Mouse CXCL14/BRAK Antibody
Mouse CXCL14/BRAK Antibody Summary
Accession # Q9JHH7
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
CXCL14/BRAK, also named MIP-2 gamma, KEC (kidney-expressed chemokine), and BMAC (B cell and monocyte-activating chemokine), is a member of the CXC chemokine superfamily (1‑5). The deduced 99 amino acid (aa) residue precursor has a 22 aa putative signal peptide that is cleaved to produce the 77 aa mature protein. Mature human and mouse CXCL14 differ by only 2 residues. Mouse CXCL14 shares approximately 30% aa sequence identity with mouse MIP-2. Unlike
MIP‑2, CXCL14 lacks the ELR domain preceding the CXC motif. CXCL14 transcripts are constitutively expressed at high levels in the basal layer of epidermal keratinocytes and dermal fibroblasts of skin tissues as well as lamina propria cells in normal intestinal tissues. CXCL14 has been shown to be a highly selective chemoattractant for monocytes that have been treated with prostaglandin E2 or forskolin, agents that activate adenylate cyclase. CXCL14 has been proposed to be important in regulating the trafficking of macrophage precursor to regions in skin and mucosal tissues that support their development. Consistent with this hypothesis, macrophages were frequently found to co-localize with CXCL14‑producing cells in the dermis and lamina propria.
- Hromas, R. et al. (1999) Biochem. Biophys. Res. Commun. 255:703.
- Cao, X. et al. (2000) J. Immunol. 165:2588.
- Kurth, I. et al. (2001) J. Exp. Med. 194:855.
- Frederick, M.J. et al. (2000) Am. J. Pathol. 156:1937.
- Sleeman, M.A. et al. (2000) Int. Immunol. 12:677.
Citations for Mouse CXCL14/BRAK Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 2
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CXCL14 Overexpression Attenuates Sepsis-Associated Acute Kidney Injury by Inhibiting Proinflammatory Cytokine Production
Authors: J Lv, ZL Wu, Z Gan, P Gui, SL Yao
Mediators Inflamm., 2020;2020(0):2431705.
Sample Types: Tissue Homogenate
Applications: ELISA Detection
Disruption of CXC motif chemokine ligand-14 in mice ameliorates obesity-induced insulin resistance.
Authors: Nara N, Nakayama Y, Okamoto S, Tamura H, Kiyono M, Muraoka M, Tanaka K, Taya C, Shitara H, Ishii R, Yonekawa H, Minokoshi Y, Hara T
J. Biol. Chem., 2007;282(42):30794-803.
Sample Types: Cell Lysates
Applications: Western Blot
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