Bone homeostasis is dependent on the balance of deposition by osteoblasts and resorption by osteoclasts. This dynamic process is responsible for the continuous remodeling of bone tissue and is crucial for maintenance of bone size, shape, and integrity. Disruptions of bone homeostasis accompany disorders that include osteoporosis, arthritis, and many inheritable skeletal diseases. R&D Systems offers products that can be used as cell-type specific markers for osteoblasts (i.e. osteocalcin, DMP-1, osteoahderin) and osteoclasts (i.e. RANK, OSCAR, Calcitonin).