Human GABA-A R beta 1 (NP_000803) VersaClone cDNA

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RDC0852
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Human GABA-A R beta 1 (NP_000803) VersaClone cDNA Summary

GABA A (γ-aminobutyric acid-type A) receptors are members of the cysteine-loop family of neurotransmitter-gated ion channels. GABA binding to A-type receptors induces anion-selective ion channel opening. These receptors are the principal fast inhibitory neurotransmitter receptors in the CNS. GABA A receptors are heteropentamer combinations of seven subunit types; α, β, γ, δ, ε, θ, and π. Three subunits, α, β, and γ, have at least three separate gene products in mammals, and typical GABA A receptors have some combination of α, β, and γ subunits.

The rat β1 isoform is a 58 - 60 kDa, 449 amino acid (aa), 4 transmembrane protein with two terminal extracellular regions. The ligand-binding region is in the N-terminus (aa 13 - 218). The β1 subunit is known to be phosphorylated on a consensus phosphorylation site (S409 of the precursor) that exists in the cytoplasmic domain between transmembrane segments 3 and 4. PKA or PKC βII-induced phosphorylation decreases GABA A receptor activity.

Specifications

Shipping Conditions
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at -20 to -70 °C. Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Do not use past expiration date.
Species
Human

Product Datasheets

Background: GABA-A R beta 1

Long Name
gamma-Aminobutyric Acid Type A Receptor, beta-1 Polypeptide
Entrez Gene IDs
2560 (Human); 14400 (Mouse); 25450 (Rat); 282239 (Bovine)
Alternate Names
GABA A R beta 1; GABA(A) receptor subunit beta-1; GABAAR beta 1; GABAARb1; GABRB1; gamma-aminobutyric acid (GABA) A receptor, beta 1; gamma-aminobutyric acid receptor subunit beta-1

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