Human Kallikrein 8/Neuropsin Antibody
Human Kallikrein 8/Neuropsin Antibody Summary
Accession # O60259
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: Kallikrein 8/Neuropsin
Kallikrein 8 (KLK8), also known as neuropsin or ovasin, is a member of the human tissue kallikrein family (1). Two alternatively spliced forms exist, resulting in 260 (isoform 1) and 305 (isoform 2) amino acid sequences, respectively (2). Isoform 1 consists of a signal peptide (residues 1 to 28), a short pro peptide (residues 29 to 32) and the mature chain (residues 33 to 260). Isoform 2 is identical to isoform 1, except that a 45 amino acid segment is inserted in isoform 2 between residues 23 and 24 in isoform 1. Isoform 1 is predominantly expressed in pancreas whereas isoform 2 is preferentially expressed in adult brain and hippocampus, although both forms are expressed in fetal brain and placenta in comparable levels. The brain function of KLK8 seems evident in neuropsin knockout mice that showed abnormalities of synapses and neurons and predisposation to global seizure activity (3, 4). KLK8 is a novel marker for ovarian and cervical cancer carcinomas (5, 6). Recombinant human KLK8, after being activated by lysyl endopeptidase, can cleave fibronectin and several small peptide substrates (7, 8). This activity can be inhibited by rhSerpin A5, rhSerpin F2 and AEBSF (R&D Systems, Catalog # 1266-PI, 1470-PI and EI001, respectively). Recombinant human KLK8 produced by R&D Systems corresponds to isoform 1.
- Yousef, G.M. and E.P. Diamandis (2001) Endocrine Rev. 22:184.
- Mitsui, S. et al. (1999) Eur. J. Biochem. 260:627.
- Hirata, A. et al. (2001) Mol. Cell. Neurosci. 17:600.
- Davies, B. et al. (2001) J. Neurosci. 21:6993.
- Kishi, T. et al. (2003) Cancer Res. 63:2771.
- Cane, S. et al. (2004) Am. J. Obstet. Gynecol. 190:60.
- Oka, T. et al. (2002) J. Biol. Chem. 277:14724.
- Shimizu, C. et al. (1998) J. Biol. Chem. 273:11189.
Citations for Human Kallikrein 8/Neuropsin Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 2
Filter your results:
Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase.
Authors: Tan, Frederic, Elowitz, Michael
Proc Natl Acad Sci U S A, 2014-04-14;111(17):E1740-8.
Sample Types: Whole Cells
Applications: Flow Cytometry
Novel expression of kallikreins, kallikrein-related peptidases and kinin receptors in human pleural mesothelioma.
Authors: Chee J, Singh J, Naran A, Misso NL, Thompson PJ, Bhoola KD
Biol. Chem., 2007-11-01;388(11):1235-42.
Sample Types: Whole Tissue
No product specific FAQs exist for this product, however you mayView all Antibody FAQs
Reviews for Human Kallikrein 8/Neuropsin Antibody
There are currently no reviews for this product. Be the first to review Human Kallikrein 8/Neuropsin Antibody and earn rewards!
Have you used Human Kallikrein 8/Neuropsin Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image