cabié, N Marchi, F Gosselet, Y Simonin, S Salinas
MBio, 2020;11(4):.
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The L1 cell adhesion molecule affects protein kinase D1 activity in the cerebral cortex in a mouse model of Alzheimer's disease
Authors: S Chen, Q Jiang, P Huang, C Hu, H Shen, M Schachner, W Zhao
Brain Res. Bull., 2020;162(0):141-150.
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Development of immortalized human hepatocyte-like hybrid cells by fusion of multi-lineage progenitor cells with primary hepatocytes
Authors: DP Collins, JH Hapke, RN Aravalli, CJ Steer
PLoS ONE, 2020;15(6):e0234002.
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Mechanisms of Epstein-Barr virus nuclear antigen 1 favor Tregs accumulation in nasopharyngeal carcinoma
Authors: J Wang, Y Luo, P Bi, J Lu, F Wang, X Liu, B Zhang, X Li
Cancer Med, 2020;0(0):.
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miR-23a-3p is a Key Regulator of IL-17C-Induced Tumor Angiogenesis in Colorectal Cancer
Authors: Y Lee, SJ Kim, J Choo, G Heo, JW Yoo, Y Jung, SH Rhee, E Im
Cells, 2020;9(6):.
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Endogenous antisense RNA curbs CD39 expression in Crohn's disease
Authors: RP Harshe, A Xie, M Vuerich, LA Frank, B Gromova, H Zhang, RJ Robles, S Mukherjee, E Csizmadia, E Kokkotou, AS Cheifetz, AC Moss, SK Kota, SC Robson, MS Longhi
Nat Commun, 2020;11(1):5894.
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Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In�Vivo
Authors: Y Miao, A Ha, W de Lau, K Yuki, AJM Santos, C You, MH Geurts, J Puschhof, C Pleguezuel, WC Peng, R Senlice, C Piani, JW Buikema, OM Gbenedio, M Vallon, J Yuan, S de Haan, W Hemrika, K Rösch, LT Dang, D Baker, M Ott, P Depeille, SM Wu, J Drost, R Nusse, JP Roose, J Piehler, SF Boj, CY Janda, H Clevers, CJ Kuo, KC Garcia
Cell Stem Cell, 2020;0(0):.
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Impact of deranged B cell subsets distribution in the development of HCV-related cirrhosis and HCC in type two diabetes mellitus
Authors: FA Abdelwahab, KM Hassanein, HF Hetta, MO Abdelmalek, AM Zahran, O El-Badawy
Sci Rep, 2020;10(1):20383.
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Functionally enhanced placenta-derived mesenchymal stem cells inhibit adipogenesis in orbital fibroblasts with Graves' ophthalmopathy
Authors: JY Kim, S Park, HJ Lee, H Lew, GJ Kim
Stem Cell Res Ther, 2020;11(1):469.
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M1 Macrophages Promote TRAIL Expression in Adipose Tissue-Derived Stem Cells, Which Suppresses Colitis-Associated Colon Cancer by Increasing Apoptosis of CD133+ Cancer Stem Cells and Decreasing M2 Macrophage Population
Authors: YW Eom, R Akter, W Li, S Lee, S Hwang, J Kim, MY Cho
Int J Mol Sci, 2020;21(11):.
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Subtilase cytotoxin induces a novel form of Lipocalin 2, which promotes Shiga-toxigenic Escherichia coli survival
Authors: K Yahiro, K Ogura, Y Goto, S Iyoda, T Kobayashi, H Takeuchi, M Ohnishi, J Moss
Sci Rep, 2020;10(1):18943.
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Hepatic protein-tyrosine phosphatase 1B disruption and pharmacological inhibition attenuate ethanol-induced oxidative stress and ameliorate alcoholic liver disease in mice
Authors: MF Hsu, S Koike, A Mello, LE Nagy, FG Haj
Redox Biol, 2020;36(0):101658.
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Neuromuscular Activity Induces Paracrine Signaling and Triggers Axonal Regrowth after Injury in Microfluidic Lab-On-Chip Devices
Authors: J Sala-Jarqu, F Mesquida-V, M Badiola-Ma, J Samitier, A Hervera, JA Del Río
Cells, 2020;9(2):.
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Transcriptional and functional insights into the host immune response against the emerging fungal pathogen Candida auris
Authors: M Bruno, S Kersten, JM Bain, M Jaeger, D Rosati, MD Kruppa, DW Lowman, PJ Rice, B Graves, Z Ma, YN Jiao, A Chowdhary, G Renieris, FL van de Vee, BJ Kullberg, EJ Giamarello, A Hoischen, NAR Gow, AJP Brown, JF Meis, DL Williams, MG Netea
Nat Microbiol, 2020;0(0):.
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Upregulation of DR5 and Downregulation of Survivin by IITZ-01, Lysosomotropic Autophagy Inhibitor, Potentiates TRAIL-Mediated Apoptosis in Renal Cancer Cells via Ubiquitin-Proteasome Pathway
Authors: SA Shahriyar, SU Seo, KJ Min, P Kubatka, DS Min, JS Chang, DE Kim, SM Woo, TK Kwon
Cancers (Basel), 2020;12(9):.
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Induction of IkappaB? Augments Cytokine and Chemokine Production by IL-33 in Mast Cells
Authors: H Ohto-Ozaki, M Hayakawa, N Kamoshita, T Maruyama, SI Tominaga, T Ohmori
J. Immunol., 2020;204(8):2033-2042.
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Delayed treatment with an autophagy inhibitor 3-MA alleviates the progression of hyperuricemic nephropathy
Authors: Y Shi, M Tao, X Ma, Y Hu, G Huang, A Qiu, S Zhuang, N Liu
Cell Death Dis, 2020;11(6):467.
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IFITM3 functions as a PIP3 scaffold to amplify PI3K signalling in B�cells
Authors: J Lee, ME Robinson, N Ma, D Artadji, MA Ahmed, G Xiao, T Sadras, G Deb, J Winchester, KN Cosgun, H Geng, LN Chan, K Kume, TP Miettinen, Y Zhang, MA Nix, L Klemm, CW Chen, J Chen, V Khairnar, AP Wiita, A Thomas-Tik, M Farzan, JU Jung, DM Weinstock, SR Manalis, MS Diamond, N Vaidehi, M Müschen
Nature, 2020;0(0):.
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Notch signalling drives synovial fibroblast identity and arthritis pathology
Authors: K Wei, I Korsunsky, JL Marshall, A Gao, GFM Watts, T Major, AP Croft, J Watts, PE Blazar, JK Lange, TS Thornhill, A Filer, K Raza, LT Donlin,, CW Siebel, CD Buckley, S Raychaudhu, MB Brenner
Nature, 2020;582(7811):259-264.
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CD154 inhibits death of T cells via a Cis interaction with the alpha5beta1 integrin
Authors: M Bachsais, S Salti, K Zaoui, GS Hassan, F Aoudjit, W Mourad
PLoS ONE, 2020;15(8):e0235753.
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Persistent DNA damage-induced NLRP12 improves hematopoietic stem cell function
Authors: Q Lin, L Wu, Z Ma, FA Chowdhury, HH Mazumder, W Du
JCI Insight, 2020;5(10):.
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Hydrophobicity drives receptor-mediated uptake of heat-processed proteins by THP-1 macrophages and dendritic cells, but not cytokine responses
Authors: Y Deng, C Govers, M Teodorowic, I Liobyte, I De Simone, K Hettinga, HJ Wichers
PLoS ONE, 2020;15(8):e0236212.
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In situ neutrophil efferocytosis shapes T cell immunity to influenza infection
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LncRNA-TWIST1 Promoted Osteogenic Differentiation Both in PPDLSCs and in HPDLSCs by Inhibiting TWIST1 Expression
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Enhanced uropathogenic Escherichia coli-induced infection in uroepithelial cells by sugar through TLR-4 and JAK/STAT1 signaling pathways
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Mesangial Cells Exhibit Features of Antigen-Presenting Cells and Activate CD4+ T Cell Responses
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Fibronectin Promotes Cell Growth and Migration in Human Renal Cell Carcinoma Cells
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AXL Is a Novel Predictive Factor and Therapeutic Target for Radioactive Iodine Refractory Thyroid Cancer
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The IL-33/ST2 pathway shapes the regulatory T cell phenotype to promote intestinal cancer
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Cysteine-type cathepsins promote the effector phase of acute cutaneous delayed-type hypersensitivity reactions
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PPAR?/? ligands regulate the expression of immune response mediators in the porcine endometrium - An in�vitro study
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RNA Virus-Based Episomal Vector with a Fail-Safe Switch Facilitating Efficient Genetic Modification and Differentiation of iPSCs
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Elaeagnus glabra f. oxyphylla Attenuates Scopolamine-Induced Learning and Memory Impairments in Mice by Improving Cholinergic Transmission via Activation of CREB/NGF Signaling
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Metabolomic and transcriptional analyses reveal atmospheric oxygen during human induced pluripotent stem cell generation impairs metabolic reprogramming
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Wnt Signaling Separates the Progenitor and Endocrine Compartments during Pancreas Development
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The m6A reader YTHDF1 regulates axon guidance through translational control of Robo3.1 expression
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Senescence-related deterioration of intercellular junctions in the peritoneal mesothelium promotes the transmesothelial invasion of ovarian cancer cells
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Histopathology and expression of the chemokines CXCL10, CXCL13, and CXCR3 and the endogenous TLR-4 ligand S100A8/A9 in lymph nodes of patients with adult-onset Still's disease
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Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells
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Obesity Reduces mTORC1 Activity in Mucosal-Associated Invariant T Cells, Driving Defective Metabolic and Functional Responses
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Translational repression of Ccl5 and Cxcl10 by 4E-BP1 and 4E-BP2 restrains the ability of mouse macrophages to induce migration of activated T�cells
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Stemness underpinning all steps of human colorectal cancer defines the core of effective therapeutic strategies
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A novel fully human antibody targeting extracellular domain of PSMA inhibits tumor growth in prostate cancer
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MMP14-Containing Exosomes Cleave VEGFR1 and Promote VEGFA-Induced Migration and Proliferation of Vascular Endothelial Cells
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Transcriptomic analysis of human IL-7 receptor alpha low and high effector memory CD8+ T cells reveals an age-associated signature linked to influenza vaccine response in older adults
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Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death
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3-deazaneplanocin A protects against cisplatin-induced renal tubular cell apoptosis and acute kidney injury by restoration of E-cadherin expression
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Immunoglobulin G responses against falciparum malaria specific antigens are higher in children with homozygous sickle cell trait than those with normal hemoglobin
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BMC Immunol., 2019-04-27;20(1):12.
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A cell-penetrating peptide blocks Toll-like receptor-mediated downstream signaling and ameliorates autoimmune and inflammatory diseases in mice
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Downregulation of CD73 associates with T cell exhaustion in AML patients
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Glucagon reduces airway hyperreactivity, inflammation, and remodeling induced by ovalbumin
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Interleukin-4 and Interleukin-13 Exacerbate Neurotoxicity of Prothrombin Kringle-2 in Cortex In Vivo via Oxidative Stress
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Methylglyoxal-Induced Retinal Angiogenesis in Zebrafish Embryo: A Potential Animal Model of Neovascular Retinopathy
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Chemokines CCL2 and CCL7, but not CCL12, play a significant role in the development of pain-related behavior and opioid-induced analgesia
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Glucocorticoid-dependent expression of IAP participates in the protection against TNF-mediated cytotoxicity in MCF7 cells
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Siglec-9 regulates an effector memory CD8+ T-cell subset that congregates in the melanoma tumor microenvironment
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Potentiating Oncolytic Virus-Induced Immune-Mediated Tumor Cell Killing Using Histone Deacetylase Inhibition
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In-depth serum proteomics reveals biomarkers of psoriasis severity and response to traditional Chinese medicine
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Interleukin-12p35 Deficiency Reverses the Th1/Th2 Imbalance, Aggravates the Th17/Treg Imbalance, and Ameliorates Atherosclerosis in ApoE-/- Mice
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Neutrophil extracellular traps (NETs) contribute to pathological changes of ocular graft-vs.-host disease (oGVHD) dry eye: Implications for novel biomarkers and therapeutic strategies
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Highly glycosylated CD147 promotes hemorrhagic transformation after rt-PA treatment in diabetes: a novel therapeutic target?
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Oncogenic D816V-KIT signaling in mast cells causes persistent IL-6 production
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Haematologica, 2019-04-04;0(0):.
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Low Plasma IL-8 Levels During Chemotherapy Are Predictive of Excellent Long-Term Survival in Metastatic Breast Cancer
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Nuclear positioning facilitates amoeboid migration along the path of least resistance
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Generation of iPSCs from Jaw Periosteal Cells Using Self-Replicating RNA
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Activation of the hypoxia pathway in breast cancer tissue and patient survival are inversely associated with tumor ascorbate levels
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Glycoprotein V is a relevant immune target in patients with immune thrombocytopenia
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RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3
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Expression of c-Kit discriminates between two functionally distinct subsets of human type 2 innate lymphoid cells
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B7H3 regulates differentiation and serves as a potential biomarker and theranostic target for human glioblastoma
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Lab. Invest., 2019-03-26;0(0):.
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Soluble TREM2 ameliorates pathological phenotypes by modulating microglial functions in an Alzheimer's disease model
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Synthesis and Biological Evaluation of Fangchinoline Derivatives as Anti-Inflammatory Agents through Inactivation of Inflammasome
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PI3K activation increases SDF-1 production and number of osteoclast precursors, and enhances SDF-1-mediated osteoclast precursor migration
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Bone Rep, 2019-03-22;10(0):100203.
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Change in Renal Glomerular Collagens and Glomerular Filtration Barrier-Related Proteins in a Dextran Sulfate Sodium-Induced Colitis Mouse Model
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Potassium chloride released from contracting skeletal muscle may stimulate development of its hypertrophy
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Biochem Biophys Rep, 2019-03-21;18(0):100627.
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Glycosaminoglycans influence enzyme activity of MMP2 and MMP2/TIMP3 complex formation - Insights at cellular and molecular level
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Sci Rep, 2019-03-20;9(1):4905.
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Adipose Lipocalin 2 overexpression protects against age-related decline in thermogenic function of adipose tissue and metabolic deterioration
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Mol Metab, 2019-03-20;0(0):.
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Downregulation of the Netrin-1 Receptor UNC5b Underlies Increased Placental Angiogenesis in Human Gestational Diabetes Mellitus
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Int J Mol Sci, 2019-03-20;20(6):.
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Metalloproteinases TACE and MMP-9 Differentially Regulate Death Factors on Adult and Neonatal Monocytes After Infection with Escherichia coli
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Int J Mol Sci, 2019-03-20;20(6):.
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Function and Immunogenicity of Gene-corrected iPSC-derived Hepatocyte-Like Cells in Restoring Low Density Lipoprotein Uptake in Homozygous Familial Hypercholesterolemia
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A comprehensive characterisation of large-scale expanded human bone marrow and umbilical cord mesenchymal stem cells
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Phosphatase inhibitor PPP1R11 modulates resistance of human T cells toward Treg-mediated suppression of cytokine expression
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HSP70 is a negative regulator of NLRP3 inflammasome activation
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RIPK1 inhibition attenuates experimental autoimmune arthritis via suppression of osteoclastogenesis
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Ginsenoside Rk1 Induces Apoptosis in Neuroblastoma Cells Through Loss of Mitochondrial Membrane Potential and Activation of Caspases
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Metformin Inhibits the NLRP3 Inflammasome via AMPK/mTOR-dependent Effects in Diabetic Cardiomyopathy
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Bacillus anthracis Edema Toxin Inhibits Efferocytosis in Human Macrophages and Alters Efferocytic Receptor Signaling
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Iron alters macrophage polarization status and leads to steatohepatitis and fibrogenesis
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Effects of divergent selection upon adrenocortical activity on immune traits in pig
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Inhibition of lymphatic proliferation by the selective VEGFR-3 inhibitor SAR131675 ameliorates diabetic nephropathy in db/db mice
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Siglec-15 as an immune suppressor and potential target for normalization cancer immunotherapy
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Effects of resveratrol on Th17 cell-related immune responses under tacrolimus-based immunosuppression
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Temporal Regulation of Dendritic Spines Through NrCAM-Semaphorin3F Receptor Signaling in Developing Cortical Pyramidal Neurons
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The Role of NK Cells in the Control of Viral Infection in HTLV-1 Carriers
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Thrombin cleaves and activates the protease-activated receptor 2 dependent on thrombomodulin co-receptor availability
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A Novel TNF-?-Targeting Aptamer for TNF-?-Mediated Acute Lung Injury and Acute Liver Failure
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Osteoblasts are "educated" by crosstalk with metastatic breast cancer cells in the bone tumor microenvironment
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Extrinsic or Intrinsic Apoptosis by Curcumin and Light: Still a Mystery
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Comparison of Immunosuppressive and Angiogenic Properties of Human Amnion-Derived Mesenchymal Stem Cells between 2D and 3D Culture Systems
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Int. J. Cardiol., 2018-05-01;258(0):7-13.
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The combination of ionizing radiation and proteasomal inhibition by bortezomib enhances the expression of NKG2D ligands in multiple myeloma cells
Authors: YS Lee, W Heo, J Nam, YH Jeung, J Bae
J. Radiat. Res., 2018-05-01;0(0):.
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Targeted deletion of T cell S1P receptor 1 ameliorates cardiac fibrosis in streptozotocin-induced diabetic mice
Authors: CS Abdullah, ZQ Jin
FASEB J., 2018-04-26;0(0):fj201800231R.
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Gene expression profiling of primary human type I alveolar epithelial cells exposed to Bacillus anthracis spores reveals induction of neutrophil and monocyte chemokines
Authors: JL Booth, ES Duggan, VI Patel, W Wu, DM Burian, DC Hutchings, VL White, KM Coggeshall, MG Dozmorov, JP Metcalf
Microb. Pathog., 2018-04-25;0(0):.
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Pleiotropy of ABO gene: correlation of rs644234 with E-selectin and lipid levels
Authors: AA Arguinano, NC Ndiaye, C Masson, S Visvikis-S
Clin. Chem. Lab. Med., 2018-04-25;0(0):.
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Analytical and functional similarity of Amgen biosimilar ABP 215 to bevacizumab
Authors: N Seo, A Polozova, M Zhang, Z Yates, S Cao, H Li, S Kuhns, G Maher, HJ McBride, J Liu
MAbs, 2018-04-20;0(0):1-58.
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The group VIA calcium-independent phospholipase A2 and NFATc4 pathway mediates IL-1β-induced expression of chemokines CCL2 and CXCL10 in rat fibroblasts
Authors: H Kuwata, C Yuzurihara, N Kinoshita, Y Taki, Y Ikegami, S Washio, Y Hirakawa, E Yoda, T Aiuchi, H Itabe, Y Nakatani, S Hara
FEBS J., 2018-04-18;0(0):.
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Lymphatic exosomes promote dendritic cell migration along guidance cues
Authors: M Brown, LA Johnson, DA Leone, P Majek, K Vaahtomeri, D Senfter, N Bukosza, H Schachner, G Asfour, B Langer, R Hauschild, K Parapatics, YK Hong, KL Bennett, R Kain, M Detmar, M Sixt, DG Jackson, D Kerjaschki
J. Cell Biol., 2018-04-12;0(0):.
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Visualization of Proliferative Vascular Endothelial Cells in Tumors in�Vivo by Imaging Their Partner of Sld5-1 Promoter Activity
Authors: D Yamakawa, W Jia, H Kidoya, S Hosojima, M Torigata, L Zhang, N Takakura
Am. J. Pathol., 2018-04-09;0(0):.
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Caspase-2 associates with FAN through direct interaction and overlapping functionality
Authors: J Forsberg, X Li, AV Zamaraev, T Panaretaki, B Zhivotovsk, M Olsson
Biochem. Biophys. Res. Commun., 2018-04-07;0(0):.
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PD-1 and PD-L1 Up-regulation Promotes T-cell Apoptosis in Gastric Adenocarcinoma
Authors: YM Chiu, CL Tsai, JT Kao, CT Hsieh, DC Shieh, YJ Lee, GJ Tsay, KS Cheng, YY Wu
Anticancer Res., 2018-04-01;38(4):2069-2078.
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Serglycin is involved in inflammatory response in articular mouse chondrocytes
Authors: A D'Ascola, M Scuruchi, A Avenoso, G Bruschetta, S Campo, G Mandraffin, GM Campo
Biochem. Biophys. Res. Commun., 2018-03-31;0(0):.
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Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines
Authors: SS Rao, Y Hu, PL Xie, J Cao, ZX Wang, JH Liu, H Yin, J Huang, YJ Tan, J Luo, MJ Luo, SY Tang, TH Chen, LQ Yuan, EY Liao, R Xu, ZZ Liu, CY Chen, H Xie
Bone Res, 2018-03-30;6(0):9.
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The microRNA-200 family coordinately regulates cell adhesion and proliferation in hair morphogenesis
Authors: JE Hoefert, GA Bjerke, D Wang, R Yi
J. Cell Biol., 2018-03-30;0(0):.
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Thalidomide Reduces Hemorrhage of Brain Arteriovenous Malformations in a Mouse Model
Authors: W Zhu, W Chen, D Zou, L Wang, C Bao, L Zhan, D Saw, S Wang, E Winkler, Z Li, M Zhang, F Shen, S Shaligram, M Lawton, H Su
Stroke, 2018-03-28;0(0):.
-
SDF-1 is an Autocrine Insulin-Desensitizing Factor in Adipocytes
Authors: J Shin, A Fukuhara, T Onodera, S Kita, C Yokoyama, M Otsuki, I Shimomura
Diabetes, 2018-03-26;0(0):.
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?-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor
Authors: K Kim, IJ Goldberg, MJ Graham, M Sundaram, E Bertaggia, SX Lee, L Qiang, RA Haeusler, D Metzger, P Chambon, Z Yao, HN Ginsberg, UB Pajvani
Cell Metab., 2018-03-22;0(0):.
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iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications
Authors: J Ou, JM Ball, Y Luan, T Zhao, KJ Miyagishim, Y Xu, H Zhou, J Chen, DK Merriman, Z Xie, BS Mallon, W Li
Cell, 2018-03-22;0(0):.
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TNFSF14 (LIGHT) Exhibits Inflammatory Activities in Lung Fibroblasts Complementary to IL-13 and TGF-β
Authors: R da Silva A, AK Mehta, L Madge, J Tocker, M Croft
Front Immunol, 2018-03-19;9(0):576.
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The deficiency of CX3CL1/CX3CR1 system ameliorates high fructose diet-induced kidney injury by regulating NF-κB pathways in CX3CR1-knock out mice
Authors: YW Yu, MX Li, ZY Zhang, H Yu
Int. J. Mol. Med., 2018-03-16;41(6):3577-3585.
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Memantine protects against ischemia/reperfusion-induced brain endothelial permeability
Authors: Y Liu, Y Huang, Y Xu, P Qu, M Wang
IUBMB Life, 2018-03-15;0(0):.
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Multivalent binding and biomimetic cell rolling improves the sensitivity and specificity of circulating tumor cell�capture
Authors: JH Myung, MJ Eblan, JM Caster, S Park, MJ Poellmann, K Wang, JE Tepper, KA Tam, SM Miller, C Shen, RC Chen, T Zhang, B Chera, AZ Wang, S Hong
Clin. Cancer Res., 2018-03-15;0(0):.
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Modulation of human osteoclastogenesis and osteoblastogenesis by lycopene
Authors: J Costa-Rodr, MH Fernandes, O Pinho, PRR Monteiro
J. Nutr. Biochem., 2018-03-15;57(0):26-34.
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Casein kinase 1? mediates degradation of receptors for type I and type II interferons caused by hemagglutinin of influenza A virus
Authors: C Xia, JJ Wolf, M Vijayan, CJ Studstill, W Ma, B Hahm
J. Virol., 2018-03-14;0(0):.
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Beta-Catenin maintains lung epithelial progenitors after lung specification
Authors: EJ Ostrin, DR Little, KN Gerner-Mau, EA Sumner, R Ríos-Corzo, E Ambrosio, SE Holt, NR Forcioli-C, H Akiyama, SM Hanash, S Kimura, SXL Huang, J Chen
Development, 2018-03-09;0(0):.
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Absence of a neutralizing antibody response to humanized cobra venom factor in mice
Authors: M Ing, BE Hew, DC Fritzinger, S Delignat, S Lacroix-De, CW Vogel, J Rayes
Mol. Immunol., 2018-03-08;97(0):1-7.
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Mass cytometry reveals innate lymphoid cell differentiation pathways in the human fetal intestine
Authors: N Li, V van Unen, T Höllt, A Thompson, J van Bergen, N Pezzotti, E Eisemann, A Vilanova, SM Chuva de S, BPF Lelieveldt, F Koning
J. Exp. Med., 2018-03-06;0(0):.
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Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets
Authors: CE Macdougall, EG Wood, J Loschko, V Scagliotti, FC Cassidy, ME Robinson, N Feldhahn, L Castellano, MB Voisin, F Marelli-Be, C Gaston-Mas, M Charalambo, MP Longhi
Cell Metab., 2018-03-06;27(3):588-601.e4.
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The Long Pentraxin 3 Plays a Role in Bone Turnover and Repair
Authors: D Gr?evi?, M Sironi, S Valentino, L Deban, H Cvija, A Inforzato, N Kova?i?, V Katavi?, T Kelava, I Kalajzi?, A Mantovani, B Bottazzi
Front Immunol, 2018-03-05;9(0):417.
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Caffeic acid phenethyl ester down-regulates claudin-2 expression at the transcriptional and post-translational levels and enhances chemosensitivity to doxorubicin in lung adenocarcinoma A549 cells
Authors: H Sonoki, A Tanimae, T Furuta, S Endo, T Matsunaga, K Ichihara, A Ikari
J. Nutr. Biochem., 2018-03-02;56(0):205-214.
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ROR?-expressing T regulatory cells restrain allergic skin inflammation
Authors: N Malhotra, JM Leyva-Cast, U Jadhav, O Barreiro, C Kam, NK O'Neill, F Meylan, P Chambon, UH von Andria, RM Siegel, EC Wang, R Shivdasani, RS Geha
Sci Immunol, 2018-03-02;3(21):.
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Early and late changes in natural killer cells in response to ledipasvir/sofosbuvir treatment
Authors: L Golden-Mas, RH McMahan, MS Kriss, AL Kilgore, L Cheng, RJ Dran, A Wieland, HR Rosen
Hepatol Commun, 2018-03-01;2(4):364-375.
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Serial Monitoring of Immune Markers Being Represented Regulatory T Cell/T Helper 17 Cell Ratio: Indicating Tolerance for Tapering Immunosuppression after Liver Transplantation
Authors: J Jhun, SH Lee, SK Lee, HY Kim, ES Jung, DG Kim, J Choi, SH Bae, SK Yoon, BH Chung, CW Yang, ML Cho, JY Choi
Front Immunol, 2018-03-01;9(0):352.
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BTKCys481Serdrives ibrutinib resistance via ERK1/2, and protects BTKWild-TypeMYD88 mutated cells by a paracrine mechanism
Authors: JG Chen, X Liu, M Munshi, L Xu, N Tsakmaklis, MG Demos, A Kofides, ML Guerrera, GG Chan, CJ Patterson, KE Meid, J Gustine, T Dubeau, P Severns, JJ Castillo, ZR Hunter, J Wang, SJ Buhrlage, NS Gray, SP Treon, G Yang
Blood, 2018-03-01;0(0):.
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Sulfation degree not origin of chondroitin sulfate derivatives modulates keratinocyte response
Authors: L Corsuto, S Rother, L Koehler, E Bedini, S Moeller, M Schnabelra, V Hintze, C Schiraldi, D Scharnwebe
Carbohydr Polym, 2018-03-01;191(0):53-64.
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STAT-3-independent production of IL-17 by mouse innate-like ?? T cells controls ocular infection
Authors: AJ St Leger, AM Hansen, H Karauzum, R Horai, CR Yu, A Laurence, KD Mayer-Barb, P Silver, R Villasmil, C Egwuagu, SK Datta, RR Caspi
J. Exp. Med., 2018-02-28;0(0):.
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Sonic Hedgehog Signaling Regulates Hematopoietic Stem/Progenitor Cell Activation during the Granulopoietic Response to Systemic Bacterial Infection
Authors: X Shi, S Wei, KJ Simms, DN Cumpston, TJ Ewing, P Zhang
Front Immunol, 2018-02-26;9(0):349.
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Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor
Authors: HJ Kim, SK Kang, WS Kwon, TS Kim, I Jeong, HC Jeung, M Kragh, ID Horak, HC Chung, SY Rha
Int. J. Cancer, 2018-02-23;0(0):.
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Interleukin-6/Stat3 signaling has an essential role in the host antimicrobial response to urinary tract infection
Authors: CB Ching, S Gupta, B Li, H Cortado, N Mayne, AR Jackson, KM McHugh, B Becknell
Kidney Int., 2018-02-21;0(0):.
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Disruption of Wnt/?-catenin exerts anti-leukemia activity and synergizes with FLT3 inhibition in FLT3-mutant acute myeloid leukemia
Authors: X Jiang, PY Mak, H Mu, D Mak, S Kornblau, Q Zhang, P Ruvolo, JK Burks, W Zhang, T McQueen, R Pan, H Zhou, M Konopleva, JE Cortes, Q Liu, M Andreeff, BZ Carter, W Tao
Clin. Cancer Res., 2018-02-20;0(0):.
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Generation and Characterization of a Novel Small Biologic Alternative to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Antibodies, DS-9001a, Albumin Binding Domain-Fused Anticalin Protein
Authors: Y Masuda, S Yamaguchi, C Suzuki, T Aburatani, Y Nagano, R Miyauchi, E Suzuki, N Yamamura, K Nagatomo, H Ishihara, K Okuno, F Nara, G Matschiner, R Hashimoto, T Takahashi, T Nishizawa
J. Pharmacol. Exp. Ther., 2018-02-20;365(2):368-378.
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Increased GPNMB, phospho-ERK1/2, and MMP-9 in cystic fibrosis in association with reduced arylsulfatase B
Authors: S Bhattachar, L Feferman, G Sharma, JK Tobacman
Mol. Genet. Metab., 2018-02-20;0(0):.
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Cannabinoids prevent depressive-like symptoms and alterations in BDNF expression in a rat model of PTSD
Authors: O Burstein, N Shoshan, R Doron, I Akirav
Prog. Neuropsychopharmacol. Biol. Psychiatry, 2018-02-17;84(0):129-139.
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Adiponectin Receptor Agonist AdipoRon Decreased Ceramide, and Lipotoxicity, and Ameliorated Diabetic Nephropathy
Authors: SR Choi, JH Lim, MY Kim, EN Kim, Y Kim, BS Choi, YS Kim, HW Kim, KM Lim, MJ Kim, CW Park
Metab. Clin. Exp., 2018-02-17;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Distinct CD40L receptors mediate inflammasome activation and secretion of IL-1? and MCP-1 in cultured human retinal pigment epithelial cells
Authors: ZM Bian, MG Field, SG Elner, JM Kahlenberg, VM Elner
Exp. Eye Res., 2018-02-16;170(0):29-39.
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Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling
Authors: T Goncharov, S Hedayati, MM Mulvihill, A Izrael-Tom, K Zobel, S Jeet, AV Fedorova, C Eidenschen, J deVoss, K Yu, AS Shaw, DS Kirkpatric, WJ Fairbrothe, K Deshayes, D Vucic
Mol. Cell, 2018-02-15;69(4):551-565.e7.
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Restoring tracheal defects in a rabbit model with tissue engineered patches based on TGF-?3-encapsulating electrospun poly(l-lactic acid-co-?-caprolactone)/collagen scaffolds
Authors: H Jing, B Gao, M Gao, H Yin, X Mo, X Zhang, K Luo, B Feng, W Fu, J Wang, W Zhang, M Yin, Z Zhu, X He, J Zheng
Artif Cells Nanomed Biotechnol, 2018-02-15;0(0):1-11.
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GDF11 expression in the adult rat central nervous system
Authors: Y Hayashi, S Mikawa, K Masumoto, F Katou, K Sato
J. Chem. Neuroanat., 2018-02-12;0(0):.
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Prolyl isomerase Pin1 is required sperm production by promoting mitosis progression of spermatogonial stem cells
Authors: A Kurita-Suz, Y Kamo, C Uchida, K Tanemura, K Hara, T Uchida
Biochem. Biophys. Res. Commun., 2018-02-10;0(0):.
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Antiproliferative effects of the CDK6 inhibitor PD0332991 and its effect on signaling networks in gastric cancer cells
Authors: D Wang, Y Sun, W Li, F Ye, Y Zhang, Y Guo, DY Zhang, J Suo
Int. J. Mol. Med., 2018-02-06;0(0):.
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Depot-specific and GH-dependent regulation of IGF binding protein-4, pregnancy-associated plasma protein-A, and stanniocalcin-2 in murine adipose tissue
Authors: R Hjortebjer, DE Berryman, R Comisford, EO List, C Oxvig, M Bjerre, J Frystyk, JJ Kopchick
Growth Horm. IGF Res., 2018-02-03;0(0):.
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P21-activated kinase 2 is essential in maintenance of peripheral Foxp3+ regulatory T cells
Authors: J Choi, DR Pease, S Chen, B Zhang, H Phee
Immunology, 2018-02-02;0(0):.
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The degree of peri-implant osteolysis induced by PEEK, CoCrMo, and HXLPE wear particles: a study based on a porous Ti6Al4V implant in a rabbit model
Authors: Z Du, Z Zhu, Y Wang
J Orthop Surg Res, 2018-01-31;13(1):23.
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Iron released from reactive microglia by noggin improves myelin repair in the ischemic brain
Authors: JA Shin, YA Kim, HW Kim, HS Kim, KE Lee, JL Kang, EM Park
Neuropharmacology, 2018-01-31;0(0):.
Species: Mouse
Sample Types: Cell Lysate
Applications: Western Blot -
MicroRNA-31 is required for astrocyte specification
Authors: GP Meares, R Rajbhandar, M Gerigk, CL Tien, C Chang, SC Fehling, A Rowse, KC Mulhern, S Nair, GK Gray, NF Berbari, M Bredel, EN Benveniste, SE Nozell
Glia, 2018-01-30;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry, Stimulation -
Targeting angiogenesis in multiple myeloma by the VEGF and HGF blocking DARPin� protein MP0250: a preclinical study
Authors: L Rao, K De Veirman, D Giannico, I Saltarella, V Desantis, MA Frassanito, AG Solimando, D Ribatti, M Prete, A Harstrick, U Fiedler, H De Raeve, V Racanelli, K Vanderkerk, A Vacca
Oncotarget, 2018-01-30;9(17):13366-13381.
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Increased Interleukin-23 in Hashimoto's Thyroiditis Disease Induces Autophagy Suppression and Reactive Oxygen Species Accumulation
Authors: T Zheng, C Xu, C Mao, X Mou, F Wu, X Wang, L Bu, Y Zhou, X Luo, Q Lu, H Liu, G Yuan, S Wang, D Chen, Y Xiao
Front Immunol, 2018-01-29;9(0):96.
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Molecular basis for intestinal mucin recognition by galectin-3 and C-type lectins
Authors: C Leclaire, K Lecointe, PA Gunning, S Tribolo, DW Kavanaugh, A Wittmann, D Latousakis, DA MacKenzie, N Kawasaki, N Juge
FASEB J., 2018-01-29;0(0):fj201700619R.
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Blockade of Tumor-Expressed PD-1 promotes lung cancer growth
Authors: S Du, N McCall, K Park, Q Guan, P Fontina, A Ertel, T Zhan, AP Dicker, B Lu
Oncoimmunology, 2018-01-29;7(4):e1408747.
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Trichinella spiralis Excretory-Secretory Products Induce Tolerogenic Properties in Human Dendritic CellsviaToll-Like Receptors 2 and 4
Authors: N Ilic, A Gruden-Mov, J Cvetkovic, S Tomic, DB Vucevic, C Aranzamend, M Colic, E Pinelli, L Sofronic-M
Front Immunol, 2018-01-24;9(0):11.
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Absence of Tumor Necrosis Factor Supports Alternative Activation of Macrophages in the Liver after Infection with
Authors: S Hu, C Marshall, J Darby, W Wei, AB Lyons, H Körner
Front Immunol, 2018-01-19;9(0):1.
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MicroRNA-149-5p regulates blood-brain barrier permeability after transient middle cerebral artery occlusion in rats by targeting S1PR2 of pericytes
Authors: Y Wan, HJ Jin, YY Zhu, Z Fang, L Mao, Q He, YP Xia, M Li, Y Li, X Chen, B Hu
FASEB J., 2018-01-18;0(0):fj201701121R.
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Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation
Authors: J Emgård, H Kammoun, B García-Cas, J Chesné, SM Parigi, JM Jacob, HW Cheng, E Evren, S Das, P Czarnewski, N Sleiers, F Melo-Gonza, E Kvedaraite, M Svensson, E Scandella, MR Hepworth, S Huber, B Ludewig, L Peduto, EJ Villablanc, H Veiga-Fern, JP Pereira, RA Flavell, T Willinger
Immunity, 2018-01-16;48(1):120-132.e8.
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Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-?B signaling
Authors: T Kanaya, S Sakakibara, T Jinnohara, M Hachisuka, N Tachibana, S Hidano, T Kobayashi, S Kimura, T Iwanaga, T Nakagawa, T Katsuno, N Kato, T Akiyama, T Sato, IR Williams, H Ohno
J. Exp. Med., 2018-01-16;0(0):.
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Metabolic Induction of Trained Immunity through the Mevalonate Pathway
Authors: S Bekkering, RJW Arts, B Novakovic, I Kourtzelis, CDCC van der He, Y Li, CD Popa, R Ter Horst, J van Tuijl, RT Netea-Maie, FL van de Vee, T Chavakis, LAB Joosten, JWM van der Me, H Stunnenber, NP Riksen, MG Netea
Cell, 2018-01-11;172(1):135-146.e9.
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Establishment and characterization of five immortalized human scalp dermal papilla cell lines
Authors: MH Kwack, JM Yang, GH Won, MK Kim, JC Kim, YK Sung
Biochem. Biophys. Res. Commun., 2018-01-10;0(0):.
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PEDF Expression Affects the Oxidative and Inflammatory State of Choroidal Endothelial Cells
Authors: M Farnoodian, CM Sorenson, N Sheibani
Am. J. Physiol., Cell Physiol., 2018-01-10;0(0):.
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Histone deacetylase 2 (HDAC2) attenuates lipopolysaccharide (LPS)-induced inflammation by regulating PAI-1 expression
Authors: WF Fang, YM Chen, CY Lin, HL Huang, H Yeh, YT Chang, KT Huang, MC Lin
J Inflamm (Lond), 2018-01-10;15(0):3.
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Regulatory CD4 T cells inhibit HIV-1 expression of other CD4 T cell subsets via interactions with cell surface regulatory proteins
Authors: M Zhang, TO Robinson, A Duverger, O Kutsch, SL Heath, RQ Cron
Virology, 2018-01-08;516(0):21-29.
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Multiple myeloma cells adapted to long-exposure of hypoxia exhibit stem cell characters with TGF-?/Smad pathway activation
Authors: Y Nakagawa, E Ashihara, H Yao, A Yokota, Y Toda, Y Miura, S Nakata, H Hirai, T Maekawa
Biochem. Biophys. Res. Commun., 2018-01-06;0(0):.
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Origin and Segmental Diversity of Spinal Inhibitory Interneurons
Authors: LB Sweeney, JB Bikoff, MI Gabitto, S Brenner-Mo, M Baek, JH Yang, EG Tabak, JS Dasen, CR Kintner, TM Jessell
Neuron, 2018-01-04;0(0):.
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Nitric Oxide Is Involved in Activation of Toll-Like Receptor 4 Signaling through Tyrosine Nitration of Src Homology Protein Tyrosine Phosphatase 2 in Murine Dextran Sulfate-Induced Colitis
Authors: X Tun, K Yasukawa, KI Yamada
Biol. Pharm. Bull., 2018-01-01;41(12):1843-1852.
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The effect of human placental chorionic villi derived mesenchymal stem cell on triple-negative breast cancer hallmarks
Authors: AT Alshareeda, E Rakha, A Alghwainem, B Alrfaei, B Alsowayan, A Albugami, AM Alsubayyil, M Abomraee, NK Mohd Zin
PLoS ONE, 2018;13(11):e0207593.
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Relationship of systemic IL-10 levels with proinflammatory cytokine responsiveness and lung function in agriculture workers.
Authors: Tricia D LeVan, Debra J Romberger, Mohammad Siahpush, Brandon L Grimm, Athena K Ramos, Patrik L Johansson, Tzeyu L Michaud, Art J Heires, Todd A Wyatt, Jill A Poole
Respiratory Research, 2018;0(0):1465-993X.
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Effects of concentrated growth factor on proliferation, migration, and differentiation of human dental pulp stem cells in vitro
Authors: R Jin, G Song, J Chai, X Gou, G Yuan, Z Chen
J Tissue Eng, 2018;9(0):2041731418817.
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TRAF2 COOPERATES WITH FOCAL ADHESION SIGNALING TO REGULATE CANCER CELL SUSCEPTIBILITY TO ANOIKIS
Authors: S Daniela da, B Xu, M Maschietto, FA Marchi, MI Alkailani, K Bijian, D Xiao, MA Alaoui-Jam
Mol. Cancer Ther., 2018;0(0):.
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Vimentin deficiency in macrophages induces increased oxidative stress and vascular inflammation but attenuates atherosclerosis in mice
Authors: L Håversen, JP Sundelin, A Mardinoglu, M Rutberg, M Ståhlman, U Wilhelmsso, LM Hultén, M Pekny, P Fogelstran, JF Bentzon, M Levin, J Borén
Sci Rep, 2018;8(1):16973.
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Tumour-vasculature development via endothelial-to-mesenchymal transition after radiotherapy controls CD44v6+ cancer cell and macrophage polarization
Authors: SH Choi, AR Kim, JK Nam, JM Kim, JY Kim, HR Seo, HJ Lee, J Cho, YJ Lee
Nat Commun, 2018;9(1):5108.
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Exosomal Wnt-induced dedifferentiation of colorectal cancer cells contributes to chemotherapy resistance
Authors: YB Hu, C Yan, L Mu, YL Mi, H Zhao, H Hu, XL Li, DD Tao, YQ Wu, JP Gong, JC Qin
Oncogene, 2018;0(0):.
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Mesenchymal Stem Cells Promote the Osteogenesis in Collagen-Induced Arthritic Mice through the Inhibition of TNF-?
Authors: C Liu, H Zhang, X Tang, R Feng, G Yao, W Chen, W Li, J Liang, X Feng, L Sun
Stem Cells Int, 2018;2018(0):4069032.
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Pathological Remodeling of Mitral Valve Leaflets from Unphysiologic Leaflet Mechanics after Undersized Mitral Annuloplasty to Repair Ischemic Mitral Regurgitation
Authors: A Sielicka, EL Sarin, W Shi, F Sulejmani, D Corporan, K Kalra, VH Thourani, W Sun, RA Guyton, M Padala
J Am Heart Assoc, 2018;7(21):e009777.
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Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis
Authors: AM Falcão, D van Brugge, S Marques, M Meijer, S Jäkel, E Agirre, Samudyata, EM Floriddia, DP Vanichkina, C Ffrench-Co, A Williams, AO Guerreiro-, G Castelo-Br
Nat. Med., 2018;0(0):.
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Myelodysplastic syndrome progression to acute myeloid leukemia at the stem cell level
Authors: J Chen, YR Kao, D Sun, TI Todorova, D Reynolds, SR Narayanaga, C Montagna, B Will, A Verma, AU Steidl
Nat. Med., 2018;0(0):.
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Evasion of Immune Surveillance in Low Oxygen Environments Enhances Candida albicans Virulence
Authors: JP Lopes, M Stylianou, E Backman, S Holmberg, J Jass, R Claesson, CF Urban
MBio, 2018;9(6):.
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Activation of the Regulatory T-Cell/Indoleamine 2,3-Dioxygenase Axis Reduces Vascular Inflammation and Atherosclerosis in Hyperlipidemic Mice.
Authors: Maria J Forteza, Konstantinos A Polyzos, Roland Baumgartn, Bianca E Suur, Marion Mussbache, Daniel K Johansson, Andreas Hermansso, Göran K Hansson, Daniel F J Ketelhuth
Frontiers in Immunology, 2018;0(0):1664-3224.
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Comparative Study of MSCA-1 and CD146 Isolated Periosteal Cell Subpopulations
Authors: F Umrath, C Thomalla, S Pöschel, K Schenke-La, S Reinert, D Alexander
Cell. Physiol. Biochem., 2018;51(3):1193-1206.
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Thalidomide Reduces Hemorrhage of Brain Arteriovenous Malformations in a Mouse Model
Authors: W Zhu, W Chen, D Zou, L Wang, C Bao, L Zhan, D Saw, S Wang, E Winkler, Z Li, M Zhang, F Shen, S Shaligram, M Lawton, H Su
Stroke, 2018;0(0):.
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Mast cells are essential intermediaries in regulating IL-33/ST2 signaling for an immune network favorable to mucosal healing in experimentally inflamed colons
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The deficiency of CX3CL1/CX3CR1 system ameliorates high fructose diet-induced kidney injury by regulating NF-κB pathways in CX3CR1-knock out mice
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PD-1 and PD-L1 Up-regulation Promotes T-cell Apoptosis in Gastric Adenocarcinoma
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The KDM4A/KDM4C/NF-?B and WDR5 epigenetic cascade regulates the activation of B cells
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Metabolic Induction of Trained Immunity through the Mevalonate Pathway
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Caffeic acid phenethyl ester down-regulates claudin-2 expression at the transcriptional and post-translational levels and enhances chemosensitivity to doxorubicin in lung adenocarcinoma A549 cells
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Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling
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IL-25 dampens the growth of human germinal center-derived B-cell non Hodgkin Lymphoma by curtailing neoangiogenesis
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Absence of Tumor Necrosis Factor Supports Alternative Activation of Macrophages in the Liver after Infection with
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Forty-nine gastric cancer cell lines with integrative genomic profiling for development of c-MET inhibitor
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Temporal Regulation of Dendritic Spines Through NrCAM-Semaphorin3F Receptor Signaling in Developing Cortical Pyramidal Neurons
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Increased Interleukin-23 in Hashimoto's Thyroiditis Disease Induces Autophagy Suppression and Reactive Oxygen Species Accumulation
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Interleukin-6/Stat3 signaling has an essential role in the host antimicrobial response to urinary tract infection
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Trichinella spiralis Excretory-Secretory Products Induce Tolerogenic Properties in Human Dendritic CellsviaToll-Like Receptors 2 and 4
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Origin and Segmental Diversity of Spinal Inhibitory Interneurons
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Neuron, 2018;0(0):.
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Synergistic effect of interleukin-17 and tumor necrosis factor-α on inflammatory response in hepatocytes through interleukin-6 dependent and independent pathways
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Visualization of Proliferative Vascular Endothelial Cells in Tumors in�Vivo by Imaging Their Partner of Sld5-1 Promoter Activity
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Am. J. Pathol., 2018;0(0):.
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Beta-Catenin maintains lung epithelial progenitors after lung specification
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Development, 2018;0(0):.
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Omentin-1 prevents inflammation-induced osteoporosis by downregulating the pro-inflammatory cytokines
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Bone Res, 2018;6(0):9.
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Blood outgrowth endothelial cells (BOECs) as a novel tool for studying adhesion of Plasmodium falciparum-infected erythrocytes
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PLoS ONE, 2018;13(10):e0204177.
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The effect of S53P4-based borosilicate glasses and glass dissolution products on the osteogenic commitment of human adipose stem cells
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PLoS ONE, 2018;13(8):e0202740.
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Blocking the FSTL1-DIP2A Axis Improves Anti-tumor Immunity
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Cell Rep, 2018;24(7):1790-1801.
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Targeting angiogenesis in multiple myeloma by the VEGF and HGF blocking DARPin� protein MP0250: a preclinical study
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Oncotarget, 2018;9(17):13366-13381.
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Atorvastatin provides a new lipidome improving early regeneration after partial hepatectomy in osteopontin deficient mice
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Sci Rep, 2018;8(1):14626.
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Focal Adhesion Kinase and ROCK Signaling Are Switch-Like Regulators of Human Adipose Stem Cell Differentiation towards Osteogenic and Adipogenic Lineages
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Stem Cells Int, 2018;2018(0):2190657.
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Characterization of the attachment and infection by Porcine reproductive and respiratory syndrome virus 1 isolates in bone marrow-derived dendritic cells
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Vet. Microbiol., 2018;223(0):181-188.
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Oxysterol Sensing through the Receptor GPR183 Promotes the Lymphoid-Tissue-Inducing Function of Innate Lymphoid Cells and Colonic Inflammation
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Immunity, 2018;48(1):120-132.e8.
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Development of intestinal M cells and follicle-associated epithelium is regulated by TRAF6-mediated NF-?B signaling
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Disruption of renal arginine metabolism promotes kidney injury in hepatorenal syndrome
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Hepatology, 2018;0(0):.
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The group VIA calcium-independent phospholipase A2 and NFATc4 pathway mediates IL-1β-induced expression of chemokines CCL2 and CXCL10 in rat fibroblasts
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FEBS J., 2018;0(0):.
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The microRNA-200 family coordinately regulates cell adhesion and proliferation in hair morphogenesis
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Blockade of Tumor-Expressed PD-1 promotes lung cancer growth
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Oncoimmunology, 2018;7(4):e1408747.
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Lymphatic exosomes promote dendritic cell migration along guidance cues
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TNFSF14 (LIGHT) Exhibits Inflammatory Activities in Lung Fibroblasts Complementary to IL-13 and TGF-β
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Front Immunol, 2018;9(0):576.
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APC-activated long non-coding RNA inhibits colorectal carcinoma pathogenesis through reducing exosome production
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Sulfation degree not origin of chondroitin sulfate derivatives modulates keratinocyte response
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Carbohydr Polym, 2018;191(0):53-64.
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Targeted deletion of T cell S1P receptor 1 ameliorates cardiac fibrosis in streptozotocin-induced diabetic mice
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FASEB J., 2018;0(0):fj201800231R.
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Modulation of human osteoclastogenesis and osteoblastogenesis by lycopene
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J. Nutr. Biochem., 2018;57(0):26-34.
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Generation and Characterization of a Novel Small Biologic Alternative to Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Antibodies, DS-9001a, Albumin Binding Domain-Fused Anticalin Protein
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Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of ?-amyloid
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J Neuroinflammation, 2018;15(1):247.
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Aggregation of Human Trophoblast Cells into Three-Dimensional Culture System Enhances Anti-Inflammatory Characteristics through Cytoskeleton Regulation
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Int J Mol Sci, 2018;19(8):.
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Restoring tracheal defects in a rabbit model with tissue engineered patches based on TGF-?3-encapsulating electrospun poly(l-lactic acid-co-?-caprolactone)/collagen scaffolds
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Artif Cells Nanomed Biotechnol, 2018;0(0):1-11.
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MicroRNA-149-5p regulates blood-brain barrier permeability after transient middle cerebral artery occlusion in rats by targeting S1PR2 of pericytes
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FASEB J., 2018;0(0):fj201701121R.
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PEDF Expression Affects the Oxidative and Inflammatory State of Choroidal Endothelial Cells
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Am. J. Physiol., Cell Physiol., 2018;0(0):.
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The Long Pentraxin 3 Plays a Role in Bone Turnover and Repair
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Front Immunol, 2018;9(0):417.
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FGFR2 amplification is predictive of sensitivity to regorafenib in gastric and colorectal cancers in vitro
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Mol Oncol, 2018;0(0):.
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Activation and induction of antigen-specific T follicular helper cells (TFH) play a critical role in LAIV-induced human mucosal anti-influenza antibody response
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Analytical and functional similarity of Amgen biosimilar ABP 215 to bevacizumab
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MAbs, 2018;0(0):1-58.
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Memantine protects against ischemia/reperfusion-induced brain endothelial permeability
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IUBMB Life, 2018;0(0):.
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Absence of a neutralizing antibody response to humanized cobra venom factor in mice
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Mol. Immunol., 2018;97(0):1-7.
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The combination of ionizing radiation and proteasomal inhibition by bortezomib enhances the expression of NKG2D ligands in multiple myeloma cells
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J. Radiat. Res., 2018;0(0):.
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ROR?-expressing T regulatory cells restrain allergic skin inflammation
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Sci Immunol, 2018;3(21):.
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X-linked inhibitor of apoptosis inhibition sensitizes acute myeloid leukemia cell response to TRAIL and chemotherapy through potentiated induction of proapoptotic machinery
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Mol Oncol, 2018;12(1):33-47.
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Casein kinase 1? mediates degradation of receptors for type I and type II interferons caused by hemagglutinin of influenza A virus
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J. Virol., 2018;0(0):.
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Molecular basis for intestinal mucin recognition by galectin-3 and C-type lectins
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FASEB J., 2018;0(0):fj201700619R.
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Regulatory CD4 T cells inhibit HIV-1 expression of other CD4 T cell subsets via interactions with cell surface regulatory proteins
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Virology, 2018;516(0):21-29.
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Pleiotropy of ABO gene: correlation of rs644234 with E-selectin and lipid levels
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Clin. Chem. Lab. Med., 2018;0(0):.
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P21-activated kinase 2 is essential in maintenance of peripheral Foxp3+ regulatory T cells
Authors: J Choi, DR Pease, S Chen, B Zhang, H Phee
Immunology, 2018;0(0):.
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Histone deacetylase 2 (HDAC2) attenuates lipopolysaccharide (LPS)-induced inflammation by regulating PAI-1 expression
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J Inflamm (Lond), 2018;15(0):3.
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Multiple myeloma cells adapted to long-exposure of hypoxia exhibit stem cell characters with TGF-?/Smad pathway activation
Authors: Y Nakagawa, E Ashihara, H Yao, A Yokota, Y Toda, Y Miura, S Nakata, H Hirai, T Maekawa
Biochem. Biophys. Res. Commun., 2018;0(0):.
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Retinoic Acid Regulates Endothelial ?-catenin Expression and Pericyte Numbers in the Developing Brain Vasculature
Authors: S Bonney, BJC Dennison, M Wendlandt, JA Siegenthal
Front Cell Neurosci, 2018;12(0):476.
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Establishment and characterization of five immortalized human scalp dermal papilla cell lines
Authors: MH Kwack, JM Yang, GH Won, MK Kim, JC Kim, YK Sung
Biochem. Biophys. Res. Commun., 2018;0(0):.
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Living Neurons with Tau Filaments Aberrantly Expose Phosphatidylserine and Are Phagocytosed by Microglia
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Cell Rep, 2018;24(8):1939-1948.e4.
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WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids
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Elife, 2018;7(0):.
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Treatment with placental growth factor attenuates myocardial ischemia/reperfusion injury
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PLoS ONE, 2018;13(9):e0202772.
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Reg3? is associated with cardiac inflammation and provides prognostic information in patients with acute coronary syndrome
Authors: H Lörchner, C Widera, Y Hou, A Elsässer, H Warnecke, E Giannitsis, JS Hulot, T Braun, KC Wollert, J Pöling
Int. J. Cardiol., 2018;258(0):7-13.
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Sonic Hedgehog Signaling Regulates Hematopoietic Stem/Progenitor Cell Activation during the Granulopoietic Response to Systemic Bacterial Infection
Authors: X Shi, S Wei, KJ Simms, DN Cumpston, TJ Ewing, P Zhang
Front Immunol, 2018;9(0):349.
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Serial Monitoring of Immune Markers Being Represented Regulatory T Cell/T Helper 17 Cell Ratio: Indicating Tolerance for Tapering Immunosuppression after Liver Transplantation
Authors: J Jhun, SH Lee, SK Lee, HY Kim, ES Jung, DG Kim, J Choi, SH Bae, SK Yoon, BH Chung, CW Yang, ML Cho, JY Choi
Front Immunol, 2018;9(0):352.
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Iron released from reactive microglia by noggin improves myelin repair in the ischemic brain
Authors: JA Shin, YA Kim, HW Kim, HS Kim, KE Lee, JL Kang, EM Park
Neuropharmacology, 2018;0(0):.
Species: Mouse
Sample Types: Cell Lysate
Applications: Western Blot -
Intravenous Transplantation of Mesenchymal Stem Cells Reduces the Number of Infiltrated Ly6C+ Cells but Enhances the Proportions Positive for BDNF, TNF-1?, and IL-1? in the Infarct Cortices of dMCAO Rats
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Stem Cells Int, 2018;2018(0):9207678.
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Control release of mitochondria-targeted antioxidant by injectable self-assembling peptide hydrogel ameliorated persistent mitochondrial dysfunction and inflammation after acute kidney injury
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Drug Deliv, 2018;25(1):546-554.
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Cannabinoids prevent depressive-like symptoms and alterations in BDNF expression in a rat model of PTSD
Authors: O Burstein, N Shoshan, R Doron, I Akirav
Prog. Neuropsychopharmacol. Biol. Psychiatry, 2018;84(0):129-139.
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Prolyl isomerase Pin1 is required sperm production by promoting mitosis progression of spermatogonial stem cells
Authors: A Kurita-Suz, Y Kamo, C Uchida, K Tanemura, K Hara, T Uchida
Biochem. Biophys. Res. Commun., 2018;0(0):.
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SDF-1 is an Autocrine Insulin-Desensitizing Factor in Adipocytes
Authors: J Shin, A Fukuhara, T Onodera, S Kita, C Yokoyama, M Otsuki, I Shimomura
Diabetes, 2018;0(0):.
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Distinct CD40L receptors mediate inflammasome activation and secretion of IL-1? and MCP-1 in cultured human retinal pigment epithelial cells
Authors: ZM Bian, MG Field, SG Elner, JM Kahlenberg, VM Elner
Exp. Eye Res., 2018;170(0):29-39.
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GDF11 expression in the adult rat central nervous system
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J. Chem. Neuroanat., 2018;0(0):.
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The degree of peri-implant osteolysis induced by PEEK, CoCrMo, and HXLPE wear particles: a study based on a porous Ti6Al4V implant in a rabbit model
Authors: Z Du, Z Zhu, Y Wang
J Orthop Surg Res, 2018;13(1):23.
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Hydroxypropyl-beta and -gamma cyclodextrins rescue cholesterol accumulation in Niemann-Pick C1 mutant cell via lysosome-associated membrane protein 1
Authors: A Singhal, L Szente, JEK Hildreth, B Song
Cell Death Dis, 2018;9(10):1019.
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STAT-3-independent production of IL-17 by mouse innate-like ?? T cells controls ocular infection
Authors: AJ St Leger, AM Hansen, H Karauzum, R Horai, CR Yu, A Laurence, KD Mayer-Barb, P Silver, R Villasmil, C Egwuagu, SK Datta, RR Caspi
J. Exp. Med., 2018;0(0):.
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Adiponectin Receptor Agonist AdipoRon Decreased Ceramide, and Lipotoxicity, and Ameliorated Diabetic Nephropathy
Authors: SR Choi, JH Lim, MY Kim, EN Kim, Y Kim, BS Choi, YS Kim, HW Kim, KM Lim, MJ Kim, CW Park
Metab. Clin. Exp., 2018;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Depot-specific and GH-dependent regulation of IGF binding protein-4, pregnancy-associated plasma protein-A, and stanniocalcin-2 in murine adipose tissue
Authors: R Hjortebjer, DE Berryman, R Comisford, EO List, C Oxvig, M Bjerre, J Frystyk, JJ Kopchick
Growth Horm. IGF Res., 2018;0(0):.
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Antiproliferative effects of the CDK6 inhibitor PD0332991 and its effect on signaling networks in gastric cancer cells
Authors: D Wang, Y Sun, W Li, F Ye, Y Zhang, Y Guo, DY Zhang, J Suo
Int. J. Mol. Med., 2018;0(0):.
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MicroRNA-31 is required for astrocyte specification
Authors: GP Meares, R Rajbhandar, M Gerigk, CL Tien, C Chang, SC Fehling, A Rowse, KC Mulhern, S Nair, GK Gray, NF Berbari, M Bredel, EN Benveniste, SE Nozell
Glia, 2018;0(0):.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry -
Proteinase 3 expression on the neutrophils of patients with paroxysmal nocturnal hemoglobinuria
Authors: H Liu, Y Liu, Y Li, Z Liu, L Li, S Ding, Y Wang, T Zhang, L Li, Z Shao, R Fu
Exp Ther Med, 2018;15(3):2525-2532.
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?-Secretase Inhibition Lowers Plasma Triglyceride-Rich Lipoproteins by Stabilizing the LDL Receptor
Authors: K Kim, IJ Goldberg, MJ Graham, M Sundaram, E Bertaggia, SX Lee, L Qiang, RA Haeusler, D Metzger, P Chambon, Z Yao, HN Ginsberg, UB Pajvani
Cell Metab., 2018;0(0):.
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iPSCs from a Hibernator Provide a Platform for Studying Cold Adaptation and Its Potential Medical Applications
Authors: J Ou, JM Ball, Y Luan, T Zhao, KJ Miyagishim, Y Xu, H Zhou, J Chen, DK Merriman, Z Xie, BS Mallon, W Li
Cell, 2018;0(0):.
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BTKCys481Serdrives ibrutinib resistance via ERK1/2, and protects BTKWild-TypeMYD88 mutated cells by a paracrine mechanism
Authors: JG Chen, X Liu, M Munshi, L Xu, N Tsakmaklis, MG Demos, A Kofides, ML Guerrera, GG Chan, CJ Patterson, KE Meid, J Gustine, T Dubeau, P Severns, JJ Castillo, ZR Hunter, J Wang, SJ Buhrlage, NS Gray, SP Treon, G Yang
Blood, 2018;0(0):.
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Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets
Authors: CE Macdougall, EG Wood, J Loschko, V Scagliotti, FC Cassidy, ME Robinson, N Feldhahn, L Castellano, MB Voisin, F Marelli-Be, C Gaston-Mas, M Charalambo, MP Longhi
Cell Metab., 2018;27(3):588-601.e4.
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Mass cytometry reveals innate lymphoid cell differentiation pathways in the human fetal intestine
Authors: N Li, V van Unen, T Höllt, A Thompson, J van Bergen, N Pezzotti, E Eisemann, A Vilanova, SM Chuva de S, BPF Lelieveldt, F Koning
J. Exp. Med., 2018;0(0):.
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Multivalent binding and biomimetic cell rolling improves the sensitivity and specificity of circulating tumor cell�capture
Authors: JH Myung, MJ Eblan, JM Caster, S Park, MJ Poellmann, K Wang, JE Tepper, KA Tam, SM Miller, C Shen, RC Chen, T Zhang, B Chera, AZ Wang, S Hong
Clin. Cancer Res., 2018;0(0):.
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CRB3 and the FERM protein EPB41L4B regulate proliferation of mammary epithelial cells through the release of amphiregulin
Authors: SJ Walker, LM Selfors, BL Margolis, JS Brugge
PLoS ONE, 2018;13(11):e0207470.
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Proteinase 3 expression on the neutrophils of patients with paroxysmal nocturnal hemoglobinuria
Authors: H Liu, Y Liu, Y Li, Z Liu, L Li, S Ding, Y Wang, T Zhang, L Li, Z Shao, R Fu
Exp Ther Med, 2017-12-21;15(3):2525-2532.
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Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation
Authors: CA Nold-Petry, MF Nold, O Levy, Y Kliger, A Oren, I Borukhov, C Becker, S Wirtz, MK Sandhu, M Neurath, CA Dinarello
Front Immunol, 2017-12-11;8(0):1531.
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X-linked inhibitor of apoptosis inhibition sensitizes acute myeloid leukemia cell response to TRAIL and chemotherapy through potentiated induction of proapoptotic machinery
Authors: J Zhou, X Lu, TZ Tan, WJ Chng
Mol Oncol, 2017-12-01;12(1):33-47.
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IL-25 dampens the growth of human germinal center-derived B-cell non Hodgkin Lymphoma by curtailing neoangiogenesis
Authors: E Ferretti, E Di Carlo, E Ognio, G Fraternali, A Corcione, B Belmonte, JL Ravetti, C Tripodo, D Ribatti, V Pistoia
Oncoimmunology, 2017-11-27;7(3):e1397249.
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Regulation of inflammatory factors by double-stranded RNA receptors in breast cancer cells
Authors: A Venkatesh, H Nandigam, M Muccioli, M Singh, T Loftus, D Lewis, M Pate, F Benencia
Immunobiology, 2017-11-22;0(0):.
-
Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo
Authors: S Beel, M Moisse, M Damme, L De Muynck, W Robberecht, L Van Den Bo, P Saftig, P Van Damme
Hum. Mol. Genet., 2017-08-01;26(15):2850-2863.
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Discrete microfluidics for the isolation of circulating tumor cell subpopulations targeting fibroblast activation protein alpha and epithelial cell adhesion molecule
Authors: MA Witek, RD Aufforth, H Wang, JW Kamande, JM Jackson, SR Pullagurla, ML Hupert, J Usary, WZ Wysham, D Hilliard, S Montgomery, V Bae-Jump, LA Carey, PA Gehrig, MI Milowsky, CM Perou, JT Soper, YE Whang, JJ Yeh, G Martin, SA Soper
NPJ Precis Oncol, 2017-07-25;1(0):.
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Interleukin 37 promotes angiogenesis through TGF-? signaling
Authors: M Zhao, Y Hu, J Jin, Y Yu, S Zhang, J Cao, Y Zhai, R Wei, J Shou, W Cai, S Liu, X Yang, GT Xu, J Yang, DB Corry, SB Su, X Liu, T Yang
Sci Rep, 2017-07-21;7(1):6113.
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Dexamethasone induced inhibition of Dectin-1 activation of antigen presenting cells is mediated via STAT-3 and NF-?B signaling pathways.
Authors: Philipp Kotthoff, Annkristin Heine, Stefanie Andrea Erika Held, Peter Brossart
Scientific Reports, 2017-07-03;0(0):2045-2322.
-
Gp96 Peptide Antagonist gp96-II Confers Therapeutic Effects in Murine Intestinal Inflammation
Authors: CA Nold-Petry, MF Nold, O Levy, Y Kliger, A Oren, I Borukhov, C Becker, S Wirtz, MK Sandhu, M Neurath, CA Dinarello
Front Immunol, 2017;8(0):1531.
-
Dexamethasone induced inhibition of Dectin-1 activation of antigen presenting cells is mediated via STAT-3 and NF-?B signaling pathways.
Authors: Philipp Kotthoff, Annkristin Heine, Stefanie Andrea Erika Held, Peter Brossart
Scientific Reports, 2017;0(0):2045-2322.
-
Interleukin 37 promotes angiogenesis through TGF-? signaling
Authors: M Zhao, Y Hu, J Jin, Y Yu, S Zhang, J Cao, Y Zhai, R Wei, J Shou, W Cai, S Liu, X Yang, GT Xu, J Yang, DB Corry, SB Su, X Liu, T Yang
Sci Rep, 2017;7(1):6113.
-
Regulation of inflammatory factors by double-stranded RNA receptors in breast cancer cells
Authors: A Venkatesh, H Nandigam, M Muccioli, M Singh, T Loftus, D Lewis, M Pate, F Benencia
Immunobiology, 2017;0(0):.
-
Discrete microfluidics for the isolation of circulating tumor cell subpopulations targeting fibroblast activation protein alpha and epithelial cell adhesion molecule
Authors: MA Witek, RD Aufforth, H Wang, JW Kamande, JM Jackson, SR Pullagurla, ML Hupert, J Usary, WZ Wysham, D Hilliard, S Montgomery, V Bae-Jump, LA Carey, PA Gehrig, MI Milowsky, CM Perou, JT Soper, YE Whang, JJ Yeh, G Martin, SA Soper
NPJ Precis Oncol, 2017;1(0):.
-
Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo
Authors: S Beel, M Moisse, M Damme, L De Muynck, W Robberecht, L Van Den Bo, P Saftig, P Van Damme
Hum. Mol. Genet., 2017;26(15):2850-2863.
-
Proangiogenic Interactions of Vascular Endothelial MMP14 With VEGF Receptor 1 in VEGFA-Mediated Corneal Angiogenesis.
Authors: Kyu-Yeon Han, Jin-Hong Chang, Hyun Lee, Dimitri T Azar
Investigative Ophthalmology & Visual Science, 2016-06-01;0(0):1552-5783.
-
Interleukin-10 Contributes to Therapeutic Effect of Mesenchymal Stem Cells for Acute Liver Failure via Signal Transducer and Activator of Transcription 3 Signaling Pathway.
Authors: Hu-Cheng Ma, Xin Wang, Min-Na Wu, Xin Zhao, Xian-Wen Yuan, Xiao-Lei Shi
Chinese Medical Journal, 2016-04-20;0(0):0366-6999.
-
Regulatory T cells inhibit CD34+ cell differentiation into NK cells by blocking their proliferation.
Authors: Isabela Pedroza-Pa, Divya Shah, Anna Domogala, Martha Luevano, Michael Blundell, Nicola Jackson, Adrian Thrasher, Alejandro Madrigal, Aurore Saudemont
Scientific Reports, 2016-02-26;0(0):2045-2322.
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Serum chemokine (CC motif) ligand 2 level as a diagnostic, predictive, and prognostic biomarker for prostate cancer.
Authors: Kouji Izumi, Atsushi Mizokami, Hsiu-Ping Lin, Hui-Min Ho, Hiroaki Iwamoto, Aerken Maolake, Ariunbold Natsagdor, Yasuhide Kitagawa, Yoshifumi Kadono, Hiroshi Miyamoto, Chiung-Kuei Huang, Mikio Namiki, Wen-Jye Lin
Oncotarget, 2016-02-16;0(0):1949-2553.
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Wnt5a-Ror2 signaling in mesenchymal stem cells promotes proliferation of gastric cancer cells by activating CXCL16-CXCR6 axis.
Authors: Gosuke Takiguchi, Michiru Nishita, Kana Kurita, Yoshihiro Kakeji, Yasuhiro Minami
Cancer Science, 2016-02-09;0(0):1349-7006.
-
Serum chemokine (CC motif) ligand 2 level as a diagnostic, predictive, and prognostic biomarker for prostate cancer.
Authors: Kouji Izumi, Atsushi Mizokami, Hsiu-Ping Lin, Hui-Min Ho, Hiroaki Iwamoto, Aerken Maolake, Ariunbold Natsagdor, Yasuhide Kitagawa, Yoshifumi Kadono, Hiroshi Miyamoto, Chiung-Kuei Huang, Mikio Namiki, Wen-Jye Lin
Oncotarget, 2016;0(0):1949-2553.
-
Regulatory T cells inhibit CD34+ cell differentiation into NK cells by blocking their proliferation.
Authors: Isabela Pedroza-Pa, Divya Shah, Anna Domogala, Martha Luevano, Michael Blundell, Nicola Jackson, Adrian Thrasher, Alejandro Madrigal, Aurore Saudemont
Scientific Reports, 2016;0(0):2045-2322.
-
Interleukin-10 Contributes to Therapeutic Effect of Mesenchymal Stem Cells for Acute Liver Failure via Signal Transducer and Activator of Transcription 3 Signaling Pathway.
Authors: Hu-Cheng Ma, Xin Wang, Min-Na Wu, Xin Zhao, Xian-Wen Yuan, Xiao-Lei Shi
Chinese Medical Journal, 2016;0(0):0366-6999.
-
Wnt5a-Ror2 signaling in mesenchymal stem cells promotes proliferation of gastric cancer cells by activating CXCL16-CXCR6 axis.
Authors: Gosuke Takiguchi, Michiru Nishita, Kana Kurita, Yoshihiro Kakeji, Yasuhiro Minami
Cancer Science, 2016;0(0):1349-7006.
-
Proangiogenic Interactions of Vascular Endothelial MMP14 With VEGF Receptor 1 in VEGFA-Mediated Corneal Angiogenesis.
Authors: Kyu-Yeon Han, Jin-Hong Chang, Hyun Lee, Dimitri T Azar
Investigative Ophthalmology & Visual Science, 2016;0(0):1552-5783.
-
CD44v6 is a marker of constitutive and reprogrammed cancer stem cells driving colon cancer metastasis.
Authors: Todaro M, Gaggianesi M, Catalano V, Benfante A, Iovino F, Biffoni M, Apuzzo T, Sperduti I, Volpe S, Cocorullo G, Gulotta G, Dieli F, De Maria R, Stassi G
Cell Stem Cell, 2014-03-06;14(3):342-56.
Species: Human
Sample Types: Cell Culture Supernates
Applications: Flow Cytometry -
Artemin-GFRalpha3 interactions partially contribute to acute inflammatory hypersensitivity.
Authors: Thornton P, Hatcher J, Robinson I, Sargent B, Franzen B, Martino G, Kitching L, Glover C, Anderson D, Forsmo-Bruce H, Low C, Cusdin F, Dosanjh B, Williams W, Steffen A, Thompson S, Eklund M, Lloyd C, Chessell I, Hughes J
Neurosci Lett, 2013-04-19;545(0):23-8.
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IFATS collection: Combinatorial peptides identify alpha5beta1 integrin as a receptor for the matricellular protein SPARC on adipose stromal cells.
Authors: Nie J, Chang B, Traktuev DO, Sun J, March K, Chan L, Sage EH, Pasqualini R, Arap W, Kolonin MG
Stem Cells, 2008-06-26;26(10):2735-45.
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CD44 is exposed to the extracellular matrix at invasive sites in basal cell carcinomas.
Authors: Dingemans KP, Ramkema MD, Pals ST
Lab. Invest., 2002-03-01;82(3):313-22.
Species: Human
Sample Types: Whole Tissue
Applications: Immunogold Electron Microscopy -
CD44 is exposed to the extracellular matrix at invasive sites in basal cell carcinomas.
Authors: Dingemans KP, Ramkema MD, Pals ST
Lab. Invest., 2002;82(3):313-22.
Species: Human
Sample Types: Whole Cells
Applications: Electron Microscopy -
Artemin-GFRalpha3 interactions partially contribute to acute inflammatory hypersensitivity.
Authors: Thornton P, Hatcher J, Robinson I, Sargent B, Franzen B, Martino G, Kitching L, Glover C, Anderson D, Forsmo-Bruce H, Low C, Cusdin F, Dosanjh B, Williams W, Steffen A, Thompson S, Eklund M, Lloyd C, Chessell I, Hughes J
Neurosci Lett, 0;545(0):23-8.
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Phospho-regulation of the Shugoshin - Condensin interaction at the centromere in budding yeast
Authors: G Yahya, Y Wu, K Peplowska, J Röhrl, YM Soh, F Bürmann, S Gruber, Z Storchova
PLoS Genet., 0;0(8):.
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Long-term post-mortem studies following neurturin gene therapy in patients with advanced Parkinson's disease.
Authors: Chu Y, Bartus R, Manfredsson F, Olanow C, Kordower J
Brain, 0;143(3):960-975.
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