Human TRAIL R3/TNFRSF10C Antibody
Human TRAIL R3/TNFRSF10C Antibody Summary
Accession # O14798
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
TRAIL R3/TNFRSF10C Inhibition of TRAIL/TNFSF10-induced Cytotoxicity and Neutralization by Human TRAIL R3/TNFRSF10C Antibody. In the presence of the metabolic inhibitor actinomycin D (1 µg/mL), Recombinant Human TRAIL R3/TNFRSF10C Fc Chimera (Catalog # 630-TR) inhibits Recombinant Human TRAIL/TNFSF10 (Catalog # 375-TEC) induced cytotoxicity in the L-929 mouse fibroblast cell line in a dose-dependent manner (orange line). Under these conditions, inhibition of Recombinant Human TRAIL/TNFSF10 (20 ng/mL) activity elicited by Recombinant Human TRAIL R3/TNFRSF10C Fc Chimera (10 ng/mL) is neutralized (green line) by increasing concentrations of Human TRAIL R3/TNFRSF10C Monoclonal Antibody (Catalog # MAB630). The ND50 is typically 0.02-0.08 µg/mL.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: TRAIL R3/TNFRSF10C
TRAIL R3, also called TNFRSF10C, DcR1 (decoy receptor 1), LIT, and TRID, is a glycosylphosphatidylinositol-linked membrane protein which binds TRAIL (Apo2 Ligand) with high affinity (1, 2). TRAIL R3 contains a TRAIL-binding extracellular cysteine-rich domain but lacks an intracellular signaling domain. As a result, binding of TRAIL to TRAIL R3 does not trigger a pro-apoptotic signal. TRAIL R3 has been shown to protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-induced apoptosis.
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