Mouse IFN-alpha Antibody

Catalog # Availability Size / Price Qty
22100-1

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Product Details
Citations (5)
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Mouse IFN-alpha Antibody Summary

Species Reactivity
Mouse
Specificity
Neutralizes mouse interferon alpha; binds to mouse interferon alpha
Source
Monoclonal Rat IgG1 Clone # RMMA-1
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Mouse Interferon alpha
Formulation
50mM Sodium Bicarbonate; 0.2M Sodium Chloride, pH 8.0
Endotoxin Level
<1.0 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
ELISA
Please refer to the PDF datasheet for specifications.
Neutralization

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
After receipt, the product may be stored at -20°C for short-term use (≤ 6 months). For long-term storage, we recommend storing the product at -70°C or below for retention of full activity. When thawing, the contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum. Re-freezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution of the product should be in buffers containing protein such as 0.1% bovine serum albumin (BSA).

Background: IFN-alpha

Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.

References
  1. Asselin-Paturel, C. et al. 2005, J. Exp. Med. 201:1157.
  2. Mellor, A.L. et al. 2005, J. Immunol. 175:5601.
Long Name
Interferon alpha
Entrez Gene IDs
3440 (Human)
Alternate Names
IFNA; IFNA2; IFNA2b; IFNalpha; IFN-alpha; IFN-alphaA; INFA2; interferon alpha 2; LeIF D

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Citations for Mouse IFN-alpha Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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  1. Postoperative plasmacytoid dendritic cells secrete IFN-alpha to promote recruitment of myeloid-derived suppressor cells and drive hepatocellular carcinoma recurrence
    Authors: K Man, L Pang, OWH Yeung, KTP Ng, H Liu, J Zhu, J Liu, X Yang, T Ding, W Qiu, Y Wang, TLS Chiu, Z Chen, CM Lo
    Cancer Research, 2022-11-15;0(0):.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  2. Pharmacokinetic characteristics, pharmacodynamic effect and in vivo antiviral efficacy of liver-targeted interferon alpha.
    Authors: Rycroft D, Sosabowski J, Coulstock E, Davies M, Morrey J, Friel S, Kelly F, Hamatake R, Ovecka M, Prince R, Goodall L, Sepp A, Walker A
    PLoS ONE, 2015-02-17;10(2):e0117847.
    Species: Mouse
    Sample Types: Serum
    Applications: ELISA Development
  3. Identification of Toll-like receptor 9 as parapoxvirus ovis-sensing receptor in plasmacytoid dendritic cells.
    Authors: von Buttlar H, Siegemund S, Buttner M, Alber G
    PLoS ONE, 2014-08-29;9(8):e106188.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  4. Microarray analyses demonstrate the involvement of type I interferons in psoriasiform pathology development in D6-deficient mice.
    Authors: Baldwin H, Pallas K, King V, Jamieson T, McKimmie C, Nibbs R, Carballido J, Jaritz M, Rot A, Graham G
    J Biol Chem, 2013-11-05;288(51):36473-83.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  5. Effects of type I interferons on the adjuvant properties of plasmid granulocyte-macrophage colony-stimulating factor in vivo.
    Authors: Qin L, Greenland JR, Moriya C
    J. Virol., 2007-07-25;81(19):10606-13.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization

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