Human CX3CL1/Fractalkine Chemokine Domain Antibody

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Product Details
Citations (10)
Supplemental Products
Reviews (1)

Human CX3CL1/Fractalkine Chemokine Domain Antibody Summary

Species Reactivity
Detects human CX3CL1/Fractalkine Chemokine Domain in direct ELISAs and Western blots.
Monoclonal Mouse IgG1 Clone # 81513
Protein A or G purified from hybridoma culture supernatant
NS0 and E. coli-derived recombinant human CX3CL1/Fractalkine Chemokine Domain
Gln25-Arg339 (Ser199Asn)
Accession # P78423
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
1 µg/mL
Recombinant Human CX3CL1/Fractalkine Full Length (Catalog # 365-FR)
8-25 µg/mL
Immersion fixed paraffin-embedded sections of human Alzheimer's disease brain

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Reconstitute at 0.5 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: CX3CL1/Fractalkine

CX3CL1 is a type I membrane protein in which an extracellular chemokine domain possessing a unique C-X3-C cysteine motif is tethered on a long mucin-like stalk. It can also be released as a soluble molecule upon proteolysis at a membrane proximal site.

Entrez Gene IDs
6376 (Human); 20312 (Mouse); 89808 (Rat); 102117496 (Cynomolgus Monkey)
Alternate Names
ABCD-3; C3Xkine; chemokine (C-X3-C motif) ligand 1; CX3C membrane-anchored chemokine; CX3CL1; CXC3; CXC3C; FKN; Fractalkine; Neurotactin; neurotactin); NTNsmall inducible cytokine subfamily D (Cys-X3-Cys), member 1 (fractalkine; NTTSmall-inducible cytokine D1; SCYD1C-X3-C motif chemokine 1; small inducible cytokine subfamily D (Cys-X3-Cys), member-1

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Citations for Human CX3CL1/Fractalkine Chemokine Domain Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

10 Citations: Showing 1 - 10
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  1. Molecular Profiling of Tissue Samples with Chronic Rejection from Patients with Chronic Lung Allograft Dysfunction: A Pilot Study in Cystic Fibrosis Patients
    Authors: F Lunardi, DI Abbrescia, L Vedovelli, F Pezzuto, F Fortarezza, GM Comacchio, V Guzzardo, P Ferrigno, M Loy, C Giraudo, AS Fraia, E Faccioli, F Braccioni, E Cozzi, D Gregori, GM Verleden, F Calabrese, FP Schena, F Rea
    Biomolecules, 2023;13(1):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  2. CX3CL1 homo-oligomerization drives cell-to-cell adherence
    Authors: MA Ostuni, P Hermand, E Saindoy, N Guillou, J Guellec, A Coens, C Hattab, E Desuzinges, A Jawhari, S Iatmanen-H, O Lequin, P Fuchs, JJ Lacapere, C Combadière, F Pincet, P Deterre
    Sci Rep, 2020;10(1):9069.
    Species: Human
    Sample Types: Plasma
    Applications: Western Blot
  3. Macrophages in the Human Cochlea: Saviors or Predators-A Study Using Super-Resolution Immunohistochemistry
    Authors: W Liu, M Molnar, C Garnham, H Benav, H Rask-Ander
    Front Immunol, 2018;9(0):223.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC
  4. Serum level of soluble CX3CL1/fractalkine is elevated in patients with polymyositis and dermatomyositis, which is correlated with disease activity.
    Authors: Suzuki F, Kubota T
    Arthritis Res. Ther., 2012;14(2):R48.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  5. Expression of ADAM-17, TIMP-3 and fractalkine in the human adult brain endothelial cell line, hCMEC/D3, following pro-inflammatory cytokine treatment.
    Authors: Hurst LA, Bunning RA, Couraud PO, Romero IA, Weksler BB, Sharrack B, Woodroofe MN
    J. Neuroimmunol., 2009;210(1):108-12.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  6. Constitutive endocytosis of the chemokine CX3CL1 prevents its degradation by cell surface metalloproteases.
    Authors: Huang YW, Su P, Liu GY, Crow MR, Chaukos D, Yan H, Robinson LA
    J. Biol. Chem., 2009;284(43):29644-53.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  7. CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis.
    Authors: Truman LA, Ford CA, Pasikowska M, Pound JD, Wilkinson SJ, Dumitriu IE, Melville L, Melrose LA, Ogden CA, Nibbs R, Graham G, Combadiere C, Gregory CD
    Blood, 2008;112(13):5026-36.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  8. Thrombin-induced expression of endothelial CX3CL1 potentiates monocyte CCL2 production and transendothelial migration.
    Authors: Popovic M, Laumonnier Y, Burysek L, Syrovets T, Simmet T
    J. Leukoc. Biol., 2008;84(1):215-23.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot
  9. The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma.
    Authors: Marchesi F, Piemonti L, Fedele G, Destro A, Roncalli M, Albarello L, Doglioni C, Anselmo A, Doni A, Bianchi P, Laghi L, Malesci A, Cervo L, Malosio M, Reni M, Zerbi A, Di Carlo V, Mantovani A, Allavena P
    Cancer Res., 2008;68(21):9060-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  10. Distinctive expression of chemokines and transforming growth factor-beta signaling in human arterial endothelium during atherosclerosis.
    Authors: Volger OL, Fledderus JO, Kisters N, Fontijn RD, Moerland PD, Kuiper J, van Berkel TJ, Bijnens AP, Daemen MJ, Pannekoek H, Horrevoets AJ
    Am. J. Pathol., 2007;171(1):326-37.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC


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Human CX3CL1/Fractalkine Chemokine Domain Antibody
By Anonymous on 08/30/2021
Application: IHC Sample Tested: Lymphatic endothelium Species: Human