Mouse Olfactomedin-1/Noelin-1 Antibody
Mouse Olfactomedin-1/Noelin-1 Antibody Summary
Accession # NP_062371
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Olfactomedin‑1 (neuronal olfactomedin-related endoplasmic reticulum-localized-1), also known as Olfactomedin-1 or pancortin, is a 75 kDa secreted extracellular matrix glycoprotein expressed in the brain (1‑3). Alternate promoter usage and splicing creates four forms of Noelin (Noelin 1‑4) that are combinations of a common central region with alternate N- and C-termini (3, 4). Noelin-1 is the longest of the four isoforms, encoding a 16 amino acid (aa) signal sequence and a 469 aa mature protein with a coiled-coil region for multimerization and an olfactomedin-like domain. The shortest isoforms, Noelin-3 and -4, are truncated within the coiled-coil region and lack the olfactomedin-like domain (4). In the species tested, these isoforms appear to oppose actions of the longer isoforms (5). All isoforms are capable of forming homo‑ or heterodimers through cysteines in their common central region (2). The C‑terminus of Noelin-1 (mouse aa 482‑485) contains a putative endoplasmic reticulum retention sequence that has not been included in the R&D Systems protein (6). Mouse Noelin-1 (aa 17‑481) shares > 99%, 99%, 97%, 96% and 93% aa identity with corresponding regions of rat, human, opossum, chicken and Xenopus Noelin-1, respectively. In vivo expression patterns differ somewhat between species (1). In chick early development, Noelin-1 shows highest concentration in areas that produce neural crest cells and is produced by migrating neural crest cells (7). Overproduction of Noelin-1 prolongs neural crest cell formation (7). Noelin-1 is also expressed in mouse neural crest, but not frog (1‑3). All three species express Noelin-1 later in differentiating neural tissues in the spinal cord, brain and cranial ganglia (1‑3).
- Moreno, T.A. & M. Bronner-Fraser (2002) Mech. Dev. 119:121.
- Ando, K. et al. (2005) Neuroscience 133:947.
- Nagano, T. et al. (1998) Brain Res. Mol. Brain Res. 53:13.
- Danielson, P.E. et al. (1994) J. Neurosci. Res. 38:468.
- Moreno, T.A. & M. Bronner-Fraser (2005) Dev. Biol. 288:434.
- Moreno, T.A. & M. Bronner-Fraser (2001) Dev. Biol. 240:340.
- Barembaum, M. et al. (2000) Nat. Cell Biol. 2:219.
Citations for Mouse Olfactomedin-1/Noelin-1 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
Citations: Showing 1 - 4
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Environmental cues from neural crest derivatives act as metastatic triggers in an embryonic neuroblastoma model
Authors: D Ben Amar, K Thoinet, B Villalard, O Imbaud, C Costechare, L Jarrosson, F Reynaud, J Novion Duc, Y Couté, JF Brunet, V Combaret, N Corradini, C Delloye-Bo, V Castellani
Nature Communications, 2022-05-10;13(1):2549.
Sample Types: Whole Cells
Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer
Authors: N Apóstolo, SN Smukowski, J Vanderlind, G Condomitti, V Rybakin, J Ten Bos, L Trobiani, S Portegies, KM Vennekens, NV Gounko, D Comoletti, KD Wierda, JN Savas, J de Wit
Nat Commun, 2020-10-14;11(1):5171.
Sample Types: Whole Tissue
Olfactomedin-1 activity identifies a cell invasion checkpoint during epithelial-mesenchymal transition in the chick embryonic heart.
Authors: Lencinas A, Chhun D, Dan K, Ross K, Hoover E, Antin P, Runyan R
Dis Model Mech, 2012-12-20;6(0):632-42.
Sample Types: Tissue Homogenates, Whole Tissue
Applications: Bioassay, Western Blot
High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes.
Species: Mouse, Rat
Sample Types: Protein, Tissue Homogenates
Applications: Affinity Purification, BN-MS
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