Mouse GDF-6/BMP-13 Antibody

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GDF‑6/BMP‑13 in Mouse Embryo.
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Mouse GDF-6/BMP-13 Antibody Summary

Species Reactivity
Detects mouse GDF-6/BMP-13 in direct ELISAs.
Polyclonal Sheep IgG
Antigen Affinity-purified
E. coli-derived recombinant mouse GDF-6/BMP-13
Accession # P43028
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
5-15 µg/mL
See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Immunohistochemistry GDF-6/BMP-13 antibody in Mouse Embryo by Immunohistochemistry (IHC-Fr). View Larger

GDF‑6/BMP‑13 in Mouse Embryo. GDF-6/BMP-13 was detected in immersion fixed frozen sections of mouse embryo (E13.5) using Sheep Anti-Mouse GDF-6/ BMP-13 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF855) at 10 µg/mL overnight at 4 °C. Tissue was stained using the NorthernLights™ 557-conjugated Anti-Sheep IgG Secondary Antibody (red; Catalog # NL010) and counterstained with DAPI (blue). Specific staining was localized to dorsal neural tube. View our protocol for Fluorescent IHC Staining of Frozen Tissue Sections.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: GDF-6/BMP-13

Growth Differentiation Factor 6 (GDF-6), also known as bone morphogenetic protein 13 (BMP-13) or cartilage-derived morphogenetic protein 2 (CDMP-2), is a member of the bone morphogenetic protein (BMP) family which belongs to the transforming growth factor  beta (TGF-beta ) superfamily. The mature GDF-6 with 120 amino acids is a homodimeric protein containing the characteristic seven conserved cysteine residues. GDF-5, GDF-6 and GDF-7, which share 80‑86% identity, define a new subgroup within the BMP family. Like other TGF-beta superfamily proteins, GDF-6 is highly conserved across species. At the amino acid sequence level, human and mouse GDF‑6 are 99% identical. It has been reported that GDF-6 has multiple functions including regulation of myogenesis, regulation of chondrogenesis, bone morphogenesis, and neuron differentiation and survival. GDF-6 response is mediated by the formation of hetero-oligomeric complexes of type I (BMPR-IB) and type II (BMPR-II or Activin R-II) sereine/threonine kinase receptors, and the activation of Smad proteins (Smad 1, 5, and 8).

  1. Storm, E.E. et al. (1994) Nature 368:639.
  2. Nishitoh, H. et al. (1996) J. Biol. Chem. 271:21345.
  3. Francis-West, P.H. et al. (1999) Development 126:1035.
  4. Massague, J. et al. (2000) Genes and Dev. 14:627.
  5. Inada, M. et al. (1996) BBRC, 222:317.
  6. Settle, S.H., Jr. et al. (2003) Dev. Biol. 254:116.
Long Name
Growth Differentiation Factor 6
Entrez Gene IDs
392255 (Human); 242316 (Mouse)
Alternate Names
BMP13; BMP-13; CDMP2; GDF16; GDF6; GDF-6; growth differentiation factor 6; Growth/differentiation factor 16; growth/differentiation factor 6; KFS; KFS1; KFSL; MCOP4; MCOPCB6; MGC158100; MGC158101; SCDO4; SGM1

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