Mouse IFN-alpha ELISA Kit

(14 citations)
(1 Review)
  
  • Assay Length
    27.25 hours
  • Sample Type & Volume Required Per Well
    Cell Culture Supernates (100 uL)
  • Sensitivity
    12.5 pg/mL
  • Assay Range
    12.5 - 400 pg/mL (Cell Culture Supernates)
  • Specificity
    Mouse IFN-alpha
  • Cross-reactivity
    < 0.5% cross-reactivity observed with available related molecules.< 50% cross-species reactivity observed with species tested.
  • Interference
    No significant interference observed with available related molecules.
Preparation and Storage
  • Storage
    Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Background: IFN-alpha
Interferon-alpha (IFN-alpha), also known as leukocyte interferon, represents a group of related but distinct proteins that share over 95% amino acid sequence homology. They are members of the type I interferon family which share a common cell surface receptor composed of two subunits, a 100 kDa ligand-binding subunit (IFN-alpha R2) and a 125 kDa ligand binding and signal transduction subunit (IFN-alpha R1) that is involved both in ligand binding and signal transduction. IFN-alpha has both anti-viral and immunomodulatory activities on target cells.
    • Long Name
      Interferon alpha
    • Entrez Gene IDs
      3440 (Human);
    • Alternate Names
      IFNalpha; IFN-alpha;
    Related Research Areas
    Citations:

    R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

    14 Citations: Showing 1 - 10
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    Species
    Sample Type
    1. DNase II-dependent DNA digestion is required for DNA sensing by TLR9.
      Authors: Chan, Mei Po, Onji, Masahiro, Fukui, Ryutaro, Kawane, Kohki, Shibata, Takuma, Saitoh, Shin-ich, Ohto, Umeharu, Shimizu, Toshiyuk, Barber, Glen N, Miyake, Kensuke
      Nat Commun, 2015;6(0):5853.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    2. WNT5A transforms intestinal CD8alphaalpha(+) IELs into an unconventional phenotype with pro-inflammatory features.
      Authors: Zhao D, Xu A, Dai Z, Peng J, Zhu M, Shen J, Zheng Q, Ran Z
      BMC Gastroenterol, 2015;15(0):173.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    3. Activation of A1-adenosine receptors promotes leukocyte recruitment to the lung and attenuates acute lung injury in mice infected with influenza A/WSN/33 (H1N1) virus.
      Authors: Aeffner F, Woods P, Davis I
      J Virol, 2014;88(17):10214-27.
      Species: Mouse
      Sample Type: BALF
    4. Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction.
      Authors: Desch, A Nicole, Gibbings, Sophie L, Clambey, Eric T, Janssen, William, Slansky, Jill E, Kedl, Ross M, Henson, Peter M, Jakubzick, Claudia
      Nat Commun, 2014;5(0):4674.
      Species: Mouse
      Sample Type: Tissue Culture Supernates
    5. STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge.
      Authors: Dulek D, Newcomb D, Toki S, Goliniewska K, Cephus J, Reiss S, Bates J, Crowe J, Boyd K, Moore M, Zhou W, Peebles R
      J Virol, 2014;88(17):9655-72.
      Species: Mouse
      Sample Type: Tissue Homogenates
    6. IL-15 complexes induce NK- and T-cell responses independent of type I IFN signaling during rhinovirus infection.
      Authors: Jayaraman A, Jackson D, Message S, Pearson R, Aniscenko J, Caramori G, Mallia P, Papi A, Shamji B, Edwards M, Westwick J, Hansel T, Stanciu L, Johnston S, Bartlett N
      Mucosal Immunol, 2014;7(5):1151-64.
      Species: Mouse
      Sample Type: BALF
    7. Recombinant human interferon alpha 2b prevents and reverses experimental pulmonary hypertension.
      Authors: Bauer E, Zheng H, Lotze M, Bauer P
      PLoS ONE, 2014;9(5):e96720.
      Species: Mouse
      Sample Type: Serum
    8. Plasminogen controls inflammation and pathogenesis of influenza virus infections via fibrinolysis.
      Authors: Berri F, Rimmelzwaan G, Hanss M, Albina E, Foucault-Grunenwald M, Le V, Vogelzang-van Trierum S, Gil P, Camerer E, Martinez D, Lina B, Lijnen R, Carmeliet P, Riteau B
      PLoS Pathog, 2013;9(3):e1003229.
      Species: Mouse
      Sample Type: BALF
    9. Modulation of dendritic cell function and immune response by cysteine protease inhibitor from murine nematode parasite Heligmosomoides polygyrus.
      Authors: Sun Y, Liu G, Li Z, Chen Y, Liu Y, Liu B, Su Z
      Immunology, 2013;138(4):370-81.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    10. Suppression of cytokine storm with a sphingosine analog provides protection against pathogenic influenza virus.
      Authors: Walsh KB, Teijaro JR, Wilker PR
      Proc. Natl. Acad. Sci. U.S.A., 2011;108(29):12018-23.
      Species: Mouse
      Sample Type: BALF
    11. ChemR23 dampens lung inflammation and enhances anti-viral immunity in a mouse model of acute viral pneumonia.
      Authors: Bondue B, Vosters O, de Nadai P, Glineur S, De Henau O, Luangsay S, Van Gool F, Communi D, De Vuyst P, Desmecht D, Parmentier M
      PLoS Pathog., 2011;7(11):e1002358.
      Species: Mouse
      Sample Type: Tissue Homogenates
    12. The TLR7 ligand 9-benzyl-2-butoxy-8-hydroxy adenine inhibits IL-17 response by eliciting IL-10 and IL-10-inducing cytokines.
      Authors: Vultaggio A, Nencini F, Pratesi S, Maggi L, Guarna A, Annunziato F, Romagnani S, Parronchi P, Maggi E
      J. Immunol., 2011;186(8):4707-15.
      Species: Mouse
      Sample Type: Serum
    13. Selective induction of host genes by MVA-B, a candidate vaccine against HIV/AIDS.
      Authors: Guerra S, Gonzalez JM, Climent N, Reyburn H, Lopez-Fernandez LA, Najera JL, Gomez CE, Garcia F, Gatell JM, Gallart T, Esteban M
      J. Virol., 2010;84(16):8141-52.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    14. Effects of type I interferons on the adjuvant properties of plasmid granulocyte-macrophage colony-stimulating factor in vivo.
      Authors: Qin L, Greenland JR, Moriya C
      J. Virol., 2007;81(19):10606-13.
      Species: Mouse
      Sample Type: Tissue Homogenates
    Expand to show all 14 Citations
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    Sample TestedCell culture supernatant

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