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Human p15INK4b/CDKN2B Alexa Fluor® 647-conjugated Antibody

Catalog #: FAB6798R Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
FAB6798R-100UG

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Human p15INK4b/CDKN2B Alexa Fluor® 647-conjugated Antibody Summary

Species Reactivity
Human
Specificity
Detects human p15INK4b/CDKN2B in direct ELISAs and Western blots. In Western blots, approximately 50% cross-reactivity with recombinant human (rh) p16INK4a and no cross-reactivity with rhp18INK4c or rhp19INK4d is observed.
Source
Monoclonal Mouse IgG2b Clone # 651308
Purification
Protein A or G purified
Immunogen
E. coli-derived recombinant human p15INK4b/CDKN2B
Arg2-Asp138
Accession # P42772
Formulation
Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide
Label
Alexa Fluor 647 (Excitation= 650 nm, Emission= 668 nm)

Applications

Recommended Concentration
Sample
Western Blot
Optimal dilution of this antibody should be experimentally determined.
 
Immunocytochemistry
Optimal dilution of this antibody should be experimentally determined.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied

Background: p15INK4b/CDKN2B

p15INK4B is an approximately 15 kDa member of the p16INK4 family. Human p15INK4B is 138 amino acids (aa) in length and contains four ankyrin repeats, a common structural sequence found in members of the INK4 family. The first 50 aa of p15INK4B share 44% sequence identity with p16INK4. Following this is an 81 aa region sharing 97% sequence identity, after which the two proteins diverge. Human p15INK4B shares 83% aa sequence identity with mouse and rat p15INK4B. Functionally, p15INK4B interacts strongly with CDK4 and CDK6 and is a potent inhibitor. p15INK4B can potentially induce cell cycle arrest by acting as an effector of TGF-beta.

Long Name
p15 Cyclin Dependent Kinase 4 Inhibitor 2B
Entrez Gene IDs
1030 (Human); 12579 (Mouse); 25164 (Rat)
Alternate Names
CDK4I; CDKN2B; cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); cyclin-dependent kinases 4 and 6 binding protein; INK4BCDK4B inhibitor; MTS2; MTS-2; MTS2CDK inhibitory protein; Multiple tumor suppressor 2; p14_CDK inhibitor; p14_INK4B; p14-INK4b; p15 CDK inhibitor; p15_INK4B; P15cyclin-dependent kinase 4 inhibitor B; p15INK4b; p15-INK4b; TP15

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