Human Chitotriosidase/CHIT1 Antibody
Human Chitotriosidase/CHIT1 Antibody Summary
Accession # Q13231
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Chitotriosidase encoded by the CHIT1 gene is a member of the chitinase family that is selectively expressed in activated tissue macrophages (1). It is distinct from another member, known as acidic mammalian chitinase (AMC) encoded by the CHIA gene and expressed mainly in the gastrointestinal tract and lung (2). Both CHIA and CHIT1 are secreted as 50 kDa proteins. In contrast to CHIA, CHIT1 is not stable under acidic pHs and can be processed into a C-terminally truncated 39 kDa form (2, 3). CHIT1 is the best biomarker in the monitoring of Gaucher disease among the three most commonly used markers that also include acid phosphatase and angiotensin-converting enzyme (ACE) (4). CHIT1 is also a specific marker of macrophage activation in acute ischemic stroke (5).
- Aguilera, B. et al. (2003) J. Biol. Chem. 278:40911.
- Boot, R.G. et al. (2001) J. Biol. Chem. 276:6770.
- Renkema, G.H. et al. (1997) Eur. J. Biochem. 244:279.
- Vellodi, A. et al. (2005) J. Inherit. Metab. Dis. 28:585.
- Sotgiu, S. et al. (2005) Eur. Neurol. 54:149.
Citations for Human Chitotriosidase/CHIT1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 2
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Spontaneous Chitin Accumulation in Airways and Age-Related Fibrotic Lung Disease
Authors: SJ Van Dyken, HE Liang, RP Naikawadi, PG Woodruff, PJ Wolters, DJ Erle, RM Locksley
Sample Types: BALF
Applications: Western Blot
Macrophage chitinase 1 stratifies chronic obstructive lung disease.
Authors: Agapov E, Battaile JT, Tidwell R, Hachem R, Patterson GA, Pierce RA, Atkinson JJ, Holtzman MJ
Am. J. Respir. Cell Mol. Biol., 2009;41(4):379-84.
Sample Types: Whole Tissue
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