Human/Mouse/Rat UBASH3B/STS1 Antibody

UBASH3B (Ubiquitin-associated domain SH3 domain-containing protein B; also STS1 and TULA2) is a cytosolic 72-74 kDa member of the TULA (T cell ubiquitin ligand) family of proteins. It is widely expressed and appears to perform multiple functions. As a histidine phosphatase, it dephosphorylates Syk and Syk-related molecules, thus dampening signaling pathways. Via ubiquitin and SH3 binding domains, it binds to monoubiquitinated RTKs and Cbl, thereby increasing RTK activity by blocking its polyubiquitination and subsequent lysosomal degradation. There is also the potential for phosphodiesterase activity directed towards tRNA activity. Human UBASH3B is 649 amino acids (aa) in length. It contains one UBA domain (aa 39-75), a proline-rich ligand binding SH3 region (aa 257-316), and a PGM/histidine phosphatase domain (aa 386-598). UBASH3B is suggested to dimerize. Over aa 47-253, human and mouse UBASH3B are identical in amino acid sequence.