IFN-beta (Interferon-beta) is a cytokine that is produced by fibroblasts and pathogen-exposed dendritic cells, macrophages, and endothelial cells. It signals through the heterodimeric IFN-alpha/beta Receptor. IFN-beta-deficient mice show increased susceptibility to experimental autoimmune encephalomyelitis (EAE), a disease model of human multiple sclerosis (MS). Furthermore, IFN-beta has been shown to suppress the Th17 cell response in both MS and EAE and has commonly been used as a treatment for MS.
Mouse IFN‑ beta Antibody
R&D Systems | Catalog # 22400-1
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Key Product Details
Species Reactivity
Validated:
Mouse
Cited:
Mouse
Applications
Validated:
Direct ELISA
Cited:
Neutralization, ELISA Development
Label
Unconjugated
Antibody Source
Monoclonal Rat IgG2A Clone # RMMB-1
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Product Specifications
Immunogen
Human interferon beta
Specificity
Weakly neutralizes mouse interferon beta, but not recommended for neutralization assays; binds to mouse interferon beta
Clonality
Monoclonal
Host
Rat
Isotype
IgG2A
Applications for Mouse IFN‑ beta Antibody
Application
Recommended Usage
Direct ELISA
Optimal dilutions of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified from hybridoma culture supernatant
Formulation
Phosphate buffered saline (PBS) containing 0.1% bovine serum albumin (BSA)
Shipping
The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
After receipt, the product may be stored at -20°C for short-term use (≤ 6 months). For long-term storage, we recommend storing the product at -70°C or below for retention of full activity. When thawing, the contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum. Refreezing should be done on dry ice or in a dry ice/alcohol bath. Further dilution of the product should be in buffers containing protein such as 0.1% bovine serum albumin (BSA).
Background: IFN-beta
Long Name
Interferon beta
Alternate Names
IFB, IFF, IFNB, IFNB1, IFNbeta
Gene Symbol
IFNB1
Additional IFN-beta Products
Product Documents for Mouse IFN‑ beta Antibody
Certificate of Analysis
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Note: Certificate of Analysis not available for kit components.
Product Specific Notices for Mouse IFN‑ beta Antibody
For research use only
Citations for Mouse IFN‑ beta Antibody
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