Mouse IL-22BP Antibody

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Product Details
Citations (2)
Supplemental Products

Mouse IL-22BP Antibody Summary

Species Reactivity
Detects mouse IL-22BP in direct ELISAs and Western blots. In Western blots, approximately 10% cross‑reactivity with recombinant human (rh) IL-22BP is observed and approximately 5% cross-reactivity with rhIL-22 R is observed.
Polyclonal Sheep IgG
Antigen Affinity-purified
Mouse myeloma cell line NS0-derived recombinant mouse IL‑22BP
Thr19-Pro230 (Asp149Glu)
Accession # Q80XF5
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Mouse IL‑22BP Fc Chimera (Catalog # 2376-BP)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

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Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IL-22BP

Interleukin 22 binding protein (IL-22BP), also known as CRF2-10, CRF2-X, and IL-22 RA2, is a 35‑45 kDa secreted glycoprotein belonging to the type II cytokine receptor family (CRF). IL-22 signals through a receptor complex consisting of IL-22 R and IL-10 R beta. IL-10 R beta is also a component of the receptor complexes for IL‑10, IL-26, IL-28, and IL-29 (1‑4). IL‑10 R beta is widely expressed, and other cell types express either IL-10 R alpha or IL-22 R but not both (5). The mouse IL-22BP cDNA encodes a 230 amino acid (aa) precursor that includes a 20 aa signal sequence and two fibronectin type-III domains (6). Mouse IL-22BP shares 59% and 85% aa sequence identity with human and rat IL-22BP, respectively. Among type II cytokine receptors, IL-22BP is most closely related to the extracellular domain of IL-22 R, sharing 36% aa sequence identity. Splice variants of human IL-22BP exist but have not been detected for the mouse protein (6‑8). IL-22BP binds an epitope on IL-22 that is required for the interaction of IL-22 with the transmembrane IL-22 R (8‑10), thereby preventing the association of IL-22 R with IL-10 R beta (10). IL-22BP blocks IL‑22‑induced responses including induction of MHC class I expression, Stat1 and Stat3 activation, SOCS3 gene expression,the production of reactive oxygen species (6, 9) and the modulation of the proinflammatory effects of IL-22 (11). Mouse IL-22 BP neutralizes both mouse and human IL-22 (6). IL-22BP is secreted by epithelial cells, dendritic cells, activated B cells, and activated monocytes (6, 8, 12, 13).

  1. Donnelly, R.P. et al. (2004) J. Leukoc. Biol. 76:314.
  2. Pestka, S. et al. (2004) Annu. Rev. Immunol. 22:929.
  3. Langer, J.A. et al. (2004) Cytokine Growth Factor Rev. 15:33.
  4. Kotenko, S.V. (2002) Cytokine Growth Factor Rev. 13:223.
  5. Wolk, K. et al. (2005) Genes Immun. 6:8.
  6. Wei, C.-C. et al. (2003) Genes Immun. 4:204.
  7. Dumoutier, L. et al. (2001) J. Immunol. 166:7090.
  8. Xu, W. et al. (2001) Proc. Natl. Acad. Sci. USA 98:9511.
  9. Kotenko, S.V. et al. (2001) J. Immunol. 166:7096.
  10. Li, J. et al. (2004) Int. Immunopharmacol. 4:693.
  11. Whittington, H.A. et al. (2004) Am. J. Respir. Cell Mol. Biol. 31:220.
  12. Lecart, S. et al. (2002) Int. Immunol. 14:1351.
  13. Nagalakshmi, M.L. et al. (2004) Int. Immunopharmacol. 4:577.
Long Name
Interleukin 22 Binding Protein
Entrez Gene IDs
116379 (Human); 237310 (Mouse)
Alternate Names
class II cytokine receptor; CRF2-10; CRF2-S1IL22BP; CRF2-X; Cytokine receptor class-II member 10; Cytokine receptor family 2 member 10; Cytokine receptor family type 2, soluble 1; IL-22 RA2; IL-22 receptor subunit alpha-2; IL22BP; IL-22BP; IL-22BPCRF2X; IL22RA2; IL-22RA2; IL-22R-alpha-2; interleukin 22 receptor, alpha 2; interleukin 22-binding protein; interleukin-22 receptor subunit alpha-2; Interleukin-22-binding protein; MGC150509; MGC150510; zcytoR16

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Citations for Mouse IL-22BP Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

2 Citations: Showing 1 - 2
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  1. Blocking Dectin-1 prevents colorectal tumorigenesis by suppressing prostaglandin E2 production in myeloid-derived suppressor cells and enhancing IL-22 binding protein expression
    Authors: C Tang, H Sun, M Kadoki, W Han, X Ye, Y Makusheva, J Deng, B Feng, D Qiu, Y Tan, X Wang, Z Guo, C Huang, S Peng, M Chen, Y Adachi, N Ohno, S Trombetta, Y Iwakura
    Nature Communications, 2023-03-17;14(1):1493.
  2. Induction of MET Receptor Tyrosine Kinase Down-regulation through Antibody-mediated Receptor Clustering
    Authors: W Li, A Dick, F Lu, H Zhang, H Sun
    Sci Rep, 2019-02-13;9(1):1988.
    Species: Human
    Sample Types: Cell Lysates
    Applications: Western Blot


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