Mouse Olfactomedin-1/Noelin-1 Antibody

Catalog # Availability Size / Price Qty
Product Details
Citations (4)
Supplemental Products

Mouse Olfactomedin-1/Noelin-1 Antibody Summary

Species Reactivity
Detects mouse Olfactomedin‑1/Noelin‑1 in direct ELISAs and Western blots.
Polyclonal Sheep IgG
Antigen Affinity-purified
Mouse myeloma cell line NS0-derived recombinant mouse Olfactomedin‑1/Noelin‑1
Accession # NP_062371
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.


Recommended Concentration
Western Blot
0.1 µg/mL
Recombinant Mouse Olfactomedin‑1/Noelin‑1 (Catalog # 4636-NL)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

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Preparation and Storage

Reconstitute at 0.2 mg/mL in sterile PBS.
Reconstitution Buffer Available
Reconstitution Buffer 1 (PBS)
Catalog #
Size / Price
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: Olfactomedin-1/Noelin-1

Olfactomedin‑1 (neuronal olfactomedin-related endoplasmic reticulum-localized-1), also known as Olfactomedin-1 or pancortin, is a 75 kDa secreted extracellular matrix glycoprotein expressed in the brain (1‑3). Alternate promoter usage and splicing creates four forms of Noelin (Noelin 1‑4) that are combinations of a common central region with alternate N- and C-termini (3, 4). Noelin-1 is the longest of the four isoforms, encoding a 16 amino acid (aa) signal sequence and a 469 aa mature protein with a coiled-coil region for multimerization and an olfactomedin-like domain. The shortest isoforms, Noelin-3 and -4, are truncated within the coiled-coil region and lack the olfactomedin-like domain (4). In the species tested, these isoforms appear to oppose actions of the longer isoforms (5). All isoforms are capable of forming homo‑ or heterodimers through cysteines in their common central region (2). The C‑terminus of Noelin-1 (mouse aa 482‑485) contains a putative endoplasmic reticulum retention sequence that has not been included in the R&D Systems protein (6). Mouse Noelin-1 (aa 17‑481) shares > 99%, 99%, 97%, 96% and 93% aa identity with corresponding regions of rat, human, opossum, chicken and Xenopus Noelin-1, respectively. In vivo expression patterns differ somewhat between species (1). In chick early development, Noelin-1 shows highest concentration in areas that produce neural crest cells and is produced by migrating neural crest cells (7). Overproduction of Noelin-1 prolongs neural crest cell formation (7). Noelin-1 is also expressed in mouse neural crest, but not frog (1‑3). All three species express Noelin-1 later in differentiating neural tissues in the spinal cord, brain and cranial ganglia (1‑3).

  1. Moreno, T.A. & M. Bronner-Fraser (2002) Mech. Dev. 119:121.
  2. Ando, K. et al. (2005) Neuroscience 133:947.
  3. Nagano, T. et al. (1998) Brain Res. Mol. Brain Res. 53:13.
  4. Danielson, P.E. et al. (1994) J. Neurosci. Res. 38:468.
  5. Moreno, T.A. & M. Bronner-Fraser (2005) Dev. Biol. 288:434.
  6. Moreno, T.A. & M. Bronner-Fraser (2001) Dev. Biol. 240:340.
  7. Barembaum, M. et al. (2000) Nat. Cell Biol. 2:219.
Entrez Gene IDs
10439 (Human)
Alternate Names
AMY; AMYolfactomedin related ER localized protein; neuroblastoma protein; Neuronal olfactomedin-related ER localized protein; NOE1; NOE1noelin; NOEL1; NOELIN; NOELIN1; Noelin-1; OlfA; olfactomedin 1; Olfactomedin1; Olfactomedin-1; OLFM1; pancortin 1

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Citations for Mouse Olfactomedin-1/Noelin-1 Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

4 Citations: Showing 1 - 4
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  1. Environmental cues from neural crest derivatives act as metastatic triggers in an embryonic neuroblastoma model
    Authors: D Ben Amar, K Thoinet, B Villalard, O Imbaud, C Costechare, L Jarrosson, F Reynaud, J Novion Duc, Y Couté, JF Brunet, V Combaret, N Corradini, C Delloye-Bo, V Castellani
    Nature Communications, 2022-05-10;13(1):2549.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Neutralization
  2. Synapse type-specific proteomic dissection identifies IgSF8 as a hippocampal CA3 microcircuit organizer
    Authors: N Apóstolo, SN Smukowski, J Vanderlind, G Condomitti, V Rybakin, J Ten Bos, L Trobiani, S Portegies, KM Vennekens, NV Gounko, D Comoletti, KD Wierda, JN Savas, J de Wit
    Nat Commun, 2020-10-14;11(1):5171.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  3. Olfactomedin-1 activity identifies a cell invasion checkpoint during epithelial-mesenchymal transition in the chick embryonic heart.
    Authors: Lencinas A, Chhun D, Dan K, Ross K, Hoover E, Antin P, Runyan R
    Dis Model Mech, 2012-12-20;6(0):632-42.
    Species: Chicken
    Sample Types: Tissue Homogenates, Whole Tissue
    Applications: Bioassay, Western Blot
  4. High-resolution proteomics unravel architecture and molecular diversity of native AMPA receptor complexes.
    Neuron, 2012-05-24;74(4):621-33.
    Species: Mouse, Rat
    Sample Types: Protein, Tissue Homogenates
    Applications: Affinity Purification, BN-MS


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