SLURP1 in Human Skin. SLURP1 was detected in immersion fixed paraffin-embedded sections of human skin using Sheep Anti-Human SLURP1 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF4479) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS019) and counterstained with hematoxylin (blue). Specific staining was localized to keratinocytes. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.
Preparation and Storage
Sterile PBS to a final concentration of 0.2 mg/mL.
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
12 months from date of receipt, -20 to -70 °C as supplied.
1 month, 2 to 8 °C under sterile conditions after reconstitution.
6 months, -20 to -70 °C under sterile conditions after reconstitution.
SLURP1 (Secreted Ly6/uPAR-related protein 1; also ARS Component B and ANUP) is a 9-10 kDa secreted member of the Ly6/uPAR Superfamily of proteins. It is expressed by restricted cell types, including sensory neurons, ciliated bronchial epithelium, T and B cells, and stratified squamous epithelium of the skin, vagina and esophagus. SLURP1 binds to the alpha 7 nicotinic acetylcholine receptor, which suggests it regulates Ca and Na transport. This translates into reduced TNF alpha release by macrophages, and activation of select cellular caspases. Mature human SLURP1 is 82 amino acids (aa) in length (aa 22-103). It contains one UPAR/Ly6 domain (aa 24‑73), and forms noncovalent homodimers. Mature human SLURP1 shares 67% aa identity with mouse SLURP1.
Secreted Ly-6/uPAR-related Protein 1
Entrez Gene IDs:
57152 (Human); 57277 (Mouse); 300016 (Rat)
ANUPARS(component B)-81/S; ARS Component B; ArsB; ARSlymphocyte antigen 6-like secreted; LY6LS; MDMsecreted Ly-6/uPAR-related protein 1; neoplastic urinary protein; secreted LY6/PLAUR domain containing 1; secreted Ly6/uPAR related protein 1; SLURP1; SLURP-1
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