• Assay Length
    4.5 hours
  • Sample Type & Volume Required Per Well
    Cell Culture Supernates (100 uL), Serum (40 uL), EDTA Plasma (40 uL), Heparin Plasma (40 uL)
  • Sensitivity
    15.4 pg/mL
  • Assay Range
    31.2 - 2,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma)
  • Specificity
    Natural and recombinant TGF-beta 1. This kit also recognizes human TGF-beta 1.2.
  • Cross-reactivity
    Cross-reactivity observed with 1 or more available related molecules.Cross-species reactivity not tested.
  • Interference
    Interference observed with 1 or more available related molecules.
Ancillary Reagent Kit Available
Product Summary
The Quantikine Mouse/Rat/Porcine/Canine TGF-beta 1 Immunoassay is a 4.5 hour solid phase ELISA designed to measure TGF-beta 1 in acid activated cell culture supernates, serum, and plasma. It contains recombinant TGF-beta 1 expressed by CHO cells and has been shown to quantitate the recombinant factor accurately. Results obtained using natural TGF-beta 1 showed linear curves that were parallel to the standard curves obtained using the recombinant kit standards. These results indicate that this kit will provide accurate quantitation for both recombinant and natural TGF-beta 1.

Precision
Intra-Assay Precision (Precision within an assay) Three samples of known concentration were tested on one plate to assess intra-assay precision.
Inter-Assay Precision (Precision between assays) Three samples of known concentration were tested in separate assays to assess inter-assay precision.
Cell Culture Supernates
Intra-Assay Precision Inter-Assay Precision
Sample123123
n202020222122
Mean8819881697209826
Standard Deviation34.919.68.117.347
CV%3.42.52.48.48.35.7

Serum, EDTA Plasma, Heparin Plasma
Intra-Assay Precision Inter-Assay Precision
Sample123123
n202020283730
Mean7818069579185730
Standard Deviation2.33.417.37.217.246.8
CV%2.91.92.59.19.36.4

Recovery

The recovery of TGF-beta 1 spiked to levels throughout the range of the assay followed by activation was evaluated.

Sample Type Average % Recovery Range %
Mouse Cell Culture Supernates (n=4) 105 83-114
Porcine Cell Culture Supernates (n=2) 109 102-118
Rat Cell Culture Supernates (n=3) 112 93-125
Linearity
To assess the linearity of the assay, the activated samples containing and/or spiked with high concentrations of TGF-beta 1 were diluted with Calibrator Diluent and then assayed.
Mouse/Rat/Porcine/Canine TGF-beta 1 Quantikine ELISA Kit
Mouse/Rat/Porcine/Canine TGF-beta 1 Quantikine ELISA Kit
Mouse/Rat/Porcine/Canine TGF-beta 1 Quantikine ELISA Kit
Mouse/Rat/Porcine/Canine TGF-beta 1 Quantikine ELISA Kit
Preparation and Storage
  • Storage
    Store the unopened product at 2 - 8 °C. Do not use past expiration date.
Background: TGF-beta 1

Transforming Growth Factor Beta 1, 2, and 3 (TGF-beta 1, TGF-beta 2, and TGF-beta 3) are highly pleiotropic cytokines that virtually all cell types secrete. TGF-beta molecules are proposed to act as cellular switches that regulate processes such as immune function, proliferation, and epithelial-mesenchymal transition. Targeted deletions of these genes in mice show that each TGF-beta isoform has some non-redundant functions: TGF-beta 1 is involved in hematopoiesis and endothelial differentiation; TGF-beta 2 affects development of cardiac, lung, craniofacial, limb, eye, ear, and urogenital systems; and TGF-beta 3 influences palatogenesis and pulmonary development. The full range of in vitro biological activities of TGF-beta 5 has not yet been explored. However, TGF-beta 1, TGF-beta 2, TGF-beta 3, and TGF-beta 5 have been found to be largely interchangeable in an inhibitory bioassay, and it is anticipated that TGF-beta 5 will show a spectrum of activities similar to the other TGF-beta family members. To date, the production of TGF-beta 5 has only been demonstrated in Xenopus.

TGF-beta ligands are initially synthesized as precursor proteins that undergo proteolytic cleavage. The mature segments form active ligand dimers via a disulfide-rich core consisting of the characteristic 'cysteine knot'. TGF-beta signaling begins with binding to a complex of the accessory receptor betaglycan (also known as TGF-beta RIII) and a type II serine/threonine kinase receptor termed TGF-beta RII. This receptor then phosphorylates and activates a type I serine/threonine kinase receptor, either ALK-1 or TGF-beta RI (also called ALK-5). The activated type I receptor phosphorylates and activates Smad proteins that regulate transcription. Use of other signaling pathways that are Smad-independent allows for distinct actions observed in response to TGF-beta in different contexts.

    • Long Name
      Transforming Growth Factor beta 1
    • Entrez Gene IDs
      7040 (Human); 21803 (Mouse); 59086 (Rat); 397078 (Porcine); 100033900 (Equine);
    • Alternate Names
      CEDLAP; DPD1; latency-associated peptide; TGFB; TGFB1; TGF-beta 1 protein; TGFbeta 1; TGF-beta 1; TGFbeta; TGF-beta-1; transforming growth factor beta-1; transforming growth factor, beta 1;
    Related Research Areas
    Citations:

    R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

    156 Citations: Showing 1 - 10
    Filter your results:

    Species
    Sample Type
    1. Pharmacologic targeting ERK1/2 attenuates the development and progression of hyperuricemic nephropathy in rats
      Authors: N Liu, L Xu, Y Shi, L Fang, H Gu, H Wang, X Ding, S Zhuang
      Oncotarget, 2017;8(20):33807-33826.
      Species: Rat
      Sample Type: Tissue Culture Supernates
    2. Enhanced antiviral and antifibrotic effects of short hairpin RNAs targeting HBV and TGF-? in HBV-persistent mice
      Authors: L Ye, F Kan, T Yan, J Cao, L Zhang, Z Wu, W Li
      Sci Rep, 2017;7(1):3860.
    3. Ablation of IL-17 expression moderates experimental autoimmune myasthenia gravis disease severity
      Authors: G Aguilo-Sea, Y Xie, J Sheehan, LL Kusner, HJ Kaminski
      Cytokine, 2017;96(0):279-285.
      Species: Mouse
      Sample Type: Serum
    4. Rosmarinic acid attenuates hepatic fibrogenesis via suppression of hepatic stellate cell activation/proliferation and induction of apoptosis
      Authors: NM El-Lakkany, WH El-Maadawy, SH Seif El-Di, OA Hammam, SH Mohamed, SM Ezzat, MM Safar, S Saleh
      Asian Pac J Trop Med, 2017;10(5):444-453.
      Species: Rat
      Sample Type: Tissue Homogenates
    5. Tenascin-C expression and its associated pathway in BMSCs following co-culture with mechanically stretched ligament fibroblasts
      Authors: B Zhao, M Hu, H Wu, C Ren, J Wang, S Cui
      Mol Med Rep, 2017;15(5):2465-2472.
      Species: Rat
      Sample Type: Cell Culture Supernates
    6. Mesenteric lymph node stromal cell-derived extracellular vesicles contribute to peripheral de novo induction of Foxp3(+) regulatory T cells
      Authors: M Pasztoi, J Pezoldt, M Beckstette, C Lipps, D Wirth, M Rohde, K Paloczi, EI Buzas, J Huehn
      Eur. J. Immunol., 2017;0(0):.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    7. Lipoxin A4 encapsulated in PLGA microparticles accelerates wound healing of skin ulcers
      Authors: MB Reis, PAT Pereira, GF Caetano, MN Leite, AF Galvão, FWG Paula-Silv, MAC Frade, LH Faccioli
      PLoS ONE, 2017;12(7):e0182381.
      Species: Rat
      Sample Type: Tissue Homogenates
    8. Changes in skin structure of the Zip13-KO mouse by Makomo (Zizania latifolia) feeding
      Authors: T Yamauchi, T Hirose, K Sato, K Iwai, N Takahashi, J Minaguchi, T Ueno, P Tangkawatt, K Takehana
      J. Vet. Med. Sci., 2017;0(0):.
      Species: Mouse
      Sample Type: Plasma
    9. Fungal immunomodulatory protein-fve could modulate airway remodel through by affect IL17 cytokine
      Authors: YT Lee, CT Wu, HL Sun, JL Ko, KH Lue
      J Microbiol Immunol Infect, 2017;0(0):.
      Species: Mouse
      Sample Type: BALF
    10. A critical role of platelet TGF-? release in podoplanin-mediated tumour invasion and metastasis
      Authors: A Takemoto, M Okitaka, S Takagi, M Takami, S Sato, M Nishio, S Okumura, N Fujita
      Sci Rep, 2017;7(0):42186.
      Species: Human
      Sample Type: Cell Culture Supernates
    11. TGF-?1 autocrine signalling and enamel matrix components
      Sci Rep, 2016;6(0):33644.
      Species: Porcine
      Sample Type:
    12. TGF-? and Physiological Root Resorption of Deciduous Teeth
      Int J Mol Sci, 2016;18(1):.
      Species: Porcine
      Sample Type: Tissue Homogenates
    13. Regulatory T cells exhibit neuroprotective effect in a mouse model of traumatic brain injury
      Mol Med Rep, 2016;14(6):5556-5566.
      Species: Mouse
      Sample Type: Tissue Homogenates
    14. Interferon regulatory factor 4 (IRF4) controls myeloid-derived suppressor cell (MDSC) differentiation and function
      J Leukoc Biol, 2016;0(0):.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    15. Freeze-Dried Platelet-Rich Plasma Accelerates Bone Union with Adequate Rigidity in Posterolateral Lumbar Fusion Surgery Model in Rats
      Sci Rep, 2016;6(0):36715.
      Species: Rat
      Sample Type: Plasma
    16. Ductular reaction-on-a-chip: Microfluidic co-cultures to study stem cell fate selection during liver injury
      Sci Rep, 2016;6(0):36077.
      Species: Rat
      Sample Type: Cell Culture Supernates
    17. Impact of LbSapSal Vaccine in Canine Immunological and Parasitological Features before and after Leishmania chagasi-Challenge
      PLoS ONE, 2016;11(8):e0161169.
      Species: Canine
      Sample Type: Cell Culture Supernates
    18. TGF-? Neutralization Enhances AngII-Induced Aortic Rupture and Aneurysm in Both Thoracic and Abdominal Regions
      Authors: X Chen, DL Rateri, DA Howatt, A Balakrishn, JJ Moorleghen, LA Cassis, A Daugherty
      PLoS ONE, 2016;11(4):e0153811.
      Species: Mouse
      Sample Type: Serum
    19. High Physiological Concentrations of Progesterone Reverse Estradiol-Mediated Changes in Differentiation and Functions of Bone Marrow Derived Dendritic Cells
      Authors: F Xiu, VC Anipindi, PV Nguyen, J Boudreau, H Liang, Y Wan, DP Snider, C Kaushic
      PLoS ONE, 2016;11(4):e0153304.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    20. CP-25, a novel compound, protects against autoimmune arthritis by modulating immune mediators of inflammation and bone damage
      Sci Rep, 2016;6(0):26239.
      Species: Rat
      Sample Type: Serum
    21. Phagocyte respiratory burst activates macrophage erythropoietin signalling to promote acute inflammation resolution
      Nat Commun, 2016;7(0):12177.
      Species: Mouse
      Sample Type: Peritoneal Fluid
    22. Tolerogenic Phenotype of IFN-?-Induced IDO+ Dendritic Cells Is Maintained via an Autocrine IDO-Kynurenine/AhR-IDO Loop
      Authors: Qingsheng Li
      J Immunol, 2016;0(0):.
      Species: Mouse
      Sample Type: Whole Cells
    23. Pleural inhibition of the caspase-1/IL-1? pathway diminishes profibrotic lung toxicity of bleomycin
      Respir. Res, 2016;17(1):162.
      Species: Mouse
      Sample Type: Pleural Lavage
    24. Soluble Vascular Cell Adhesion Molecule-1 (VCAM-1) as a Biomarker in the Mouse Model of Experimental Autoimmune Myocarditis (EAM)
      PLoS ONE, 2016;11(8):e0158299.
      Species: Mouse
      Sample Type: Tissue Homogenates
    25. P311 induces the transdifferentiation of epidermal stem cells to myofibroblast-like cells by stimulating transforming growth factor ?1 expression
      Stem Cell Res Ther, 2016;7(1):175.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    26. Suppression of ROS Production by Exendin-4 in PSC Attenuates the High Glucose-Induced Islet Fibrosis
      PLoS ONE, 2016;11(12):e0163187.
      Species: Rat
      Sample Type: Cell Culture Supernates
    27. Inhibition of Interleukin 17-A but not Interleukin-17F Signaling Lowers Blood Pressure and Reduces End-organ Inflammation in Angiotensin II-induced Hypertension
      Authors: MA Saleh, AE Norlander, MS Madhur
      JACC Basic Transl Sci, 2016;1(7):606-616.
      Species: Mouse
      Sample Type: Tissue Homogenates
    28. Critical role for IL-18 in spontaneous lung inflammation caused by autophagy deficiency.
      Authors: Abdel Fattah E, Bhattacharya A, Herron A, Safdar Z, Eissa N
      J Immunol, 2015;194(11):5407-16.
      Species: Mouse
      Sample Type: BALF
    29. Microglial Kv1.3 Channels and P2Y12 Receptors Differentially Regulate Cytokine and Chemokine Release from Brain Slices of Young Adult and Aged Mice.
      Authors: Charolidi N, Schilling T, Eder C
      PLoS ONE, 2015;10(5):e0128463.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    30. Mesenchymal Stromal Cells Prevent Renal Fibrosis in a Rat Model of Unilateral Ureteral Obstruction by Suppressing the Renin-Angiotensin System via HuR.
      Authors: Gregorini M, Corradetti V, Rocca C, Pattonieri E, Valsania T, Milanesi S, Serpieri N, Bedino G, Esposito P, Libetta C, Avanzini M, Mantelli M, Ingo D, Peressini S, Albertini R, Dal Canton A, Rampino T
      PLoS ONE, 2015;11(2):e0148542.
      Species: Rat
      Sample Type: Tissue Homogenates
    31. Effect of Silodosin, an Alpha1A-Adrenoceptor Antagonist, on Ventral Prostatic Hyperplasia in the Spontaneously Hypertensive Rat.
      Authors: Shimizu S, Shimizu T, Tsounapi P, Higashi Y, Martin D, Nakamura K, Honda M, Inoue K, Saito M
      PLoS ONE, 2015;10(8):e0133798.
      Species: Rat
      Sample Type: Tissue Homogenates
    32. Low TGFbeta1 expression prevents and high expression exacerbates diabetic nephropathy in mice.
      Authors: Hathaway C, Gasim A, Grant R, Chang A, Kim H, Madden V, Bagnell C, Jennette J, Smithies O, Kakoki M
      Proc Natl Acad Sci U S A, 2015;112(18):5815-20.
      Species: Mouse
      Sample Type: Plasma
    33. Alcohol inhibits osteopontin-dependent transforming growth factor-beta1 expression in human mesenchymal stem cells.
      Authors: Driver J, Weber C, Callaci J, Kothari A, Zapf M, Roper P, Borys D, Franzen C, Gupta G, Wai P, Zhang J, Denning M, Kuo P, Mi Z
      J Biol Chem, 2015;290(16):9959-73.
      Species: Mouse
      Sample Type: Tissue Homogenates
    34. MDSC and TGFbeta Are Required for Facilitation of Tumor Growth in the Lungs of Mice Exposed to Carbon Nanotubes.
      Authors: Shvedova A, Kisin E, Yanamala N, Tkach A, Gutkin D, Star A, Shurin G, Kagan V, Shurin M
      Cancer Res, 2015;75(8):1615-23.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    35. WNT5A transforms intestinal CD8alphaalpha(+) IELs into an unconventional phenotype with pro-inflammatory features.
      Authors: Zhao D, Xu A, Dai Z, Peng J, Zhu M, Shen J, Zheng Q, Ran Z
      BMC Gastroenterol, 2015;15(0):173.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    36. Iron-hepcidin dysmetabolism, anemia and renal hypoxia, inflammation and fibrosis in the remnant kidney rat model.
      Authors: Garrido P, Ribeiro S, Fernandes J, Vala H, Bronze-da-Rocha E, Rocha-Pereira P, Belo L, Costa E, Santos-Silva A, Reis F
      PLoS ONE, 2015;10(4):e0124048.
      Species: Rat
      Sample Type: Serum
    37. AKT regulation of mesothelial-to-mesenchymal transition in peritoneal dialysis is modulated by Smurf2 and deubiquitinating enzyme USP4.
      Authors: Xiao L, Peng X, Liu F, Tang C, Hu C, Xu X, Wang M, Luo Y, Yang S, Song P, Xiao P, Kanwar Y, Sun L
      BMC Cell Biol, 2015;16(0):7.
      Species: Mouse
      Sample Type: Peritoneal Dialysate
    38. GP96 is a GARP chaperone and controls regulatory T cell functions.
      Authors: Zhang Y, Wu B, Metelli A, Thaxton J, Hong F, Rachidi S, Ansa-Addo E, Sun S, Vasu C, Yang Y, Liu B, Li Z
      J Clin Invest, 2015;125(2):859-69.
      Species: Mouse
      Sample Type: Serum
    39. Riboswitch-mediated Attenuation of Transgene Cytotoxicity Increases Adeno-associated Virus Vector Yields in HEK-293 Cells.
      Authors: Strobel B, Klauser B, Hartig J, Lamla T, Gantner F, Kreuz S
      Mol Ther, 2015;23(10):1582-91.
      Species: Human
      Sample Type: Cell Culture Supernates
    40. Time-dependent and somatically acquired mitochondrial DNA mutagenesis and respiratory chain dysfunction in a scleroderma model of lung fibrosis.
      Authors: Gazdhar A, Lebrecht D, Roth M, Tamm M, Venhoff N, Foocharoen C, Geiser T, Walker U
      Sci Rep, 2014;4(0):5336.
      Species: Rat
      Sample Type: Tissue Homogenates
    41. Prostatic ischemia induces ventral prostatic hyperplasia in the SHR; possible mechanism of development of BPH.
      Authors: Saito M, Tsounapi P, Oikawa R, Shimizu S, Honda M, Sejima T, Kinoshita Y, Tomita S
      Sci Rep, 2014;4(0):3822.
      Species: Rat
      Sample Type: Tissue Homogenates
    42. Magnetic resonance colonography for fibrosis assessment in rats with chronic colitis.
      Authors: Melchior C, Loeuillard E, Marion-Letellier R, Nicol L, Mulder P, Guerin C, Bole-Feysot C, Aziz M, Dechelotte P, Vera P, Savoye G, Savoye-Collet C
      PLoS ONE, 2014;9(7):e100921.
      Species: Rat
      Sample Type: Tissue Homogenates
    43. Absence of fibromodulin affects matrix composition, collagen deposition and cell turnover in healthy and fibrotic lung parenchyma.
      Authors: Rydell-Tormanen K, Andreasson K, Hesselstrand R, Westergren-Thorsson G
      Sci Rep, 2014;4(0):6383.
      Species: Mouse
      Sample Type: Serum
    44. Pivotal role of phospholipase D1 in tumor necrosis factor-alpha-mediated inflammation and scar formation after myocardial ischemia and reperfusion in mice.
      Authors: Schonberger T, Jurgens T, Muller J, Armbruster N, Niermann C, Gorressen S, Sommer J, Tian H, di Paolo G, Scheller J, Fischer J, Gawaz M, Elvers M
      Am J Pathol, 2014;184(9):2450-64.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    45. Oral administration of Lactobacillus plantarum strain AYA enhances IgA secretion and provides survival protection against influenza virus infection in mice.
      Authors: Kikuchi, Yosuke, Kunitoh-Asari, Ayami, Hayakawa, Katsuyuk, Imai, Shinjiro, Kasuya, Kenji, Abe, Kimio, Adachi, Yu, Fukudome, Shin-Ich, Takahashi, Yoshimas, Hachimura, Satoshi
      PLoS ONE, 2014;9(1):e86416.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    46. Prostaglandin E2 negatively regulates the production of inflammatory cytokines/chemokines and IL-17 in visceral leishmaniasis.
      Authors: Saha A, Biswas A, Srivastav S, Mukherjee M, Das P, Ukil A
      J Immunol, 2014;193(5):2330-9.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    47. Resolvin D1 and lipoxin A4 improve alveolarization and normalize septal wall thickness in a neonatal murine model of hyperoxia-induced lung injury.
      Authors: Martin C, Zaman M, Gilkey C, Salguero M, Hasturk H, Kantarci A, Van Dyke T, Freedman S
      PLoS ONE, 2014;9(6):e98773.
      Species: Mouse
      Sample Type: Tissue Homogenates
    48. Role of Lactobacillus pentosus Strain b240 and the Toll-like receptor 2 axis in Peyer's patch dendritic cell-mediated immunoglobulin A enhancement.
      Authors: Kotani Y, Kunisawa J, Suzuki Y, Sato I, Saito T, Toba M, Kohda N, Kiyono H
      PLoS ONE, 2014;9(3):e91857.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    49. Expression of regulatory T cells in jejunum, colon, and cervical and mesenteric lymph nodes of dogs naturally infected with Leishmania infantum.
      Authors: Figueiredo M, Deoti B, Amorim I, Pinto A, Moraes A, Carvalho C, da Silva S, de Assis A, de Faria A, Tafuri W
      Infect Immun, 2014;82(9):3704-12.
      Species: Canine
      Sample Type: Tissue Homogenates
    50. Mesenchymal stem cells from rats with chronic kidney disease exhibit premature senescence and loss of regenerative potential.
      Authors: Klinkhammer B, Kramann R, Mallau M, Makowska A, van Roeyen C, Rong S, Buecher E, Boor P, Kovacova K, Zok S, Denecke B, Stuettgen E, Otten S, Floege J, Kunter U
      PLoS ONE, 2014;9(3):e92115.
      Species: Rat
      Sample Type: Cell Culture Supernates
    51. Time-dependent expression profiles of microRNAs and mRNAs in rat milk whey.
      Authors: Izumi, Hirohisa, Kosaka, Nobuyosh, Shimizu, Takashi, Sekine, Kazunori, Ochiya, Takahiro, Takase, Mitsunor
      PLoS ONE, 2014;9(2):e88843.
      Species: Rat
      Sample Type: Serum
    52. Transplanted neural stem cells modulate regulatory T, gammadelta T cells and corresponding cytokines after intracerebral hemorrhage in rats.
      Authors: Gao L, Lu Q, Huang L, Ruan L, Yang J, Huang W, ZhuGe W, Zhang Y, Fu B, Jin K, ZhuGe Q
      Int J Mol Sci, 2014;15(3):4431-41.
      Species: Rat
      Sample Type: Serum
    53. The aldosterone receptor antagonist spironolactone prevents peritoneal inflammation and fibrosis.
      Authors: Zhang L, Hao J, Ren L, Ding J, Hao L
      Lab Invest, 2014;94(8):839-50.
      Species: Rat
      Sample Type: Abdominal Cavity Fluid
    54. Autoimmune diabetes is suppressed by treatment with recombinant human tissue Kallikrein-1.
      Authors: Maneva-Radicheva L, Amatya C, Parker C, Ellefson J, Radichev I, Raghavan A, Charles M, Williams M, Robbins M, Savinov A
      PLoS ONE, 2014;9(9):e107213.
      Species: Mouse
      Sample Type: Serum
    55. Inhibition of mammalian target of rapamycin improves neurobehavioral deficit and modulates immune response after intracerebral hemorrhage in rat.
      Authors: Lu Q, Gao L, Huang L, Ruan L, Yang J, Huang W, Li Z, Zhang Y, Jin K, ZhuGe Q
      J Neuroinflammation, 2014;11(0):44.
      Species: Rat
      Sample Type: Serum
    56. Integrin-mediated type II TGF-beta receptor tyrosine dephosphorylation controls SMAD-dependent profibrotic signaling.
      Authors: Chen X, Wang H, Liao H, Hu W, Gewin L, Mernaugh G, Zhang S, Zhang Z, Vega-Montoto L, Vanacore R, Fassler R, Zent R, Pozzi A
      J Clin Invest, 2014;124(8):3295-310.
      Species: Mouse
      Sample Type: Tissue Homogenates
    57. Dystrophic mdx mice develop severe cardiac and respiratory dysfunction following genetic ablation of the anti-inflammatory cytokine IL-10.
      Authors: Nitahara-Kasahara Y, Hayashita-Kinoh H, Chiyo T, Nishiyama A, Okada H, Takeda S, Okada T
      Hum Mol Genet, 2014;23(15):3990-4000.
      Species: Mouse
      Sample Type: Tissue Homogenates
    58. Antitumor activity of total flavonoids from Tetrastigma hemsleyanum Diels et Gilg is associated with the inhibition of regulatory T cells in mice.
      Authors: Feng Z, Hao W, Lin X, Fan D, Zhou J
      Onco Targets Ther, 2014;7(0):947-56.
      Species: Mouse
      Sample Type: Serum
    59. Leishmania donovani targets tumor necrosis factor receptor-associated factor (TRAF) 3 for impairing TLR4-mediated host response.
      Authors: Gupta P, Giri J, Srivastav S, Chande A, Mukhopadhyaya R, Das P, Ukil A
      FASEB J, 2014;28(4):1756-68.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    60. Activin A induces growth arrest through a SMAD- dependent pathway in hepatic progenitor cells.
      Authors: Chen L, Zhang W, Liang H, Zhou Q, Ding Z, Yang H, Liu W, Wu Y, Man Q, Zhang B, Chen X
      Cell Commun Signal, 2014;12(0):18.
      Species: Rat
      Sample Type: Cell Culture Supernates
    61. Enhanced immunogenicity of a tricomponent mannan tetanus toxoid conjugate vaccine targeted to dendritic cells via Dectin-1 by incorporating beta-glucan.
      Authors: Lipinski T, Fitieh A, St Pierre J, Ostergaard H, Bundle D, Touret N
      J Immunol, 2013;190(8):4116-28.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    62. Antifibrotic effects of a recombinant adeno-associated virus carrying small interfering RNA targeting TIMP-1 in rat liver fibrosis.
      Authors: Cong M, Liu T, Wang P, Fan X, Yang A, Bai Y, Peng Z, Wu P, Tong X, Chen J, Li H, Cong R, Tang S, Wang B, Jia J, You H
      Am J Pathol, 2013;182(5):1607-16.
      Species: Rat
      Sample Type: Serum
    63. Transforming growth factor-beta3 (TGF-beta3) knock-in ameliorates inflammation due to TGF-beta1 deficiency while promoting glucose tolerance.
      Authors: Hall B, Wankhade U, Konkel J, Cherukuri K, Nagineni C, Flanders K, Arany P, Chen W, Rane S, Kulkarni A
      J Biol Chem, 2013;288(44):32074-92.
      Species: Mouse
      Sample Type: Serum
    64. Effects of combination therapy with dipeptidyl peptidase-IV and histone deacetylase inhibitors in the non-obese diabetic mouse model of type 1 diabetes.
      Authors: Cabrera S, Colvin S, Tersey S, Maier B, Nadler J, Mirmira R
      Clin Exp Immunol, 2013;172(3):375-82.
      Species: Mouse
      Sample Type: Serum
    65. CP7_E2alf oral vaccination confers partial protection against early classical swine fever virus challenge and interferes with pathogeny-related cytokine responses.
      Authors: Renson P, Le Dimna M, Keranflech A, Cariolet R, Koenen F, Le Potier M
      Vet Res, 2013;44(0):9.
      Species: Porcine
      Sample Type: Serum
    66. Spironolactone attenuates bleomycin-induced pulmonary injury partially via modulating mononuclear phagocyte phenotype switching in circulating and alveolar compartments.
      Authors: Ji W, Ma Y, Zhou X, Zhang Y, Lu R, Guo Z, Sun H, Hu D, Yang G, Li Y, Wei L
      PLoS ONE, 2013;8(11):e81090.
      Species: Mouse
      Sample Type: BALF
    67. Early cardiac changes in a rat model of prediabetes: brain natriuretic peptide overexpression seems to be the best marker.
      Authors: Nunes S, Soares E, Fernandes J, Viana S, Carvalho E, Pereira F, Reis F
      Cardiovasc Diabetol, 2013;12(0):44.
      Species: Rat
      Sample Type: Serum
    68. The soluble interleukin-6 receptor is a mediator of hematopoietic and skeletal actions of parathyroid hormone.
      Authors: Cho S, Pirih F, Koh A, Michalski M, Eber M, Ritchie K, Sinder B, Oh S, Al-Dujaili S, Lee J, Kozloff K, Danciu T, Wronski T, McCauley L
      J Biol Chem, 2013;288(10):6814-25.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    69. FAK-related nonkinase is a multifunctional negative regulator of pulmonary fibrosis.
      Authors: Ding Q, Cai G, Hu M, Yang Y, Zheng A, Tang Q, Gladson C, Hayasaka H, Wu H, You Z, Southern B, Grove L, Rahaman S, Fang H, Olman M
      Am J Pathol, 2013;182(5):1572-84.
      Species: Mouse
      Sample Type: Tissue Culture Supernates
    70. Conditional expression of TGF-beta1 in skeletal muscles causes endomysial fibrosis and myofibers atrophy.
      Authors: Narola J, Pandey S, Glick A, Chen Y
      PLoS ONE, 2013;8(11):e79356.
      Species: Mouse
      Sample Type: Tissue Homogenates
    71. Severe dermatitis with loss of epidermal Langerhans cells in human and mouse zinc deficiency.
      Authors: Kawamura T, Ogawa Y, Nakamura Y
      J. Clin. Invest., 2012;122(2):722-32.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    72. Activated protein C inhibits pancreatic islet inflammation, stimulates T regulatory cells, and prevents diabetes in non-obese diabetic (NOD) mice.
      Authors: Xue M, Dervish S, Harrison LC, Fulcher G, Jackson CJ
      J. Biol. Chem., 2012;287(20):16356-64.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    73. Therapeutic blockade of transforming growth factor beta fails to promote clearance of a persistent viral infection.
      J. Virol., 2012;86(13):7060-71.
      Species: Mouse
      Sample Type: Serum
    74. Inhibition of SLPI ameliorates disease activity in experimental autoimmune encephalomyelitis.
      Authors: Muller AM, Jun E, Conlon H, Sadiq SA
      BMC Neurosci, 2012;13(0):30.
      Species: Mouse
      Sample Type: Serum
    75. Anti-inflammatory effects of FTY720 do not prevent neuronal cell loss in a rat model of optic neuritis.
      Authors: Rau CR, Hein K, Sattler MB, Kretzschmar B, Hillgruber C, McRae BL, Diem R, Bahr M
      Am. J. Pathol., 2012;178(4):1770-81.
      Species: Rat
      Sample Type: Tissue Homogenates
    76. TLR-mediated distinct IFN-gamma/IL-10 pattern induces protective immunity against murine visceral leishmaniasis.
      Eur. J. Immunol., 2012;42(8):2087-99.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    77. Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1-, IL-17-, and G-CSF-dependent manner.
      Blood, 2012;120(13):2600-9.
      Species: Mouse
      Sample Type: Tissue Homogenates
    78. Comparison of the effect of calcium gluconate and batroxobin on the release of transforming growth factor beta 1 in canine platelet concentrates.
      Authors: Silva R, Carmona J, Rezende C
      BMC Vet Res, 2012;8(0):121.
      Species: Canine
      Sample Type: Plasma
    79. Natural IgM is required for suppression of inflammatory arthritis by apoptotic cells.
      Authors: Notley CA, Brown MA, Wright GP, Ehrenstein MR
      J. Immunol., 2011;186(8):4967-72.
      Species: Mouse
      Sample Type: Serum
    80. Tumors Suppress In Situ Proliferation of Cytotoxic T Cells by Promoting Differentiation of Gr-1+ Conventional Dendritic Cells through IL-6.
      Authors: Diao J, Zhao J, Winter E
      J. Immunol., 2011;186(9):5058-67.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    81. Involvement of adenosine A2A receptors in engulfment-dependent apoptotic cell suppression of inflammation.
      Authors: Koroskenyi K, Duro E, Pallai A, Sarang Z, Kloor D, Ucker DS, Beceiro S, Castrillo A, Chawla A, Ledent CA, Fésüs L, Szondy Z
      J. Immunol., 2011;186(12):7144-55.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    82. Calpain mediates pulmonary vascular remodeling in rodent models of pulmonary hypertension, and its inhibition attenuates pathologic features of disease.
      Authors: Ma W, Han W, Greer PA, Tuder RM, Toque HA, Wang KK, Caldwell RW, Su Y
      J. Clin. Invest., 2011;121(11):4548-66.
      Species: Mouse
      Sample Type: Plasma
    83. Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function.
      Authors: Hall BE, Zheng C, Swaim WD, Cho A, Nagineni CN, Eckhaus MA, Flanders KC, Ambudkar IS, Baum BJ, Kulkarni AB
      Lab. Invest., 2011;90(4):543-55.
      Species: Mouse
      Sample Type: Serum
    84. Epithelial overexpression of SOCS-3 in transgenic mice exacerbates wound inflammation in the presence of elevated TGF-beta1.
      Authors: Linke A, Goren I, Bosl MR, Pfeilschifter J, Frank S
      J. Invest. Dermatol., 2010;130(3):866-75.
      Species: Mouse
      Sample Type: Tissue Homogenates
    85. Microbial exposure early in life regulates airway inflammation in mice after infection with Streptococcus pneumoniae with enhancement of local resistance.
      Authors: Yasuda Y, Matsumura Y, Kasahara K, Ouji N, Sugiura S, Mikasa K, Kita E
      Am. J. Physiol. Lung Cell Mol. Physiol., 2010;298(1):L67-78.
      Species: Mouse
      Sample Type: BALF
    86. Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease.
      Authors: Liu X, Leung S, Wang C, Tan Z, Wang J, Guo TB, Fang L, Zhao Y, Wan B, Qin X, Lu L, Li R, Pan H, Song M, Liu A, Hong J, Lu H, Zhang JZ
      Nat. Med., 2010;16(2):191-7.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    87. Chemerin peptides promote phagocytosis in a ChemR23- and Syk-dependent manner.
      Authors: Cash JL, Christian AR, Greaves DR
      J. Immunol., 2010;184(9):5315-24.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    88. Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model.
      Authors: Yoshizaki A, Yanaba K, Iwata Y
      J. Immunol., 2010;185(4):2502-15.
      Species: Mouse
      Sample Type: Serum
    89. Poly(ADP-ribose) polymerase (PARP) inhibition counteracts multiple manifestations of kidney disease in long-term streptozotocin-diabetic rat model.
      Authors: Shevalye H, Stavniichuk R, Xu W, Zhang J, Lupachyk S, Maksimchyk Y, Drel VR, Floyd EZ, Slusher B, Obrosova IG
      Biochem. Pharmacol., 2010;79(7):1007-14.
      Species: Rat
      Sample Type: Tissue Homogenates
    90. Anti-Asthma Simplified Herbal Medicine Intervention-induced long-lasting tolerance to allergen exposure in an asthma model is interferon-gamma, but not transforming growth factor-beta dependent.
      Authors: Srivastava K, Zhang T, Yang N, Sampson H, Li XM
      Clin. Exp. Allergy, 2010;40(11):1678-88.
      Species: Mouse
      Sample Type: BALF
    91. Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling.
      Authors: Graham BB, Mentink-Kane MM, El-Haddad H
      Am. J. Pathol., 2010;177(3):1549-61.
      Species: Mouse
      Sample Type: Tissue Homogenates
    92. Inhaled multiwalled carbon nanotubes potentiate airway fibrosis in murine allergic asthma.
      Authors: Ryman-Rasmussen JP, Tewksbury EW, Moss OR, Cesta MF, Wong BA, Bonner JC
      Am. J. Respir. Cell Mol. Biol., 2009;40(3):349-58.
      Species: Mouse
      Sample Type: BALF
    93. Loss of Thy-1 inhibits alveolar development in the newborn mouse lung.
      Authors: Nicola T, Hagood JS, James ML, Macewen MW, Williams TA, Hewitt MM, Schwiebert L, Bulger A, Oparil S, Chen YF, Ambalavanan N
      Am. J. Physiol. Lung Cell Mol. Physiol., 2009;296(5):L738-50.
      Species: Mouse
      Sample Type: Tissue Homogenates
    94. TNFalpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation.
      Authors: Borges VM, Vandivier RW, McPhillips KA, Kench JA, Morimoto K, Groshong SD, Richens TR, Graham BB, Muldrow AM, Van Heule L, Henson PM, Janssen WJ
      Am. J. Physiol. Lung Cell Mol. Physiol., 2009;297(4):L586-95.
      Species: Mouse
      Sample Type: BALF
    95. Osteopontin deficiency protects against airway remodeling and hyperresponsiveness in chronic asthma.
      Authors: Simoes DC, Xanthou G, Petrochilou K, Panoutsakopoulou V, Roussos C, Gratziou C
      Am. J. Respir. Crit. Care Med., 2009;179(10):894-902.
      Species: Mouse
      Sample Type: Tissue Homogenates
    96. Vaccination route that induces transforming growth factor beta production fails to elicit protective immunity against Leishmania donovani infection.
      Authors: Bhowmick S, Mazumdar T, Ali N
      Infect. Immun., 2009;77(4):1514-23.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    97. Poly(Adenosine 5'-diphosphate-ribose) polymerase inhibition counteracts multiple manifestations of experimental type 1 diabetic nephropathy.
      Authors: Drel VR, Xu W, Zhang J, Pavlov IA, Shevalye H, Slusher B, Obrosova IG
      Endocrinology, 2009;150(12):5273-83.
      Species: Rat
      Sample Type: Tissue Homogenates
    98. Differential IL-23 requirement for IL-22 and IL-17A production during innate immunity against Salmonella enterica serovar Enteritidis.
      Authors: Siegemund S, Schutze N, Schulz S, Wolk K, Nasilowska K, Straubinger RK, Sabat R, Alber G
      Int. Immunol., 2009;21(5):555-65.
      Species: Mouse
      Sample Type: Peritoneal Lavage
    99. Macrophage migration inhibitory factor homologs of anisakis simplex suppress Th2 response in allergic airway inflammation model via CD4+CD25+Foxp3+ T cell recruitment.
      Authors: Park SK, Cho MK, Park HK, Lee KH, Lee SJ, Choi SH, Ock MS, Jeong HJ, Lee MH, Yu HS
      J. Immunol., 2009;182(11):6907-14.
      Species: Mouse
      Sample Type: BALF
    100. A small molecule CRTH2 antagonist inhibits FITC-induced allergic cutaneous inflammation.
      Authors: Boehme SA, Franz-Bacon K, Chen EP, Sasik R, Sprague LJ, Ly TW, Hardiman G, Bacon KB
      Int. Immunol., 2009;21(1):81-93.
      Species: Mouse
      Sample Type: Tissue Homogenates
    101. Effects of a leukotriene B4 receptor antagonist on bleomycin-induced pulmonary fibrosis.
      Authors: Izumo T, Kondo M, Nagai A
      Eur. Respir. J., 2009;34(6):1444-51.
      Species: Mouse
      Sample Type: BALF
    102. Autologous mesenchymal stem cells produce reverse remodelling in chronic ischaemic cardiomyopathy.
      Authors: Schuleri KH, Feigenbaum GS, Centola M, Weiss ES, Zimmet JM, Turney J, Kellner J, Zviman MM, Hatzistergos KE, Detrick B, Conte JV, McNiece I, Steenbergen C, Lardo AC, Hare JM
      Eur. Heart J., 2009;30(22):2722-32.
      Species: Porcine
      Sample Type: Serum
    103. Attenuation of AD-like neuropathology by harnessing peripheral immune cells: local elevation of IL-10 and MMP-9.
      Authors: Koronyo-Hamaoui M, Ko MK, Koronyo Y, Azoulay D, Seksenyan A, Kunis G, Pham M, Bakhsheshian J, Rogeri P, Black KL, Farkas DL, Schwartz M
      J. Neurochem., 2009;111(6):1409-24.
      Species: Mouse
      Sample Type: Tissue Homogenates
    104. Intravenous tolerance modulates macrophage classical activation and antigen presentation in experimental autoimmune encephalomyelitis.
      Authors: Li H, Ciric B, Yang J, Xu H, Fitzgerald DC, Elbehi M, Fonseca-Kelly Z, Yu S, Zhang GX, Rostami A
      J. Neuroimmunol., 2009;208(1):54-60.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    105. Oridonin promotes CD4+/CD25+ Treg differentiation, modulates Th1/Th2 balance and induces HO-1 in rat splenic lymphocytes.
      Authors: Hu AP, Du JM, Li JY, Liu JW
      Inflamm. Res., 2008;57(4):163-70.
      Species: Rat
      Sample Type: Cell Culture Supernates
    106. Adverse functions of IL-17A in experimental sepsis.
      Authors: Flierl MA, Rittirsch D, Gao H, Hoesel LM, Nadeau BA, Day DE, Zetoune FS, Sarma JV, Huber-Lang MS, Ferrara JL, Ward PA
      FASEB J., 2008;22(7):2198-205.
      Species: Mouse
      Sample Type: Plasma
    107. The LTK63 adjuvant improves protection conferred by Ag85B DNA-protein prime-boosting vaccination against Mycobacterium tuberculosis infection by dampening IFN-gamma response.
      Authors: Palma C, Iona E, Giannoni F, Pardini M, Brunori L, Fattorini L, Del Giudice G, Cassone A
      Vaccine, 2008;26(33):4237-43.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    108. Chemokine receptor CX3CR1 mediates skin wound healing by promoting macrophage and fibroblast accumulation and function.
      Authors: Ishida Y, Gao JL, Murphy PM
      J. Immunol., 2008;180(1):569-79.
      Species: Mouse
      Sample Type: Tissue Homogenates
    109. The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice.
      Authors: Guo B, Chang EY, Cheng G
      J. Clin. Invest., 2008;118(5):1680-90.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    110. Antifibrotic action of pirfenidone and prednisolone: different effects on pulmonary cytokines and growth factors in bleomycin-induced murine pulmonary fibrosis.
      Authors: Oku H, Shimizu T, Kawabata T, Nagira M, Hikita I, Ueyama A, Matsushima S, Torii M, Arimura A
      Eur. J. Pharmacol., 2008;590(1):400-8.
      Species: Mouse
      Sample Type: Tissue Homogenates
    111. Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis.
      Authors: Munitz A, Brandt EB, Mingler M, Finkelman FD, Rothenberg ME
      Proc. Natl. Acad. Sci. U.S.A., 2008;105(20):7240-5.
      Species: Mouse
      Sample Type: BALF
    112. A3 adenosine receptor signaling influences pulmonary inflammation and fibrosis.
      Authors: Morschl E, Molina JG, Volmer JB, Mohsenin A, Pero RS, Hong JS, Kheradmand F, Lee JJ, Blackburn MR
      Am. J. Respir. Cell Mol. Biol., 2008;39(6):697-705.
      Species: Mouse
      Sample Type: BALF
    113. Pin1 regulates TGF-beta1 production by activated human and murine eosinophils and contributes to allergic lung fibrosis.
      Authors: Shen ZJ, Esnault S, Rosenthal LA, Szakaly RJ, Sorkness RL, Westmark PR, Sandor M, Malter JS
      J. Clin. Invest., 2008;118(2):479-90.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    114. Pulmonary stromal cells induce the generation of regulatory DC attenuating T-cell-mediated lung inflammation.
      Authors: Li Q, Guo Z, Xu X, Xia S, Cao X
      Eur. J. Immunol., 2008;38(10):2751-61.
      Species: Mouse
      Sample Type: BALF
    115. Tissue transglutaminase contributes to interstitial renal fibrosis by favoring accumulation of fibrillar collagen through TGF-beta activation and cell infiltration.
      Authors: Shweke N, Boulos N, Jouanneau C, Vandermeersch S, Melino G, Dussaule JC, Chatziantoniou C, Ronco P, Boffa JJ
      Am. J. Pathol., 2008;173(3):631-42.
      Species: Mouse
      Sample Type: Tissue Homogenates
    116. Thymic stromal lymphopoietin and thymic stromal lymphopoietin-conditioned dendritic cells induce regulatory T-cell differentiation and protection of NOD mice against diabetes.
      Authors: Besin G, Gaudreau S, Menard M, Guindi C, Dupuis G, Amrani A
      Diabetes, 2008;57(8):2107-17.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    117. IL-13 receptor alpha2 selectively inhibits IL-13-induced responses in the murine lung.
      Authors: Zheng T, Liu W, Oh SY, Zhu Z, Hu B, Homer RJ, Cohn L, Grusby MJ, Elias JA
      J. Immunol., 2008;180(1):522-9.
      Species: Mouse
      Sample Type: BALF
    118. Novel immunomodulatory properties of berbamine through selective down-regulation of STAT4 and action of IFN-gamma in experimental autoimmune encephalomyelitis.
      Authors: Ren Y, Lu L, Guo TB, Qiu J, Yang Y, Liu A, Zhang JZ
      J. Immunol., 2008;181(2):1491-8.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    119. Molecular mechanisms of TGFbeta receptor-triggered signaling cascades rapidly induced by the calcineurin inhibitors cyclosporin A and FK506.
      Authors: Akool el-S, Doller A, Babelova A, Tsalastra W, Moreth K, Schaefer L, Pfeilschifter J, Eberhardt W
      J. Immunol., 2008;181(4):2831-45.
      Species: Rat
      Sample Type: Urine
    120. Cytokine production by M-CSF- and GM-CSF-induced mouse bone marrow-derived macrophages upon coculturing with late apoptotic cells.
      Authors: Yamazaki T, Nagata K, Kobayashi Y
      Cell. Immunol., 2008;251(2):124-30.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    121. Observations on the microvasculature of bone defects filled with biodegradable nanoparticulate hydroxyapatite.
      Authors: Kilian O, Wenisch S, Karnati S, Baumgart-Vogt E, Hild A, Fuhrmann R, Jonuleit T, Dingeldein E, Schnettler R, Franke RP
      Biomaterials, 2008;29(24):3429-37.
      Species: Porcine
      Sample Type: Plasma
    122. Dendritic cells derived from TBP-2-deficient mice are defective in inducing T cell responses.
      Authors: Son A, Nakamura H, Okuyama H, Oka S, Yoshihara E, Liu W, Matsuo Y, Kondo N, Masutani H, Ishii Y, Iyoda T, Inaba K, Yodoi J
      Eur. J. Immunol., 2008;38(5):1358-67.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    123. A novel mechanism for CCR4 in the regulation of macrophage activation in bleomycin-induced pulmonary fibrosis.
      Authors: Trujillo G, O'Connor EC, Kunkel SL, Hogaboam CM
      Am. J. Pathol., 2008;172(5):1209-21.
      Species: Mouse
      Sample Type: Tissue Homogenates
    124. Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1- and M2-type characteristics.
      Authors: Umemura N, Saio M, Suwa T, Kitoh Y, Bai J, Nonaka K, Ouyang GF, Okada M, Balazs M, Adany R, Shibata T, Takami T
      J. Leukoc. Biol., 2008;83(5):1136-44.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    125. Lipopolysaccharide-activated IL-10-secreting dendritic cells suppress experimental autoimmune uveoretinitis by MHCII-dependent activation of CD62L-expressing regulatory T cells.
      Authors: Lau AW, Biester S, Cornall RJ, Forrester JV
      J. Immunol., 2008;180(6):3889-99.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    126. T and B lymphocyte depletion has a marked effect on the fibrosis of dystrophic skeletal muscles in the scid/mdx mouse.
      Authors: Farini A, Meregalli M, Belicchi M, Battistelli M, Parolini D, D'Antona G, Gavina M, Ottoboni L, Constantin G, Bottinelli R, Torrente Y
      J. Pathol., 2007;213(2):229-38.
      Species: Mouse
      Sample Type: Tissue Homogenates
    127. The role of the receptor for advanced glycation end-products in lung fibrosis.
      Authors: He M, Kubo H, Ishizawa K, Hegab AE, Yamamoto Y, Yamamoto H, Yamaya M
      Am. J. Physiol. Lung Cell Mol. Physiol., 2007;293(6):L1427-36.
      Species: Mouse
      Sample Type: BALF
    128. A new murine model for bronchiolitis obliterans post-bone marrow transplant.
      Authors: Panoskaltsis-Mortari A, Tram KV, Price AP, Wendt CH, Blazar BR
      Am. J. Respir. Crit. Care Med., 2007;176(7):713-23.
      Species: Mouse
      Sample Type: Serum
    129. IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice.
      Authors: Gasse P, Mary C, Guenon I, Noulin N, Charron S, Schnyder-Candrian S, Schnyder B, Akira S, Quesniaux VF, Lagente V, Ryffel B, Couillin I
      J. Clin. Invest., 2007;117(12):3786-99.
      Species: Mouse
      Sample Type: BALF
    130. Cysteinyl-leukotriene 1 receptor antagonist attenuates bleomycin-induced pulmonary fibrosis in mice.
      Authors: Izumo T, Kondo M, Nagai A
      Life Sci., 2007;80(20):1882-6.
      Species: Mouse
      Sample Type: BALF
    131. Although pig allogeneic mesenchymal stem cells are not immunogenic in vitro, intracardiac injection elicits an immune response in vivo.
      Authors: Poncelet AJ, Vercruysse J, Saliez A, Gianello P
      Transplantation, 2007;83(6):783-90.
      Species: Porcine
      Sample Type: Cell Culture Supernates
    132. Secreted protein acidic and rich in cysteine deficiency ameliorates renal inflammation and fibrosis in angiotensin hypertension.
      Authors: Socha MJ, Manhiani M, Said N, Imig JD, Motamed K
      Am. J. Pathol., 2007;171(4):1104-12.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    133. Chronic intranasal administration of mould spores or extracts to unsensitized mice leads to lung allergic inflammation, hyper-reactivity and remodelling.
      Authors: Denis O, van den Brule S, Heymans J, Havaux X, Rochard C, Huaux F, Huygen K
      Immunology, 2007;122(2):268-78.
      Species: Mouse
      Sample Type: BALF
    134. Somatic excision demonstrates that c-Jun induces cellular migration and invasion through induction of stem cell factor.
      Authors: Katiyar S, Jiao X, Wagner E, Lisanti MP, Pestell RG
      Mol. Cell. Biol., 2007;27(4):1356-69.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    135. Reversion of immune tolerance in advanced malignancy: modulation of myeloid-derived suppressor cell development by blockade of stem-cell factor function.
      Authors: Pan PY, Wang GX, Yin B, Ozao J, Ku T, Divino CM, Chen SH
      Blood, 2007;111(1):219-28.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    136. Pharmacological inhibition of epsilon PKC suppresses chronic inflammation in murine cardiac transplantation model.
      Authors: Koyanagi T, Noguchi K, Ootani A, Inagaki K, Robbins RC, Mochly-Rosen D
      J. Mol. Cell. Cardiol., 2007;43(4):517-22.
      Species: Mouse
      Sample Type: Tissue Homogenates
    137. Liposomal retinoic acids modulate asthma manifestations in mice.
      Authors: Maret M, Ruffie C, Periquet B, Campo AM, Menevret M, Phelep A, Dziewiszek K, Druilhe A, Pretolani M
      J. Nutr., 2007;137(12):2730-6.
      Species: Mouse
      Sample Type: BALF
    138. Characterization of in vitro antimurine thymocyte globulin-induced regulatory T cells that inhibit graft-versus-host disease in vivo.
      Authors: Ruzek MC, Waire JS, Hopkins D, Lacorcia G, Sullivan J, Roberts BL, Richards SM, Nahill SR, Williams JM, Scaria A, Dzuris J, Shankara S, Garman RD
      Blood, 2007;111(3):1726-34.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    139. Intercellular adhesion molecule-1 expression is required on multiple cell types for the development of experimental autoimmune encephalomyelitis.
      Authors: Bullard DC, Hu X, Schoeb TR, Collins RG, Beaudet AL, Barnum SR
      J. Immunol., 2007;178(2):851-7.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    140. Bim deficiency leads to exacerbation and prolongation of joint inflammation in experimental arthritis.
      Authors: Scatizzi JC, Bickel E, Hutcheson J, Haines GK, Perlman H
      Arthritis Rheum., 2006;54(10):3182-93.
      Species: Mouse
      Sample Type: Tissue Homogenates
    141. Modulation of airway remodeling and airway inflammation by peroxisome proliferator-activated receptor gamma in a murine model of toluene diisocyanate-induced asthma.
      Authors: Lee KS, Park SJ, Kim SR, Min KH, Jin SM, Lee HK, Lee YC
      J. Immunol., 2006;177(8):5248-57.
      Species: Mouse
      Sample Type: BALF
    142. Oxidative stress during peritoneal dialysis: implications in functional and structural changes in the membrane.
      Authors: Noh H, Kim JS, Han KH, Lee GT, Song JS, Chung SH, Jeon JS, Ha H, Lee HB
      Kidney Int., 2006;69(11):2022-8.
      Species: Rat
      Sample Type: Tissue Homogenates
    143. Inhibition of p38 mitogen-activated protein kinase and transforming growth factor-beta1/Smad signaling pathways modulates the development of fibrosis in adriamycin-induced nephropathy.
      Authors: Li J, Campanale NV, Liang RJ, Deane JA, Bertram JF, Ricardo SD
      Am. J. Pathol., 2006;169(5):1527-40.
      Species: Mouse
      Sample Type: Tissue Homogenates
    144. Fibroblast growth factor 2 modulates transforming growth factor beta signaling in mouse embryonic fibroblasts and human ESCs (hESCs) to support hESC self-renewal.
      Authors: Greber B, Lehrach H, Adjaye J
      Stem Cells, 2006;25(2):455-64.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    145. Oral administration of an immunostimulatory DNA sequence from Bifidobacterium longum improves Th1/Th2 balance in a murine model.
      Authors: Takahashi N, Kitazawa H, Iwabuchi N, Xiao JZ, Miyaji K, Iwatsuki K, Saito T
      Biosci. Biotechnol. Biochem., 2006;70(8):2013-7.
      Species: Mouse
      Sample Type: Cell Culture Supernates
    146. Leukocyte-derived IL-10 reduces subepithelial fibrosis associated with chronically inhaled endotoxin.
      Authors: Garantziotis S, Brass DM, Savov J, Hollingsworth JW, McElvania-TeKippe E, Berman K, Walker JK, Schwartz DA
      Am. J. Respir. Cell Mol. Biol., 2006;35(6):662-7.
      Species: Mouse
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    147. Tumor metastasis in an orthotopic murine model of head and neck cancer: possible role of TGF-beta 1 secreted by the tumor cells.
      Authors: Dasgupta S, Bhattacharya-Chatterjee M, O'Malley BW, Chatterjee SK
      J. Cell. Biochem., 2006;97(5):1036-51.
      Species: Mouse
      Sample Type: Serum
    148. Transglutaminase 2 limits murine peritoneal acute gout-like inflammation by regulating macrophage clearance of apoptotic neutrophils.
      Authors: Rose DM, Sydlaske AD, Agha-Babakhani A, Johnson K, Terkeltaub R
      Arthritis Rheum., 2006;54(10):3363-71.
      Species: Mouse
      Sample Type: Peritoneal Lavage
    149. Inhaled nitric oxide improves the survival of the paraquat-injured rats.
      Authors: Cho JH, Yang DK, Kim L, Ryu JS, Lee HL, Lim CM, Koh YS
      Vascul. Pharmacol., 2005;42(4):171-8.
      Species: Rat
      Sample Type: Serum
    150. Vaccination of apoptotic Fas ligand-expressing tumors decreased antitumor responses by enhanced production of immunosuppressive cytokines.
      Authors: Wada A, Tada Y, Shimozato O, Takiguchi Y, Tatsumi K, Kuriyama T, Tagawa M
      Anticancer Res., 2005;25(1):299-303.
      Species: Mouse
      Sample Type: Tissue Secretion
    151. Nitric oxide induces TIMP-1 expression by activating the transforming growth factor beta-Smad signaling pathway.
      Authors: Akool el-S, Doller A, Muller R, Gutwein P, Xin C, Huwiler A, Pfeilschifter J, Eberhardt W
      J. Biol. Chem., 2005;280(47):39403-16.
      Species: Rat
      Sample Type: Cell Culture Supernates
    152. Suppression of cytokine-inducible nitric oxide synthesis during intraperitoneal Meth A tumor growth.
      Authors: Kwon OD, Yim CY, Jeong KS, Park SC, Jung KY, McGregor JR, Bastian NR, Samlowski WE
      J. Vet. Med. Sci., 2004;66(5):357-65.
      Species: Mouse
      Sample Type: Ascites Fluid
    153. Transforming growth factor beta1 expression and activation is increased in the alcoholic rat lung.
      Authors: Bechara RI, Brown LA, Roman J, Joshi PC, Guidot DM
      Am. J. Respir. Crit. Care Med., 2004;170(2):188-94.
      Species: Rat
      Sample Type: Tissue Homogenates
    154. Measurement of bone morphogenetic proteins and other growth factors in demineralized bone matrix.
      Authors: Blum B, Moseley J, Miller L, Richelsoph K, Haggard W
      Orthopedics, 2004;27(1):161-5.
      Species: Human
      Sample Type: Tissue Homogenates
    155. T cell-specific ablation of Fas leads to Fas ligand-mediated lymphocyte depletion and inflammatory pulmonary fibrosis.
      Authors: Hao Z, Hampel B, Yagita H, Rajewsky K
      J. Exp. Med., 2004;199(10):1355-65.
      Species: Mouse
      Sample Type: Serum
    156. Marked airway eosinophilia prevents development of airway hyper-responsiveness during an allergic response in IL-5 transgenic mice.
      Authors: Kobayashi T, Iijima K, Kita H
      J. Immunol., 2003;170(11):5756-63.
      Species: Mouse
      Sample Type: BALF
    Expand to show all 156 Citations
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    Sample TestedRAW 264.7 mouse monocyte/macrophage cell line
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    Sample TestedMesenchymal stem cells

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    Other Experimental DetailsWe use to monitor immunomodulatory effects of MSCs.
     Mouse/Rat/Porcine/Canine TGF-beta 1 Quantikine ELISA Kit MB100B
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     Mouse/Rat/Porcine/Canine TGF-beta 1 Quantikine ELISA Kit MB100B
    : Mouse/Rat/Porcine/Canine TGF-beta 1 Quantikine ELISA Kit [MB100B]

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    Sample TestedCell culture supernatant

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