IRS1 [p Tyr1179] Antibody

Name: IRS1 [p Tyr1179] Antibody
Brand: Novus Biologicals
SKU: NB100-74450
Price: 179 USD
Availability: InStock

Novus Biologicals | Catalog # NB100-74450

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Product Specifications
Scientific Data
Applications
Preparation & Storage
Background
Product Documents
Specific Notices
Research Areas

Key Product Details

Validated by

Biological Validation

Species Reactivity

Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

View all IRS1 Primary Antibodies »

Product Specifications

Immunogen

Synthetic phosphopeptide corresponding to residues L(1173) E N G L N (pY) I D L D L V K(1186) of human IRS-1.

Modification

p Tyr1179

Localization

Cytoplasmic

Specificity

Detects phosphorylated IRS-1 (Tyr1173) in mouse cells.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for IRS1 [p Tyr1179] Antibody

Western Blot: IRS1 [p Tyr1179] Antibody [NB100-74450]

Western Blot: IRS1 [p Tyr1179] Antibody [NB100-74450] - Lysate from insulin-treated 3T3 L1 cells.

Applications for IRS1 [p Tyr1179] Antibody

Application

Recommended Usage

Western Blot

1:100 - 1:2000

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS with 1 mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: IRS1

Insulin receptor substrates (IRS) are responsible for several insulin related activities, such as glucose homeostasis, cell growth, cell transformation, apoptosis and insulin signal transduction. Serine/threonine phosphorylation of IRS-1 has been demonstrated to be a negative regulator of insulin signaling and is responsible for its degradation, although IRS-1 degradation pathways are not well understood. IRS-1 has also been shown to be constitutively activated in cancers such as breast cancer, Wilm's tumors, and adrenal cortical carcinomas, thus making IRS-1 phosphorylation and subsequent degradation an attractive therapeutic target. To date there have been four subtypes identified: IRS-1, 2, 3 and 4, with IRS-1 being widely expressed.

Long Name

Insulin Receptor Substrate 1

Alternate Names

HIRS-1, insulin receptor substrate 1, IRS-1

Entrez Gene IDs

16367 (Mouse)

Gene Symbol

IRS1

Additional IRS1 Products

Product Documents for IRS1 [p Tyr1179] Antibody

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Certificate of Analysis

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Product Specific Notices for IRS1 [p Tyr1179] Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.