Mouse NGFR/TNFRSF16 Biotinylated Antibody
Mouse NGFR/TNFRSF16 Biotinylated Antibody Summary
Accession # Q9Z0W1
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
The low affinity nerve growth factor receptor (NGF R), also named p75 neurotrophin receptor, is a type I transmembrane protein that belongs to the tumor necrosis factor receptor family and has been designated TNFRSF16. NGF R cDNA encodes a 427 amino acid (aa) residue precursor protein with a 28 aa residue signal peptide, a 222 aa residue extracellular domain, a 22 aa residue transmembrane domain and a 155 aa residue intracellular domain. The extracellular region contains four cysteine-rich domains and binds NGF, BDNF, NT-3, and NT-4 approximately equally with low affinity. The cytoplasmic region of the receptor contains a subtype 2 death domain.
NGF R expression has been shown to occur widely during development and in the adult. Expression has been detected in both neuronal and non-neuronal cells. NGF R was originally reported to function as a positive regulator of TrkA activity. NGF R has also been shown to signal by itself. Depending on its cellular environment, NGF R has now been shown to regulate cell migration, gene expression and to mediate apoptosis. Recombinant NGF R Fc chimera binds NGF with high affinity and is a potent NGF antagonist. Naturally occurring truncated NGF R containing the extracellular domain and lacking the transmembrane or intracellular domain has been detected in vivo in urine, plasma, and in the amniotic fluid of humans and rats (1‑3).
- Barker, P.A. and R.A. Murphy (1992) Molecular and Cellular Biochemistry 110:1.
- Bamji, A.X. et al. (1998) J. Cell Biol. 140:911.
- Feinstein, E. et al. (1995) Trends Biochem. Sci. 20:342.
Citations for Mouse NGFR/TNFRSF16 Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 3
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A Preclinical Model of Malignant Peripheral Nerve Sheath Tumor-like Melanoma Is Characterized by Infiltrating Mast Cells
Authors: Michael Hölzel
Cancer Res, 2015-10-28;76(2):251-63.
Sample Types: Whole Tissue
Applications: IHC, IHC-P
Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4.
Authors: Skucas VA, Mathews IB, Yang J
J. Neurosci., 2011-04-27;31(17):6392-7.
Sample Types: Tissue Homogenates
Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury.
Authors: Jansen P, Giehl K, Nyengaard JR, Teng K, Lioubinski O, Sjoegaard SS, Breiderhoff T, Gotthardt M, Lin F, Eilers A, Petersen CM, Lewin GR, Hempstead BL, Willnow TE, Nykjaer A
Nat. Neurosci., 2007-10-14;10(11):1449-57.
Sample Types: Whole Tissue
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