Human TNF-alpha DuoSet ELISA Summary
* Provided that the recommended microplates, buffers, diluents, substrates and solutions are used, and the assay is run as summarized in the Assay Procedure provided.
This DuoSet ELISA Development kit contains the basic components required for the development of sandwich ELISAs to measure natural and recombinant human TNF-alpha. The suggested diluent is suitable for the analysis of most cell culture supernate samples. Diluents for complex matrices, such as serum and plasma, should be evaluated prior to use in this DuoSet.
Product Features
- Optimized capture and detection antibody pairings with recommended concentrations save lengthy development time
- Development protocols are provided to guide further assay optimization
- Assay can be customized to your specific needs
- Economical alternative to complete kits
Kit Content
- Capture Antibody
- Detection Antibody
- Recombinant Standard
- Streptavidin conjugated to horseradish-peroxidase (Streptavidin-HRP)
Other Reagents Required
DuoSet Ancillary Reagent Kit 2 (5 plates): (Catalog # DY008) containing 96 well microplates, plate sealers, substrate solution, stop solution, plate coating buffer (PBS), wash buffer, and Reagent Diluent Concentrate 2.
The components listed above may be purchased separately:
PBS: (Catalog # DY006), or 137 mM NaCl, 2.7 mM KCl, 8.1 mM Na2HPO4, 1.5 mM KH2PO4, pH 7.2 - 7.4, 0.2 µm filtered
Wash Buffer: (Catalog # WA126), or 0.05% Tween® 20 in PBS, pH 7.2-7.4
Reagent Diluent: (Catalog # DY995), or 1% BSA in PBS, pH 7.2-7.4, 0.2 µm filtered
Substrate Solution: 1:1 mixture of Color Reagent A (H2O2) and Color Reagent B (Tetramethylbenzidine) (Catalog # DY999)
Stop Solution: 2 N H2SO4 (Catalog # DY994)
Microplates: R&D Systems (Catalog # DY990)
Plate Sealers: ELISA Plate Sealers (Catalog # DY992)
Data Example
Product Datasheets
Preparation and Storage
Background: TNF-alpha
Tumor Necrosis Factor alpha (TNF-alpha ), also known as cachectin and TNFSF1A, is the prototypic ligand of the TNF superfamily (1). It is a pleiotropic molecule that plays a central role in inflammation, immune system development, apoptosis, and lipid metabolism (2-5). TNF-alpha is also involved in a number of pathological conditions including asthma, Crohn's disease, rheumatoid arthritis, neuropathic pain, obesity, type 2 diabetes, septic shock, autoimmunity, and cancer (5-11).
Assay Procedure
GENERAL ELISA PROTOCOL
Plate Preparation
- Dilute the Capture Antibody to the working concentration in PBS without carrier protein. Immediately coat a 96-well microplate with 100 μL per well of the diluted Capture Antibody. Seal the plate and incubate overnight at room temperature.
- Aspirate each well and wash with Wash Buffer, repeating the process two times for a total of three washes. Wash by filling each well with Wash Buffer (400 μL) using a squirt bottle, manifold dispenser, or autowasher. Complete removal of liquid at each step is essential for good performance. After the last wash, remove any remaining Wash Buffer by aspirating or by inverting the plate and blotting it against clean paper towels.
- Block plates by adding 300 μL Reagent Diluent to each well. Incubate at room temperature for a minimum of 1 hour.
- Repeat the aspiration/wash as in step 2. The plates are now ready for sample addition.
Assay Procedure
- Add 100 μL of sample or standards in Reagent Diluent, or an appropriate diluent, per well. Cover with an adhesive strip and incubate 2 hours at room temperature.
- Repeat the aspiration/wash as in step 2 of Plate Preparation.
- Add 100 μL of the Detection Antibody, diluted in Reagent Diluent, to each well. Cover with a new adhesive strip and incubate 2 hours at room temperature.
- Repeat the aspiration/wash as in step 2 of Plate Preparation.
- Add 100 μL of the working dilution of Streptavidin-HRP to each well. Cover the plate and incubate for 20 minutes at room temperature. Avoid placing the plate in direct light.
- Repeat the aspiration/wash as in step 2.
- Add 100 μL of Substrate Solution to each well. Incubate for 20 minutes at room temperature. Avoid placing the plate in direct light.
- Add 50 μL of Stop Solution to each well. Gently tap the plate to ensure thorough mixing.
- Determine the optical density of each well immediately, using a microplate reader set to 450 nm. If wavelength correction is available, set to 540 nm or 570 nm. If wavelength correction is not available, subtract readings at 540 nm or 570 nm from the readings at 450 nm. This subtraction will correct for optical imperfections in the plate. Readings made directly at 450 nm without correction may be higher and less accurate.
Citations for Human TNF-alpha DuoSet ELISA
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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1,25-dihydroxy Vitamin D3 and Interleukin-6 Blockade Synergistically Regulate Rheumatoid Arthritis by Suppressing Interleukin-17 Production and Osteoclastogenesis
Authors: H Kim, S Baek, SM Hong, J Lee, SM Jung, J Lee, M Cho, SK Kwok, SH Park
J. Korean Med. Sci., 2020;35(6):e40.
Species: Human
Sample Types: Cell Culture Supernates
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Erythromycin inhibits neutrophilic inflammation and mucosal disease by upregulating DEL-1
Authors: T Maekawa, H Tamura, H Domon, T Hiyoshi, T Isono, D Yonezawa, N Hayashi, N Takahashi, K Tabeta, T Maeda, M Oda, A Ziogas, V? Alexaki, T Chavakis, Y Terao, G Hajishenga
JCI Insight, 2020;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
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Gaps in Study Design for Immune Parameter Research for Latent Tuberculosis Infection: A Systematic Review
Authors: M Herrera, C Vera, Y Keynan, ZV Rueda
J Immunol Res, 2020;2020(0):8074183.
Species: Human
Sample Types: Cell Culture Supernates
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Persistent elevation of intrathecal pro-inflammatory cytokines leads to multiple sclerosis-like cortical demyelination and neurodegeneration
Authors: RE James, R Schalks, E Browne, I Eleftheria, CP Munoz, ND Mazarakis, R Reynolds
Acta Neuropathol Commun, 2020;8(1):66.
Species: Human
Sample Types: Cell Culutre Supernatant
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Antifibrotic Effects of a Barbituric Acid Derivative on Liver Fibrosis by Blocking the NF-&kappaB Signaling Pathway in Hepatic Stellate Cells
Authors: YH Wang, FM Suk, CL Liu, TL Chen, YC Twu, MH Hsu, YJ Liao
Front Pharmacol, 2020;11(0):388.
Species: Human
Sample Types: Cell Culture Supernates
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The Set7 Lysine Methyltransferase Regulates Plasticity in Oxidative Phosphorylation Necessary for Trained Immunity Induced by &beta-Glucan
Authors: ST Keating, L Groh, CDCC van der He, H Rodriguez, JC Dos Santos, S Fanucchi, J Okabe, H Kaipananic, JH van Puffel, L Helder, MP Noz, V Matzaraki, Y Li, LCJ de Bree, VACM Koeken, SJCFM Moorlag, VP Mourits, J Domínguez-, M Oosting, EP Bulthuis, WJH Koopman, M Mhlanga, A El-Osta, LAB Joosten, MG Netea, NP Riksen
Cell Rep, 2020;31(3):107548.
Species: Human
Sample Types: Cell Culture Supernates
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Anti-Inflammatory Principles from Tamarix aphylla L.: A Bioassay-Guided Fractionation Study
Authors: AS Gadallah, Mujeeb-Ur-, Atta-Ur-Ra, S Yousuf, Atia-Tul-W, A Jabeen, MM Swilam, SAM Khalifa, HR El-Seedi, MI Choudhary
Molecules, 2020;25(13):.
Species: Human
Sample Types: Cell Culture Supernates
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Altered iron metabolism in cystic fibrosis macrophages: the impact of CFTR modulators and implications for Pseudomonas aeruginosa survival
Authors: HF Hazlett, TH Hampton, DS Aridgides, DA Armstrong, JA Dessaint, DL Mellinger, AB Nymon, A Ashare
Sci Rep, 2020;10(1):10935.
Species: Human
Sample Types: Cell Culture Supernates
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The Delivery of &alpha1-Antitrypsin Therapy Through Transepidermal Route: Worthwhile to Explore
Authors: S Tumpara, B Martinez-D, G Gomez-Mari, B Liu, DS DeLuca, E Korenbaum, D Jonigk, F Jugert, FM Wurm, MJ Wurm, T Welte, S Janciauski
Front Pharmacol, 2020;11(0):983.
Species: Human
Sample Types: Cell Culture Supernates
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Activation of Human &gamma&delta T Cells: Modulation by Toll-Like Receptor 8 Ligands and Role of Monocytes
Authors: R Serrano, D Wesch, D Kabelitz
Cells, 2020;9(3):.
Species: Human
Sample Types: Cell Culture Supernates
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Loss of function of the mitochondrial peptidase PITRM1 induces proteotoxic stress and Alzheimer's disease-like pathology in human cerebral organoids
Authors: MJ Pérez, D Ivanyuk, V Panagiotak, G Di Napoli, S Kalb, D Brunetti, R Al-Shaana, SA Kaeser, SA Fraschka, M Jucker, M Zeviani, C Viscomi, M Deleidi
Mol. Psychiatry, 2020;0(0):.
Species: Human
Sample Types: Cell Culture Lysates
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Cerebrospinal fluid of chronic osteoarthritic patients induced interleukin-6 release in human glial cell-line T98G
Authors: W Liu, C Li, FCK Tan, HJ Neo, YH Chan, CM Low, TL Lee
BMC Anesthesiol, 2020;20(1):69.
Species: Human
Sample Types: Cell Culture Supernates
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Regulation of Transcription Factor E2-2 in Human Plasmacytoid Dendritic Cells by Monocyte-Derived TNF&alpha
Authors: HK Dewald, HJ Hurley, P Fitzgerald
Viruses, 2020;12(2):.
Species: Human
Sample Types: Cell Culture Supernates
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The non-saponin fraction of Korean Red Ginseng (KGC05P0) decreases glucose uptake and transport in�vitro and modulates glucose production via down-regulation of the PI3K/AKT pathway in�vivo
Authors: SJ Park, D Lee, D Kim, M Lee, G In, ST Han, SW Kim, MH Lee, OK Kim, J Lee
J Ginseng Res, 2020;44(2):362-372.
Species: Human
Sample Types: Serum
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CD4+FOXP3+ T Cells in Rheumatoid Arthritis Bone Marrow Are Partially Impaired
Authors: M Massalska, A Radzikowsk, E Kuca-Warna, M Plebanczyk, M Prochorec-, U Skalska, W Kurowska, P Maldyk, E Kontny, HJ Gober, W Maslinski
Cells, 2020;9(3):.
Species: Human
Sample Types: Cell Culture Supernates
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Whole-cell fungal-mediated structural transformation of anabolic drug metenolone acetate into potent anti-inflammatory metabolites
Authors: M Siddiqui, Atia-Tul-W, A Jabeen, Y Wang, W Wang, Atta-Ur-Ra, MI Choudhary
J Adv Res, 2020;24(0):69-78.
Species: Aspergillus alliaceus
Sample Types: Cell Culture Supernates
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The TLR4 adaptor TRAM controls the phagocytosis of Gram-negative bacteria by interacting with the Rab11-family interacting protein 2
Authors: A Skjesol, M Yurchenko, K Bösl, C Gravastran, KE Nilsen, LM Grøvdal, F Agliano, F Patane, G Lentini, H Kim, G Teti, A Kumar Shar, RK Kandasamy, B Sporsheim, KK Starheim, DT Golenbock, H Stenmark, M McCaffrey, T Espevik, H Husebye
PLoS Pathog., 2019;15(3):e1007684.
Species: Human
Sample Types: Cell Culture Supernates
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Human metapneumovirus activates NOD-like receptor protein 3 inflammasome via its small hydrophobic protein which plays a detrimental role during infection in mice
Authors: VB Lê, J Dubois, C Couture, MH Cavanagh, O Uyar, A Pizzorno, M Rosa-Calat, MÈ Hamelin, G Boivin
PLoS Pathog., 2019;15(4):e1007689.
Species: Human
Sample Types: Cell Culture Supernates
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Newly defined ABCB5+ dermal mesenchymal stem cells promote healing of chronic iron overload wounds via secretion of interleukin-1 receptor antagonist
Authors: S Vander Bek, JC de Vries, B Meier-Schi, P Meyer, D Jiang, A Sindrilaru, FF Ferreira, A Hainzl, S Schatz, J Muschhamme, NJ Scheurmann, P Kampilafko, AM Seitz, L Dürselen, A Ignatius, MA Kluth, C Ganss, M Wlaschek, K Singh, P Maity, NY Frank, MH Frank, K Scharffett
Stem Cells, 2019;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
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Crosstalk between cancer cells and tumor associated macrophages is required for mesenchymal circulating tumor cell-mediated colorectal cancer metastasis
Authors: C Wei, C Yang, S Wang, D Shi, C Zhang, X Lin, Q Liu, R Dou, B Xiong
Mol. Cancer, 2019;18(1):64.
Species: Human
Sample Types: Cell Culture Supernates
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Role of vimentin in modulating immune cell apoptosis and inflammatory responses in sepsis
Authors: L Su, P Pan, P Yan, Y Long, X Zhou, X Wang, R Zhou, B Wen, L Xie, D Liu
Sci Rep, 2019;9(1):5747.
Species: Human
Sample Types: Cell Culture Supernates
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Calcineurin inhibitors reduce NFAT-dependent expression of antifungal pentraxin-3 by human monocytes
Authors: K Bendí?ková, F Tidu, M De Zuani, MH Kohoutková, I Andrej?ino, A Pompeiano, S B?lášková, G Forte, T Zelante, J Fri?
J. Leukoc. Biol., 2019;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
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Secondhand smoke exposure and sleep-related breathing problems in toddlers
Authors: JA Groner, L Nicholson, H Huang, JA Bauer
Acad Pediatr, 2019;0(0):.
Species: Human
Sample Types: Serum
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High expression of S100 calgranulin genes in peripheral blood mononuclear cells from patients with Takayasu arteritis
Authors: J Kabeerdoss, M Thomas, R Goel, H Mohan, S Danda, J L, D Danda
Cytokine, 2019;114(0):61-66.
Species: Human
Sample Types: Cell Culture Supernates
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Engulfment, persistence and fate of Bdellovibrio bacteriovorus predators inside human phagocytic cells informs their future therapeutic potential
Authors: D Raghunatha, PM Radford, C Gell, D Negus, C Moore, R Till, PJ Tighe, SP Wheatley, L Martinez-P, RE Sockett, J Tyson
Sci Rep, 2019;9(1):4293.
Species: Human
Sample Types: Cell Culture Supernates
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Historical BCG vaccination combined with drug treatment enhances inhibition of mycobacterial growth ex vivo in human peripheral blood cells
Authors: SA Prabowo, A Zelmer, L Stockdale, U Ojha, SG Smith, K Seifert, HA Fletcher
Sci Rep, 2019;9(1):4842.
Species: Human
Sample Types: Cell Culture Supernates
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D-2-Hydroxyglutarate and L-2-Hydroxyglutarate Inhibit IL-12 Secretion by Human Monocyte-Derived Dendritic Cells
Authors: I Ugele, ZE Cárdenas-C, K Hammon, M Wehrstein, C Bruss, K Peter, K Singer, E Gottfried, J Boesch, P Oefner, K Dettmer, K Renner, M Kreutz
Int J Mol Sci, 2019;20(3):.
Species: Human
Sample Types: Cell Culture Supernates
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Human Blood and Tonsil Plasmacytoid Dendritic Cells Display Similar Gene Expression Profiles but Exhibit Differential Type I IFN Responses to Influenza A Virus Infection
Authors: S Vangeti, J Gertow, M Yu, S Liu, F Baharom, S Scholz, D Friberg, M Starkhamma, A Ahlberg, A Smed-Sören
J. Immunol., 2019;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
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Flagellin-independent effects of a Toll-like receptor 5 polymorphism in the inflammatory response to Burkholderia pseudomallei
Authors: AK Dickey, N Chantratit, S Tandhavana, D Ducken, L Lovelace-M, S Seal, J Robertson, ND Myers, S Schwarz, MM Wurfel, S Kosamo, TE West
PLoS Negl Trop Dis, 2019;13(5):e0007354.
Species: Human
Sample Types: Cell Culture Supernates
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Phenotypic and functional stability of leukocytes from human peripheral blood samples: considerations for the design of immunological studies
Authors: A Navas, L Giraldo-Pa, MD Prieto, J Cabrera, MA Gómez
BMC Immunol., 2019;20(1):5.
Species: Human
Sample Types: Cell Culture Supernates
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Large-scale secretome analyses unveil the superior immunosuppressive phenotype of umbilical cord stromal cells as compared to other adult mesenchymal stromal cells
Authors: A Islam, I Urbarova, JA Bruun, I Martinez-Z
Eur Cell Mater, 2019;37(0):153-174.
Species: Human
Sample Types: Cell Culture Supernates
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Evolving understanding of cardiovascular, cerebrovascular and peripheral arterial disease in people living with HIV and role of novel biomarkers. A study of the Spanish CoRIS cohort, 2004-2015
Authors: M Masiá, S Padilla, JA García, J García-Abe, M Fernández, I Bernardino, M Montero, J Peraire, B Pernas, F Gutiérrez
PLoS ONE, 2019;14(4):e0215507.
Species: Human
Sample Types: Plasma
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25(OH)D3 and 1.25(OH)2D3 inhibits TNF-? expression in human monocyte derived macrophages
Authors: A Rafique, L Rejnmark, L Heickendor, HJ Møller
PLoS ONE, 2019;14(4):e0215383.
Species: Human
Sample Types: Cell Culture Supernates
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Type 1 diabetic mellitus patients with increased atherosclerosis risk display decreased CDKN2A/2B/2BAS gene expression in leukocytes
Authors: S Martínez-H, V Sánchez-Ga, A Herrero-Ce, Á Vinué, JT Real, JF Ascaso, DJ Burks, H González-N
J Transl Med, 2019;17(1):222.
Species: Human
Sample Types: Plasma
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Relative Contributions of Extracellular and Internalized Bacteria to Early Macrophage Proinflammatory Responses to Streptococcus pneumoniae
Authors: J Periselner, G Ercoli, T Pollard, S Chimalapat, E Camberlein, G Szylar, C Hyams, G Tomlinson, FC Petersen, RA Floto, M Noursadegh, JS Brown
MBio, 2019;10(5):.
Species: Human
Sample Types: Cell Culture Supernates
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Replication of Genome-Wide Association Analysis Identifies New Susceptibility Loci at Long Noncoding RNA Regions for Vogt-Koyanagi-Harada Disease
Authors: J Qi, L Du, J Deng, Y Qin, G Su, S Hou, M Lv, Q Zhang, A Kijlstra, P Yang
Invest. Ophthalmol. Vis. Sci., 2019;60(14):4820-4829.
Species: Human
Sample Types: Cell Culture Supernates
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Echinochrome A Reduces Colitis in Mice and Induces In Vitro Generation of Regulatory Immune Cells
Authors: SJ Oh, Y Seo, JS Ahn, YY Shin, JW Yang, HK Kim, J Han, NP Mishchenko, SA Fedoreyev, VA Stonik, HS Kim
Mar Drugs, 2019;17(11):.
Species: Human
Sample Types: Cell Culture Supernates
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Physiologic intestinal 18F-FDG uptake is associated with alteration of gut microbiota and proinflammatory cytokine levels in breast cancer
Authors: HJ Yoon, HN Kim, JI Bang, W Lim, BI Moon, NS Paik, BS Kim, HL Kim
Sci Rep, 2019;9(1):18273.
Species: Human
Sample Types: Serum
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Human immune cells infiltrate the spinal cord and impair recovery after spinal cord injury in humanized mice
Authors: RS Carpenter, RR Jiang, FH Brennan, JCE Hall, MK Gottipati, S Niewiesk, PG Popovich
Sci Rep, 2019;9(1):19105.
Species: Transgenic Mouse
Sample Types: Serum
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Comparative Investigation of Frankincense Nutraceuticals: Correlation of Boswellic and Lupeolic Acid Contents with Cytokine Release Inhibition and Toxicity against Triple-Negative Breast Cancer Cells
Authors: M Schmiech, SJ Lang, J Ulrich, K Werner, LJ Rashan, T Syrovets, T Simmet
Nutrients, 2019;11(10):.
Species: Human
Sample Types: Plasma
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Disrupting prolonged sitting reduces IL-8 and lower leg swell in active young adults
Authors: S Dogra, M Wolf, MP Jeffrey, RCA Foley, H Logan-Spre, H Jones-Tagg, JM Green-John
BMC Sports Sci Med Rehabil, 2019;11(0):23.
Species: Human
Sample Types: Saliva
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β-Glucan-Induced Trained Immunity Protects against Leishmania braziliensis Infection: a Crucial Role for IL-32
Authors: JC Dos Santos, AM Barroso de, MV Teodoro Si, B Cirovic, LCJ de Bree, MSMA Damen, SJCFM Moorlag, RS Gomes, MM Helsen, M Oosting, ST Keating, A Schlitzer, MG Netea, F Ribeiro-Di, LAB Joosten
Cell Rep, 2019;28(10):2659-2672.e6.
Species: Human
Sample Types: Cell Culture Supernates
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C13 Megastigmane Derivatives From Epipremnum pinnatum: beta-Damascenone Inhibits the Expression of Pro-Inflammatory Cytokines and Leukocyte Adhesion Molecules as Well as NF-kappaB Signaling
Authors: SP Pan, T Pirker, O Kunert, N Kretschmer, S Hummelbrun, SL Latkolik, J Rappai, VM Dirsch, V Bochkov, R Bauer
Front Pharmacol, 2019;10(0):1351.
Species: Human
Sample Types: Cell Culture Supernates
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Correction of bleeding in experimental severe hemophilia A by systemic delivery of factor VIII-encoding mRNA
Authors: J Russick, S Delignat, P Milanov, O Christophe, G Boros, CV Denis, PJ Lenting, SV Kaveri, S Lacroix-De
Haematologica, 2019;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
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Matrix metalloproteinases inactivate the proinflammatory functions of secreted moonlighting tryptophanyl-tRNA synthetase
Authors: PG Jobin, N Solis, Y Machado, PA Bell, NH Kwon, S Kim, CM Overall, GS Butler
J. Biol. Chem., 2019;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
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Mitochondrial function in liver cells is resistant to perturbations in NAD+ salvage capacity
Authors: M Dall, SAJ Trammell, M Asping, AS Hassing, M Agerholm, SG Vienberg, MP Gillum, S Larsen, JT Treebak
J. Biol. Chem., 2019;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
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The Effects of Varying Degree of MWCNT Carboxylation on Bioactivity in Various In Vivo and In Vitro Exposure Models
Authors: RF Hamilton, Z Wu, S Mitra, A Holian
Int J Mol Sci, 2018;19(2):.
Species: Human
Sample Types: Cell Culture Supernates
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PDGF enhances the protective effect of adipose stem cell-derived extracellular vesicles in a model of acute hindlimb ischemia
Authors: T Lopatina, E Favaro, C Grange, M Cedrino, A Ranghino, S Occhipinti, S Fallo, F Buffolo, DA Gaykalova, MM Zanone, R Romagnoli, G Camussi
Sci Rep, 2018;8(1):17458.
Species: Human
Sample Types: Cell Culture Supernates
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Anti-CD137 monoclonal antibody enhances trastuzumab-induced, natural killer cell-mediated cytotoxicity against pancreatic cancer cell lines with low human epidermal growth factor-like receptor 2 expression
Authors: T Masu, M Atsukawa, K Nakatsuka, M Shimizu, D Miura, T Arai, H Harimoto, C Kondo, K Kaneko, S Futagami, C Kawamoto, H Takahashi, K Iwakiri
PLoS ONE, 2018;13(12):e0200664.
Species: Human
Sample Types: Cell Culture Supernates
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Sulphamethazine derivatives as immunomodulating agents: New therapeutic strategies for inflammatory diseases
Authors: H Siddiqui, HM Haniffa, A Jabeen, AU -Rahman, MI Choudhary
PLoS ONE, 2018;13(12):e0208933.
Species: Human
Sample Types: Cell Culture Supernates
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S100B regulates inflammatory response during osteoarthritis via fibroblast growth factor receptor 1 signaling
Authors: L Zhu, Z Weng, P Shen, J Zhou, J Zeng, F Weng, X Zhang, H Yang
Mol Med Rep, 2018;18(6):4855-4864.
Species: Human
Sample Types: Cell Culture Supernates
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Overproduction of IL-6 and Type-I IFN in a Lethal Case of Chikungunya Virus Infection in an Elderly Man During the 2017 Italian Outbreak
Authors: F Colavita, S Vita, E Lalle, F Carletti, L Bordi, D Vincenti, I Pozzetto, M Aiuti, F Vairo, MR Capobianch, M Lichtner, C Castillett
Open Forum Infect Dis, 2018;5(11):ofy276.
Species: Human
Sample Types: Plasma
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The novel immunoglobulin super family receptor SLAMF9 identified in TAM of murine and human melanoma influences pro-inflammatory cytokine secretion and migration
Authors: C Dollt, J Michel, L Kloss, S Melchers, K Schledzews, K Becker, A Sauer, A Krewer, F Koll, A Schmieder
Cell Death Dis, 2018;9(10):939.
Species: Human
Sample Types: Cell Culture Supernates
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Electrophilic properties of itaconate and derivatives regulate the�I?B?-ATF3 inflammatory axis
Authors: M Bambouskov, L Gorvel, V Lampropoul, A Sergushich, E Loginichev, K Johnson, D Korenfeld, ME Mathyer, H Kim, LH Huang, D Duncan, H Bregman, A Keskin, A Santeford, RS Apte, R Sehgal, B Johnson, GK Amarasingh, MP Soares, T Satoh, S Akira, T Hai, C de Guzman, K Auclair, TP Roddy, SA Biller, M Jovanovic, E Klechevsky, KM Stewart, GJ Randolph, MN Artyomov
Nature, 2018;556(7702):501-504.
Species: Human
Sample Types: Cell Culture Supernates
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TiO2 nanoparticles can selectively bind CXCL8 impacting on neutrophil chemotaxis
Authors: J Batt, M Milward, I Chapple, M Grant, H Roberts, O Addison
Eur Cell Mater, 2018;35(0):13-24.
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Disabled-2 (DAB2) Overexpression Inhibits Monocyte-Derived Dendritic Cells' Function in Vogt-Koyanagi-Harada Disease
Authors: S Yi, R Chang, J Hu, Y Qiu, Q Wang, Q Cao, G Yuan, G Su, C Zhou, Y Wang, A Kijlstra, P Yang
Invest. Ophthalmol. Vis. Sci., 2018;59(11):4662-4669.
Species: Human
Sample Types: Cell Culture Supernates
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Allergic Conjunctivitis-induced Retinal Inflammation Promotes Myopia Progression
Authors: CC Wei, YJ Kung, CS Chen, CY Chang, CJ Lin, PT Tien, HY Chang, HJ Chen, YS Huang, HJ Lin, L Wan
EBioMedicine, 2018;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
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Microsomal prostaglandin E synthase-1 gene deletion impairs neuro-immune circuitry of the cholinergic anti-inflammatory pathway in endotoxaemic mouse spleen
Authors: P Revathikum, J Estelius, U Karmakar, E Le Maître, M Korotkova, PJ Jakobsson, J Lampa
PLoS ONE, 2018;13(2):e0193210.
Species: Human
Sample Types: Cell Culture Supernates
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TET-2 up-regulation is associated with the anti-inflammatory action of Vicenin-2
Authors: N Hassan, A Ali, C Withycombe, M Ahluwalia, RH Al-Nasseri, A Tonks, K Morris
Cytokine, 2018;108(0):37-42.
Species: Human
Sample Types: Cell Culture Supernates
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Augmentation of Human Monocyte Responses to Lipopolysaccharide by the Protein S and Mer/Tyro3 Receptor Tyrosine Kinase Axis
Authors: ND Barth, JA Marwick, MJ Heeb, AJ Gale, AG Rossi, I Dransfield
J. Immunol., 2018;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
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CD47 as a potential prognostic marker for oral leukoplakia and oral squamous cell carcinoma
Authors: X Ye, X Wang, R Lu, J Zhang, X Chen, G Zhou
Oncol Lett, 2018;15(6):9075-9080.
Species: Human
Sample Types: Cell Culture Supernates
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Serum metabolomic profiling predicts synovial gene expression in rheumatoid arthritis
Authors: R Narasimhan, R Coras, SB Rosenthal, SR Sweeney, A Lodi, S Tiziani, D Boyle, A Kavanaugh, M Guma
Arthritis Res. Ther., 2018;20(1):164.
Species: Human
Sample Types: Serum
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Clinically compliant spatial and temporal imaging of chimeric antigen receptor T-cells
Authors: N Emami-Shah, J Foster, R Kashani, P Gazinska, C Cook, J Sosabowski, J Maher, S Papa
Nat Commun, 2018;9(1):1081.
Species: Human
Sample Types: Cell Culture Supernates
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p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response
Authors: P Arcidiacon, CM Webb, MA Brooke, H Zhou, PJ Delaney, KE Ng, DC Blaydon, A Tinker, DP Kelsell, A Chikh
Nat Commun, 2018;9(1):1021.
Species: Human
Sample Types: Cell Culture Supernates
-
iTAP, a novel iRhom interactor, controls TNF secretion by policing the stability of iRhom/TACE
Authors: I Oikonomidi, E Burbridge, M Cavadas, G Sullivan, B Collis, H Naegele, D Clancy, J Brezinova, T Hu, A Bileck, C Gerner, A Bolado, A von Kriegs, SJ Martin, F Steinberg, K Strisovsky, C Adrain
Elife, 2018;7(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Modulation of salivary cytokines in response to alcohol, tobacco and caffeine consumption: a pilot study
Authors: CC Sheth, RM López-Pedr, MDM Jovani-San, R González-M, V Veses
Sci Rep, 2018;8(1):16687.
Species: Human
Sample Types: Saliva
-
Human caspase-4 detects tetra-acylated LPS and cytosolic Francisella and functions differently from murine caspase-11
Authors: B Lagrange, S Benaoudia, P Wallet, F Magnotti, A Provost, F Michal, A Martin, F Di Lorenzo, BF Py, A Molinaro, T Henry
Nat Commun, 2018;9(1):242.
Species: Human
Sample Types: Cell Culture Supernates
-
Combining Calcium Phosphates with Polysaccharides: A Bone-Inspired Material Modulating Monocyte/Macrophage Early Inflammatory Response
Authors: H Rammal, C Bour, M Dubus, L Entz, L Aubert, SC Gangloff, S Audonnet, NB Bercu, F Boulmedais, C Mauprivez, H Kerdjoudj
Int J Mol Sci, 2018;19(11):.
Species: Human
Sample Types: Cell Culture Supernates
-
STAG2 deficiency induces interferon responses via cGAS-STING pathway and restricts virus infection
Authors: S Ding, J Diep, N Feng, L Ren, B Li, YS Ooi, X Wang, KF Brulois, LL Yasukawa, X Li, CJ Kuo, DA Solomon, JE Carette, HB Greenberg
Nat Commun, 2018;9(1):1485.
Species: Human
Sample Types: Cell Culture Supernates
-
Epicutaneous administration of the pattern recognition receptor agonist polyinosinic-polycytidylic acid activates the MDA5/MAVS pathway in Langerhans cells
Authors: P Tajpara, C Schuster, E Schön, P Kienzl, M Vierhapper, M Mildner, A Elbe-Bürge
FASEB J., 2018;0(0):fj201701090R.
Species: Human
Sample Types: Cell Culture Supernates
-
SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages
Authors: M Yurchenko, A Skjesol, L Ryan, GM Richard, RK Kandasamy, N Wang, C Terhorst, H Husebye, T Espevik
J. Cell Biol., 2018;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Capture -
The effects of repeated Toll-like receptors 2 and 4 stimulation in COPD alveolar macrophages
Authors: SR Lea, SL Reynolds, M Kaur, KD Simpson, SR Hall, EM Hessel, D Singh
Int J Chron Obstruct Pulmon Dis, 2018;13(0):771-780.
Species: Human
Sample Types: Cell Culture Supernates
-
A low-gluten diet induces changes in the intestinal microbiome of healthy Danish adults
Authors: LBS Hansen, HM Roager, NB Søndertoft, RJ Gøbel, M Kristensen, M Vallès-Col, S Vieira-Sil, S Ibrügger, MV Lind, RB Mærkedahl, MI Bahl, ML Madsen, J Havelund, G Falony, I Tetens, T Nielsen, KH Allin, HL Frandsen, B Hartmann, JJ Holst, MH Sparholt, J Holck, A Blennow, JM Moll, AS Meyer, C Hoppe, JH Poulsen, V Carvalho, D Sagnelli, MD Dalgaard, AF Christense, MC Lydolph, AB Ross, S Villas-Bôa, S Brix, T Sicheritz-, K Buschard, A Linneberg, JJ Rumessen, CT Ekstrøm, C Ritz, K Kristianse, HB Nielsen, H Vestergaar, NJ Færgeman, J Raes, H Frøkiær, T Hansen, L Lauritzen, R Gupta, TR Licht, O Pedersen
Nat Commun, 2018;9(1):4630.
Species: Human
Sample Types: Cell Culture Supernates
-
Effects of agricultural organic dusts on human lung-resident mesenchymal stem (stromal) cell function
Authors: TM Nordgren, KL Bailey, AJ Heires, D Katafiasz, DJ Romberger
Toxicol. Sci., 2018;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Haplosaurus computes protein haplotypes for use in precision drug design
Authors: W Spooner, W McLaren, T Slidel, DK Finch, R Butler, J Campbell, L Eghobamien, D Rider, CM Kiefer, MJ Robinson, C Hardman, F Cunningham, T Vaughan, P Flicek, CC Huntington
Nat Commun, 2018;9(1):4128.
Species: Human
Sample Types: Cell Culture Supernates
-
Streptococcus agalactiae Induces Placental Macrophages To Release Extracellular Traps Loaded with Tissue Remodeling Enzymes via an Oxidative Burst-Dependent Mechanism
Authors: RS Doster, JA Sutton, LM Rogers, DM Aronoff, JA Gaddy
MBio, 2018;9(6):.
Species: Human
Sample Types:
-
Analysis of the association between Fc receptor family gene polymorphisms and ocular Beh�et's disease in Han Chinese
Authors: D Zhang, J Qin, L Li, G Su, G Huang, Q Cao, A Kijlstra, P Yang
Sci Rep, 2018;8(1):4850.
Species: Human
Sample Types: Cell Culture Supernates
-
Association of Long Noncoding RNAs Polymorphisms With Ankylosing Spondylitis, Vogt-Koyanagi-Harada Disease, and Behcet's Disease
Authors: Y Yue, J Zhang, L Yang, S Liu, J Qi, Q Cao, C Zhou, Y Wang, A Kijlstra, P Yang, S Hou
Invest. Ophthalmol. Vis. Sci., 2018;59(2):1158-1166.
Species: Human
Sample Types: Cell Culture Supernates
-
Broad adsorption of sepsis-related PAMP and DAMP molecules, mycotoxins, and cytokines from whole blood using CytoSorb� sorbent porous polymer beads
Authors: MC Gruda, KG Ruggeberg, P O'Sullivan, T Guliashvil, AR Scheirer, TD Golobish, VJ Capponi, PP Chan
PLoS ONE, 2018;13(1):e0191676.
Species: Human
Sample Types: Complex Sample Type
-
Fecal Galectin-3: A New Promising Biomarker for Severity and Progression of Colorectal Carcinoma
Authors: M Jovanovic, N Gajovic, N Zdravkovic, M Jovanovic, M Jurisevic, D Vojvodic, V Maric, A Arsenijevi, I Jovanovic
Mediators Inflamm., 2018;2018(0):8031328.
Species: Human
Sample Types: Feces
-
Comparison of pro- and anti-inflammatory responses in paired human primary airway epithelial cells and alveolar macrophages
Authors: RA Mubarak, N Roberts, RJ Mason, S Alper, HW Chu
Respir. Res., 2018;19(1):126.
Species: Human
Sample Types: Cell Culture Supernates
-
Plasmodium falciparum Treated with Artemisinin-based Combined Therapy Exhibits Enhanced Mutation, Heightened Cortisol and TNF-? Induction
Authors: AO Idowu, S Bhattachar, S Gradus, W Oyibo, Z George, C Black, J Igietseme, AA Azenabor
Int J Med Sci, 2018;15(13):1449-1457.
Species: Human
Sample Types: Plasma
-
Respiratory hazard assessment of combined exposure to complete gasoline exhaust and respirable volcanic ash in a multicellular human lung model at the air-liquid interface
Authors: I Tomašek, CJ Horwell, C Bisig, DE Damby, P Comte, J Czerwinski, A Petri-Fink, MJD Clift, B Drasler, B Rothen-Rut
Environ. Pollut., 2018;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Association of genetic variations in PTPN2 and CD122 with ocular Behcet's disease
Authors: Q Zhang, H Li, S Hou, H Yu, G Su, B Deng, J Qi, C Zhou, A Kijlstra, P Yang
Br J Ophthalmol, 2018;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Allostimulatory capacity of conditionally immortalized proximal tubule cell lines for bioartificial kidney application
Authors: M Mihajlovic, LP van den He, JG Hoenderop, J Jansen, MJ Wilmer, AJF Westheim, WA Allebes, D Stamatiali, LB Hilbrands, R Masereeuw
Sci Rep, 2017;7(1):7103.
Species: Human
Sample Types: Cell Culture Supernates
-
Role of Vitamin D in Maintaining Renal Epithelial Barrier Function in Uremic Conditions
Authors: M Mihajlovic, M Fedecostan, MJ Oost, SKP Steenhuis, EGWM Lentjes, I Maitimu-Sm, MJ Janssen, LB Hilbrands, R Masereeuw
Int J Mol Sci, 2017;18(12):.
Species: Human
Sample Types: Cell Culture Supernates
-
Periodontitis and type 2 diabetes among women with previous gestational diabetes: epidemiological and immunological aspects in a follow-up of three years
Authors: RP Esteves Li, LO Cota, TA Silva, SC Cortelli, JR Cortelli, FO Costa
J Appl Oral Sci, 2017;25(2):130-139.
Species: Human
Sample Types: Saliva
-
Specific Biomarkers Associated With Neurological Complications and Congenital Central Nervous System Abnormalities From Zika Virus-Infected Patients in Brazil
Authors: YW Kam, JA Leite, FM Lum, JJL Tan, B Lee, CC Judice, DAT Teixeira, R Andreata-S, MA Vinolo, R Angerami, MR Resende, ARR Freitas, E Amaral, RP Junior, ML Costa, JP Guida, CW Arns, LCS Ferreira, L Rénia, JL Proença-Mo, LFP Ng, FTM Costa,
J. Infect. Dis., 2017;216(2):172-181.
Species: Human
Sample Types: Serum
-
Changes in peripheral immune cell numbers and functions in octogenarian walkers - an acute exercise study
Authors: KS van der Ge, Q Wang, TM Eijsvogels, HJ Koenen, I Joosten, E Brouwer, MT Hopman, JF Jacobs, AM Boots
Immun Ageing, 2017;14(0):5.
Species: Human
Sample Types: Cell Culture Supernates
-
Associations between TNFSF4, TNFSF8 and TNFSF15 and Beh�et's disease but not VKH syndrome in Han Chinese
Authors: Y Jiang, L Cheng, X Li, W Zhou, L Zhang
Oncotarget, 2017;8(62):105037-105046.
Species: Human
Sample Types: Cell Culture Supernates
-
Immunoregulatory Activity of the Natural Product Laminarin Varies Widely as a Result of Its Physical Properties
Authors: AJ Smith, B Graves, R Child, PJ Rice, Z Ma, DW Lowman, HE Ensley, KT Ryter, JT Evans, DL Williams
J. Immunol., 2017;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
CLEC5A is a critical receptor in innate immunity against Listeria infection
Authors: ST Chen, FJ Li, TY Hsu, SM Liang, YC Yeh, WY Liao, TY Chou, NJ Chen, M Hsiao, WB Yang, SL Hsieh
Nat Commun, 2017;8(1):299.
Species: Human
Sample Types: Cell Culture Supernates
-
TSG-6 Downregulates IFN-Alpha and TNF-Alpha Expression by Suppressing IRF7 Phosphorylation in Human Plasmacytoid Dendritic Cells
Authors: L Kui, GC Chan, PP Lee
Mediators Inflamm., 2017;2017(0):7462945.
Species: Human
Sample Types: Cell Culture Supernates
-
Does Transcranial Direct Current Stimulation Combined with Peripheral Electrical Stimulation Have an Additive Effect in the Control of Hip Joint Osteonecrosis Pain Associated with Sickle Cell Disease? A Protocol for a One-Session Double Blind, Block-Randomized Clinical Trial
Authors: TDS Lopes, WDS Silva, SB Ribeiro, CA Figueiredo, FQ Campbell, GC Daltro, A Valenzuela, P Montoya, RCS Lucena, AF Baptista
Front Hum Neurosci, 2017;11(0):633.
Species: Human
Sample Types: Serum
-
Cross-Tissue Transcriptomic Analysis of Human Secondary Lymphoid Organ-Residing ILC3s Reveals a Quiescent State in the Absence of Inflammation
Authors: YE Bar-Ephrai, F Cornelisse, N Papazian, T Konijn, RM Hoogenboez, MA Sanders, BA Westerman, M Gönültas, J Kwekkeboom, JMM Den Haan, RM Reijmers, RE Mebius, T Cupedo
Cell Rep, 2017;21(3):823-833.
Species: Human
Sample Types: Cell Culture Supernates
-
Dexamethasone induced inhibition of Dectin-1 activation of antigen presenting cells is mediated via STAT-3 and NF-?B signaling pathways.
Authors: Philipp Kotthoff, Annkristin Heine, Stefanie Andrea Erika Held, Peter Brossart
Scientific Reports, 2017;0(0):2045-2322.
Species: Human
Sample Types: Cell Culture Supernates
-
Effect of pre-emptive analgesia on clinical parameters and tissue levels of TNF-? and IL-1? in third molar surgery: a triple-blind, randomized, placebo-controlled study
Authors: AFM Albuquerqu, CSR Fonteles, DR do Val, HV Chaves, MM Bezerra, KMA Pereira, PG de Barros, BB de Lima, ECS Soares, TR Ribeiro, FWG Costa
Int J Oral Maxillofac Surg, 2017;0(0):.
Species: Human
Sample Types: Tissue Homogenates
-
On the cytokine/chemokine network during Plasmodium vivax malaria: new insights to understand the disease
Authors: NS Hojo-Souza, DB Pereira, FS de Souza, TA de Oliveir, MS Cardoso, MS Tada, GM Zanini, DC Bartholome, RT Fujiwara, LL Bueno
Malar. J, 2017;16(1):42.
Species: Human
Sample Types: Plasma
-
TB lymphadenitis is associated with enhanced baseline and antigen - specific induction of Type 1 and Type 17 cytokines and reduced IL-1? and IL-18 at the site of infection
Authors: GR Kathamuthu, K Moideen, D Baskaran, VV Banurekha, D Nair, G Sekar, R Sridhar, B Vidyajayan, G Gajendrara, DK Parandhama, A Srinivasan, S Babu
Clin. Vaccine Immunol, 2017;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Minocycline modulates NF?B phosphorylation and enhances antimicrobial activity against Staphylococcus aureus in mesenchymal stromal/stem cells
Authors: AD Guerra, WE Rose, P Hematti, WJ Kao
Stem Cell Res Ther, 2017;8(1):171.
Species: Human
Sample Types: Cell Culture Supernates
-
Neutrophil Extracellular Traps Reprogram IL-4/GM-CSF-Induced Monocyte Differentiation to Anti-inflammatory Macrophages
Authors: AB Guimarães-, NC Rochael, F Oliveira, J Echevarria, EM Saraiva
Front Immunol, 2017;8(0):523.
Species: Human
Sample Types: Cell Culture Supernates
-
Increased expression of Siglec-9 in chronic obstructive pulmonary disease
Authors: Z Zeng, M Li, M Wang, X Wu, Q Li, Q Ning, J Zhao, Y Xu, J Xie
Sci Rep, 2017;7(1):10116.
Species: Human
Sample Types: Cell Culture Supernates
-
Pre- and post-surgical evaluation of the inflammatory response in patients with aortic stenosis treated with different types of prosthesis
Authors: ME Soto, JL Salas, J Vargas-Bar, R Marquez, A Rodriguez-, R Bojalil-Pa, I Pérez-Torr, V Guarner-La
BMC Cardiovasc Disord, 2017;17(1):100.
Species: Human
Sample Types: Serum
-
Altered distribution of peripheral blood dendritic cell subsets in patients with pulmonary paracoccidioidomycosis
Authors: J Venturini, RS Cavalcante, DV Moris, M de Assis G, AD Levorato, KH Dos Reis, MSP de Arruda, RP Mendes
Acta Trop., 2017;0(0):.
Species: Human
Sample Types: Serum
-
SP and IL-33 together markedly enhance TNF synthesis and secretion from human mast cells mediated by the interaction of their receptors
Authors: A Taracanova, M Alevizos, A Karagkouni, Z Weng, E Norwitz, P Conti, SE Leeman, TC Theoharide
Proc. Natl. Acad. Sci. U.S.A., 2017;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5
Authors: AS Gilbert, PI Seoane, P Sephton-Cl, A Bojarczuk, R Hotham, E Giurisato, AR Sarhan, A Hillen, GV Velde, NS Gray, DR Alessi, DL Cunningham, C Tournier, SA Johnston, RC May
Sci Adv, 2017;3(8):e1700898.
Species: Human
Sample Types: Cell Culture Supernates
-
Assessment of long-term cultivated human precision-cut lung slices as an ex vivo system for evaluation of chronic cytotoxicity and functionality
Authors: V Neuhaus, D Schaudien, T Golovina, UA Temann, C Thompson, T Lippmann, C Bersch, O Pfennig, D Jonigk, P Braubach, HG Fieguth, G Warnecke, V Yusibov, K Sewald, A Braun
J Occup Med Toxicol, 2017;12(0):13.
Species: Human
Sample Types: Cell Culture Supernates
-
Vitamin D both facilitates and attenuates the cellular response to lipopolysaccharide
Authors: L Chen, MS Eapen, GR Zosky
Sci Rep, 2017;7(0):45172.
Species: Human
Sample Types: Cell Culture Supernates
-
Analgesic and anti-inflammatory properties of novel, selective, and potent EP4 receptor antagonists
Authors: S Chandrasek, XP Yu, AK Harvey, JL Oskins, C Lin, X Wang, MJ Blanco, MJ Fisher, SL Kuklish, MA Schiffler, T Vetman, AM Warshawsky, JS York, AM Bendele, MG Chambers
Pharmacol Res Perspect, 2017;5(3):e00316.
Species: Human
Sample Types: Plasma
-
IL-18/IL-15/IL-12 synergy induces elevated and prolonged IFN-? production by ex vivo expanded NK cells which is not due to enhanced STAT4 activation
Authors: E Lusty, SM Poznanski, K Kwofie, TS Mandur, DA Lee, CD Richards, AA Ashkar
Mol. Immunol., 2017;88(0):138-147.
Species: Human
Sample Types: Cell Culture Supernates
-
Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro
Authors: E Redondo-Ca, C Cunningham, J Miller, L Martuscell, S Aoulad-Ali, NJ Rothwell, CM Kielty, SM Allan, E Pinteaux
Stem Cell Res Ther, 2017;8(1):79.
Species: Human
Sample Types: Cell Culture Supernates
-
Temperature responsive porous silicon nanoparticles for cancer therapy - spatiotemporal triggering through infrared and radiofrequency electromagnetic heating
J Control Release, 2016;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
?-Glucan Reverses the Epigenetic State of LPS-Induced Immunological Tolerance
Authors: Hendrik G Stunnenber
Cell, 2016;167(5):1354-1368.e14.
Species: Human
Sample Types: Cell Culture Supernates
-
New Anti-Inflammatory Metabolites by Microbial Transformation of Medrysone
Authors: S Bano, AT Wahab, S Yousuf, A Jabeen, MA Mesaik, AU Rahman, MI Choudhary
PLoS ONE, 2016;11(4):e0153951.
Species: Human
Sample Types: Cell Culture Supernates
-
Stromal fibroblasts support dendritic cells to maintain IL-23/Th17 responses after exposure to ionizing radiation
Authors: A Malecka, Q Wang, S Shah, RV Sutavani, I Spendlove, JM Ramage, J Greensmith, HA Franks, MJ Gough, A Saalbach, PM Patel, AM Jackson
J Leukoc Biol, 2016;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Reduced systemic and mycobacterial antigen-stimulated concentrations of IL-1? and IL-18 in tuberculous lymphadenitis
Cytokine, 2016;90(0):66-72.
Species: Human
Sample Types: Cell Culture Supernates
-
17-oxo-DHA displays additive anti-inflammatory effects with fluticasone propionate and inhibits the NLRP3 inflammasome
Sci Rep, 2016;6(0):37625.
Species: Human
Sample Types: Cell Culture Supernates
-
CD16 is indispensable for antibody-dependent cellular cytotoxicity by human monocytes
Sci Rep, 2016;6(0):34310.
Species: Human
Sample Types: Whole Cells
-
Soluble alpha-enolase activates monocytes by CD14-dependent TLR4 signalling pathway and exhibits a dual function
Authors: C Guillou, M Fréret, E Fondard, C Derambure, G Avenel, ML Golinski, M Verdet, O Boyer, F Caillot, P Musette, T Lequerré, O Vittecoq
Sci Rep, 2016;6(0):23796.
Species: Human
Sample Types: Cell Culture Supernates
-
Serum from Varicose Patients Induces Senescence-Related Dysfunction of Vascular Endothelium Generating Local and Systemic Proinflammatory Conditions
Oxid Med Cell Longev, 2016;2016(0):2069290.
Species: Human
Sample Types: Serum
-
Analysis of receptor tyrosine kinase genetics identifies two novel risk loci in GAS6 and PROS1 in Beh�et's disease
Sci Rep, 2016;6(0):26662.
Species: Human
Sample Types: Cell Culture Supernates
-
Bortezomib treatment sensitizes oncolytic HSV-1 treated tumors to NK cell immunotherapy
Clin Cancer Res, 2016;0(0):.
Species: Mouse
Sample Types: Serum
-
Rational design of a Kv1.3 channel-blocking antibody as a selective immunosuppressant
Proc Natl Acad Sci USA, 2016;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Characterization of the MMP/TIMP Imbalance and Collagen Production Induced by IL-1? or TNF-? Release from Human Hepatic Stellate Cells
Authors: S Robert, T Gicquel, A Bodin, V Lagente, E Boichot
PLoS ONE, 2016;11(4):e0153118.
Species: Human
Sample Types: Cell Culture Supernates
-
vIL-10-overexpressing human MSCs modulate na�ve and activated T lymphocytes following induction of collagenase-induced osteoarthritis
Stem Cell Res Ther, 2016;7(1):74.
Species: Human
Sample Types: Cell Culture Supernates
-
Activated monocytes resist elimination by retinal pigment epithelium and downregulate their OTX2 expression via TNF-?
Aging Cell, 2016;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Amyloid precursor protein mediated changes in intestinal epithelial phenotype in vitro.
Authors: Puig K, Manocha G, Combs C
PLoS ONE, 2016;10(3):e0119534.
Species: Human
Sample Types: Cell Culture Supernates
-
Combined exposure of diesel exhaust particles and respirable Soufri�re Hills volcanic ash causes a (pro-)inflammatory response in an in vitro multicellular epithelial tissue barrier model
Authors: Ines Tomašek
Part Fibre Toxicol, 2016;13(1):67.
Species: Human
Sample Types: Cell Culture Supernates
-
DHA-derived oxylipins, neuroprostanes and protectins, differentially and dose-dependently modulate the inflammatory response in human macrophages: putative mechanisms through PPAR activation
Authors: Rémy Bosviel
Free Radic. Biol. Med, 2016;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Genetic polymorphisms of cell adhesion molecules in Behcet's disease in a Chinese Han population
Authors: M Zheng, L Zhang, H Yu, J Hu, Q Cao, G Huang, Y Huang, G Yuan, A Kijlstra, P Yang
Sci Rep, 2016;6(0):24974.
Species: Human
Sample Types: Cell Culture Supernates
-
Biocompatibility of primers and an adhesive used for implant-retained maxillofacial prostheses: An in�vitro analysis
Authors: Daniela Micheline Dos Santos
J Prosthet Dent, 2016;0(0):.
-
MODELING STROMA-INDUCED DRUG RESISTANCE IN A TISSUE-ENGINEERED TUMOR MODEL OF EWING SARCOMA
Authors: Marco Santoro
Tissue Eng Part A, 2016;0(0):.
Species: Human
Sample Types: Cell Culture Supernates
-
Engineered CAR T Cells Targeting the Cancer-Associated Tn-Glycoform of the Membrane Mucin MUC1 Control Adenocarcinoma
Authors: Avery D Posey
Immunity, 2016;44(6):1444-54.
Species: Human
Sample Types: Cell Culture Supernates
-
CD36-Mediated Uptake of Surfactant Lipids by Human Macrophages Promotes Intracellular Growth of Mycobacterium tuberculosis
J. Immunol., 2016;197(12):4727-4735.
Species: Human
Sample Types: Cell Culture Supernates
-
Differential IL-1? secretion by monocyte subsets is regulated by Hsp27 through modulating mRNA stability
Sci Rep, 2016;6(0):39035.
Species: Human
Sample Types: Cell Culture Supernates
-
Exposure to diesel exhaust particle extracts (DEPe) impairs some polarization markers and functions of human macrophages through activation of AhR and Nrf2.
Authors: Jaguin M, Fardel O, Lecureur V
PLoS ONE, 2015;10(2):e0116560.
Species: Human
Sample Types: Cell Culture Supernates
-
Macrophage activation in acute exacerbation of idiopathic pulmonary fibrosis.
Authors: Schupp J, Binder H, Jager B, Cillis G, Zissel G, Muller-Quernheim J, Prasse A
PLoS ONE, 2015;10(1):e0116775.
Species: Human
Sample Types: BALF
-
Interleukin-23 Receptor Gene Polymorphism May Enhance Expression of the IL-23 Receptor, IL-17, TNF-alpha and IL-6 in Behcet's Disease.
Authors: Jiang Z, Hennein L, Tao Y, Tao L
PLoS ONE, 2015;10(7):e0134632.
Species: Human
Sample Types: Cell Culture Supernates
-
Phagocytosis-dependent activation of a TLR9-BTK-calcineurin-NFAT pathway co-ordinates innate immunity to Aspergillus fumigatus.
Authors: Herbst S, Shah A, Mazon Moya M, Marzola V, Jensen B, Reed A, Birrell M, Saijo S, Mostowy S, Shaunak S, Armstrong-James D
EMBO Mol Med, 2015;7(3):240-58.
Species: Human
Sample Types: Cell Culture Supernates
-
Innate immune response to Streptococcus pyogenes depends on the combined activation of TLR13 and TLR2.
Authors: Fieber C, Janos M, Koestler T, Gratz N, Li X, Castiglia V, Aberle M, Sauert M, Wegner M, Alexopoulou L, Kirschning C, Chen Z, von Haeseler A, Kovarik P
PLoS ONE, 2015;10(3):e0119727.
Species: Human
Sample Types: Cell Culture Supernates
-
Vpr Enhances Tumor Necrosis Factor Production by HIV-1-Infected T Cells.
Authors: Roesch F, Richard L, Rua R, Porrot F, Casartelli N, Schwartz O
J Virol, 2015;89(23):12118-30.
Species: Human
Sample Types: Cell Culture Supernates
-
Characterization of host and microbial determinants in individuals with latent tuberculosis infection using a human granuloma model.
Authors: Guirado E, Mbawuike U, Keiser T, Arcos J, Azad A, Wang S, Schlesinger L
MBio, 2015;6(1):e02537-14.
Species: Human
Sample Types: Cell Culture Supernates
-
SRSF1 facilitates cytosolic DNA-induced production of type I interferons recognized by RIG-I.
Authors: Xue F, Li X, Zhao X, Wang L, Liu M, Shi R, Zheng J
PLoS ONE, 2015;10(2):e0115354.
Species: Human
Sample Types: Cell Culture Supernates
-
Sensor Function for Butyrophilin 3A1 in Prenyl Pyrophosphate Stimulation of Human Vgamma2Vdelta2 T Cells.
Authors: Wang H, Morita C
J Immunol, 2015;195(10):4583-94.
Species: Human
Sample Types: Cell Culture Supernates
-
In vitro progesterone modulation on bacterial endotoxin-induced production of IL-1beta, TNFalpha, IL-6, IL-8, IL-10, MIP-1alpha, and MMP-9 in pre-labor human term placenta.
Authors: Garcia-Ruiz G, Flores-Espinosa P, Preciado-Martinez E, Bermejo-Martinez L, Espejel-Nunez A, Estrada-Gutierrez G, Maida-Claros R, Flores-Pliego A, Zaga-Clavellina V
Reprod Biol Endocrinol, 2015;13(0):115.
Species: Human
Sample Types: Cell Culture Supernates
-
An Autocrine Cytokine/JAK/STAT-Signaling Induces Kynurenine Synthesis in Multidrug Resistant Human Cancer Cells.
Authors: Campia I, Buondonno I, Castella B, Rolando B, Kopecka J, Gazzano E, Ghigo D, Riganti C
PLoS ONE, 2015;10(5):e0126159.
Species: Human
Sample Types: Cell Culture Supernates
-
Phenotypic profiling of CD8(+) T cells during Plasmodium vivax blood-stage infection.
Authors: Hojo-Souza N, Pereira D, Passos L, Gazzinelli-Guimaraes P, Cardoso M, Tada M, Zanini G, Bartholomeu D, Fujiwara R, Bueno L
BMC Infect Dis, 2015;15(0):35.
Species: Human
Sample Types: Plasma
-
Sourcing of an alternative pericyte-like cell type from peripheral blood in clinically relevant numbers for therapeutic angiogenic applications.
Authors: Blocki A, Wang Y, Koch M, Goralczyk A, Beyer S, Agarwal N, Lee M, Moonshi S, Dewavrin J, Peh P, Schwarz H, Bhakoo K, Raghunath M
Mol Ther, 2015;23(3):510-22.
Species: Human
Sample Types: Cell Culture Supernates
-
Transcriptomic Analyses of the Biological Effects of Airborne PM2.5 Exposure on Human Bronchial Epithelial Cells.
Authors: Zhou Z, Liu Y, Duan F, Qin M, Wu F, Sheng W, Yang L, Liu J, He K
PLoS ONE, 2015;10(9):e0138267.
Species: Human
Sample Types: Cell Culture Supernates
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Smac mimetics and innate immune stimuli synergize to promote tumor death.
Authors: Beug S, Tang V, Lacasse E, Cheung H, Beauregard C, Brun J, Nuyens J, Earl N, St-Jean M, Holbrook J, Dastidar H, Mahoney D, Ilkow C, Le Boeuf F, Bell J, Korneluk R
Nat Biotechnol, 2014;32(2):182-90.
Species: Human
Sample Types: Cell Culture Supernates
-
Engagement of SLAMF2/CD48 prolongs the time frame of effective T cell activation by supporting mature dendritic cell survival.
Authors: Kis-Toth K, Tsokos G
J Immunol, 2014;192(9):4436-42.
Species: Human
Sample Types: Cell Culture Supernates
-
Neisseria gonorrhoeae modulates iron-limiting innate immune defenses in macrophages.
Authors: Zughaier, Susu M, Kandler, Justin L, Shafer, William
PLoS ONE, 2014;9(1):e87688.
Species: Human
Sample Types: Cell Culture Supernates
-
The small GTPase Arf6 is essential for the Tram/Trif pathway in TLR4 signaling.
Authors: Van Acker T, Eyckerman S, Vande Walle L, Gerlo S, Goethals M, Lamkanfi M, Bovijn C, Tavernier J, Peelman F
J Biol Chem, 2014;289(3):1364-76.
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The aryl hydrocarbon receptor is functionally upregulated early in the course ofvhuman T-cell activation.
Authors: Prigent L, Robineau M, Jouneau S, Morzadec C, Louarn L, Vernhet L, Fardel O, Sparfel L
Eur J Immunol, 2014;44(5):1330-40.
Species: Human
Sample Types: Cell Culture Supernates
-
Anti-inflammatory effects of green soybean extract irradiated with visible light.
Authors: Tanaka K, Ohgo Y, Katayanagi Y, Yasui K, Hiramoto S, Ikemoto H, Nakata Y, Miyoshi N, Isemura M, Ohashi N, Imai S
Sci Rep, 2014;4(0):4732.
Species: Human
Sample Types: Cell Culture Supernates
-
A functional variant of PTPN22 confers risk for Vogt-Koyanagi-Harada syndrome but not for ankylosing spondylitis.
Authors: Zhang Q, Qi J, Hou S, DU L, Yu H, Cao Q, Zhou Y, Liao D, Kijlstra A, Yang P
PLoS ONE, 2014;9(5):e96943.
Species: Human
Sample Types: Cell Culture Supernates
-
CD137 ligand signalling induces differentiation of primary acute myeloid leukaemia cells.
Authors: Cheng K, Wong S, Linn Y, Ho L, Chng W, Schwarz H
Br J Haematol, 2014;165(1):134-44.
Species: Human
Sample Types: Cell Culture Supernates
-
TRAF5 and TRAF3IP2 gene polymorphisms are associated with Behcet's disease and Vogt-Koyanagi-Harada syndrome: a case-control study.
Authors: Xiang Q, Chen L, Hou S, Fang J, Zhou Y, Bai L, Liu Y, Kijlstra A, Yang P
PLoS ONE, 2014;9(1):e84214.
Species: Human
Sample Types: Cell Culture Supernates
-
Identification of the flagellin glycosylation system in Burkholderia cenocepacia and the contribution of glycosylated flagellin to evasion of human innate immune responses.
Authors: Hanuszkiewicz A, Pittock P, Humphries F, Moll H, Rosales A, Molinaro A, Moynagh P, Lajoie G, Valvano M
J Biol Chem, 2014;289(27):19231-44.
Species: Human
Sample Types: Cell Culture Supernates
-
Immunoepidemiological profiling of onchocerciasis patients reveals associations with microfilaria loads and ivermectin intake on both individual and community levels.
Authors: Arndts, Kathrin, Specht, Sabine, Debrah, Alexande, Tamarozzi, Francesc, Klarmann Schulz, Ute, Mand, Sabine, Batsa, Linda, Kwarteng, Alexande, Taylor, Mark, Adjei, Ohene, Martin, Coralie, Layland, Laura E, Hoerauf, Achim
PLoS Negl Trop Dis, 2014;8(2):e2679.
Species: Human
Sample Types: Cell Culture Supernates
-
Activin A as a mediator of NK-dendritic cell functional interactions.
Authors: Seeger P, Bosisio D, Parolini S, Badolato R, Gismondi A, Santoni A, Sozzani S
J Immunol, 2014;192(3):1241-8.
Species: Human
Sample Types: Cell Culture Supernates
-
Separately or combined, LukG/LukH is functionally unique compared to other staphylococcal bicomponent leukotoxins.
Authors: Yanai M, Rocha M, Matolek A, Chintalacharuvu A, Taira Y, Chintalacharuvu K, Beenhouwer D
PLoS ONE, 2014;9(2):e89308.
Species: Human
Sample Types: Cell Culture Supernates
-
Technical advance: live-imaging analysis of human dendritic cell migrating behavior under the influence of immune-stimulating reagents in an organotypic model of lung.
Authors: Nguyen Hoang A, Chen P, Bjornfot S, Hogstrand K, Lock J, Grandien A, Coles M, Svensson M
J Leukoc Biol, 2014;96(3):481-9.
Species: Human
Sample Types: Cell Culture Supernates
-
Increased prevalence of Methanosphaera stadtmanae in inflammatory bowel diseases.
Authors: Blais Lecours P, Marsolais D, Cormier Y, Berberi M, Hache C, Bourdages R, Duchaine C
PLoS ONE, 2014;9(2):e87734.
Species: Human
Sample Types: Cell Culture Supernates
-
Activated factor X signaling via protease-activated receptor 2 suppresses pro-inflammatory cytokine production from lipopolysaccharide-stimulated myeloid cells.
Authors: Gleeson E, O'Donnell J, Hams E, Ni Ainle F, Kenny B, Fallon P, Preston R
Haematologica, 2014;99(1):185-93.
Species: Human
Sample Types: Cell Culture Supernates
-
Low adiposity during early infancy is associated with a low risk for developing dengue hemorrhagic fever: a preliminary model.
Authors: Libraty D, Zhang L, Woda M, Giaya K, Kathivu C, Acosta L, Tallo V, Segubre-Mercado E, Bautista A, Obcena A, Brion J, Capeding R
PLoS ONE, 2014;9(2):e88944.
Species: Human
Sample Types: Cell Culture Supernates
-
Linkage of inflammation and oxidative stress via release of glutathionylated peroxiredoxin-2, which acts as a danger signal.
Authors: Salzano S, Checconi P, Hanschmann E, Lillig C, Bowler L, Chan P, Vaudry D, Mengozzi M, Coppo L, Sacre S, Atkuri K, Sahaf B, Herzenberg L, Herzenberg L, Mullen L, Ghezzi P
Proc Natl Acad Sci U S A, 2014;111(33):12157-62.
Species: Mouse
Sample Types: Cell Culture Supernates
-
Glycosylation in a mammalian expression system is critical for the production of functionally active leukocyte immunoglobulin-like receptor A3 protein.
Authors: Lee T, Mitchell A, Liu Lau S, An H, Rajeaskariah P, Wasinger V, Raftery M, Bryant K, Tedla N
J Biol Chem, 2013;288(46):32873-85.
Species: Human
Sample Types: Cell Culture Supernates
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Survey of innate immune responses to Burkholderia pseudomallei in human blood identifies a central role for lipopolysaccharide.
Authors: Chantratita N, Tandhavanant S, Myers N, Seal S, Arayawichanont A, Kliangsa-Ad A, Hittle L, Ernst R, Emond M, Wurfel M, Day N, Peacock S, West T
PLoS ONE, 2013;8(11):e81617.
Species: Human
Sample Types: Cell Culture Supernates
-
Identification of binding sites for myeloid differentiation primary response gene 88 (MyD88) and Toll-like receptor 4 in MyD88 adapter-like (Mal).
Authors: Bovijn C, Desmet A, Uyttendaele I, Van Acker T, Tavernier J, Peelman F
J Biol Chem, 2013;288(17):12054-66.
Species: Human
Sample Types: Cell Culture Supernates
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Tumor necrosis factor receptor 1 associates with CD137 ligand and mediates its reverse signaling.
Authors: Moh M, Lorenzini P, Gullo C, Schwarz H
FASEB J, 2013;27(8):2957-66.
Species: Human
Sample Types: Cell Culture Supernates
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S100A12 suppresses pro-inflammatory, but not pro-thrombotic functions of serum amyloid A.
Authors: Chung Y, Goyette J, Tedla N, Hsu K, Geczy C
PLoS ONE, 2013;8(4):e62372.
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Association of TLR2 gene polymorphisms with ocular Behcet's disease in a Chinese Han population.
Authors: Fang J, Hu R, Hou S, Ye Z, Xiang Q, Qi J, Zhou Y, Kijlstra A, Yang P
Invest Ophthalmol Vis Sci, 2013;54(13):8384-92.
Species: Human
Sample Types: Cell Culture Supernates
-
Effects of high-dose cholecalciferol on serum markers of inflammation and immunity in patients with early chronic kidney disease.
Authors: Alvarez J, Zughaier S, Law J, Hao L, Wasse H, Ziegler T, Tangpricha V
Eur J Clin Nutr, 2013;67(3):264-9.
Species: Human
Sample Types: Serum
-
Thrombin-cleaved fragments of osteopontin are overexpressed in malignant glial tumors and provide a molecular niche with survival advantage.
Authors: Yamaguchi Y, Shao Z, Sharif S, Du X, Myles T, Merchant M, Harsh G, Glantz M, Recht L, Morser J, Leung L
J Biol Chem, 2013;288(5):3097-111.
Species: Human
Sample Types: CSF
-
Fcgamma receptor-induced soluble vascular endothelial growth factor receptor-1 (VEGFR-1) production inhibits angiogenesis and enhances efficacy of anti-tumor antibodies.
Authors: Justiniano S, Elavazhagan S, Fatehchand K, Shah P, Mehta P, Roda J, Mo X, Cheney C, Hertlein E, Eubank T, Marsh C, Muthusamy N, Butchar J, Byrd J, Tridandapani S
J Biol Chem, 2013;288(37):26800-9.
Species: Human
Sample Types: Cell Culture Supernates
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Leptin up-regulates TLR2 in human monocytes.
Authors: Jaedicke K, Roythorne A, Padget K, Todryk S, Preshaw P, Taylor J
J Leukoc Biol, 2013;93(4):561-71.
Species: Human
Sample Types: Cell Culture Supernates
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Human neutrophil peptide-1 (HNP-1): a new anti-leishmanial drug candidate.
Authors: Dabirian S, Taslimi Y, Zahedifard F, Gholami E, Doustdari F, Motamedirad M, Khatami S, Azadmanesh K, Nylen S, Rafati S
PLoS Negl Trop Dis, 2013;7(10):e2491.
Species: Human
Sample Types: Cell Culture Supernates
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Trappin-2/elafin modulate innate immune responses of human endometrial epithelial cells to PolyI:C.
Authors: Drannik AG, Nag K, Yao XD, Henrick BM, Sallenave JM, Rosenthal KL
PLoS ONE, 2012;7(4):e35866.
Species: Human
Sample Types: Cell Culture Supernates
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Age-related changes in expression and function of Toll-like receptors in human skin.
Authors: Iram N, Mildner M, Prior M, Petzelbauer P, Fiala C, Hacker S, Schoppl A, Tschachler E, Elbe-Burger A
Development, 2012;139(22):4210-9.
Species: Human
Sample Types: Cell Culture Supernates
-
Impact of vitamin D supplementation on markers of inflammation in adults with cystic fibrosis hospitalized for a pulmonary exacerbation.
Eur J Clin Nutr, 2012;66(9):1072-4.
Species: Human
Sample Types: Plasma
-
TRAIL induces necroptosis involving RIPK1/RIPK3-dependent PARP-1 activation.
Authors: Jouan-Lanhouet S, Arshad M, Piquet-Pellorce C, Martin-Chouly C, Le Moigne-Muller G, Van Herreweghe F, Takahashi N, Sergent O, Lagadic-Gossmann D, Vandenabeele P, Samson M, Dimanche-Boitrel M
Cell Death Differ, 2012;19(12):2003-14.
Species: Human
Sample Types: Cell Culture Supernates
-
Transglutaminase is essential for IgA nephropathy development acting through IgA receptors.
Authors: Berthelot L, Papista C, Maciel TT, Biarnes-Pelicot M, Tissandie E, Wang PH, Tamouza H, Jamin A, Bex-Coudrat J, Gestin A, Boumediene A, Arcos-Fajardo M, England P, Pillebout E, Walker F, Daugas E, Vrtosvnik F, Flamant M, Benhamou M, Cogne M, Moura IC, Monteiro RC
J. Exp. Med., 2012;209(4):793-806.
Species: Human
Sample Types: Cell Culture Supernates
-
Characterization and function of the human macrophage dopaminergic system: implications for CNS disease and drug abuse.
J Neuroinflammation, 2012;9(0):203.
Species: Human
Sample Types: Cell Culture Supernates
-
Regulation of progranulin expression in human microglia and proteolysis of progranulin by matrix metalloproteinase-12 (MMP-12).
Authors: Suh HS, Choi N, Tarassishin L, Lee SC
PLoS ONE, 2012;7(4):e35115.
Species: Human
Sample Types: Cell Culture Supernates
-
Anti-Tumour Effects of a Specific Anti-ADAM17 Antibody in an Ovarian Cancer Model In Vivo.
Authors: Richards FM, Tape CJ, Jodrell DI, Murphy G
PLoS ONE, 2012;7(7):e40597.
Species: Human
Sample Types: Tissue Homogenates
-
Elevated adaptive immune responses are associated with latent infections of Wuchereria bancrofti.
Authors: Arndts K, Deininger S, Specht S, Klarmann U, Mand S, Adjobimey T, Debrah AY, Batsa L, Kwarteng A, Epp C, Taylor M, Adjei O, Layland LE, Hoerauf A
PLoS Negl Trop Dis, 2012;6(4):e1611.
Species: Human
Sample Types: Cell Culture Supernates
-
Monocytic microparticles activate endothelial cells in an IL-1{beta}-dependent manner.
Authors: Wang JG, Williams JC, Davis BK, Jacobson K, Doerschuk CM, Ting JP, Mackman N
Blood, 2011;118(8):2366-74.
Species: Human
Sample Types: Cell Lysates
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Inhibition of IL-32 activation by alpha-1 antitrypsin suppresses alloreactivity and increases survival in an allogeneic murine marrow transplantation model.
Authors: Marcondes AM, Li X, Tabellini L, Bartenstein M, Kabacka J, Sale GE, Hansen JA, Dinarello CA, Deeg HJ
Blood, 2011;118(18):5031-9.
Species: Human
Sample Types: Cell Culture Supernates
-
Adipokine resistin predicts anti-inflammatory effect of glucocorticoids in asthma.
Authors: Leivo-Korpela S, Lehtimaki L, Vuolteenaho K, Nieminen R, Kankaanranta H, Saarelainen S, Moilanen E
J Inflamm (Lond), 2011;8(0):12.
Species: Human
Sample Types: Cell Culture Supernates
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Increased secretion of Gas6 by smooth muscle cells in human atherosclerotic carotid plaques.
Authors: Clauser S, Meilhac O, Bieche I, Raynal P, Bruneval P, Michel JB, Borgel D
Thromb. Haemost., 2011;107(1):140-9.
Species: Human
Sample Types: Cell Culture Supernates
-
Plasma levels of procalcitonin and eight additional inflammatory molecules in febrile neutropenic patients.
Authors: Neuenschwander LC, Bittencourt H, Ribeiro AF, Teixeira AL, Teixeira MM, Teixeira JC, Nobre V
Clinics (Sao Paulo), 2011;66(10):1699-705.
Species: Human
Sample Types: Plasma
-
Reactive oxygen species-independent activation of the IL-1beta inflammasome in cells from patients with chronic granulomatous disease.
Authors: van de Veerdonk FL, Smeekens SP, Joosten LA, Kullberg BJ, Dinarello CA, Van der Meer JW, Netea MG
Proc. Natl. Acad. Sci. U.S.A., 2010;107(7):3030-3.
Species: Human
Sample Types: Cell Culture Supernates
-
Activation of platelets by Aspergillus fumigatus and potential role of platelets in the immunopathogenesis of Aspergillosis.
Authors: Rodland EK, Ueland T, Pedersen TM, Halvorsen B, Muller F, Aukrust P, Froland SS
Infect. Immun., 2010;78(3):1269-75.
Species: Human
Sample Types: Cell Culture Supernates
-
KR-003048, a potent, orally active inhibitor of p38 mitogen-activated protein kinase.
Authors: Montalban AG, Boman E, Chang CD, Ceide SC, Dahl R, Dalesandro D, Delaet NG, Erb E, Ernst J, Gibbs A, Kahl J, Kessler L, Lundstrom J, Miller S, Nakanishi H, Roberts E, Saiah E, Sullivan R, Wang Z, Larson CJ
Eur. J. Pharmacol., 2010;632(1):93-102.
Species: Human
Sample Types: Cell Culture Supernates
-
IL-17 amplifies human contact hypersensitivity by licensing hapten nonspecific Th1 cells to kill autologous keratinocytes.
Authors: Pennino D, Eyerich K, Scarponi C, Carbone T, Eyerich S, Nasorri F, Garcovich S, Traidl-Hoffmann C, Albanesi C, Cavani A
J. Immunol., 2010;184(9):4880-8.
Species: Human
Sample Types: Cell Culture Supernates
-
The role of RGD-tagged helical rosette nanotubes in the induction of inflammation and apoptosis in human lung adenocarcinoma cells through the P38 MAPK pathway.
Authors: Suri SS, Rakotondradany F, Myles AJ, Fenniri H, Singh B
Biomaterials, 2009;30(17):3084-90.
Species: Human
Sample Types: Cell Culture Supernates
-
Survival and migration of human dendritic cells are regulated by an IFN-alpha-inducible Axl/Gas6 pathway.
Authors: Scutera S, Fraone T, Musso T, Cappello P, Rossi S, Pierobon D, Orinska Z, Paus R, Bulfone-Paus S, Giovarelli M
J. Immunol., 2009;183(5):3004-13.
Species: Human
Sample Types: Cell Culture Supernates
-
Heat shock protein 96 is elevated in rheumatoid arthritis and activates macrophages primarily via TLR2 signaling.
Authors: Huang QQ, Sobkoviak R, Jockheck-Clark AR, Shi B, Mandelin AM, Tak PP, Haines GK, Nicchitta CV, Pope RM
J. Immunol., 2009;182(8):4965-73.
Species: Human
Sample Types: Cell Culture Supernates
-
Interferon-beta treatment in multiple sclerosis attenuates inflammatory gene expression through inducible activity of the phosphatase SHP-1.
Authors: Christophi GP, Panos M, Hudson CA, Tsikkou C, Mihai C, Mejico LJ, Jubelt B, Massa PT
Clin. Immunol., 2009;133(1):27-44.
Species: Human
Sample Types: Plasma
-
Reduced ex vivo interleukin-6 production by dietary fish oil is not modified by linoleic acid intake in healthy men.
Authors: Damsgaard CT, Lauritzen L, Calder PC, Kjaer TR, Frokiaer H
J. Nutr., 2009;139(7):1410-4.
Species: Human
Sample Types: Cell Culture Supernates
-
Helminth antigens modulate immune responses in cells from multiple sclerosis patients through TLR2-dependent mechanisms.
Authors: Correale J, Farez M
J. Immunol., 2009;183(9):5999-6012.
Species: Human
Sample Types: Cell Culture Supernates
-
Helminth infections associated with multiple sclerosis induce regulatory B cells.
Authors: Correale J, Farez M, Razzitte G
Ann. Neurol., 2008;64(2):187-99.
Species: Human
Sample Types: Cell Culture Supernates
-
Impact of tobacco-smoke on key signaling pathways in the innate immune response in lung macrophages.
Authors: Birrell MA, Wong S, Catley MC, Belvisi MG
J. Cell. Physiol., 2008;214(1):27-37.
Species: Human
Sample Types: Cell Culture Supernates
-
Inorganic arsenic activates reduced NADPH oxidase in human primary macrophages through a Rho kinase/p38 kinase pathway.
Authors: Lemarie A, Bourdonnay E, Morzadec C, Fardel O, Vernhet L
J. Immunol., 2008;180(9):6010-7.
Species: Human
Sample Types: Cell Culture Supernates
-
Divergent effects of hypoxia on dendritic cell functions.
Authors: Mancino A, Schioppa T, Larghi P, Pasqualini F, Nebuloni M, Chen IH, Sozzani S, Austyn JM, Mantovani A, Sica A
Blood, 2008;112(9):3723-34.
Species: Human
Sample Types: Cell Culture Supernates
-
Fungal proteases induce Th2 polarization through limited dendritic cell maturation and reduced production of IL-12.
Authors: Lamhamedi-Cherradi SE, Martin RE, Ito T, Kheradmand F, Corry DB, Liu YJ, Moyle M
J. Immunol., 2008;180(9):6000-9.
Species: Human
Sample Types: Cell Culture Supernates
-
Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: implications for chronic inflammation and aging.
Authors: Yang SR, Wright J, Bauter M, Seweryniak K, Kode A, Rahman I
Am. J. Physiol. Lung Cell Mol. Physiol., 2007;292(2):L567-76.
Species: Human
Sample Types: Cell Culture Supernates
-
Early cytokine responses after percutaneous magnetic resonance imaging guided laser thermoablation of malignant liver tumors.
Authors: Kallio R, Sequeiros R, Surcel HM, Ohtonen P, Kiviniemi H, Syrjala H
Cytokine, 2007;34(5):278-83.
Species: Human
Sample Types: Serum
-
Tumor-associated leukemia inhibitory factor and IL-6 skew monocyte differentiation into tumor-associated macrophage-like cells.
Authors: Duluc D, Delneste Y, Tan F, Moles MP, Grimaud L, Lenoir J, Preisser L, Anegon I, Catala L, Ifrah N, Descamps P, Gamelin E, Gascan H, Hebbar M, Jeannin P
Blood, 2007;110(13):4319-30.
Species: Human
Sample Types: Cell Culture Supernates
-
Novel role for the liver X nuclear receptor in the suppression of lung inflammatory responses.
Authors: Birrell MA, Catley MC, Hardaker E, Wong S, Willson TM, McCluskie K, Leonard T, Farrow SN, Collins JL, Haj-Yahia S, Belvisi MG
J. Biol. Chem., 2007;282(44):31882-90.
Species: Human
Sample Types: Cell Culture Supernates
-
Human epithelial cells establish direct antifungal defense through TLR4-mediated signaling.
Authors: Weindl G, Naglik JR, Kaesler S, Biedermann T, Hube B, Korting HC, Schaller M
J. Clin. Invest., 2007;117(12):3664-3672.
Species: Human
Sample Types: Cell Culture Supernates
-
Cytokine response to strenuous exercise in athletes and non-athletes--an adaptive response.
Authors: Gokhale R, Chandrashekara S, Vasanthakumar KC
Cytokine, 2007;40(2):123-7.
Species: Human
Sample Types: Plasma
-
The differential effect of Eriobotrya japonica hydrophilic leaf extract on cytokines production and modulation.
Authors: Matalka KZ, Ali D, Khawad AE, Qa'dan F
Cytokine, 2007;40(3):235-40.
Species: Human
Sample Types: Cell Culture Supernates
-
Bronchial epithelial cell growth regulation in fibroblast cocultures: the role of hepatocyte growth factor.
Authors: Skibinski G, Elborn JS, Ennis M
Am. J. Physiol. Lung Cell Mol. Physiol., 2007;293(1):L69-76.
Species: Human
Sample Types: Cell Culture Supernates
-
Modulation of neonatal microbial recognition: TLR-mediated innate immune responses are specifically and differentially modulated by human milk.
Authors: LeBouder E, Rey-Nores JE, Raby AC, Affolter M, Vidal K, Thornton CA, Labeta MO
J. Immunol., 2006;176(6):3742-52.
Species: Human
Sample Types: Cell Culture Supernates
-
Splice variants of human FOXP3 are functional inhibitors of human CD4+ T-cell activation.
Authors: Smith EL, Finney HM, Nesbitt AM, Ramsdell F, Robinson MK
Immunology, 2006;119(2):203-11.
Species: Human
Sample Types: Cell Culture Supernates
-
A cyanobacterial LPS antagonist prevents endotoxin shock and blocks sustained TLR4 stimulation required for cytokine expression.
Authors: Macagno A, Molteni M, Rinaldi A
J. Exp. Med., 2006;203(6):1481-92.
Species: Human
Sample Types: Cell Culture Supernates
-
Transmission of Mycobacterium tuberculosis undetected by tuberculin skin testing.
Authors: Anderson ST, Williams AJ, Brown JR, Newton SM, Simsova M, Nicol MP, Sebo P, Levin M, Wilkinson RJ, Wilkinson KA
Am. J. Respir. Crit. Care Med., 2006;173(9):1038-42.
Species: Human
Sample Types: Cell Culture Supernates
-
The direct effects of Toll-like receptor ligands on human NK cell cytokine production and cytotoxicity.
Authors: Lauzon NM, Mian F, MacKenzie R, Ashkar AA
Cell. Immunol., 2006;241(2):102-12.
Species: Human
Sample Types: Cell Culture Supernates
-
Dynamic changes of apoptosis-inducing ligands and Th1/Th2 like subpopulations in Hantaan virus-induced hemorrhagic fever with renal syndrome.
Authors: Liu JM, Zhu Y, Xu ZW, Ouyang WM, Wang JP, Liu XS, Cao YX, Li Q, Fang L, Zhuang R, Yang AG, Jin BQ
Clin. Immunol., 2006;119(3):245-51.
Species: Human
Sample Types: Plasma
-
Role of matrix metalloproteinases in the inflammatory response in human airway cell-based assays and in rodent models of airway disease.
Authors: Birrell MA, Wong S, Dekkak A, De Alba J, Haj-Yahia S, Belvisi MG
J. Pharmacol. Exp. Ther., 2006;318(2):741-50.
Species: Human
Sample Types: Cell Culture Supernates
-
A combination of E. coli DNA fragments and modified lipopolysaccharides as a cancer immunotherapy.
Authors: Cho YJ, Ahn BY, Lee NG, Lee DH, Kim DS
Vaccine, 2006;24(31):5862-71.
Species: Human
Sample Types: Cell Culture Supernates
-
Enhanced apoptotic cell clearance capacity and B cell survival factor production by IL-10-activated macrophages: implications for Burkitt's lymphoma.
Authors: Pound JD, Batth BK, Johannessen I, Wood K
J. Immunol., 2005;174(5):3015-23.
Species: Human
Sample Types: Cell Culture Supernates
-
Microbial exposure, symptoms and inflammatory mediators in nasal lavage fluid of kitchen and clerical personnel in schools.
Authors: Lignell U, Meklin T, Putus T, Vepsalainen A, Roponen M, Torvinen E, Reeslev M, Pennanen S, Hirvonen MR, Kalliokoski P, Nevalainen A
Int J Occup Med Environ Health, 2005;18(2):139-50.
Species: Human
Sample Types: Nasal Lavage Fluid
-
Synergistic stimulation of human monocytes and dendritic cells by Toll-like receptor 4 and NOD1- and NOD2-activating agonists.
Authors: Fritz JH, Girardin SE, Fitting C, Werts C, Mengin-Lecreulx D, Caroff M, Cavaillon JM, Philpott DJ, Adib-Conquy M
Eur. J. Immunol., 2005;35(8):2459-70.
Species: Human
Sample Types: Cell Culture Supernates
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Association of type 2 cytokines with hepatic fibrosis in human Schistosoma mansoni infection.
Authors: de Jesus AR, Magalhaes A, Miranda DG, Miranda RG, Araujo MI, de Jesus AA, Silva A, Santana LB, Pearce E, Carvalho EM
Infect. Immun., 2004;72(6):3391-7.
Species: Human
Sample Types: Cell Culture Supernates
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The Toll-like receptor-2/6 agonist macrophage-activating lipopeptide-2 cooperates with IFN-gamma to reverse the Th2 skew in an in vitro allergy model.
Authors: Weigt H, Muhlradt PF, Larbig M, Krug N, Braun A
J. Immunol., 2004;172(10):6080-6.
Species: Human
Sample Types: Cell Culture Supernates
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IL-15 and the initiation of cell contact-dependent synovial fibroblast-T lymphocyte cross-talk in rheumatoid arthritis: effect of methotrexate.
Authors: Miranda-Carus ME, Balsa A, Benito-Miguel M, Perez de Ayala C, Martin-Mola E
J. Immunol., 2004;173(2):1463-76.
Species: Human
Sample Types: Cell Culture Supernates
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Activation of resting human primary T cells with chimeric receptors: costimulation from CD28, inducible costimulator, CD134, and CD137 in series with signals from the TCR zeta chain.
Authors: Finney HM, Akbar AN, Lawson AD
J. Immunol., 2004;172(1):104-13.
Species: Human
Sample Types: Cell Culture Supernates
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Stimulation of toll-like receptor 2 by Coxiella burnetii is required for macrophage production of pro-inflammatory cytokines and resistance to infection.
Authors: Zamboni DS, Campos MA, Torrecilhas AC, Kiss K, Samuel JE, Golenbock DT, Lauw FN, Roy CR, Almeida IC, Gazzinelli RT
J. Biol. Chem., 2004;279(52):54405-15.
Species: Human
Sample Types: Cell Culture Supernates
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Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis.
Authors: Groh V, Bruhl A, El-Gabalawy H, Nelson JL, Spies T
Proc. Natl. Acad. Sci. U.S.A., 2003;100(16):9452-7.
Species: Human
Sample Types: Cell Culture Supernates
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Comparison of inflammatory elements in nasal lavage and induced sputum following occupational exposure to moldy-building microbes.
Authors: Purokivi M, Hirvonen MR, Roponen M, Randell J, Vahteristo M, Tukiainen H
Inhal Toxicol, 2002;14(6):653-62.
Species: Human
Sample Types: Sputum
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Inflammatory mediators in nasal lavage, induced sputum and serum of employees with rheumatic and respiratory disorders.
Authors: Roponen M, Kiviranta J, Seuri M, Tukiainen H, Myllykangas-Luosujarvi R, Hirvonen MR
Eur. Respir. J., 2001;18(3):542-8.
Species: Human
Sample Types: Serum
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Reproducibility of measurements of exhaled NO, and cell count and cytokine concentrations in induced sputum.
Authors: Purokivi M, Randell J, Hirvonen MR, Tukiainen H
Eur. Respir. J., 2000;16(2):242-6.
Species: Human
Sample Types: Sputum
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Effects of a short-course of amoxicillin/clavulanic acid on systemic and mucosal immunity in healthy adult humans.
Authors: Dufour V, Millon L, Faucher JF, Bard E, Robinet E, Piarroux R, Vuitton DA, Meillet D
Int. Immunopharmacol., 205;5(5):917-28.
Species: Human
Sample Types: Feces
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Natural killer cell-produced IFN-gamma and TNF-alpha induce target cell cytolysis through up-regulation of ICAM-1.
Authors: Wang R, Jaw JJ, Jaw J, Stutzman N, Stutzman NC, Zou Z, Sun PD
J Leukoc Biol, 0;91(2):299-309.
Species: Human
Sample Types: Cell Culture Supernates
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Enhancing CAR T cell persistence through ICOS and 4-1BB costimulation.
Authors: Guedan S, Posey A, Shaw C, Wing A, Da T, Patel P, McGettigan S, Casado-Medrano V, Kawalekar O, Uribe-Herranz M, Song D, Melenhorst J, Lacey S, Scholler J, Keith B, Young R, June C
JCI Insight, 0;3(1):.
Species: Human
Sample Types: Cell Culture Supernates
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Interleukin (IL)-4, IL-13, and IL-17A differentially affect the profibrotic and proinflammatory functions of fibrocytes from asthmatic patients.
Authors: Bellini A, Marini MA, Bianchetti L, Barczyk M, Schmidt M, Mattoli S
Mucosal Immunol, 0;5(2):140-9.
Species: Human
Sample Types: Cell Culture Supernates
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24-hour stimulation of THP-1 cells to rotenone with or without TLR inhibitor
R-squared value of 0.98 using sigmoidal 4-parameter logistic plot
TNFa was measured in the supernatant of human kidney tissue homogenate stimulated with LPS for 24 hours.
This is a new lot of the Human TNF-alpha DuoSet ELISA kit. The results are reproducible and the quality of the kit consistent. Monocyte-derived human macrophages were treated with 20 μg/ml zymosan for 24 hours and TNFa was assessed in the supernatant.
TNFa secretion was measured in the supernatant of LPS-stimulated (100 ng/ml) cultured human dendritic cells after 18 hours.
Monocytes were stimulated with LPS (100 ng/ml) for 24 hours. After 24 hours, TNFa was assessed in the supernatant.
TNFa levels in PBM supernatants after dIgG treatment.