Mouse/Rat TrkC Antibody Summary
Cys32-Thr429
Accession # Q6VNS1
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Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data

Detection of Mouse and Rat TrkC by Western Blot. Western blot shows lysates of mouse brain (cerebellum) tissue, mouse brain (cortex) tissue, and rat brain tissue. PVDF membrane was probed with 0.5 µg/mL of Goat Anti-Mouse/Rat TrkC Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1404) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). Specific bands were detected for TrkC at approximately 100 and 140 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Detection of Mouse TrkC by Simple WesternTM. Simple Western lane view shows lysates of mouse brain tissue, loaded at 0.2 mg/mL. Specific bands were detected for TrkC at approximately 111 and 159 kDa (as indicated) using 25 µg/mL of Goat Anti-Mouse/Rat TrkC Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1404) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: TrkC
The neurotrophins, including NGF, BDNF, NT‑3 and NT‑4/5, constitute a group of structurally related, secreted proteins that play an important role in the development and function of the nervous system. The biological activities of the neurotrophins are mediated by binding to and activating two unrelated receptor types: the p75 neurotrophin receptor (p75NTR) and the Trk family of receptor tyrosine kinases (1, 2). p75NTR is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and has been designated TNFRSF16. It binds all neurotrophins with low affinity to transduce cellular signaling pathways that synergize or antagonize those activated by the Trk receptors. Three Trk family proteins, TrkA, TrkB, and TrkC, exhibiting different ligand specificities, have been identified. TrkA binds NGF and NT‑3, TrkB binds BDNF, NT‑3 and NT‑4/5, and TrkC only binds NT‑3 (1‑2). All Trk family proteins share a conserved, complex subdomain organization consisting of a signal peptide, two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains in the extracellular region, as well as an intracellular region that contains the tyrosine kinase domain (3). Natural splice variants of the different Trks, lacking the first cysteine-rich domain, the first and second or all three of the leucine-rich motifs, or the tyrosine kinase domain, have been described (4). At the protein sequence level, Trks are highly conserved between species with the extracellular domains of human and mouse TrkC showing 94% amino acid sequence identity (5). The proteins also exhibit cross-species activity. The primary location of TrkC expression is in the nervous system and, specifically, in regions of the CNS. Low level TrkC expression has also been observed in a wide variety of tissues outside the nervous system (6).
- Huang, E.J. and L.F. Reichardt (2003) Annu. Rev. Biochem. 72:609.
- Dechant, G. (2001) Cell Tissue Res. 305:229.
- Schneider, R. and M. Schweiger (1991) Oncogene 6:1807.
- Ninkina, N. et al. (1997) J. Biol. Chem. 272:13019.
- Menn, B. et al. (1998) J. Comp. Neurol. 401:47.
- Shelton, D. et al. (1995) J. Neurosci. 15:477.
Product Datasheets
Citations for Mouse/Rat TrkC Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 10
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Exploring the potential application of dental pulp stem cells in neuroregenerative medicine
Authors: N Sultan, BA Scheven
Neural regeneration research, 2022;17(4):775-776.
Species: Rat
Sample Types: Whole Cells
Applications: Neutralization -
Dental pulp stem cells stimulate neuronal differentiation of PC12 cells
Authors: N Sultan, LE Amin, AR Zaher, ME Grawish, BA Scheven
Neural regeneration research, 2021;16(9):1821-1828.
Species: Rat
Sample Types: Whole Cells
Applications: Neutralization -
Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates
Authors: L Faure, Y Wang, ME Kastriti, P Fontanet, KKY Cheung, C Petitpré, H Wu, LL Sun, K Runge, L Croci, MA Landy, HC Lai, GG Consalez, A de Chevign, F Lallemend, I Adameyko, S Hadjab
Nat Commun, 2020;11(1):4175.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Ameloblastomas Exhibit Stem Cell Potential, Possess Neurotrophic Properties, and Establish Connections with Trigeminal Neurons
Authors: P Pagella, J Catón, CT Meisel, TA Mitsiadis
Cells, 2020;9(3):.
Species: Human
Sample Types: Whole Tissue
Applications: IHC-P -
Generation of self-organized sensory ganglion organoids and retinal ganglion cells from fibroblasts
Authors: D Xiao, Q Deng, Y Guo, X Huang, M Zou, J Zhong, P Rao, Z Xu, Y Liu, Y Hu, Y Shen, K Jin, M Xiang
Sci Adv, 2020;6(22):eaaz5858.
Species: Mouse
Sample Types: Whole Tissue
Applications: ICC -
Cyclic Stretch of Either PNS or CNS Located Nerves Can Stimulate Neurite Outgrowth
Authors: V Kampanis, B Tolou-Dabb, L Zhou, W Roth, R Puttagunta
Cells, 2020;10(1):.
Species: Rat
Sample Types: Whole Cells
Applications: ICC -
Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates
Authors: L Faure, Y Wang, ME Kastriti, P Fontanet, KKY Cheung, C Petitpré, H Wu, LL Sun, K Runge, L Croci, MA Landy, HC Lai, GG Consalez, A de Chevign, F Lallemend, I Adameyko, S Hadjab
Nat Commun, 2020;11(1):4175.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Spinal Inhibitory Ptf1a-Derived Neurons Prevent Self-Generated Itch
Authors: A Escalante, R Klein
Cell Rep, 2020;33(8):108422.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner
Authors: M Bohic, I Marics, C Santos, P Malapert, N Ben-Arie, C Salio, A Reynders, Y Le Feuvre, AJ Saurin, A Moqrich
Cell Rep, 2020;30(3):602-610.e6.
Species: Mouse
Sample Types: Whole Tissue
Applications: IF -
Notch signalling defines dorsal root ganglia neuroglial fate choice during early neural crest cell migration
Authors: S Wiszniak, Q Schwarz
BMC Neurosci, 2019;20(1):21.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-F -
Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA
Authors: S Desiderio, S Vermeiren, C Van Campen, S Kricha, E Malki, S Richts, EV Fletcher, T Vanwelden, BZ Schmidt, KA Henningfel, T Pieler, CG Woods, V Nagy, C Verfaillie, EJ Bellefroid
Cell Rep, 2019;26(13):3522-3536.e5.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC -
Functional Local Proprioceptive Feedback Circuits Initiate and Maintain Locomotor Recovery after Spinal Cord Injury
Authors: A Takeoka, S Arber
Cell Rep, 2019;27(1):71-85.e3.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis
Authors: L Bartesaghi, Y Wang, P Fontanet, S Wanderoy, F Berger, H Wu, N Akkuratova, F Bouçanova, JJ Médard, C Petitpré, MA Landy, MD Zhang, P Harrer, C Stendel, R Stucka, M Dusl, ME Kastriti, L Croci, HC Lai, GG Consalez, A Pattyn, P Ernfors, J Senderek, I Adameyko, F Lallemend, S Hadjab, R Chrast
Cell Rep, 2019;26(13):3484-3492.e4.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice
Authors: M Zhang, Y Wang, J Geng, S Zhou, B Xiao
Cell Rep, 2019;26(6):1419-1431.e4.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
A cell fitness selection model for neuronal survival during development
Authors: Y Wang, H Wu, P Fontanet, S Codeluppi, N Akkuratova, C Petitpré, Y Xue-Franzé, K Niederreit, A Sharma, F Da Silva, G Comai, G Agirman, D Palumberi, S Linnarsson, I Adameyko, A Moqrich, A Schedl, G La Manno, S Hadjab, F Lallemend
Nat Commun, 2019;10(1):4137.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC -
Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch
Authors: D Acton, X Ren, S Di Costanz, A Dalet, S Bourane, I Bertocchi, C Eva, M Goulding
Cell Rep, 2019;28(3):625-639.e6.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Optogenetic Activation of Non-Nociceptive A? Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats
Authors: R Tashima, K Koga, M Sekine, K Kanehisa, Y Kohro, K Tominaga, K Matsushita, H Tozaki-Sai, Y Fukazawa, K Inoue, H Yawo, H Furue, M Tsuda
eNeuro, 2018;5(1):.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC -
Characteristics of sensory neuronal groups in CGRP-cre-ER reporter mice: Comparison to Nav1.8-cre, TRPV1-cre and TRPV1-GFP mouse lines
Authors: MJ Patil, AH Hovhannisy, AN Akopian
PLoS ONE, 2018;13(6):e0198601.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells
Authors: AJ Alshawaf, S Viventi, W Qiu, G D'Abaco, B Nayagam, M Erlichster, G Chana, I Everall, J Ivanusic, E Skafidas, M Dottori
Sci Rep, 2018;8(1):603.
Species: Human
Sample Types: Whole Cells
Applications: ICC -
Genetic ablation of GINIP-expressing primary sensory neurons strongly impairs Formalin-evoked pain
Authors: L Urien, S Gaillard, L Lo Re, P Malapert, M Bohic, A Reynders, A Moqrich
Sci Rep, 2017;7(0):43493.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Genetic Tracing of Cav3.2 T-Type Calcium Channel Expression in the Peripheral Nervous System
Authors: YA Bernal Sie, J Haseleu, A Kozlenkov, V Bégay, GR Lewin
Front Mol Neurosci, 2017;10(0):70.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Development of a pharmacodynamic biomarker to measure target engagement from inhibition of the NGF-TrkA pathway
Authors: EA Price, A Krasowska-, KK Nanda, SJ Stachel, DA Henze
J. Neurosci. Methods, 2017;282(0):34-42.
Species: Rat
Sample Types: Tissue Homogenates
Applications: ELISA Development (Capture) -
Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes
Authors: EG Reed-Geagh, MC Wright, LA See, PC Adelman, KH Lee, HR Koerber, SM Maricich
J Neurosci, 2016;36(15):4362-76.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Tropomyosin Receptor Kinase C Targeted Delivery of a Peptidomimetic Ligand-Photosensitizer Conjugate Induces Antitumor Immune Responses Following Photodynamic Therapy
Sci Rep, 2016;6(0):37209.
Species: Mouse
Sample Types: In Vivo
Applications: Neutralization -
Endogenous Modulation of Trkb Signaling by Treadmill Exercise After Peripheral Nerve Injury
Authors: Ariadna Arbat-Plan
Neuroscience, 2016;0(0):.
Species: Rat
Sample Types: Tissue Homogenates
Applications: Western Blot -
Distinct adhesion-independent functions of beta-catenin control stage-specific sensory neurogenesis and proliferation.
Authors: Gay M, Valenta T, Herr P, Paratore-Hari L, Basler K, Sommer L
BMC Biol, 2015;13(0):24.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Egr3-dependent muscle spindle stretch receptor intrafusal muscle fiber differentiation and fusimotor innervation homeostasis.
Authors: Oliveira Fernandes M, Tourtellotte W
J Neurosci, 2015;35(14):5566-78.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing.
Authors: Usoskin D, Furlan A, Islam S, Abdo H, Lonnerberg P, Lou D, Hjerling-Leffler J, Haeggstrom J, Kharchenko O, Kharchenko P, Linnarsson S, Ernfors P
Nat Neurosci, 2015;18(1):145-53.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor.
Authors: Gorokhova S, Gaillard S, Urien L, Malapert P, Legha W, Baronian G, Desvignes J, Alonso S, Moqrich A
PLoS Genet, 2014;10(2):e1004081.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A.
Authors: Romi E, Gokhman I, Wong E, Antonovsky N, Ludwig A, Sagi I, Saftig P, Tessier-Lavigne M, Yaron A
Nat Commun, 2014;5(0):4058.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling.
Authors: Gatto G, Dudanova I, Suetterlin P, Davies A, Drescher U, Bixby J, Klein R
J Neurosci, 2013;33(12):5399-410.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Positional differences of axon growth rates between sensory neurons encoded by Runx3.
EMBO J., 2012;31(18):3718-29.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Reduced spiral ganglion neuronal loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis.
Authors: Demel C, Hoegen T, Giese A
J Neuroinflammation, 2011;8(1):7.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-P -
Npn-1 contributes to axon-axon interactions that differentially control sensory and motor innervation of the limb.
Authors: Huettl RE, Soellner H, Bianchi E, Novitch BG, Huber AB
PLoS Biol., 2011;9(2):e1001020.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.
Authors: Vaegter CB, Jansen P, Fjorback AW
Nat. Neurosci., 2011;14(1):54-61.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC-Fr -
Neurotrophin-3 production promotes human neuroblastoma cell survival by inhibiting TrkC-induced apoptosis.
Authors: Bouzas-Rodriguez J, Cabrera JR, Delloye-Bourgeois C, Ichim G, Delcros JG, Raquin MA, Rousseau R, Combaret V, Benard J, Tauszig-Delamasure S, Mehlen P
J. Clin. Invest., 2010;120(3):850-8.
Species: Human
Sample Types: Whole Cells
Applications: Neutralization -
Runx3 is required for the specification of TrkC-expressing mechanoreceptive trigeminal ganglion neurons.
Authors: Senzaki K, Ozaki S, Yoshikawa M, Ito Y, Shiga T
Mol. Cell. Neurosci., 2010;43(3):296-307.
Species: Mouse
Sample Types: Whole Tissue
Applications: IHC -
Immunohistochemical analysis of acid-sensing ion channel 2 expression in rat dorsal root ganglion and effects of axotomy.
Authors: Kawamata T, Ninomiya T, Toriyabe M, Yamamoto J, Niiyama Y, Omote K, Namiki A
Neuroscience, 2006;143(1):175-87.
Species: Rat
Sample Types: Whole Tissue
Applications: IHC -
TRPV2, a capsaicin receptor homologue, is expressed predominantly in the neurotrophin-3-dependent subpopulation of primary sensory neurons.
Authors: Tamura S, Morikawa Y, Senba E
Neuroscience, 2005;130(1):223-8.
Species: Mouse
Sample Types: Whole Cells
Applications: ICC
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