Human Pax2 Alexa Fluor® 488-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: Pax2

Pax2 is a 40-45 kDa protein belonging to the small but developmentally important family of transcription regulators. Human Pax2 is a 416 amino acid (aa) residue protein with an N-terminal 128 aa DNA-binding paired box domain, a centrally-located octapeptide motif and a C-terminal truncated homeodomain. Based on the presence of the structural domains, Pax2 belongs to subgroup 2 in the Pax family. Pax2 is important for stem cell survival and lineage commitment during development. Pax2 is also expressed in various carcinomas where it seems to mediate anti-apoptotic functions. At least five splice isoforms of human Pax2 have been described within the region used as immunogen (shared by all isoforms). Human and mouse Pax2 share 98% aa sequence identity.

Product Datasheets

Related Research Areas

• Early Ectodermal Lineage Markers
• Epithelial Stem Cell Transcription Factors
• Intracellular Signaling Molecules in Angiogenesis
• Paired Box Transcription Factors
• Pluripotent Stem Cell Transcription Factors
• Renal Markers
• Transcription Factors and Regulators
• Transcription Factors in the Akt Pathway