Mouse/Rat MMP-2 Antibody
Mouse/Rat MMP-2 Antibody Summary
Ile34-Cys662
Accession # P33434
Complete Your Research
Complete Your Experiment
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
View Larger
MMP‑2 in Mouse Thymus. MMP-2 was detected in perfusion fixed frozen sections of mouse thymus using Goat Anti-Mouse/ Rat MMP-2 Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1488) at 15 µg/mL overnight at 4 °C. Tissue was stained using the Anti-Goat HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS008) and counterstained with hematoxylin (blue). View our protocol for Chromogenic IHC Staining of Frozen Tissue Sections.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: MMP-2
Matrix metalloproteinases are a family of zinc and calcium dependent endopeptidases with the combined ability to degrade all the components of the extracellular matrix. MMP-2 (gelatinase A), a type IV collagenase, can degrade a broad range of substrates including type IV, V, VII and X collagens as well as elastin and fibronectin. It is believed to act synergistically with interstitial collagenase (MMP-1) in the degradation of fibrillar collagens as it degrades their denatured gelatin forms. MMP-2 has been shown to be associated with many connective tissue cells as well as neutrophils, macrophages and monocytes. Structurally, MMP-2 may be divided into several distinct domains: a pro-domain which is cleaved upon activation; a catalytic domain containing the zinc binding site; a fibronectin-like domain thought to play a role in substrate targeting; and a carboxyl terminal (hemopexin-like) domain containing 2 N-linked glycosylation sites. The amino acid sequences of the proenzymes are identical between mouse and rat.
Product Datasheets
Citations for Mouse/Rat MMP-2 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
25
Citations: Showing 1 - 10
Filter your results:
Filter by:
-
Temporal and Quantitative Analysis of Aortic Immunopathologies in Elastase-Induced Mouse Abdominal Aortic Aneurysms
Authors: K Tian, C Xia, H Liu, B Xu, P Wei, W Fu, M Lu, Y Li, Y Li, D Cheng, E Liu, S Zhao
Journal of Immunology Research, 2021;2021(0):6297332.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Nicotine Exacerbates TAAD Formation Induced by Smooth Muscle-Specific Deletion of the TGF-beta Receptor 2
Authors: C Chun, X Qi, F Wang, KB Madrid, LA Saldarriag, MR Fisch, ML Brantly, GR Upchurch, Z Jiang
Journal of Immunology Research, 2021;2021(0):6880036.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Matrix metalloproteinases activation in Toxocara canis induced pulmonary pathogenesis
Authors: CY Lu, SC Lai, HH Lee, HT Chien, KP Lan, KM Chen
J Microbiol Immunol Infect, 2020;0(0):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Deficiency of peroxiredoxin 2 exacerbates angiotensin II-induced abdominal aortic aneurysm
Authors: SJ Jeong, MJ Cho, NY Ko, S Kim, IH Jung, JK Min, SH Lee, JG Park, GT Oh
Exp. Mol. Med., 2020;0(0):.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
ATRQ β-001 Vaccine Prevents Experimental Abdominal Aortic Aneurysms
Authors: H Zhang, M Liao, M Cao, Z Qiu, X Yan, Y Zhou, H Wu, Y Wang, J Zheng, J Ding, M Wang, Y Liao, X Chen
J Am Heart Assoc, 2019;8(18):e012341.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Tea Polysaccharide Prevents Colitis-Associated Carcinogenesis in Mice by Inhibiting the Proliferation and Invasion of Tumor Cells
Authors: LQ Liu, HS Li, SP Nie, MY Shen, JL Hu, MY Xie
Int J Mol Sci, 2018;19(2):.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Thrombospondin-2 promotes prostate cancer bone metastasis by the up-regulation of matrix metalloproteinase-2 through down-regulating miR-376c expression
Authors: PC Chen, CH Tang, LW Lin, CH Tsai, CY Chu, TH Lin, YL Huang
J Hematol Oncol, 2017;10(1):33.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Chemopreventive Potential of 2,3,5,4'-Tetrahydroxystilbene-2-O-?-D-glucoside on the Formation of Aberrant Crypt Foci in Azoxymethane-Induced Colorectal Cancer in Rats
Authors: CL Lin, JH Jeng, CC Wu, SL Hsieh, GC Huang, W Leung, CT Lee, CY Chen, CH Lee
Biomed Res Int, 2017;2017(0):3634915.
Species: Rat
Sample Types: Tissue Homogenates
Applications: Western Blot -
Smooth muscle cell-specific Tgfbr1 deficiency attenuates neointimal hyperplasia but promotes an undesired vascular phenotype for injured arteries
Physiol Rep, 2016;4(23):.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
The omega-3 polyunsaturated fatty acid, eicosapentaenoic acid, attenuates abdominal aortic aneurysm development via suppression of tissue remodeling.
Authors: Wang J, Eguchi K, Matsumoto S, Fujiu K, Komuro I, Nagai R, Manabe I
PLoS ONE, 2014;9(5):e96286.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Deletion of the EphA2 receptor exacerbates myocardial injury and the progression of ischemic cardiomyopathy.
Authors: O'Neal W, Griffin W, Kent S, Faiz F, Hodges J, Vuncannon J, Virag J
Front Physiol, 2014;5(0):132.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Molecular hydrogen in drinking water protects against neurodegenerative changes induced by traumatic brain injury.
Authors: Dohi, Kenji, Kraemer, Brian C, Erickson, Michelle, McMillan, Pamela J, Kovac, Andrej, Flachbartova, Zuzana, Hansen, Kim M, Shah, Gul N, Sheibani, Nader, Salameh, Therese, Banks, William
PLoS ONE, 2014;9(9):e108034.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
KLF4 regulates abdominal aortic aneurysm morphology and deletion attenuates aneurysm formation.
Authors: Salmon M, Johnston W, Woo A, Pope N, Su G, Upchurch G, Owens G, Ailawadi G
Circulation, 2013;128(11):S163-74.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
G protein-coupled receptor kinase 6 deficiency promotes angiogenesis, tumor progression, and metastasis.
Authors: Raghuwanshi S, Smith N, Rivers E, Thomas A, Sutton N, Hu Y, Mukhopadhyay S, Chen X, Leung T, Richardson R
J Immunol, 2013;190(10):5329-36.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: ELISA Development (Capture) -
Vitamin D receptor agonists increase klotho and osteopontin while decreasing aortic calcification in mice with chronic kidney disease fed a high phosphate diet.
Authors: Lau, Wei Ling, Leaf, Elizabet, Hu, Ming Cha, Takeno, Marc M, Kuro-o, Makoto, Moe, Orson W, Giachelli, Cecilia
Kidney Int, 2012;82(12):1261-70.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice.
Authors: Xue M, Dervish S, Harrison LC, Fulcher G, Jackson CJ
J. Biol. Chem., 2012;287(20):16356-64.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Site-Specific Expression of Gelatinolytic Activity during Morphogenesis of the Secondary Palate in the Mouse Embryo.
Authors: Gkantidis, Nikolaos, Blumer, Susan, Katsaros, Christos, Graf, Daniel, Chiquet, Matthias
PLoS ONE, 2012;7(10):e47762.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease.
Authors: Pai A, Leaf EM, El-Abbadi M, Giachelli CM
Am. J. Pathol., 2011;178(2):764-73.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
High dietary intake of retinol leads to bone marrow hypoxia and diaphyseal endosteal mineralization in rats.
Authors: Lind T, Lind PM, Jacobson A, Hu L, Sundqvist A, Risteli J, Yebra-Rodriguez A, Rodriguez-Navarro A, Andersson G, Melhus H
Bone, 2011;48(3):496-506.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC -
Tissue inhibitor of matrix metalloproteinase 1 (TIMP1) controls adipogenesis in obesity in mice and in humans.
Authors: Meissburger B, Stachorski L, Roder E, Rudofsky G, Wolfrum C
Diabetologia, 2011;54(6):1468-79.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
Interleukin-1 receptor type I signaling critically regulates infarct healing and cardiac remodeling.
Authors: Bujak M, Dobaczewski M, Chatila K, Mendoza LH, Li N, Reddy A, Frangogiannis NG
Am. J. Pathol., 2008;173(1):57-67.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
Genetic deficiency of heme oxygenase-1 impairs functionality and form of an arteriovenous fistula in the mouse.
Authors: Juncos JP, Tracz MJ, Croatt AJ, Grande JP, Ackerman AW, Katusic ZS, Nath KA
Kidney Int., 2008;74(1):47-51.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot -
A GMCSF and IL-15 fusokine leads to paradoxical immunosuppression in vivo via asymmetrical JAK/STAT signaling through the IL-15 receptor complex.
Authors: Rafei M, Wu JH, Annabi B, Lejeune L, Francois M, Galipeau J
Blood, 2007;109(5):2234-42.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
Characterization of lymphangiogenesis in a model of adult skin regeneration.
Authors: Rutkowski JM, Boardman KC, Swartz MA
Am. J. Physiol. Heart Circ. Physiol., 2006;291(3):H1402-10.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC -
Expression of matrix metalloproteinases subsequent to urogenital Chlamydia muridarum infection of mice.
Authors: Ramsey KH, Sigar IM, Schripsema JH, Shaba N, Cohoon KP
Infect. Immun., 2005;73(10):6962-73.
Species: Mouse
Sample Types: Tissue Homogenates
Applications: Western Blot
FAQs
No product specific FAQs exist for this product, however you may
View all Antibody FAQsIsotype Controls
Reconstitution Buffers
Secondary Antibodies
Reviews for Mouse/Rat MMP-2 Antibody
There are currently no reviews for this product. Be the first to review Mouse/Rat MMP-2 Antibody and earn rewards!
Have you used Mouse/Rat MMP-2 Antibody?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥1250 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
