Mouse/Rat Integrin  beta 5 Antibody

The beta 5 integrin is a 95-110 kDa member of the integrin beta chain family, integrin superfamily of molecules. It is expressed by select cell types, including microglia, keratinocytes, fibroblasts, endothelial cells, adhesive monocytes and macrophages, retinal pigment epithelium, immature dendritic cells and colonic epithelium. The Integrin beta 5 subunit forms a noncovalent heterodimer with the alpha v integrin subunit, and together they bind vitronectin, and the Thy-1 antigen. alpha v beta 5 is reported to participate in phagocytosis, and act in concert with CD81, CD36 and stabilin-2 on the cell surface. When alpha v beta 5 binds Thy-1, the heterodimer apparently interfers with cell membrane activation of TGF-beta. Intracellularly, it appears to regulate actin skeleton remodeling via focal adhesion complex formation, and may contribute to cryptic pathways associated with antigen presentation. Mature mouse Integrin beta 5 is a 775 amino acid (aa) type I transmembrane glycoprotein that contains a 696 aa extracellular domain (ECD) (aa 24-719) and a 56 aa cytoplasmic region. The ECD contains a 243 aa vWF-A domain (aa 136-378) and a Cys-rich tandem repeat region (aa 465-630). There is one splice variant that shows a 57 aa substitution for aa 760-798. This splice form does not appear to be expressed by the human Integrin beta 5 gene. Over aa 24-719, mouse Integrin beta 5 shares 91% and 97% aa sequence identity with human and rat Integrin beta 5, respectively.