Mouse IFN-beta Antibody

Catalog # Availability Size / Price Qty
22400-1
Product Details
Citations (3)
FAQs
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Mouse IFN-beta Antibody Summary

Species Reactivity
Mouse
Specificity
Weakly neutralizes mouse interferon beta, but not recommended for neutralization assays; binds to mouse interferon beta
Source
Monoclonal Rat IgG2A Clone # RMMB-1
Purification
Protein A or G purified from hybridoma culture supernatant
Immunogen
Human interferon beta
Formulation
Phosphate buffered saline (PBS) containing 0.1% bovine serum albumin (BSA)
Label
Unconjugated

Applications

Recommended Concentration
Sample
Direct ELISA
Please refer to the PDF datasheet for specifications.

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Shipping
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
After receipt, the product may be stored at -20°C for short-term use (≤ 6 months). For
long-term storage, we recommend storing the product at -70°C or below for retention of full activity. When thawing, the
contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum.
Refreezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution of the product should be in buffers
containing protein such as 0.1% bovine serum albumin (BSA).

Background: IFN-beta

Interferon-beta (IFN-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.

Long Name
Interferon beta
Entrez Gene IDs
3456 (Human); 15977 (Mouse); 24481 (Rat)
Alternate Names
Fibroblast interferon; IFBIFNB; IFF; IFNB1; IFNbeta; IFN-beta; interferon beta; interferon, beta 1, fibroblast; MGC96956

Product Datasheets

Citations for Mouse IFN-beta Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

3 Citations: Showing 1 - 3
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  1. Identification of Toll-like receptor 9 as parapoxvirus ovis-sensing receptor in plasmacytoid dendritic cells.
    Authors: von Buttlar H, Siegemund S, Buttner M, Alber G
    PLoS ONE, 2014;9(8):e106188.
    Species: Mouse
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development
  2. Evaluating vaccinia virus cytokine co-expression in TLR GKO mice.
    Authors: Sutherland DB, Ranasinghe C, Regner M, Phipps S, Matthaei KI, Day SL, Ramshaw IA
    Immunol. Cell Biol., 2011;89(0):706-15.
    Species: Mouse
    Sample Types: Serum
    Applications: ELISA Development
  3. Effects of type I interferons on the adjuvant properties of plasmid granulocyte-macrophage colony-stimulating factor in vivo.
    Authors: Qin L, Greenland JR, Moriya C
    J. Virol., 2007;81(19):10606-13.
    Species: Mouse
    Sample Types: In Vivo
    Applications: In vivo

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