Human RAGE Quantikine ELISA Kit

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Human RAGE ELISA Cell Culture Supernate Standard Curve
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Human RAGE Quantikine ELISA Kit Summary

Assay Type
Solid Phase Sandwich ELISA
Format
96-well strip plate
Assay Length
4.5 hours
Sample Type & Volume Required Per Well
Cell Culture Supernates (50 uL), Serum (50 uL), EDTA Plasma (50 uL), Heparin Plasma (50 uL)
Sensitivity
16.14 pg/mL
Assay Range
78.0 - 5,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma)
Specificity
Natural and recombinant human RAGE
Cross-reactivity
< 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
Interference
No significant interference observed with available related molecules.

Product Summary

The Quantikine Human RAGE Immunoassay is a 4.5 hour solid-phase ELISA designed to measure human RAGE (extracellular domain) in cell culture supernates, serum, and plasma. It contains NS0-expressed recombinant human RAGE/Fc Chimera and has been shown to accurately quantitate the recombinant factor. Results obtained using natural human RAGE showed linear curves that were parallel to the standard curves obtained using the Quantikine kit standards. These results indicate that this kit can be used to determine relative mass values for naturally occurring RAGE.

Precision

Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision

Cell Culture Supernates

Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 40 40 40
Mean (pg/mL) 571 1549 3189 563 1568 3159
Standard Deviation 34 73 191 49 110 193
CV% 5.9 4.7 6 8.7 7 6.1

Serum, EDTA Plasma, Heparin Plasma

Intra-Assay Precision Inter-Assay Precision
Sample 1 2 3 1 2 3
n 20 20 20 40 40 40
Mean (pg/mL) 546 1527 3117 519 1449 2890
Standard Deviation 34 73 189 43 119 192
CV% 6.2 4.8 6.1 8.2 8.2 6.7

Recovery

The recovery of RAGE spiked to levels throughout the range of the assay was evaluated.

Sample Type Average % Recovery Range %
Tissue Culture Media (n=4) 98 86-108

Linearity

To assess the linearity of the assay, samples containing and/or spiked with high concentrations of RAGE were serially diluted with the appropriate Calibrator Diluent to produce samples with values within the dynamic range of the assay.
Human RAGE ELISA Linearity

Scientific Data

Human RAGE ELISA Cell Culture Supernate Standard Curve

Human RAGE ELISA Serum/Plasma Standard Curve

Product Datasheets

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Preparation and Storage

Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
Store the unopened product at 2 - 8 °C. Do not use past expiration date.

Background: RAGE/AGER

RAGE (Receptor for Advanced Glycation End product) is a transmembrane glycoprotein that binds advanced glycation end products (AGEs), beta-amyloid peptides, HMGB1/Amphoterin, and several S100 family proteins. AGEs are adducts formed by the non-enzymatic glycation and oxidation of proteins and lipids. A soluble form can also be generated by MMP-mediated shedding. RAGE is expressed in the CNS during development as well as in adult endothelial cells, smooth muscle cells, pericytes, monocytes, and neurons. It is locally upregulated in vascular inflammation (e.g. diabetes, atherosclerosis, vascular injury, Alzheimer’s disease). At these sites, RAGE binding to S100A1, EN-RAGE/S100A12, or S100B induces inflammatory immune cell adhesion and infiltration as well as vascular smooth muscle proliferation, neointimal expansion, atherosclerotic plaque development, and transport of A-beta into the cerebrospinal fluid. In cancer, RAGE binding to HMGB1, S100A8, or S100A9 promotes tumor growth and metastasis in addition to inflammatory cell infiltration.

To view our complete solutions for RAGE research, visit bio-techne.com.

Long Name:
Receptor for Advanced Glycation End Products
Entrez Gene IDs:
177 (Human); 11596 (Mouse); 81722 (Rat); 403168 (Canine)
Alternate Names:
advanced glycosylation end product-specific receptor; AGER; RAGE isoform delta; RAGE isoform sRAGE-delta; RAGE; Receptor for advanced glycosylation end products; receptor for advanced glycosylation end-products; SCARJ1
&#9888; WARNING: This product can expose you to chemicals including N,N-Dimethylforamide, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.

Assay Procedure

Refer to the product for complete assay procedure.

Bring all reagents and samples to room temperature before use. It is recommended that all samples, standards, and controls be assayed in duplicate.
  1.   Prepare all reagents, standard dilutions, and samples as directed in the product insert.
  2.   Remove excess microplate strips from the plate frame, return them to the foil pouch containing the desiccant pack, and reseal.

  3. 100 µL Assay Diluent
  4.   Add 100 µL of Assay Diluent to each well.

  5. 50 µL Standard, Control, or Sample
  6.   Add 50 µL of Standard, control, or sample to each well. Cover with a plate sealer, and incubate at room temperature for 2 hours.
  7.   Aspirate each well and wash, repeating the process 3 times for a total of 4 washes.

  8. 200 µL Conjugate
  9.   Add 200 µL of Conjugate to each well. Cover with a new plate sealer, and incubate at room temperature for 2 hours.
  10.   Aspirate and wash 4 times.

  11. 200 µL Substrate Solution
  12.   Add 200 µL Substrate Solution to each well. Incubate at room temperature for 30 minutes. PROTECT FROM LIGHT.

  13. 50 µL Stop Solution
  14.   Add 50 µL of Stop Solution to each well. Read at 450 nm within 30 minutes. Set wavelength correction to 540 nm or 570 nm.

Citations for Human RAGE Quantikine ELISA Kit

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

79 Citations: Showing 1 - 10
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  1. Effects of acute aerobic exercise on circulating sTLR and sRAGE profiles in normal- and abnormal-glucose-tolerant individuals
    Authors: Perkins, RK;Miranda, ER;Varshney, P;Farabi, SS;Quinn, LT;Haus, JM;
    Physiological reports
    Species: Human
    Sample Types: Plasma
  2. Immunogenic Biomarkers HMGB1 and sRAGE Are Potential Diagnostic Tools for Ovarian Malignancies
    Authors: Schröder, L;Rupp, ABA;Gihr, KME;Kobilay, M;Domroese, CM;Mallmann, MR;Holdenrieder, S;
    Cancers
    Species: Human
    Sample Types: Serum
  3. Assessing Pulmonary Epithelial Damage in Hantavirus Cardiopulmonary Syndrome: Challenging the Predominant Role of Vascular Endothelium through sRAGE as a Potential Biomarker
    Authors: Meza-Fuentes, G;López, R;Vial, C;Cortes, LJ;Retamal, MA;Delgado, I;Vial, P;
    Viruses
    Species: Human
    Sample Types: Plasma
  4. Effectiveness of two photosensitizer-mediated photodynamic therapy for treating moderate peri-implant infections in type-II diabetes mellitus patients: A randomized clinical trial
    Authors: Elsadek, MF;
    Photodiagnosis and photodynamic therapy
    Species: Human
    Sample Types: Complex Sample Type
  5. Apoptotic Cell Death in Bicuspid-Aortic-Valve-Associated Aortopathy
    Authors: SJ Barnard, J Haunschild, L Heiser, MT Dieterlen, K Klaeske, MA Borger, CD Etz
    International Journal of Molecular Sciences, 2023-04-18;24(8):.
    Species: Human
    Sample Types: Tissue Homogenates
  6. Genetically Modified Circulating Levels of Advanced Glycation End-Products and Their Soluble Receptor (AGEs-RAGE Axis) with Risk and Mortality of Breast Cancer
    Authors: Y Peng, F Liu, Y Qiao, P Wang, H Du, C Si, X Wang, K Chen, F Song
    Cancers, 2022-12-12;14(24):.
    Species: Human
    Sample Types: Plasma
  7. High levels of soluble RAGE are associated with a greater risk of mortality in COVID-19 patients treated with dexamethasone
    Authors: L Butcher, JC Zaldua, JA Carnicero, K Hawkins, J Whitley, R Mothukuri, PA Evans, K Morris, S Pillai, JD Erusalimsk
    Respiratory Research, 2022-11-05;23(1):303.
    Species: Human
    Sample Types: Serum
  8. Advanced Glycation End Product (AGE) and Soluble Receptor of AGE (sRAGE) Levels in Relation to Periodontitis Severity and as Putative 3-Year Outcome Predictors in Patients Undergoing Coronary Artery Bypass Grafting (CABG)
    Authors: S Reichert, B Hofmann, M Kohnert, AN Santos, L Friebe, J Grollmitz, HG Schaller, S Schulz
    Journal of Clinical Medicine, 2022-07-15;11(14):.
    Species: Human
    Sample Types: Serum
  9. SCD14-ST and New Generation Inflammatory Biomarkers in the Prediction of COVID-19 Outcome
    Authors: E Galliera, L Massaccesi, L Yu, J He, M Ranucci, MM Corsi Roma
    Biomolecules, 2022-06-13;12(6):.
    Species: Human
    Sample Types: Plasma
  10. Significantly Altered Serum Levels of NAD, AGE, RAGE, CRP, and Elastin as Potential Biomarkers of Psoriasis and Aging-A Case-Control Study
    Authors: A Karas, D Holmannova, P Borsky, Z Fiala, C Andrys, K Hamakova, T Svadlakova, V Palicka, J Krejsek, V Rehacek, M Esterkova, H Kovarikova, L Borska
    Biomedicines, 2022-05-13;10(5):.
    Species: Human
    Sample Types: Serum
  11. RAGE has potential pathogenetic and prognostic value in nonintubated hospitalized patients with COVID-19
    Authors: KD Wick, L Siegel, JD Neaton, C Oldmixon, J Lundgren, RL Dewar, HC Lane, BT Thompson, MA Matthay, ACTIV-3/TI
    JCI Insight, 2022-05-09;7(9):.
    Species: Human
    Sample Types: Plasma
  12. Plasma Levels of Free N?-Carboxymethyllysine (CML) after Different Oral Doses of CML in Rats and after the Intake of Different Breakfasts in Humans: Postprandial Plasma Level of sRAGE in Humans
    Authors: C Helou, MT Nogueira S, C Niquet-Ler, P Jacolot, E Boulanger, F Delguste, A Guilbaud, M Genin, PM Anton, C Delayre-Or, T Papazian, M Howsam, FJ Tessier
    Nutrients, 2022-04-30;14(9):.
    Species: Human
    Sample Types: Plasma
  13. Association between plasma sRAGE and emphysema according to the genotypes of AGER gene
    Authors: S Sin, MN Lim, J Kim, SH Bak, WJ Kim
    BMC pulmonary medicine, 2022-02-10;22(1):58.
    Species: Human
    Sample Types: Plasma
  14. Differential Regulation of Circulating Soluble Receptor for Advanced Glycation End Products (sRAGEs) and Its Ligands S100A8/A9 Four Weeks Post an Exercise Intervention in a Cohort of Young Army Recruits
    Authors: IA Drosatos, JN Tsoporis, S Izhar, S Gupta, G Tsirebolos, E Sakadakis, AS Triantafyl, A Rigopoulos, D Rigopoulos, LS Rallidis, I Rizos, TG Parker
    Biomolecules, 2021-09-13;11(9):.
    Species: Human
    Sample Types: Plasma
  15. Soluble Receptor for Advanced Glycation End Products (sRAGE) Is a Sensitive Biomarker in Human Pulmonary Arterial Hypertension
    Authors: F Diekmann, P Chouvarine, H Sallmon, L Meyer-Kobb, M Kieslich, BD Plouffe, SK Murthy, R Lichtingha, E Legchenko, G Hansmann
    International Journal of Molecular Sciences, 2021-08-10;22(16):.
    Species: Human
    Sample Types: Plasma
  16. Cellular Response against Oxidative Stress, a Novel Insight into Lupus Nephritis Pathogenesis
    Authors: CD Ene, SR Georgescu, M Tampa, C Matei, CI Mitran, MI Mitran, MN Penescu, I Nicolae
    Journal of personalized medicine, 2021-07-22;11(8):.
    Species: Human
    Sample Types: Serum
  17. Leptin and advanced glycation end products receptor (RAGE) in tuberculosis patients
    Authors: TK Lazzari, E Cavalheiro, SE Coutinho, LF da Silva, DR Silva
    PLoS ONE, 2021-07-02;16(7):e0254198.
    Species: Human
    Sample Types: Serum
  18. SARS-CoV-2 RNAemia and proteomic trajectories inform prognostication in COVID-19 patients admitted to intensive care
    Authors: C Gutmann, K Takov, SA Burnap, B Singh, H Ali, K Theofilato, E Reed, M Hasman, A Nabeebaccu, M Fish, MJ McPhail, K O'Gallaghe, LE Schmidt, C Cassel, M Rienks, X Yin, G Auzinger, S Napoli, SF Mujib, F Trovato, B Sanderson, B Merrick, U Niazi, M Saqi, K Dimitrakop, R Fernández-, S Braun, R Kronstein-, KJ Doores, JD Edgeworth, AM Shah, SR Bornstein, T Tonn, AC Hayday, M Giacca, M Shankar-Ha, M Mayr
    Nature Communications, 2021-06-07;12(1):3406.
    Species: Human
    Sample Types: Plasma
  19. Changes in Plasma Soluble Receptor for Advanced Glycation End-Products Are Associated with Survival in Patients with Acute Respiratory Distress Syndrome
    Authors: M Jabaudon, B Pereira, E Laroche, L Roszyk, R Blondonnet, J Audard, T Godet, E Futier, JE Bazin, V Sapin, JA Bastarache, LB Ware, JM Constantin, On Behalf
    Journal of Clinical Medicine, 2021-05-12;10(10):.
    Species: Human
    Sample Types: Plasma
  20. Posttranslational Modifications Pattern in Clear Cell Renal Cell Carcinoma
    Authors: CD Ene, MN Penescu, SR Georgescu, M Tampa, I Nicolae
    Metabolites, 2020-12-27;11(1):.
    Species: Human
    Sample Types: Serum
  21. Circulating soluble receptor for advanced glycation end products and other factors in type 2 diabetes patients with colorectal cancer
    Authors: X Zhou, N Lin, M Zhang, X Wang, Y An, Q Su, P Du, B Li, H Chen
    BMC Endocr Disord, 2020-11-13;20(1):170.
    Species: Human
    Sample Types: Serum
  22. G82S RAGE polymorphism influences amyloid-RAGE interactions relevant in Alzheimer's disease pathology
    Authors: RC C, B Lukose, P Rani
    PLoS ONE, 2020-10-29;15(10):e0225487.
    Species: Human
    Sample Types: Cell Lysates
  23. RAGE Up-Regulation Differently Affects Cell Proliferation and Migration in Pancreatic Cancer Cells
    Authors: P Swami, S Thiyagaraj, A Vidger, VSK Indurthi, SW Vetter, E Leclerc
    Int J Mol Sci, 2020-10-19;21(20):.
    Species: Human
    Sample Types: Cell Lysates
  24. Circulating antibodies against age-modified proteins in patients with coronary atherosclerosis
    Authors: E Korça, V Piskovatsk, J Börgermann, A Navarrete, A Simm
    Sci Rep, 2020-10-13;10(1):17105.
    Species: Human
    Sample Types: Plasma
  25. Circulating Receptor Activator of Nuclear Factor kB Ligand and triglycerides are associated with progression of lower limb arterial calcification in type 2 diabetes: a prospective, observational cohort study
    Authors: O Bourron, F Phan, MH Diallo, D Hajage, CE Aubert, A Carlier, JE Salem, C Funck-Bren, S Kemel, P Cluzel, A Redheuil, JM Davaine, Z Massy, R Mentaverri, D Bonnefont-, P Gillery, S Jaisson, C Vermeer, JM Lacorte, N Bouziri, S Laroche, C Amouyal, A Hartemann
    Cardiovascular Diabetology, 2020-09-18;19(1):140.
    Species: Human
    Sample Types: Plasma
  26. Collagen methionine sulfoxide and glucuronidine/LW-1 are markers of coronary artery disease in long-term survivors with type 1 diabetes. The Dialong study
    Authors: KB Holte, M Svanteson, KF Hanssen, KA Sveen, I Seljeflot, S Solheim, DR Sell, VM Monnier, TJ Berg
    PLoS ONE, 2020-05-13;15(5):e0233174.
    Species: Human
    Sample Types: Serum
  27. Biomarkers of Cellular Stress Do Not Associate with sCD14 in Progressive HIV and SIV Infections in Vivo
    Authors: CL Vinton, CE Starke, AM Ortiz, SH Lai, JK Flynn, O Sortino, K Knox, I Sereti, JM Brenchley
    Pathog Immun, 2020-04-24;5(1):68-88.
    Species: Human
    Sample Types: Plasma
  28. Association between advanced glycation end products, their soluble receptor, and mortality in the general population: Results from the CARLA study
    Authors: H Ebert, ME Lacruz, A Kluttig, A Simm, KH Greiser, D Tiller, N Kartschmit, R Mikolajczy
    Exp. Gerontol., 2019-12-16;131(0):110815.
    Species: Human
    Sample Types: Plasma
  29. Systemic RAGE ligands are upregulated in tuberculosis individuals with diabetes co-morbidity and modulated by anti-tuberculosis treatment and metformin therapy
    Authors: NP Kumar, K Moideen, A Nancy, V Viswanatha, BS Shruthi, S Sivakumar, S Hissar, H Kornfeld, S Babu
    BMC Infect. Dis., 2019-12-09;19(1):1039.
    Species: Human
    Sample Types: Plasma
  30. Advanced glycation end products and their ratio to soluble receptor are associated with limitations in physical functioning only in women: results from the CARLA cohort
    Authors: H Ebert, ME Lacruz, A Kluttig, A Simm, KH Greiser, D Tiller, N Kartschmit, R Mikolajczy
    BMC Geriatr, 2019-11-04;19(1):299.
    Species: Human
    Sample Types: Plasma
  31. Soluble receptor for advanced glycation end-products independently influences individual age-dependent increase of arterial stiffness
    Authors: J Gelžinský, O Mayer, J Seidlerová, M Mate?ánkov, Š Mareš, V Kordíková, L Trefil, R Cífková, J Filipovský
    Hypertens. Res., 2019-10-21;0(0):.
    Species: Human
    Sample Types: Serum
  32. Systemic Inflammation Precedes Microalbuminuria in Diabetes
    Authors: FG Scurt, J Menne, S Brandt, A Bernhardt, PR Mertens, H Haller, C Chatzikyrk
    Kidney Int Rep, 2019-06-21;4(10):1373-1386.
    Species: Human
    Sample Types: Serum
  33. The Effect of 600 mg Alpha-lipoic Acid Supplementation on Oxidative Stress, Inflammation, and RAGE in Older Adults with Type 2 Diabetes Mellitus
    Authors: VM Mendoza-Nú, BI García-Mar, J Rosado-Pér, E Santiago-O, J Pedraza-Ch, VJ Hernández-
    Oxid Med Cell Longev, 2019-06-12;2019(0):3276958.
    Species: Human
    Sample Types: Plasma
  34. Expression of the receptor of advanced glycation end-products (RAGE) and membranal location in peripheral blood mononuclear cells (PBMC) in obesity and insulin resistance
    Authors: EDC Ruelas Cin, B Ruíz Madri, JA Domínguez, M Maldonado, L De la Cruz, SM Ramírez Me, JR Torres Bar, E Martínez L, ZH Hernández
    Iran J Basic Med Sci, 2019-06-01;22(6):623-630.
    Species: Human
    Sample Types: Serum
  35. Metabolic dysfunction in Emirati subjects in Abu Dhabi: Relationship to levels of soluble RAGEs
    Authors: A Abdulle, CK Inman, A Saleh, M Noshi, D Galani, L Abdelwaret, H Alsafar, A Elfatih, H Al Shamsi, R Ali, H Li, R Ramasamy, AM Schmidt, MM Benbarka, MH Hassan
    J Clin Transl Endocrinol, 2019-04-23;16(0):100192.
    Species: Human
    Sample Types: Plasma
  36. Advanced glycation end products (AGE) and receptor for AGE (RAGE) in patients with active tuberculosis, and their relationship between food intake and nutritional status
    Authors: LF da Silva, EC Skupien, TK Lazzari, SR Holler, EGC de Almeida, LR Zampieri, SE Coutinho, M Andrades, DR Silva
    PLoS ONE, 2019-03-14;14(3):e0213991.
    Species: Human
    Sample Types: Plasma
  37. The rationale and design of the personal diet study, a randomized clinical trial evaluating a personalized approach to weight loss in individuals with pre-diabetes and early-stage type 2 diabetes
    Authors: CJ Popp, DE St-Jules, L Hu, L Ganguzza, P Illiano, M Curran, H Li, A Schoenthal, M Bergman, AM Schmidt, E Segal, A Godneva, MA Sevick
    Contemp Clin Trials, 2019-03-04;0(0):.
    Species: Human
    Sample Types:
  38. sRAGE and early signs of cardiac target organ damage in mild hypertensives
    Authors: AM Maresca, L Guasti, S Bozzini, C Mongiardi, N Tandurella, R Corso, FG Zerba, A Squizzato, L Campiotti, F Dentali, C Klersy, AM Grandi, C Falcone
    Cardiovasc Diabetol, 2019-02-12;18(1):17.
    Species: Human
    Sample Types: Plasma
  39. The ratio of AGE to sRAGE independently associated with albuminuria in hypertensive patients
    Authors: KH Chiang, JW Chen, SS Huang, HB Leu, SJ Lin, PH Huang
    BMC Endocr Disord, 2018-11-13;18(1):84.
    Species: Human
    Sample Types: Plasma
  40. Serum AGE/RAGEs as potential biomarker in idiopathic pulmonary fibrosis
    Authors: C Machahua, A Montes-Wor, L Planas-Cer, R Buendia-Fl, M Molina-Mol, V Vicens-Zyg
    Respir. Res., 2018-11-08;19(1):215.
    Species: Human
    Sample Types: Serum
  41. Quantification of the soluble Receptor of Advanced Glycation End-Products (sRAGE) by LC-MS after enrichment by strong cation exchange (SCX) solid-phase extraction (SPE) at the protein level
    Authors: F Klont, MR Joosten, NHT Ten Hacken, P Horvatovic, R Bischoff
    Anal. Chim. Acta, 2018-09-29;1043(0):45-51.
    Species: Human
    Sample Types: Serum
  42. A prospective study of soluble receptor for advanced glycation end products and adipokines in association with pancreatic cancer in postmenopausal women
    Authors: DL White, RC Hoogeveen, L Chen, P Richardson, M Ravishanka, P Shah, L Tinker, T Rohan, EA Whitsel, HB El-Serag, L Jiao
    Cancer Med, 2018-03-23;0(0):.
    Species: Human
    Sample Types: Serum
  43. TGF?1 reinforces arterial aging in the vascular smooth muscle cell through a long-range regulation of the cytoskeletal stiffness
    Authors: W Zhu, BC Kim, M Wang, J Huang, A Isak, NM Bexiga, R Monticone, T Ha, EG Lakatta, SS An
    Sci Rep, 2018-02-08;8(1):2668.
    Species: Human
    Sample Types: Plasma
  44. Receptor for advanced glycation end-products and ARDS prediction: a multicentre observational study
    Authors: M Jabaudon, P Berthelin, T Pranal, L Roszyk, T Godet, JS Faure, R Chabanne, N Eisenmann, A Lautrette, C Belville, R Blondonnet, S Cayot, T Gillart, J Pascal, Y Skrzypczak, B Souweine, L Blanchon, V Sapin, B Pereira, JM Constantin
    Sci Rep, 2018-02-08;8(1):2603.
    Species: Human
    Sample Types: Plasma
  45. Elevations of novel cytokines in bacterial meningitis in infants
    Authors: L Srinivasan, L Kilpatrick, SS Shah, S Abbasi, MC Harris
    PLoS ONE, 2018-02-02;13(2):e0181449.
    Species: Human
    Sample Types: CSF
  46. Evolution and bad prognostic value of advanced glycation end products after acute heart failure: relation with body composition
    Authors: B Paradela-D, Á Fernández-, D Bou-Teen, S Eiras, R González-F, RM Agra, A Varela-Rom, AI Castro-Pai, MC Carreira, FF Casanueva, E Álvarez, JR González-J
    Cardiovasc Diabetol, 2017-09-15;16(1):115.
    Species: Human
    Sample Types: Plasma
  47. Club cell protein 16 and cytokeratin fragment 21-1 as early predictors of pulmonary complications in polytraumatized patients with severe chest trauma
    Authors: LL Negrin, G Halat, S Kettner, M Gregori, R Ristl, S Hajdu, T Heinz
    PLoS ONE, 2017-04-05;12(4):e0175303.
    Species: Human
    Sample Types: Serum
  48. Decreased levels of sRAGE in follicular fluid from patients with PCOS
    Authors: BiJun Wang
    Reproduction, 2016-12-13;0(0):.
    Species: Human
    Sample Types: Aspirated Follicle Fluid
  49. The Initial Months of Antiretroviral Therapy and Its Influence on AGEs, HMGB1, and sRAGE Levels in Asymptomatic HIV-Infected Individuals
    Authors: Karen Ingrid Tasca
    Mediators Inflamm, 2016-11-30;2016(0):2909576.
    Species: Human
    Sample Types: Plasma
  50. Innovative Flow Cytometry Allows Accurate Identification of Rare Circulating Cells Involved in Endothelial Dysfunction
    PLoS ONE, 2016-08-25;11(8):e0160153.
    Species: Human
    Sample Types: Plasma
  51. Soluble RAGE and atherosclerosis in youth with type 1 diabetes: a 5-year follow-up study.
    Authors: Heier M, Margeirsdottir H, Gaarder M, Stensaeth K, Brunborg C, Torjesen P, Seljeflot I, Hanssen K, Dahl-Jorgensen K
    Cardiovasc Diabetol, 2015-09-25;14(1):126.
    Species: Human
    Sample Types: Serum
  52. Serum Level of Soluble Receptor for Advanced Glycation End Products Is Associated with A Disintegrin And Metalloproteinase 10 in Type 1 Diabetes.
    Authors: Lee A, Lam J, Shiu S, Wong Y, Betteridge D, Tan K
    PLoS ONE, 2015-09-01;10(9):e0137330.
    Species: Human
    Sample Types: Serum
  53. Soluble Forms and Ligands of the Receptor for Advanced Glycation End-Products in Patients with Acute Respiratory Distress Syndrome: An Observational Prospective Study.
    Authors: Jabaudon M, Blondonnet R, Roszyk L, Pereira B, Guerin R, Perbet S, Cayot S, Bouvier D, Blanchon L, Sapin V, Constantin J
    PLoS ONE, 2015-08-14;10(8):e0135857.
    Species: Human
    Sample Types: Serum
  54. The impact of concomitant pulmonary infection on immune dysregulation in Pneumocystis jirovecii pneumonia.
    Authors: Chou C, Lin F, Tsai H, Chang S
    BMC Pulm Med, 2014-11-19;14(0):182.
    Species: Human
    Sample Types: BALF
  55. Local and systemic RAGE axis changes in pulmonary hypertension: CTEPH and iPAH.
    Authors: Moser B, Megerle A, Bekos C, Janik S, Szerafin T, Birner P, Schiefer A, Mildner M, Lang I, Skoro-Sajer N, Sadushi-Kolici R, Taghavi S, Klepetko W, Ankersmit H
    PLoS ONE, 2014-09-04;9(9):e106440.
    Species: Human
    Sample Types: Serum
  56. Higher serum soluble receptor for advanced glycation end product levels and lower prevalence of metabolic syndrome among Japanese adult men: a cross-sectional study.
    Authors: Momma H, Niu K, Kobayashi Y, Huang C, Chujo M, Otomo A, Tadaura H, Miyata T, Nagatomi R
    Diabetol Metab Syndr, 2014-03-06;6(1):33.
    Species: Human
    Sample Types: Serum
  57. GeneOptimizer program-assisted cDNA reengineering enhances sRAGE autologous expression in Chinese hamster ovary cells.
    Authors: Wei, Wen, Kim, Ji Min, Medina, Danny, Lakatta, Edward G, Lin, Li
    Protein Expr Purif, 2013-12-25;95(0):143-8.
    Species: Chinese Hamster
    Sample Types: Cell Culture Supernates
  58. Placental growth factor, pregnancy-associated plasma protein-A, soluble receptor for advanced glycation end products, extracellular newly identified receptor for receptor for advanced glycation end products binding protein and high mobility group box 1 levels in patients with acute kidney injury: a cross sectional study.
    Authors: Zakiyanov O, Kriha V, Vachek J, Zima T, Tesar V, Kalousova M
    BMC Nephrol, 2013-11-04;14(0):245.
    Species: Human
    Sample Types: Serum
  59. Diastolic dysfunction of aging is independent of myocardial structure but associated with plasma advanced glycation end-product levels.
    Authors: Campbell D, Somaratne J, Jenkins A, Prior D, Yii M, Kenny J, Newcomb A, Schalkwijk C, Black M, Kelly D
    PLoS ONE, 2012-11-26;7(11):e49813.
    Species: Human
    Sample Types: Plasma
  60. The soluble form of the receptor of advanced glycation endproducts increases after bariatric surgery in morbid obesity.
    Authors: Brix J, Hollerl F, Kopp H, Schernthaner G, Schernthaner G
    Int J Obes (Lond), 2012-07-17;36(11):1412-7.
    Species: Human
    Sample Types: Serum
  61. Methodological and Preanalytical Evaluation of a RAGE Immunoassay.
    Authors: Wittwer C, Lehner J, Fersching D, Siegele B, Stoetzer OJ, Holdenrieder S
    Anticancer Res., 2012-05-01;32(5):2075-8.
    Species: Human
    Sample Types: Serum
  62. Soluble RAGE as a severity marker in community acquired pneumonia associated sepsis.
    Authors: Narvaez-Rivera RM, Rendon A, Salinas-Carmona MC
    BMC Infect. Dis., 2012-01-20;12(0):15.
    Species: Human
    Sample Types: Serum
  63. Total soluble and endogenous secretory receptor for advanced glycation end products as predictive biomarkers of coronary heart disease risk in patients with type 2 diabetes: an analysis from the CARDS trial.
    Authors: Colhoun HM, Betteridge DJ, Durrington P, Hitman G, Neil A, Livingstone S, Charlton-Menys V, Bao W, Demicco DA, Preston GM, Deshmukh H, Tan K, Fuller JH
    Diabetes, 2011-07-19;60(9):2379-85.
    Species: Human
    Sample Types: Serum
  64. Soluble form of the receptor for advanced glycation end products is a marker of acute lung injury but not of severe sepsis in critically ill patients.
    Authors: Jabaudon M, Futier E, Roszyk L
    Crit. Care Med., 2011-03-01;39(3):480-8.
    Species: Human
    Sample Types: Plasma
  65. Proteolytic release of the receptor for advanced glycation end products from in vitro and in situ alveolar epithelial cells.
    Authors: Yamakawa N, Uchida T, Matthay MA, Makita K
    Am. J. Physiol. Lung Cell Mol. Physiol., 2011-01-21;300(4):L516-25.
    Species: Human
    Sample Types: Edema Fluid
  66. Higher plasma soluble Receptor for Advanced Glycation End Products (sRAGE) levels are associated with incident cardiovascular disease and all-cause mortality in type 1 diabetes: a 12-year follow-up study.
    Authors: Nin JW, Jorsal A, Ferreira I
    Diabetes, 2010-06-03;59(8):2027-32.
    Species: Human
    Sample Types: Plasma
  67. Circulating high-molecular-weight RAGE ligands activate pathways implicated in the development of diabetic nephropathy.
    Authors: Penfold SA, Coughlan MT, Patel SK
    Kidney Int., 2010-05-12;78(3):287-95.
    Species: Human
    Sample Types: Serum
  68. Effects of atorvastatin on serum soluble receptors for advanced glycation end-products in type 2 diabetes.
    Authors: Tam HL, Shiu SW, Wong Y, Chow WS, Betteridge DJ, Tan KC
    Atherosclerosis, 2009-08-21;209(1):173-7.
    Species: Human
    Sample Types: Serum
  69. Procoagulant alveolar microparticles in the lungs of patients with acute respiratory distress syndrome.
    Authors: Bastarache JA, Fremont RD, Kropski JA, Bossert FR, Ware LB
    Am. J. Physiol. Lung Cell Mol. Physiol., 2009-08-21;297(6):L1035-41.
    Species: Human
    Sample Types: Edema Fluid
  70. Characterization of RAGE, HMGB1, and S100beta in inflammation-induced preterm birth and fetal tissue injury.
    Authors: Buhimschi CS, Baumbusch MA, Dulay AT, Oliver EA, Lee S, Zhao G, Bhandari V, Ehrenkranz RA, Weiner CP, Madri JA, Buhimschi IA
    Am. J. Pathol., 2009-08-13;175(3):958-75.
    Species: Human
    Sample Types: Plasma
  71. Receptor for advanced glycation end products (RAGE) and its inflammatory ligand EN-RAGE in non-diabetic subjects with pre-mature coronary artery disease.
    Authors: Mahajan N, Malik N, Bahl A
    Atherosclerosis, 2009-06-11;207(2):597-602.
    Species: Human
    Sample Types: Plasma
  72. Activation of critical, host-induced, metabolic and stress pathways marks neutrophil entry into cystic fibrosis lungs.
    Authors: Makam M, Diaz D, Laval J, Gernez Y, Conrad CK, Dunn CE, Davies ZA, Moss RB, Herzenberg LA, Herzenberg LA, Tirouvanziam R
    Proc. Natl. Acad. Sci. U.S.A., 2009-03-17;106(14):5779-83.
    Species: Human
    Sample Types: Plasma
  73. Increased serum HMGB1 level is associated with coronary artery disease in nondiabetic and type 2 diabetic patients.
    Authors: Yan XX, Lu L, Peng WH, Wang LJ, Zhang Q, Zhang RY, Chen QJ, Shen WF
    Atherosclerosis, 2008-12-14;205(2):544-8.
    Species: Human
    Sample Types: Serum
  74. Serum-soluble receptor for advanced glycation end product levels in patients with amyotrophic lateral sclerosis.
    Acta Neurol. Scand., 2008-12-02;120(2):119-22.
    Species: Human
    Sample Types: Serum
  75. Nitric oxide inhalation and glucocorticoids as combined treatment in human experimental endotoxemia.
    Authors: Hallstrom L, Berghall E, Frostell C, Sollevi A, Soop AL
    Crit. Care Med., 2008-11-01;36(11):3043-7.
    Species: Human
    Sample Types: Plasma
  76. Serum endogenous secretory RAGE level is an independent risk factor for the progression of carotid atherosclerosis in type 1 diabetes.
    Authors: Katakami N, Matsuhisa M, Kaneto H, Matsuoka TA, Sakamoto K, Yasuda T, Umayahara Y, Kosugi K, Yamasaki Y
    Atherosclerosis, 2008-09-02;204(1):288-92.
    Species: Human
    Sample Types: Serum
  77. Plasma receptor for advanced glycation end products and clinical outcomes in acute lung injury.
    Authors: Calfee CS, Ware LB, Eisner MD, Parsons PE, Thompson BT, Wickersham N, Matthay MA
    Thorax, 2008-06-19;63(12):1083-9.
    Species: Human
    Sample Types: Plasma
  78. MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis.
    Authors: Rosas IO, Richards TJ, Konishi K, Zhang Y, Gibson K, Lokshin AE, Lindell KO, Cisneros J, Macdonald SD, Pardo A, Sciurba F, Dauber J, Selman M, Gochuico BR, Kaminski N
    PLoS Med., 2008-04-29;5(4):e93.
    Species: Human
    Sample Types: Serum
  79. Low levels of sRAGE are associated with increased risk for mortality in renal transplant recipients.
    Authors: Gross S, van Ree RM, Oterdoom LH, de Vries AP, van Son WJ, de Jong PE, Navis GJ, Zuurman MW, Bierhaus A, Gans RO, Bakker SJ
    Transplantation, 2007-09-15;84(5):659-63.
    Species: Human
    Sample Types: Plasma

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Human RAGE Quantikine ELISA Kit
By Anonymous on 10/11/2017
Sample Tested: Plasma