Human RelA/NFkB p65 ExactaChIP Chromatin IP Kit

Human RelA/NFkB p65 ExactaChIP Chromatin IP Kit Summary

Specifications

Product Datasheets

Background: RelA/NFkB p65

RelA belongs to a family of transcription factors (NF-kappa-B (nuclear factor kappa from B cells) complex) that play a fundamental role in inflammatory and immune responses. The NF-kappa-B complex is composed of a heterodimer of a Rel family member (RelA, c-Rel, RelB) and either NF-kappa-B1 or NF-kappa-B2 subunits. RelA and NF-kappa-B1 are the most common heterodimeric pair. The NF-kappa-B complex is sequestered in the cytoplasm by inhibitory I-kappa-B proteins. Upon cellular activation, the ubiquitin-proteosome pathway degrades the I-kappa-B proteins allowing the NF-kappa-B complex to translocate to the nucleus and activate gene transcription.

Related Research Areas

• Apoptosis Transcription Factors and Regulators
• Chemokine Receptor Intracellular Signaling
• C-type Lectin Receptors
• IL-1 Family
• IL-17 Family
• Immunoglobulin-Like Domain Transcription Factors
• Interferons
• Natural Killer T (NKT) Cells
• NFkB Pathway
• NOD-like Receptors and the Inflammasome
• PDGF Family
• RIG-I-like Receptors
• TNF Superfamily Regulators
• Toll-Like Receptors
• Transcription Factors and Regulators
• Transcription Factors in the Akt Pathway