Human FKBP52 Antibody Summary
Accession # Q02790
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Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Detection of Human FKBP52 by Western Blot. Western blot shows lysates of MCF-7 human breast cancer cell line. PVDF membrane was probed with 1 µg/mL Rat Anti-Human FKBP52 Monoclonal Antibody (Catalog # MAB4095) followed by HRP-conjugated Anti-Rat IgG Secondary Antibody (Catalog # HAF005). For additional reference, 5 ng recombinant human FKBP38, FKBP51, and FKBP52 were included. A specific band for FKBP52 was detected at approximately 62 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 3.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
FK506 binding protein, also called FKBP52 and FKBP4, is a peptidyl-prolyl isomerase that catalyzes the transition between cis- and trans- proline residues critical for proper folding of proteins. It associates with HSP90 complexes that are critical for the proper folding of steroid receptors. FKBP52 knockout mice have abnormal reproductive organ development due to disruption of androgen receptor folding; and phosphorylation of FKBP52 at Thr143 seems important for steroid receptor activity.
Citations for Human FKBP52 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 2
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Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice
Authors: M Criado-Mar, NT Gebru, DM Blazier, LA Gould, JD Baker, D Beaulieu-A, LJ Blair
Acta neuropathologica communications, 2021;9(1):65.
Sample Types: Whole Tissue
Molecular Pathways Leading to Induction of Cell Death and Anti-Proliferative Properties by Tacrolimus and mTOR Inhibitors in Liver Cancer Cells
Authors: E Navarro-Vi, P de la Cruz, L Contreras, R González, M Negrete, MA Rodríguez-, LM Marín-Góme, JM Álamo-Mart, A Calvo, MA Gómez-Brav, J de la Cruz, J Padillo, J Muntané
Cell. Physiol. Biochem., 2020;54(3):457-473.
Sample Types: Cell Lysates
Applications: Western Blot
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