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Human IL-1ra/IL-1F3 Luminex Performance Assay

Catalog #: LUH280 Datasheet / COA / SDS

Discontinued Product

LUH280 has been discontinued and is replaced by LUHM280.

R&D Systems Luminex High Performance Panel
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Human IL-1ra/IL-1F3 Luminex Performance Assay Summary

Assay Type bead-based multiplex assay for the Luminex® platform
Format 1 x 96-well microplate and antibody-coated beads
Analytes Detected Please see analyte list in assay customization tool below.
Performance Validation Luminex Assays are validated for use with cell culture supernatants, plasma and serum. All Luminex assays are tested for sensitivity, intra-assay precision, inter-assay precision and to ensure assay linearity for validated sample types. Antibody pairs are selected and tested to confirm the parallel detection of natural and recombinant standard protein and to ensure the accurate determination of target analytes within biological samples. Assays for each target analyte are screened against all target analytes to confirm low antibody cross-reactivity.

Not finding your analyte of interest? View our complete Luminex offering in the full version of our Luminex Assay Customization Tool. We also offer Custom Luminex Services.

Which Luminex Assay is right for me?

Assays for the Luminex platform are offered as High Performance Assays or Assays. The Luminex High Performance Assays are fully validated panels with a focused selection of analytes. They are available in We Mix, You Mix, and Predetermined formats. The Luminex Assays allows for the maximum number of analytes in a multiplex and is supplied as a premixed kit. View a table comparing the features and benefits of these bead-based multiplex assays.

Background: IL-1ra/IL-1F3

IL-1ra (IL-1 receptor antagonist) is a widely expressed acute phase protein that serves to dampen inflammation. IL-1ra binds to both IL-1 RI and IL-1 RII. It competitively inhibits IL-1 (alpha or beta) binding to IL-1 RI and does not trigger recruitment of the accessory molecule IL-1 R AcP or activation of IL-1 RI signaling. IL-1ra blocks the proinflammatory actions of IL-1 including Prostaglandin E2 and IL-6 release from endothelial cells, fever generation, thrombocytosis, the production of hepatic acute phase proteins, and neutrophil expansion and infiltration.

Long Name
Interleukin 1 Receptor Antagonist
Entrez Gene IDs
3557 (Human); 16181 (Mouse); 60582 (Rat); 397499 (Porcine); 100034236 (Equine)
Alternate Names
DIRA; ICIL-1ra; IL1F3; IL-1F3; IL1ra; IL-1ra; IL-1ra3; IL1RN; IL-1RN; interleukin 1 receptor antagonist; IRAP; MVCD4

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Product Specific Notices
Luminex® is a registered trademark of Luminex Corporation.

Citations for Human IL-1ra/IL-1F3 Luminex Performance Assay

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

17 Citations: Showing 1 - 10
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  1. Cytokines in relation to hCG are significantly altered in asymptomatic women with miscarriage - a pilot study
    Authors: A Freis, J Schlegel, V Daniel, J Jauckus, T Strowitzki, A Germeyer
    Reprod. Biol. Endocrinol., 2018-09-28;16(1):93.
    Species: Human
    Sample Types: Plasma
  2. Survey of innate immune responses to Burkholderia pseudomallei in human blood identifies a central role for lipopolysaccharide.
    Authors: Chantratita N, Tandhavanant S, Myers N, Seal S, Arayawichanont A, Kliangsa-Ad A, Hittle L, Ernst R, Emond M, Wurfel M, Day N, Peacock S, West T
    PLoS ONE, 2013-11-26;8(11):e81617.
    Species: Human
    Sample Types: Plasma
  3. Elevated cerebral spinal fluid cytokine levels in boys with cerebral adrenoleukodystrophy correlates with MRI severity.
    Authors: Lund TC, Stadem PS, Panoskaltsis-Mortari A, Raymond G, Miller WP, Tolar J, Orchard PJ
    PLoS ONE, 2012-02-16;7(2):e32218.
    Species: Human
    Sample Types: Serum
  4. Macrophage infiltration predicts a poor prognosis for human ewing sarcoma.
    Authors: Fujiwara T, Fukushi J, Yamamoto S, Matsumoto Y, Setsu N, Oda Y, Yamada H, Okada S, Watari K, Ono M, Kuwano M, Kamura S, Iida K, Okada Y, Koga M, Iwamoto Y
    Am. J. Pathol., 2011-07-21;179(3):1157-70.
    Species: Human
    Sample Types: Cell Culture Supernates
  5. Anti-Inflammatory Cytokines Predominate in Acute Human Plasmodium knowlesi Infections.
    Authors: Cox-Singh J, Singh B, Daneshvar C, Planche T, Parker-Williams J, Krishna S
    PLoS ONE, 2011-06-08;6(6):e20541.
    Species: Human
    Sample Types: Serum
  6. Pro- and anti-inflammatory cytokines in latent autoimmune diabetes in adults, type 1 and type 2 diabetes patients: Action LADA 4.
    Authors: Pham MN, Hawa MI, Pfleger C, Roden M, Schernthaner G, Pozzilli P, Buzzetti R, Scherbaum W, Seissler J, Kolb H, Hunter S, Leslie RD, Schloot NC
    Diabetologia, 2011-02-24;54(7):1630-8.
    Species: Human
    Sample Types: Serum
  7. Potential biomarkers of osteonecrosis in Gaucher disease.
    Authors: Pavlova EV, Deegan PB, Tindall J, McFarlane I, Mehta A, Hughes D, Wraith JE, Cox TM
    Blood Cells Mol. Dis., 2010-11-13;46(1):27-33.
    Species: Human
    Sample Types: Serum
  8. Serum IL-6: a candidate biomarker for intracranial pressure elevation following isolated traumatic brain injury.
    Authors: Hergenroeder GW, Moore AN, McCoy JP
    J Neuroinflammation, 2010-03-11;7(0):19.
    Species: Human
    Sample Types: Serum
  9. Endothelial dysfunction and specific inflammation in obesity hypoventilation syndrome.
    Authors: Borel JC, Roux-Lombard P, Tamisier R, Arnaud C, Monneret D, Arnol N, Baguet JP, Levy P, Pepin JL
    PLoS ONE, 2009-08-24;4(8):e6733.
    Species: Human
    Sample Types: Serum
  10. Fatigue in primary Sj0gren's syndrome--a link to sickness behaviour in animals?
    Authors: Harboe E, Tjensvoll AB, Vefring HK, Goransson LG, Kvaloy JT, Omdal R
    Brain Behav. Immun., 2009-06-26;23(8):1104-8.
    Species: Human
    Sample Types: CSF
  11. Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome.
    Authors: Duncan JA, Gao X, Huang MT, O'Connor BP, Thomas CE, Willingham SB, Bergstralh DT, Jarvis GA, Sparling PF, Ting JP
    J. Immunol., 2009-05-15;182(10):6460-9.
    Species: Human
    Sample Types: Cell Culture Supernates
  12. Simvastatin decreases lipopolysaccharide-induced pulmonary inflammation in healthy volunteers.
    Authors: Shyamsundar M, McKeown ST, O'Kane CM, O'Kane CM, O'Kane CM, O'Kane CM, O'Kane CM, Craig TR, Brown V, Thickett DR, Matthay MA, Taggart CC, Backman JT, Elborn JS, McAuley DF
    Am. J. Respir. Crit. Care Med., 2009-03-26;179(12):1107-14.
    Species: Human
    Sample Types: BALF
  13. Critical and differential roles of NKp46- and NKp30-activating receptors expressed by uterine NK cells in early pregnancy.
    Authors: El Costa H, Casemayou A, Aguerre-Girr M, Rabot M, Berrebi A, Parant O, Clouet-Delannoy M, Lombardelli L, Jabrane-Ferrat N, Rukavina D, Bensussan A, Piccinni MP, Le Bouteiller P, Tabiasco J
    J. Immunol., 2008-09-01;181(0):3009-17.
    Species: Human
    Sample Types: Cell Culture Supernates
  14. An evaluation of commercial fluorescent bead-based luminex cytokine assays.
    Authors: Djoba Siawaya JF, Roberts T, Babb C, Black G, Golakai HJ, Stanley K, Bapela NB, Hoal E, Parida S, van Helden P, Walzl G
    PLoS ONE, 2008-07-02;3(7):e2535.
    Species: Human
    Sample Types: Serum
  15. Association of IL-1ra and adiponectin with C-peptide and remission in patients with type 1 diabetes.
    Authors: Pfleger C, Mortensen HB, Hansen L, Herder C, Roep BO, Hoey H, Aanstoot HJ, Kocova M, Schloot NC
    Diabetes, 2008-02-25;57(4):929-37.
    Species: Human
    Sample Types: Serum
  16. Circulating levels of cytokines during pregnancy: thrombopoietin is elevated in miscarriage.
    Authors: Whitcomb BW, Schisterman EF, Klebanoff MA, Baumgarten M, Luo X, Chegini N
    Fertil. Steril., 2007-08-13;89(6):1795-802.
    Species: Human
    Sample Types: Serum
  17. Anti-inflammatory effects of UV-irradiated lymphocytes: induction of IL-1Ra upon phagocytosis by monocyte/macrophages.
    Authors: Craciun LI, DiGiambattista M, Schandene L, Laub R, Goldman M, Dupont E
    Clin. Immunol., 2005-03-01;114(3):320-6.
    Species: Human
    Sample Types: Cell Culture Supernates

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