Human IGF-I/IGF-1 Quantikine ELISA Kit

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DG100B
SG100B
PDG100B
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Human IGF-I ELISA Standard Curve
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Product Details
Citations (110)
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Human IGF-I/IGF-1 Quantikine ELISA Kit Summary

Assay Length
4.5 hours
Specificity
Natural and recombinant human IGF-1.
Cross-reactivity
Cross-reactivity observed with 1 or more available related molecules.< 50% cross-species reactivity observed with species tested.
Interference
Interference observed with 1 or more available related molecules.

Product Summary

The Quantikine® Human IGF-I/IGF-1 Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human IGF-1 in cell culture supernates, serum, and plasma. It contains E. coli-expressed recombinant human IGF-1 and has antibodies raised againt the recombinant protein. Results obtained for naturally occurring human IGF-1 showed linear curves that were parallel to the standard curves obtained using the Quantikine® kit standards. These results indicate that this kit can be used to determine relative mass values for natural human IGF-1.

Precision

Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in twenty separate assays to assess inter-assay precision. Assays were performed by at least three technicians using two lots of components

Serum-free Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma

Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 20 20 20
Mean 0.594 1.02 1.94 0.617 1.01 2.1
Standard Deviation 0.026 0.046 0.077 0.038 0.06 0.12
CV% 4.4 4.5 4 6.2 5.9 5.7

Recovery

The recovery of human IGF-1 spiked to three different levels throughout the range of the assay was evaluated. Samples were diluted prior to assay as described in the Sample Preparation section.

Sample Type Average % Recovery Range %
Cell Culture Media (n=4) 93 88-97

Linearity

To assess the linearity of the assay, samples containing and/or spiked with high concentrations of human IGF-1 were serially diluted with calibrator diluent to produce samples with values within the dynamic range of the assay. Samples were diluted prior to assay as described in the Sample Preparation section.
Human IGF-I/IGF-1 Linearity
Human IGF-I ELISA Linearity

Data Examples

Human IGF-I ELISA Standard Curve

Human IGF-I/IGF-1 Standard Curve

Product Datasheets

Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: IGF-I/IGF-1

Insulin-like growth factor 1 (IGF-1, also known as somatomedin C) is a 7.6 kDa, 70 amino acid (aa) polypeptide with three internal disulfide bonds. The sequence of human IGF-1 is identical to that of bovine and porcine IGF-1, and is 70% identical to human IGF2. IGF-1 is a single-chain molecule with about 50% identity to the sequences of the A- and B-chains of human insulin. 


 IGF-1 is a growth hormone that plays a role in a variety of biological events. It is produced primarily by hepatocytes, serving an endocrine function. It is also produced by many other cells, where it may act in an autocrine or paracrine manner. It binds two tyrosine kinase receptors, the IGF-1 receptor (IGF1R) and the insulin receptor, to initiate downstream events like the AKT and PI3K signal transduction pathways. This triggers cell proliferation and protects cells from apoptosis. IGF-1 also interacts with seven IGF-binding proteins (IGFBP-1 through IGFBP7), influencing IGF-1 binding to IGF1R and increasing IGF-1 half-life to closely regulate IGF-1 signaling. For example, IGFBP-3 binds over 90% of the total IGF in serum in a complex of IGF, IGFBP, and an acid-labile subunit. This ternary complex greatly stabilizes IGF in the circulation, changing the half-life from minutes to hours. Proteases also facilitate IGF-1R binding by cleaving IGFBPs to modify their affinity for IGF or completely eliminate the IGFBP. The interactions of IGF, IGFBP, IGFBP proteases, and IGF receptors are referred to as the IGF axis. 

 The IGF axis affects many primary physiological and pathological processes, including development, growth, metabolic regulation, tumorigenesis, atherosclerosis, and angiogenesis. Its ability to inhibit apoptosis and stimulate cell growth and proliferation plays a significant role in prenatal development, growth to adulthood, and metabolic control. Serum levels of IGF-1 have been reported to increase from birth to puberty, followed by a slow decline through adulthood. IGF-1 also induces amino acid uptake, protein synthesis, and glucose utilization. In the brain, IGF-1 acts as a neurotrophic factor to promote neurogenesis and neuronal survival. Exercise increases levels of IGF-1 in blood serum, indicating it plays a role as a key mediator of exercise-induced neurogenesis.

Long Name:
Insulin-like Growth Factor I/Insulin-like Growth Factor 1
Entrez Gene IDs:
3479 (Human); 16000 (Mouse); 24482 (Rat)
Alternate Names:
IBP1; IGF1; IGF-1; IGF1A; IGFI; IGF-I; IGF-IA; IGF-IB; insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1; insulin-like growth factor I; insulin-like growth factor IA; insulin-like growth factor IB; Mechano growth factor; MGF; Somatomedin A; Somatomedin C; somatomedin-C

Citations for Human IGF-I/IGF-1 Quantikine ELISA Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

110 Citations: Showing 1 - 10
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  1. JAK2-IGF1 axis in osteoclasts regulates postnatal growth in mice
    Authors: DW Dodington, JL Yumol, J Yang, E Pollock-Ta, T Sivasubram, SM Sacco, SA Schroer, YE Li, H Le, WE Ward, M Woo
    JCI Insight, 2021;6(5):.
    Species: Mouse
    Sample Types: Serum
  2. IGF1, serum glucose, and retinopathy of prematurity in extremely preterm infants
    Authors: B Cakir, W Hellström, Y Tomita, Z Fu, R Liegl, A Winberg, I Hansen-Pup, D Ley, A Hellström, C Löfqvist, LE Smith
    JCI Insight, 2020;5(19):.
    Species: Human
    Sample Types: Plasma
  3. PM2.5-bound PAHs exposure linked with low plasma insulin-like growth factor 1 levels and reduced child height
    Authors: Z Zeng, X Huo, Q Wang, C Wang, MN Hylkema, X Xu
    Environ Int, 2020;138(0):105660.
    Species: Human
    Sample Types: Plasma
  4. High intensity interval training combined with L-citrulline supplementation: Effects on physical performance in healthy older adults
    Authors: F Buckinx, LP Carvalho, V Marcangeli, M Dulac, G Hajj Boutr, G Gouspillou, P Gaudreau, P Noirez, M Aubertin-L
    Exp. Gerontol., 2020;0(0):111036.
    Species: Human
    Sample Types: Serum
  5. Effect of anti-inflammatory treatment on systemic inflammation, immune function, and endometrial health in postpartum dairy cows
    Authors: OB Pascottini, SJ Van Schynd, JFW Spricigo, MR Carvalho, B Mion, ES Ribeiro, SJ LeBlanc
    Sci Rep, 2020;10(1):5236.
    Species: Bovine
    Sample Types: Serum
  6. Towards a fasting-mimicking diet for critically ill patients: the pilot randomized crossover ICU-FM-1 study
    Authors: L Van Dyck, I Vanhorebee, A Wilmer, A Schrijvers, I Derese, L Mebis, PJ Wouters, G Van den Be, J Gunst, MP Casaer
    Crit Care, 2020;24(1):249.
    Species: Human
    Sample Types:
  7. Serum insulin-like growth factor-1 as a potential marker for MDD diagnosis, its clinical characteristics, and treatment efficacy validation: data from an open-label vortioxetine study
    Authors: OA Levada, AS Troyan, IY Pinchuk
    BMC Psychiatry, 2020;20(1):208.
    Species: Human
    Sample Types: Serum
  8. An Autocrine IL-6/IGF-1R Loop Mediates EMT and Promotes Tumor Growth in Non-small Cell Lung Cancer
    Authors: X Zheng, G Lu, Y Yao, W Gu
    Int. J. Biol. Sci., 2019;15(9):1882-1891.
    Species: Human
    Sample Types: Cell Culture Supernates
  9. Ginsenoside Rg1 Accelerates Paracrine Activity and Adipogenic Differentiation of Human Breast Adipose-Derived Stem Cells in a Dose-Dependent Manner In Vitro
    Authors: ZJ Liang, X Lu, DD Zhu, XL Yi, FX Wu, N He, C Tang, CY Wei, HM Li
    Cell Transplant, 2019;0(0):9636897198256.
    Species: Human
    Sample Types: Cell Culture Supernates
  10. Therapeutic Effects of rAAV-Mediated Concomittant Gene Transfer and Overexpression of TGF-? and IGF-I on the Chondrogenesis of Human Bone-Marrow-Derived Mesenchymal Stem Cells
    Authors: S Morscheid, A Rey-Rico, G Schmitt, H Madry, M Cucchiarin, JK Venkatesan
    Int J Mol Sci, 2019;20(10):.
    Species: Human
    Sample Types: Cell Culture Supernates
  11. Hypoallergenic and anti-inflammatory feeds in children with complicated severe acute malnutrition: an open randomised controlled 3-arm intervention trial in Malawi
    Authors: RH Bartels, E Chimwezi, V Watson, L Pei, I Potani, B Allubha, K Chidzalo, D Wang, Q Dube, M Mallewa, A Allen, RHJ Bandsma, WP Voskuijl, SJ Allen
    Sci Rep, 2019;9(1):2304.
    Species: Human
    Sample Types: Plasma
  12. Investigating Stress Response during Vaginal Delivery and Elective Cesarean Section through Assessment of Levels of Cortisol, Interleukin 6 (IL-6), Growth Hormone (GH) and Insulin-Like Growth Factor 1 (IGF-1)
    Authors: N Kiriakopou, S Grigoriadi, E Maziotis, A Philippou, A Rapani, P Giannelou, P Tsioulou, K Sfakianoud, A Kontogeorg, P Bakas, G Mastorakos, M Koutsilier, M Simopoulou
    J Clin Med, 2019;8(8):.
    Species: Human
    Sample Types: Serum
  13. Vitamin D Deficiency Is Associated with Muscle Atrophy and Reduced Mitochondrial Function in Patients with Chronic Low Back Pain
    Authors: KP Dzik, W Skrobot, KB Kaczor, DJ Flis, MJ Karnia, W Libionka, J Antosiewic, W Kloc, JJ Kaczor
    Oxid Med Cell Longev, 2019;2019(0):6835341.
    Species: Human
    Sample Types: Serum
  14. A Potato Peel Extract Stimulates Type I Collagen Synthesis via Akt and ERK Signaling in Normal Human Dermal Fibroblasts
    Authors: M Suto, H Masutomi, K Ishihara, H Masaki
    Biol. Pharm. Bull., 2019;42(9):1510-1516.
    Species: Human
    Sample Types: Cell Culture Supernates
  15. Impact of HIV-1 infection on the IGF-1 axis and angiogenic factors in pregnant Cameroonian women receiving antiretroviral therapy
    Authors: LF Esemu, EK Yuosembom, R Fang, S Rasay, BAY Fodjo, JT Nguasong, W Kidima, GL Ekali, JJ Chen, L Ndhlovu, JD Bigoga, DW Taylor, RGF Leke, A Babakhanya
    PLoS ONE, 2019;14(5):e0215825.
    Species: Human
    Sample Types: Plasma
  16. Serum concentrations of IGF-I/IGF-II as biomarkers of alcohol damage during foetal development and diagnostic markers of Foetal Alcohol Syndrome
    Authors: V Andreu-Fer, A Bastons-Co, E Navarro-Ta, S Sailer, O Garcia-Alg
    Sci Rep, 2019;9(1):1562.
    Species: Human
    Sample Types: Serum
  17. Early-Life Cadmium Exposure and Bone-Related Biomarkers: A Longitudinal Study in Children
    Authors: A Malin Igra, M Vahter, R Raqib, M Kippler
    Environ. Health Perspect., 2019;127(3):37003.
    Species: Human
    Sample Types: Plasma
  18. Redifferentiation of Articular Chondrocytes by Hyperacute Serum and Platelet Rich Plasma in Collagen Type I Hydrogels
    Authors: V Jeyakumar, E Niculescu-, C Bauer, Z Lacza, S Nehrer
    Int J Mol Sci, 2019;20(2):.
    Species: Human
    Sample Types: Cell Culture Supernates
  19. Growth Differentiation Factor-15 (GDF-15) is a Biomarker of Muscle Wasting and Renal Dysfunction in Preoperative Cardiovascular Surgery Patients
    Authors: T Nakajima, I Shibasaki, T Sawaguchi, A Haruyama, H Kaneda, T Nakajima, T Hasegawa, T Arikawa, S Obi, M Sakuma, H Ogawa, S Toyoda, F Nakamura, S Abe, H Fukuda, T Inoue
    J Clin Med, 2019;8(10):.
    Species: Human
    Sample Types: Serum
  20. Establishment of a novel human CIC-DUX4 sarcoma cell line, Kitra-SRS, with autocrine IGF-1R activation and metastatic potential to the lungs
    Authors: S Nakai, S Yamada, H Outani, T Nakai, N Yasuda, H Mae, Y Imura, T Wakamatsu, H Tamiya, T Tanaka, K Hamada, A Tani, A Myoui, N Araki, T Ueda, H Yoshikawa, S Takenaka, N Naka
    Sci Rep, 2019;9(1):15812.
    Species: Human
    Sample Types: Cell Culture Supernates
  21. Human cardiac progenitor cell activation and regeneration mechanisms: exploring a novel myocardial ischemia/reperfusion in vitro model
    Authors: MJ Sebastião, M Serra, R Pereira, I Palacios, P Gomes-Alve, PM Alves
    Stem Cell Res Ther, 2019;10(1):77.
    Species: Human
    Sample Types: Cell Culture Supernates
  22. Impact of Chronic Neonatal Intermittent Hypoxia on Severity of Retinal Damage in a Rat Model of Oxygen-Induced Retinopathy
    Authors: KD Beharry, CL Cai, T Ahmad, S Guzel, GB Valencia, JV Aranda
    J Nat Sci, 2018;4(3):.
    Species: Rat
    Sample Types: Tissue Homogenates
  23. Physical Exercise and Spatial Training: A Longitudinal Study of Effects on Cognition, Growth Factors, and Hippocampal Plasticity
    Authors: L Woost, PL Bazin, M Taubert, R Trampel, CL Tardif, A Garthe, G Kempermann, U Renner, G Stalla, DVM Ott, V Rjosk, H Obrig, A Villringer, E Roggenhofe, TA Klein
    Sci Rep, 2018;8(1):4239.
    Species: Human
    Sample Types: Serum
  24. Characterization of induced pluripotent stem cell-derived megakaryocyte lysates for potential regenerative applications
    Authors: A Baigger, D Eicke, Y Yuzefovych, D Pogozhykh, R Blasczyk, C Figueiredo
    J. Cell. Mol. Med., 2018;0(0):.
    Species: Human
    Sample Types: Cell Lysates
  25. Differences in biochemical markers between Heart-transplanted and Left Ventricular Assist Device implanted patients, during cardiac rehabilitation
    Authors: V Racca, P Castiglion, C Panzarino, M Saresella, I Marventano, A Verde, F Oliva, M Ferratini
    Sci Rep, 2018;8(1):10816.
    Species: Human
    Sample Types: Serum
  26. Relationships of Age and Sex with Cytokine Content and Distribution in Human Platelet Fibrin Gels
    Authors: MY Bai, MH Chuang, MF Lin, SL Tang, CC Wong, WP Chan
    Sci Rep, 2018;8(1):10642.
    Species: Rabbit
    Sample Types: Platelet Rich Fibrin
  27. The effects of a combined bodyweight-based and elastic bands resistance training, with or without protein supplementation, on muscle mass, signaling and heat shock response in healthy older people
    Authors: M Krause, D Crognale, K Cogan, S Contarelli, B Egan, P Newsholme, G De Vito
    Exp. Gerontol., 2018;115(0):104-113.
    Species: Human
    Sample Types: Plasma
  28. The effect of autologous platelet rich plasma on tenocytes of the human rotator cuff
    Authors: S Pauly, F Klatte-Sch, K Stahnke, M Scheibel, B Wildemann
    BMC Musculoskelet Disord, 2018;19(1):422.
    Species: Human
    Sample Types: Plasma
  29. Human umbilical cord blood mesenchymal stem cells engineered to overexpress growth factors accelerate outcomes in hair growth
    Authors: DH Bak, MJ Choi, SR Kim, BC Lee, JM Kim, ES Jeon, W Oh, ES Lim, BC Park, MJ Kim, J Na, BJ Kim
    Korean J. Physiol. Pharmacol., 2018;22(5):555-566.
    Species: Human
    Sample Types: Cell Culture Supernates
  30. Validation of insulin-like growth factor-1 as a prognostic parameter in patients with hepatocellular carcinoma in a European cohort
    Authors: Y Huber, F Bierling, C Labenz, S Koch, I Schmidtman, R Kloeckner, S Schotten, T Huber, H Lang, MA Woerns, PR Galle, A Weinmann, J Weinmann-M
    BMC Cancer, 2018;18(1):774.
    Species: Human
    Sample Types: Serum
  31. Evaluation of Coated Steroidal Implants Containing Trenbolone Acetate and Estradiol-17? on Live Performance, Carcass Traits, and Sera Metabolites in Finishing Steers
    Authors: ZK Smith, AJ Thompson, JP Hutcheson, WT Nichols, BJ Johnson
    J. Anim. Sci., 2018;0(0):.
    Species: Bovine
    Sample Types: Serum
  32. l-Carnitine Supplementation in Older Women. A Pilot Study on Aging Skeletal Muscle Mass and Function
    Authors: AK Sawicka, D Hartmane, P Lipinska, E Wojtowicz, W Lysiak-Szy, RA Olek
    Nutrients, 2018;10(2):.
    Species: Human
    Sample Types: Serum
  33. Human serum and platelet lysate are appropriate xeno-free alternatives for clinical-grade production of human MuStem cell batches
    Authors: C Saury, A Lardenois, C Schleder, I Leroux, B Lieubeau, L David, M Charrier, L Guével, S Viau, B Delorme, K Rouger
    Stem Cell Res Ther, 2018;9(1):128.
    Species: Human
    Sample Types: Cell Culture Supernates
  34. Relative Bioavailability of a Single 4-mg Dose of Somatropin Administered by Subcutaneous Injection or by Needle-free Device and Coadministered With the Growth Hormone Inhibitor Octreotide Acetate in Healthy Adult Subjects
    Authors: DB Brimhall, N Petri, P D'Angelo
    Clin Ther, 2018;0(0):.
    Species: Human
    Sample Types: Serum
  35. Effects of treatment of preweaning dairy calves with recombinant bovine somatotropin on immune responses and somatotropic axis
    Authors: AL Belli, RB Reis, A Veronese, R Moreira, K Flanagan, J Driver, CD Nelson, JA Clapper, MA Ballou, KC Jeong, RC Chebel
    J. Dairy Sci., 2018;0(0):.
    Species: Bovine
    Sample Types: Serum
  36. A 2-Week Specific Volleyball Training Supported by the Whole Body Cryostimulation Protocol Induced an Increase of Growth Factors and Counteracted Deterioration of Physical Performance
    Authors: J Jaworska, K Micielska, M Koz?owska, K Wnorowski, J Skrobecki, L Radzimi?sk, A Babi?ska, E Rodziewicz, G Lombardi, E Ziemann
    Front Physiol, 2018;9(0):1711.
    Species: Human
    Sample Types: Serum
  37. The levels of pro-fibrotic cytokines in pulmonary tuberculosis with minimal and extensive lesions
    Authors: T Astuti, IN Chozin, NS Damayanti, D Nugrahenny
    Lung India, 2018;35(3):204-208.
    Species: Human
    Sample Types: Plasma
  38. Matrine induces senescence of human glioblastoma cells through suppression of the IGF1/PI3K/AKT/p27 signaling pathway
    Authors: W Zhou, J Wang, Q Qi, Z Feng, B Huang, A Chen, D Zhang, W Li, Q Zhang, R Bjerkvig, X Li, J Wang
    Cancer Med, 2018;0(0):.
    Species: Human
    Sample Types: Cell Cultue Supernates
  39. 1H-NMR and MALDI-TOF MS as metabolomic quality control tests to classify platelet derived medium additives for GMP compliant cell expansion procedures
    Authors: F Agostini, M Ruzza, D Corpillo, L Biondi, E Acquadro, B Canepa, A Viale, M Battiston, F Serra, S Aime, M Mazzucato
    PLoS ONE, 2018;13(9):e0203048.
    Species: Human
    Sample Types: Cell Culture Supernates
  40. Pre-weaning injections of bovine somatotropin enhanced reproductive performance of Bos indicus-influenced replacement beef heifers
    Authors: MB Piccolo, JD Arthington, GM Silva, GC Lamb, RF Cooke, P Moriel
    J. Anim. Sci., 2018;0(0):.
    Species: Bovine
    Sample Types: Plasma
  41. Central Infusion of IGF-1 Increases Hippocampal Neurogenesis and Improves Neurobehavioral Function following Traumatic Brain Injury
    Authors: SW Carlson, KE Saatman
    J. Neurotrauma, 2018;0(0):.
    Species: Mouse
    Sample Types: Serum
  42. Shifting the IGF-axis: An age-related decline in human tear IGF-1 correlates with clinical signs of dry eye
    Authors: R Patel, M Zhu, DM Robertson
    Growth Horm. IGF Res., 2018;0(0):.
    Species: Human
    Sample Types: Tears
  43. Serum IGF-1 is associated with cognitive functions in early, drug-na�ve Parkinson's disease
    Authors: M Picillo, R Pivonello, G Santangelo, C Pivonello, R Savastano, R Auriemma, M Amboni, S Scannapiec, A Pierro, A Colao, P Barone, MT Pellecchia
    PLoS ONE, 2017;12(10):e0186508.
    Species: Human
    Sample Types: Serum
  44. Effect of Physical Activity on Cognitive Development: Protocol for a 15-Year Longitudinal Follow-Up Study
    Authors: G Zhao, M Quan, L Su, H Zhang, J Zhang, J Zhang, H Fang, ZB Cao, Z Zhu, Z Niu, R Wang, P Chen
    Biomed Res Int, 2017;2017(0):8568459.
    Species: Human
    Sample Types: Plasma
  45. A phase II randomized, double-blind, presurgical trial of Polyphenon E in bladder cancer patients to evaluate pharmacodynamics and bladder tissue biomarkers
    Authors: JR Gee, DR Saltzstein, K Kim, JM Kolesar, W Huang, TC Havighurst, BW Wollmer, J Stublaski, T Downs, H Mukhtar, M House, HL Parnes, HH Bailey
    Cancer Prev Res (Phila), 2017;0(0):.
    Species: Human
    Sample Types: Serum
  46. Five-weekly S-1 plus cisplatin therapy combined with trastuzumab therapy in HER2-positive gastric cancer: a phase II trial and biomarker study (WJOG7212G)
    Authors: Y Miura, Y Sukawa, S Hironaka, M Mori, K Nishikawa, S Tokunaga, H Okuda, T Sakamoto, K Taku, K Nishikawa, T Moriwaki, Y Negoro, Y Kimura, K Uchino, K Shinozaki, H Shinozaki, N Musha, H Yoshiyama, T Tsuda, Y Miyata, N Sugimoto, T Shirakawa, M Ito, K Yonesaka, K Yoshimura, N Boku, K Nosho, T Takano, I Hyodo
    Gastric Cancer, 2017;0(0):.
    Species: Human
    Sample Types: Serum
  47. Evaluation of autologous skeletal muscle-derived factors for regenerative medicine applications
    Authors: M Yoshikawa, T Nakasa, M Ishikawa, N Adachi, M Ochi
    Bone Joint Res, 2017;6(5):277-283.
    Species: Human
    Sample Types: Tissue Homogenates
  48. Hypoxic preconditioning of human cardiosphere-derived cell sheets enhances cellular functions via activation of the PI3K/Akt/mTOR/HIF-1? pathway
    Authors: Y Tanaka, T Hosoyama, A Mikamo, H Kurazumi, A Nishimoto, K Ueno, B Shirasawa, K Hamano
    Am J Transl Res, 2017;9(2):664-673.
    Species: Human
    Sample Types: Cell Culture Supernates
  49. Metformin inhibits the proliferation of benign prostatic epithelial cells
    Authors: Z Wang, X Xiao, R Ge, J Li, CW Johnson, C Rassoulian, AF Olumi
    PLoS ONE, 2017;12(3):e0173335.
    Species: Human
    Sample Types: Cell Culture Supernates
  50. Effects of transdermal testosterone gel or an aromatase inhibitor on serum concentration and pulsatility of growth hormone in older men with age-related low testosterone
    Authors: JP Dias, JD Veldhuis, O Carlson, M Shardell, CW Chia, D Melvin, JM Egan, S Basaria
    Metab. Clin. Exp., 2017;69(0):143-147.
    Species: Human
    Sample Types: Serum
  51. The production method affects the efficacy of platelet derivatives to expand mesenchymal stromal cells in vitro
    Authors: M Bernardi, F Agostini, K Chieregato, E Amati, C Durante, M Rassu, M Ruggeri, S Sella, E Lombardi, M Mazzucato, G Astori
    J Transl Med, 2017;15(1):90.
    Species: Human
    Sample Types: Cell Lysates
  52. Peripheral blood aspirates overexpressing IGF-I via rAAV gene transfer undergo enhanced chondrogenic differentiation processes
    Authors: J Frisch, P Orth, A Rey-Rico, JK Venkatesan, G Schmitt, H Madry, D Kohn, M Cucchiarin
    J. Cell. Mol. Med., 2017;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  53. Prenatal exposure to tobacco smoke leads to increased mitochondrial DNA content in umbilical cord serum associated to reduced gestational age
    Authors: Francesca Pirini
    Int J Environ Health Res, 2017;27(1):52-67.
    Species: Human
    Sample Types: Serum
  54. Concurrent Aerobic and Resistance Training Has Anti-Inflammatory Effects and Increases Both Plasma and Leukocyte Levels of IGF-1 in Late Middle-Aged Type 2 Diabetic Patients
    Authors: G Annibalini, F Lucertini, D Agostini, L Vallorani, A Gioacchini, E Barbieri, M Guescini, L Casadei, A Passalia, M Del Sal, G Piccoli, M Andreani, A Federici, V Stocchi
    Oxid Med Cell Longev, 2017;2017(0):3937842.
    Species: Human
    Sample Types: Plasma
  55. Relationships of insulin-like growth factor-1, its binding proteins, and cardiometabolic risk in hypertensive perimenopausal women
    Authors: A Olszanecka, A Dragan, K Kawecka-Ja, D Fedak, D Czarnecka
    Metab. Clin. Exp., 2017;69(0):96-106.
    Species: Human
    Sample Types: Plasma
  56. Angiogenesis in newly regenerated bone by secretomes of human mesenchymal stem cells
    Authors: W Katagiri, T Kawai, M Osugi, Y Sugimura-W, K Sakaguchi, T Kojima, T Kobayashi
    Maxillofac Plast Reconstr Surg, 2017;39(1):8.
    Species: Human
    Sample Types: Cell Culture Supernates
  57. Temporal changes in liver tissue metabolome of lambs fed low-quality roughage
    Authors: W Xu, N Okayama, A Iwasawa, M Yayota
    Anim. Sci. J., 2017;0(0):.
    Species: Ovine
    Sample Types: Serum
  58. Umbilical cord extracts improve diabetic abnormalities in bone marrow-derived mesenchymal stem cells and increase their therapeutic effects on diabetic nephropathy
    Authors: K Nagaishi, Y Mizue, T Chikenji, M Otani, M Nakano, Y Saijo, H Tsuchida, S Ishioka, A Nishikawa, T Saito, M Fujimiya
    Sci Rep, 2017;7(1):8484.
    Species: Human
    Sample Types: Cell Culture Supernates
  59. Evaluation of Not-Activated and Activated PRP in Hair Loss Treatment: Role of Growth Factor and Cytokine Concentrations Obtained by Different Collection Systems
    Authors: P Gentile, JP Cole, MA Cole, S Garcovich, A Bielli, MG Scioli, A Orlandi, C Insalaco, V Cervelli
    Int J Mol Sci, 2017;18(2):.
    Species: Human
    Sample Types: Plasma
  60. Impact of Hyperglycemia and Low Oxygen Tension on Adipose-Derived Stem Cells Compared with Dermal Fibroblasts and Keratinocytes: Importance for Wound Healing in Type 2 Diabetes
    PLoS ONE, 2016;11(12):e0168058.
    Species: Human
    Sample Types: Cell Culture Supernates
  61. Genetic variation in IGF1 predicts renal cell carcinoma susceptibility and prognosis in Chinese population
    Sci Rep, 2016;6(0):39014.
    Species: Human
    Sample Types: Serum
  62. Biological effects of plasma rich in growth factors (PRGF) on human endometrial fibroblasts
    Authors: Gorka Orive
    Eur. J. Obstet. Gynecol. Reprod. Biol., 2016;206(0):125-130.
    Species: Human
    Sample Types: Plasma
  63. Elevations in growth hormone and glucagon-like peptide-2 levels on admission are associated with increased mortality in trauma patients.
    Authors: Matthew P Rowan, Darrick J Beckman, Julie A Rizzo, Claire L Isbell, Christopher E White, Stephen M Cohn, Kevin K Chung
    Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 2016;0(0):1757-7241.
    Species: Human
    Sample Types: Serum
    Applications: ELISA Capture
  64. Randomized Trial Testing the Effects of Eating Frequency on Two Hormonal Biomarkers of Metabolism and Energy Balance
    Authors: Martine M Perrigue
    Nutr Cancer, 2016;0(0):1-8.
    Species: Human
    Sample Types: Plasma
  65. Neovascularization Potential of Blood Outgrowth Endothelial Cells From Patients With Stable Ischemic Heart Failure Is Preserved
    Authors: D Dauwe, B Pelacho, A Wibowo, AS Walravens, K Verdonck, H Gillijns, E Caluwe, P Pokreisz, N van Gastel, G Carmeliet, M Depypere, F Maes, N Vanden Dri, W Droogne, J Van Cleemp, J Vanhaecke, F Prosper, C Verfaillie, A Luttun, S Janssens
    J Am Heart Assoc, 2016;5(4):.
    Species: Human
    Sample Types: Cell Culture Supernates
  66. A preliminary study of pamidronic acid downregulation of angiogenic factors IGF-1/PECAM-1 expression in circulating level in bone metastatic breast cancer patients
    Authors: Zeng Wang
    Onco Targets Ther, 2016;9(0):3147-52.
    Species: Human
    Sample Types: Serum
  67. Overcoming the bottleneck of platelet lysate supply in large-scale clinical expansion of adipose-derived stem cells: A comparison of fresh versus three types of platelet lysates from outdated buffy coat-derived platelet concentrates
    Authors: Anne Fischer-Ni
    Cytotherapy, 2016;0(0):.
    Species: Human
    Sample Types: Cell Culture Supernates
  68. The tobacco-specific carcinogen-operated calcium channel promotes lung tumorigenesis via IGF2 exocytosis in lung epithelial cells
    Nat Commun, 2016;7(0):12961.
    Species: Human
    Sample Types: Cell Culture Supernates
  69. IGF1R as a Key Target in High Risk, Metastatic Medulloblastoma
    Authors: Matthew N Svalina
    Sci Rep, 2016;6(0):27012.
    Species: Human
    Sample Types: CSF
  70. An adverse immune-endocrine profile in patients with tuberculosis and type 2 diabetes
    Authors: O Bottasso
    Tuberculosis (Edinb), 2016;101(0):95-101.
    Species: Human
    Sample Types: Plasma
  71. Adipose-derived mesenchymal stem cells from patients with atherosclerotic renovascular disease have increased DNA damage and reduced angiogenesis that can be modified by hypoxia
    Stem Cell Res Ther, 2016;7(1):128.
    Species: Human
    Sample Types: Cell Culture Supernates
  72. High glycemic index diet in PCOS patients. The analysis of IGF I and TNF-? pathways in metabolic disorders
    Authors: M Szczuko
    Med. Hypotheses, 2016;96(0):42-47.
    Species: Human
    Sample Types: Plasma
  73. Phase IIa, randomized placebo-controlled trial of single high dose cholecalciferol (vitamin D3) and daily Genistein (G-2535) versus double placebo in men with early stage prostate cancer undergoing prostatectomy
    Authors: Howard H Bailey
    Am J Clin Exp Urol, 2016;4(2):17-27.
    Species: Human
    Sample Types: Serum
  74. Implantation of rAAV5-IGF-I transduced autologous chondrocytes improves cartilage repair in full-thickness defects in the equine model.
    Authors: Ortved K, Begum L, Mohammed H, Nixon A
    Mol Ther, 2015;23(2):363-73.
    Species: Equine
    Sample Types: Synovial Fluid
  75. LMP1 promotes expression of insulin-like growth factor 1 (IGF1) to selectively activate IGF1 receptor and drive cell proliferation.
    Authors: Tworkoski K, Raab-Traub N
    J Virol, 2015;89(5):2590-602.
    Species: Human
    Sample Types: Cell Culture Supernates
  76. Effects of exercise and milk fat globule membrane (MFGM) supplementation on body composition, physical function, and hematological parameters in community-dwelling frail Japanese women: a randomized double blind, placebo-controlled, follow-up trial.
    Authors: Kim H, Suzuki T, Kim M, Kojima N, Ota N, Shimotoyodome A, Hase T, Hosoi E, Yoshida H
    PLoS ONE, 2015;10(2):e0116256.
    Species: Human
    Sample Types: Serum
  77. Chondrogenic Differentiation Processes in Human Bone Marrow Aspirates upon rAAV-Mediated Gene Transfer and Overexpression of the Insulin-Like Growth Factor I
    Authors: Magali Cucchiarin
    Tissue Eng Part A, 2015;21(17):2460-71.
    Species: Human
    Sample Types: Cell Culture Supernates
  78. Overexpression of human IGF-I via direct rAAV-mediated gene transfer improves the early repair of articular cartilage defects in vivo.
    Authors: Cucchiarini M, Madry H
    Gene Ther, 2014;21(9):811-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  79. A randomized phase II presurgical trial of transdermal 4-hydroxytamoxifen gel versus oral tamoxifen in women with ductal carcinoma in situ of the breast.
    Authors: Lee O, Page K, Ivancic D, Helenowski I, Parini V, Sullivan M, Margenthaler J, Chatterton R, Jovanovic B, Dunn B, Heckman-Stoddard B, Foster K, Muzzio M, Shklovskaya J, Skripkauskas S, Kulesza P, Green D, Hansen N, Bethke K, Jeruss J, Bergan R, Khan S
    Clin Cancer Res, 2014;20(14):3672-82.
    Species: Human
    Sample Types: Plasma
  80. Role of serum concentration of VEGFR1 and TIMP2 on clinical outcome in primary cervical cancer: results of a companion protocol of the randomized, NOGGO-AGO phase III adjuvant trial of simultaneous cisplatin-based radiochemotherapy vs. carboplatin and paclitaxel containing sequential radiotherapy.
    Authors: Braicu E, Fotopoulou C, Chekerov R, Richter R, Blohmer J, Kummel S, Stamatian F, Yalcinkaya I, Mentze M, Lichtenegger W, Sehouli J
    Cytokine, 2013;61(3):755-8.
    Species: Human
    Sample Types: Serum
  81. Functional and differential proteomic analyses to identify platelet derived factors affecting ex vivo expansion of mesenchymal stromal cells.
    Authors: Kinzebach S, Dietz L, Kluter H, Thierse H, Bieback K
    BMC Cell Biol, 2013;14(0):48.
    Species: Human
    Sample Types: Cell Culture Supernates
  82. Human bone marrow-derived mesenchymal stem cells suppress human glioma growth through inhibition of angiogenesis.
    Authors: Ho I, Toh H, Ng W, Teo Y, Guo C, Hui K, Lam P
    Stem Cells, 2013;31(1):146-55.
    Species: Human
    Sample Types: Tissue Homogenates
  83. Arsenic exposure affects plasma insulin-like growth factor 1 (IGF-1) in children in rural Bangladesh.
    Authors: Ahmed S, Rekha R, Ahsan K, Doi M, Grander M, Roy A, Ekstrom E, Wagatsuma Y, Vahter M, Raqib R
    PLoS ONE, 2013;8(11):e81530.
    Species: Human
    Sample Types: Plasma
  84. Maternal and fetal placental growth hormone and IGF axis in type 1 diabetic pregnancy.
    Authors: Higgins MF, Russell NE, Crossey PA, Nyhan KC, Brazil DP, McAuliffe FM
    PLoS ONE, 2012;7(2):e29164.
    Species: Human
    Sample Types: Plasma
  85. Benefits of recombinant adeno-associated virus (rAAV)-mediated insulinlike growth factor I (IGF-I) overexpression for the long-term reconstruction of human osteoarthritic cartilage by modulation of the IGF-I axis.
    Authors: Weimer A, Madry H, Venkatesan JK
    Mol. Med., 2012;18(1):346-58.
    Species: Human
    Sample Types: Cell Culture Supernates
  86. The stature of boys is inversely correlated to the levels of their sertoli cell hormones: do the testes restrain the maturation of boys?
    Authors: Morgan K, Dennis NA, Ruffman T, Bilkey DK, McLennan IS
    PLoS ONE, 2011;6(6):e20533.
    Species: Human
    Sample Types: Serum
  87. Prognostic significance of angiogenic factors in uterine cervical cancer.
    Authors: Landt S, Wehling M, Heidecke H, Jeschke S, Korlach S, Stoblen F, Schmid P, Blohmer JU, Lichtenegger W, Sehouli J, Kummel S
    Anticancer Res., 2011;31(8):2589-95.
    Species: Human
    Sample Types: Serum
  88. Alternatives to the use of fetal bovine serum: human platelet lysates as a serum substitute in cell culture media.
    Authors: Rauch C, Feifel E, Amann EM, Spotl HP, Schennach H, Pfaller W, Gstraunthaler G
    ALTEX, 2011;28(4):305-16.
    Species: Human
    Sample Types: Cell Lysates
  89. Inflammation associated with obesity: relationship with blood and bone marrow endothelial cells.
    Authors: McGuire TR, Brusnahan SK, Bilek LD, Jackson JD, Kessinger MA, Berger AM, Garvin KL, O'Kane BJ, Tuljapurkar SR, Sharp JG
    Obesity (Silver Spring), 2011;19(11):2130-6.
    Species: Human
    Sample Types: Plasma
  90. Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer.
    Authors: Volkova E, Willis JA, Wells JE, Robinson BA, Dachs GU, Currie MJ
    Br. J. Cancer, 2011;104(1):51-9.
    Species: Human
    Sample Types: Serum
  91. Expansion of human cardiac stem cells in physiological oxygen improves cell production efficiency and potency for myocardial repair.
    Authors: Li TS, Cheng K, Malliaras K, Matsushita N, Sun B, Marban L, Zhang Y, Marban E
    Cardiovasc. Res., 2011;89(1):157-65.
    Species: Human
    Sample Types: Cell Culture Supernates
  92. Abnormalities in metalloproteinase pathways and IGF-I axis: a link between birth weight, hypertension, and vascular damage in childhood.
    Authors: Sesso R, Franco MC
    Am. J. Hypertens., 2010;23(1):6-11.
    Species: Human
    Sample Types: Plasma
  93. Hyperactivation of the insulin-like growth factor receptor I signaling pathway is an essential event for cisplatin resistance of ovarian cancer cells.
    Authors: Eckstein N, Servan K, Hildebrandt B, Politz A, von Jonquieres G, Wolf-Kummeth S, Napierski I, Hamacher A, Kassack MU, Budczies J, Beier M, Dietel M, Royer-Pokora B, Denkert C, Royer HD
    Cancer Res., 2009;69(7):2996-3003.
    Species: Human
    Sample Types: Cell Culture Supernates
  94. Insulin-like growth factor-1 and neurotrophin-3 gene therapy prevents motor decline in an X-linked adrenoleukodystrophy mouse model.
    Authors: Mastroeni R, Bensadoun JC, Charvin D, Aebischer P, Pujol A, Raoul C
    Ann. Neurol., 2009;66(1):117-22.
    Species: Human
    Sample Types: CSF
  95. Identification of transforming growth factor beta1-driven genetic programs of acute lung fibrosis.
    Authors: Pulichino AM, Wang IM, Caron A, Mortimer J, Auger A, Boie Y, Elias JA, Kartono A, Xu L, Menetski J, Sayegh CE
    Am. J. Respir. Cell Mol. Biol., 2008;39(3):324-36.
    Species: Human
    Sample Types: BALF
  96. cAMP/PKA pathway activation in human mesenchymal stem cells in vitro results in robust bone formation in vivo.
    Authors: Siddappa R, Martens A, Doorn J, Leusink A, Olivo C, Licht R, van Rijn L, Gaspar C, Fodde R, Janssen F, van Blitterswijk C, de Boer J
    Proc. Natl. Acad. Sci. U.S.A., 2008;105(20):7281-6.
    Species: Human
    Sample Types: Cell Culture Supernates
  97. Isolation and characterization of CD146+ multipotent mesenchymal stromal cells.
    Authors: Sorrentino A, Ferracin M, Castelli G, Biffoni M, Tomaselli G, Baiocchi M, Fatica A, Negrini M, Peschle C, Valtieri M
    Exp. Hematol., 2008;36(8):1035-46.
    Species: Human
    Sample Types: Cell Culture Supernates
  98. Insulin-like growth factor-1 improves survival in sepsis via enhanced hepatic bacterial clearance.
    Authors: Ashare A, Nymon AB, Doerschug KC, Morrison JM, Monick MM, Hunninghake GW
    Am. J. Respir. Crit. Care Med., 2008;178(2):149-57.
    Species: Human
    Sample Types: Serum
  99. Serum concentrations of insulin-like growth factor-I (igf-I) as a marker of liver fibrosis in patients with chronic hepatitis C.
    Authors: Lorenzo-Zuniga V, Bartoli R, Masnou H, Montoliu S, Morillas RM, Planas R
    Dig. Dis. Sci., 2007;52(11):3245-50.
    Species: Human
    Sample Types: Serum
  100. Serum insulin-like growth factor I (IGF-I) and IGF-binding protein 3 (IGFBP-3) in IVF patients with polycystic ovary syndrome: correlations with outcome.
    Authors: Schoyer KD, Liu HC, Witkin S, Rosenwaks Z, Spandorfer SD
    Fertil. Steril., 2007;88(1):139-44.
    Species: Human
    Sample Types: Serum
  101. Peripheral elevation of IGF-1 fails to alter Abeta clearance in multiple in vivo models.
    Authors: Lanz TA, Salatto CT, Semproni AR, Marconi M, Brown TM, Richter KE, Schmidt K, Nelson FR, Schachter JB
    Biochem. Pharmacol., 2007;75(5):1093-103.
    Species: Canine
    Sample Types: Plasma
  102. Clinical pharmacodynamic effects of the growth hormone receptor antagonist pegvisomant: implications for cancer therapy.
    Authors: Yin D, Vreeland F, Schaaf LJ, Millham R, Duncan BA, Sharma A
    Clin. Cancer Res., 2007;13(3):1000-9.
    Species: Human
    Sample Types: Plasma
  103. The levels of steroid hormones and cytokines in individual follicles are not associated with the fertilization outcome after intracytoplasmic sperm injection.
    Authors: Asimakopoulos B, Abu-Hassan D, Metzen E, Al-Hasani S, Diedrich K, Nikolettos N
    Fertil. Steril., 2007;90(1):60-4.
    Species: Human
    Sample Types: Follicular Fluid
  104. Muscle atrophy and hypertrophy signaling in patients with chronic obstructive pulmonary disease.
    Authors: Doucet M, Russell AP, Leger B, Debigare R, Joanisse DR, Caron MA, LeBlanc P, Maltais F
    Am. J. Respir. Crit. Care Med., 2007;176(3):261-9.
    Species: Human
    Sample Types: Plasma
  105. Insulin-like growth factor binding protein-4 (IGFBP-4) is a novel anti-angiogenic and anti-tumorigenic mediator secreted by dibutyryl cyclic AMP (dB-cAMP)-differentiated glioblastoma cells.
    Authors: Moreno MJ, Ball M, Andrade MF, McDermid A, Stanimirovic DB
    Glia, 2006;53(8):845-57.
    Species: Human
    Sample Types: Cell Culture Supernates
  106. Insulin-like growth factor-II (IGF-II), IGF-binding protein-3 (IGFBP-3), and IGFBP-4 in follicular fluid are associated with oocyte maturation and embryo development.
    Authors: Wang TH, Chang CL, Wu HM, Chiu YM, Chen CK, Wang HS
    Fertil. Steril., 2006;86(5):1392-401.
    Species: Human
    Sample Types: Follicular Fluid
  107. Quantitative assessment of growth factors in reaming aspirate, iliac crest, and platelet preparation.
    Authors: Herrmann S, Green J, Weber T, Scharfenberger A
    Bone, 2006;39(5):1156-63.
    Species: Human
    Sample Types: Tissue Homogenates
  108. Growth hormone-induced stimulation of multilineage human hematopoiesis.
    Authors: Hanley MB, Napolitano LA, McCune JM
    Stem Cells, 2005;23(8):1170-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  109. Dose response of bone mass to dietary arachidonic acid in piglets fed cow milk-based formula.
    Authors: Blanaru JL, Kohut JR, Fitzpatrick-Wong SC, Weiler HA
    Am. J. Clin. Nutr., 2004;79(1):139-47.
    Species: Porcine
    Sample Types: Plasma
  110. Insulin growth factor-1 protects against excitotoxicity in the rat striatum.
    Authors: Escartin C, Boyer F, Bemelmans AP, Hantraye P, Brouillet E
    Neuroreport, 2004;15(14):2251-4.
    Species: Human
    Sample Types: Recombinant Protein

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Human IGF-I/IGF-1 Quantikine ELISA Kit
By Anonymous on 09/25/2019
Application: Sample Tested: Bone marrow,bone putty

Human IGF-I/IGF-1 Quantikine ELISA Kit
By Anonymous on 09/25/2019
Application: Sample Tested: Cartilage tissue

Human IGF-I/IGF-1 Quantikine ELISA Kit
By Anonymous on 09/25/2019
Application: Sample Tested: Cell Culture Supernates

Human IGF-I/IGF-1 Quantikine ELISA Kit
By Anonymous on 09/25/2019
Application: Sample Tested: Serum

Human IGF-I/IGF-1 Quantikine ELISA Kit
By Anonymous on 09/25/2019
Application: Sample Tested: N/A

Human IGF-I/IGF-1 Quantikine ELISA Kit
By Anonymous on 09/25/2019
Application: Sample Tested: Human Serum

Human IGF-I/IGF-1 Quantikine ELISA Kit
By Anonymous on 09/25/2019
Application: Sample Tested: Human Plasma

Human IGF-I/IGF-1 Quantikine ELISA Kit
By Anonymous on 09/25/2019
Application: Sample Tested: Plasma

Human IGF-I/IGF-1 Quantikine ELISA Kit
By Anonymous on 09/25/2019
Application: Sample Tested: Serum

Human IGF-I/IGF-1 Quantikine ELISA Kit
By Anonymous on 09/25/2019
Application: Sample Tested: EDTA Plasma

Human IGF-I/IGF-1 Quantikine ELISA Kit
By Anonymous on 09/25/2019
Application: Sample Tested: Blood products,Recombinant protein

Human IGF-I/IGF-1 Quantikine ELISA Kit
By Anonymous on 09/25/2019
Application: Sample Tested: Serum

Human IGF-I/IGF-1 Quantikine ELISA Kit
By Anonymous on 09/25/2019
Application: Sample Tested: Serum

Human IGF-I/IGF-1 Quantikine ELISA Kit
By Anonymous on 09/25/2019
Application: Sample Tested: Plasma

Human IGF-I/IGF-1 Quantikine ELISA Kit
By Anonymous on 09/25/2019
Application: Sample Tested: Human Serum