Mouse/Rat TrkC Antibody

Catalog # Availability Size / Price Qty
AF1404
AF1404-SP
Detection of Mouse and Rat TrkC by Western Blot.
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Product Details
Citations (64)
FAQs
Supplemental Products
Reviews (2)

Mouse/Rat TrkC Antibody Summary

Species Reactivity
Mouse, Rat
Specificity
Detects mouse TrkC in direct ELISAs and Western blots. In direct ELISAs and Western blots, approximately 10% cross-reactivity with recombinant human (rh) TrkC is observed and less than 2% cross‑reactivity with recombinant mouse TrkB, recombinant rat TrkA, and rhTrkA is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
Mouse myeloma cell line NS0-derived recombinant mouse TrkC
Cys32-Thr429
Accession # Q6VNS1
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS.
Endotoxin Level
<0.10 EU per 1 μg of the antibody by the LAL method.
Label
Unconjugated

Applications

Recommended Concentration
Sample
Western Blot
0.5 µg/mL
See below
Simple Western
25 µg/mL
See below
Immunohistochemistry
5-15 µg/mL
Perfusion fixed frozen sections of mouse brain (cortex)
Blockade of Receptor-ligand Interaction
In a functional ELISA, 2-5 µg/mL of this antibody will block 50% of the binding of 1 ng/mL of Recombinant Human NT-3 (Catalog # 267-N3) to immobilized Recombinant Mouse TrkC (Catalog # 1404-TC) coated at 2 µg/mL (100 µL/well). At 100 μg/mL, this antibody will block >90% of the binding.
 

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Western Blot Detection of Mouse and Rat TrkC antibody by Western Blot. View Larger

Detection of Mouse and Rat TrkC by Western Blot. Western blot shows lysates of mouse brain (cerebellum) tissue, mouse brain (cortex) tissue, and rat brain tissue. PVDF membrane was probed with 0.5 µg/mL of Goat Anti-Mouse/Rat TrkC Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1404) followed by HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF017). Specific bands were detected for TrkC at approximately 100 and 140 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.

Simple Western Detection of Mouse TrkC antibody by Simple Western<sup>TM</sup>. View Larger

Detection of Mouse TrkC by Simple WesternTM. Simple Western lane view shows lysates of mouse brain tissue, loaded at 0.2 mg/mL. Specific bands were detected for TrkC at approximately 111 and 159 kDa (as indicated) using 25 µg/mL of Goat Anti-Mouse/Rat TrkC Antigen Affinity-purified Polyclonal Antibody (Catalog # AF1404) followed by 1:50 dilution of HRP-conjugated Anti-Goat IgG Secondary Antibody (Catalog # HAF109). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system.

Immunocytochemistry/ Immunofluorescence Detection of Mouse TrkC by Immunocytochemistry/ Immunofluorescence View Larger

Detection of Mouse TrkC by Immunocytochemistry/ Immunofluorescence Cra1/+ mice show no evidence of proprioceptive sensory neuron loss at symptomatic ages.A) Proprioceptive sensory neuron labeling and quantification with parvalbumin, (B) ER81, and (C) TrkC shows no difference between of +/+ and Cra1/+ mice at 6 months of age (Scale bar  = 20 µm). D) Parvalbumin labeling of proprioceptive sensory neuron fibers within the spinal cord shows the central projection of these sensory neurons is intact in Cra1/+ mice (Scale bar  = 20 µm; N = 3 animals per genotype). Image collected and cropped by CiteAb from the following open publication (https://dx.plos.org/10.1371/journal.pone.0016753), licensed under a CC-BY license. Not internally tested by R&D Systems.

Immunocytochemistry/ Immunofluorescence Detection of Mouse TrkC by Immunocytochemistry/ Immunofluorescence View Larger

Detection of Mouse TrkC by Immunocytochemistry/ Immunofluorescence Cra1/+ mice show no evidence of proprioceptive sensory neuron loss at symptomatic ages.A) Proprioceptive sensory neuron labeling and quantification with parvalbumin, (B) ER81, and (C) TrkC shows no difference between of +/+ and Cra1/+ mice at 6 months of age (Scale bar  = 20 µm). D) Parvalbumin labeling of proprioceptive sensory neuron fibers within the spinal cord shows the central projection of these sensory neurons is intact in Cra1/+ mice (Scale bar  = 20 µm; N = 3 animals per genotype). Image collected and cropped by CiteAb from the following open publication (https://dx.plos.org/10.1371/journal.pone.0016753), licensed under a CC-BY license. Not internally tested by R&D Systems.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below. *Small pack size (SP) is shipped with polar packs. Upon receipt, store it immediately at -20 to -70 °C
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: TrkC

The neurotrophins, including NGF, BDNF, NT‑3 and NT‑4/5, constitute a group of structurally related, secreted proteins that play an important role in the development and function of the nervous system. The biological activities of the neurotrophins are mediated by binding to and activating two unrelated receptor types: the p75 neurotrophin receptor (p75NTR) and the Trk family of receptor tyrosine kinases (1, 2). p75NTR is a member of the tumor necrosis factor receptor superfamily (TNFRSF) and has been designated TNFRSF16. It binds all neurotrophins with low affinity to transduce cellular signaling pathways that synergize or antagonize those activated by the Trk receptors. Three Trk family proteins, TrkA, TrkB, and TrkC, exhibiting different ligand specificities, have been identified. TrkA binds NGF and NT‑3, TrkB binds BDNF, NT‑3 and NT‑4/5, and TrkC only binds NT‑3 (1‑2). All Trk family proteins share a conserved, complex subdomain organization consisting of a signal peptide, two cysteine-rich domains, a cluster of three leucine-rich motifs, and two immunoglobulin-like domains in the extracellular region, as well as an intracellular region that contains the tyrosine kinase domain (3). Natural splice variants of the different Trks, lacking the first cysteine-rich domain, the first and second or all three of the leucine-rich motifs, or the tyrosine kinase domain, have been described (4). At the protein sequence level, Trks are highly conserved between species with the extracellular domains of human and mouse TrkC showing 94% amino acid sequence identity (5). The proteins also exhibit cross-species activity. The primary location of TrkC expression is in the nervous system and, specifically, in regions of the CNS. Low level TrkC expression has also been observed in a wide variety of tissues outside the nervous system (6).

References
  1. Huang, E.J. and L.F. Reichardt (2003) Annu. Rev. Biochem. 72:609.
  2. Dechant, G. (2001) Cell Tissue Res. 305:229.
  3. Schneider, R. and M. Schweiger (1991) Oncogene 6:1807.
  4. Ninkina, N. et al. (1997) J. Biol. Chem. 272:13019.
  5. Menn, B. et al. (1998) J. Comp. Neurol. 401:47.
  6. Shelton, D. et al. (1995) J. Neurosci. 15:477.
Long Name
Neurotrophic Tyrosine Kinase Receptor C
Entrez Gene IDs
4916 (Human); 18213 (Mouse); 29613 (Rat)
Alternate Names
EC 2.7.10; EC 2.7.10.1; ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; gp145(trkC); GP145-TrkC; Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; NT 3 receptor; NT-3 growth factor receptor; NTRK3; TrkC tyrosine kinase; TrkC; trk-C; TRKCneurotrophin 3 receptor; tyrosine kinase receptor C

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Citations for Mouse/Rat TrkC Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

64 Citations: Showing 1 - 10
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  1. Identification of Trigeminal Sensory Neuronal Types Innervating Masseter Muscle
    Authors: Karen A. Lindquist, Sergei Belugin, Anahit H. Hovhannisyan, Tatiana M. Corey, Adam Salmon, Armen N. Akopian
    eNeuro
  2. Targeted deletion of Atoh8 results in severe hearing loss in mice
    Authors: Qi Tang, Meng‐Yao Xie, Yong‐Li Zhang, Ruo‐Yan Xue, Xiao‐Hui Zhu, Hua Yang
    genesis
  3. TrkB-containing exosomes promote the transfer of glioblastoma aggressiveness to YKL-40-inactivated glioblastoma cells
    Authors: Sandra Pinet, Barbara Bessette, Nicolas Vedrenne, Aurélie Lacroix, Laurence Richard, Marie-Odile Jauberteau et al.
    Oncotarget
  4. Prolactin receptor expression in mouse dorsal root ganglia neuronal subtypes is sex‐dependent
    Authors: Mayur Patil, Anahit H. Hovhannisyan, Andi Wangzhou, Jennifer Mecklenburg, Wouter Koek, Vincent Goffin et al.
    Journal of Neuroendocrinology
  5. The Role of TRESK in Discrete Sensory Neuron Populations and Somatosensory Processing
    Authors: Greg A. Weir, Philippa Pettingill, Yukyee Wu, Galbha Duggal, Andrei-Sorin Ilie, Colin J. Akerman et al.
    Frontiers in Molecular Neuroscience
  6. NOP receptor agonist attenuates nitroglycerin-induced migraine-like symptoms in mice
    Authors: Katarzyna M. Targowska-Duda, Akihiko Ozawa, Zachariah Bertels, Andrea Cippitelli, Jason L. Marcus, Hanna K. Mielke-Maday et al.
    Neuropharmacology
  7. Boundary cap neural crest stem cells homotopically implanted to the injured dorsal root transitional zone give rise to different types of neurons and glia in adult rodents.
    Authors: Trolle, Carl, Konig, Niclas, Abrahamsson, Ninnie, Vasylovska, Svitlana, Kozlova, Elena N
    BMC Neurosci, 2014-05-05;15(0):60.
  8. The Familial Dysautonomia disease gene,Ikbkap/Elp1, is required in the developing and adult central nervous system
    Authors: Marta Chaverra, Lynn George, Marc Mergy, Hannah Waller, Katharine Kujawa, Connor Murnion et al.
    Disease Models & Mechanisms
  9. Dynamic expression of transcription factor Brn3b during mouse cranial nerve development
    Authors: Szilard Sajgo, Seid Ali, Octavian Popescu, Tudor Constantin Badea
    Journal of Comparative Neurology
  10. Generation of self-organized autonomic ganglion organoids from fibroblasts
    Authors: Liu S, Xiang K, Yuan F, Xiang M
    iScience
  11. Role of DSCAM in the development of the spinal locomotor and sensorimotor circuits
    Authors: Louise Thiry, Maxime Lemieux, Olivier D. Laflamme, Frédéric Bretzner
    Journal of Neurophysiology
  12. Anterograde trafficking of neurotrophin-3 in the adult olfactory system in vivo
    Authors: Huan Liu, Michael Lu, Kathleen M. Guthrie
    Experimental Neurology
  13. c-Maf-positive spinal cord neurons are critical elements of a dorsal horn circuit for mechanical hypersensitivity in neuropathy
    Authors: N Frezel, M Ranucci, E Foster, H Wende, P Pelczar, R Mendes, RP Ganley, K Werynska, S d'Aquin, C Beccarini, C Birchmeier, HU Zeilhofer, H Wildner
    Cell Reports, 2023-03-21;42(4):112295.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  14. Closing the Gap between the Auditory Nerve and Cochlear Implant Electrodes: Which Neurotrophin Cocktail Performs Best for Axonal Outgrowth and Is Electrical Stimulation Beneficial?
    Authors: D Schmidbaue, S Fink, F Rousset, H Löwenheim, P Senn, R Glueckert
    International Journal of Molecular Sciences, 2023-01-19;24(3):.
    Species: Mouse
    Sample Types: Organoid
    Applications: IHC
  15. Exploring the potential application of dental pulp stem cells in neuroregenerative medicine
    Authors: N Sultan, BA Scheven
    Neural regeneration research, 2022-04-01;17(4):775-776.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Neutralization
  16. Dental pulp stem cells stimulate neuronal differentiation of PC12 cells
    Authors: N Sultan, LE Amin, AR Zaher, ME Grawish, BA Scheven
    Neural regeneration research, 2021-09-01;16(9):1821-1828.
    Species: Rat
    Sample Types: Whole Cells
    Applications: Neutralization
  17. Cyclic Stretch of Either PNS or CNS Located Nerves Can Stimulate Neurite Outgrowth
    Authors: V Kampanis, B Tolou-Dabb, L Zhou, W Roth, R Puttagunta
    Cells, 2020-12-28;10(1):.
    Species: Rat
    Sample Types: Whole Cells
    Applications: ICC
  18. Spinal Inhibitory Ptf1a-Derived Neurons Prevent Self-Generated Itch
    Authors: A Escalante, R Klein
    Cell Rep, 2020-11-24;33(8):108422.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  19. Single cell RNA sequencing identifies early diversity of sensory neurons forming via bi-potential intermediates
    Authors: L Faure, Y Wang, ME Kastriti, P Fontanet, KKY Cheung, C Petitpré, H Wu, LL Sun, K Runge, L Croci, MA Landy, HC Lai, GG Consalez, A de Chevign, F Lallemend, I Adameyko, S Hadjab
    Nat Commun, 2020-08-21;11(1):4175.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  20. Generation of self-organized sensory ganglion organoids and retinal ganglion cells from fibroblasts
    Authors: D Xiao, Q Deng, Y Guo, X Huang, M Zou, J Zhong, P Rao, Z Xu, Y Liu, Y Hu, Y Shen, K Jin, M Xiang
    Sci Adv, 2020-05-29;6(22):eaaz5858.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: ICC, IHC
  21. Ameloblastomas Exhibit Stem Cell Potential, Possess Neurotrophic Properties, and Establish Connections with Trigeminal Neurons
    Authors: P Pagella, J Catón, CT Meisel, TA Mitsiadis
    Cells, 2020-03-06;9(3):.
    Species: Human
    Sample Types: Whole Tissue
    Applications: IHC-P
  22. Loss of bhlha9 Impairs Thermotaxis and Formalin-Evoked Pain in a Sexually Dimorphic Manner
    Authors: M Bohic, I Marics, C Santos, P Malapert, N Ben-Arie, C Salio, A Reynders, Y Le Feuvre, AJ Saurin, A Moqrich
    Cell Rep, 2020-01-21;30(3):602-610.e6.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IF
  23. A cell fitness selection model for neuronal survival during development
    Authors: Y Wang, H Wu, P Fontanet, S Codeluppi, N Akkuratova, C Petitpré, Y Xue-Franzé, K Niederreit, A Sharma, F Da Silva, G Comai, G Agirman, D Palumberi, S Linnarsson, I Adameyko, A Moqrich, A Schedl, G La Manno, S Hadjab, F Lallemend
    Nat Commun, 2019-09-12;10(1):4137.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  24. Spinal Neuropeptide Y1 Receptor-Expressing Neurons Form an Essential Excitatory Pathway for Mechanical Itch
    Authors: D Acton, X Ren, S Di Costanz, A Dalet, S Bourane, I Bertocchi, C Eva, M Goulding
    Cell Rep, 2019-07-16;28(3):625-639.e6.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  25. Notch signalling defines dorsal root ganglia neuroglial fate choice during early neural crest cell migration
    Authors: S Wiszniak, Q Schwarz
    BMC Neurosci, 2019-04-29;20(1):21.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-F
  26. Functional Local Proprioceptive Feedback Circuits Initiate and Maintain Locomotor Recovery after Spinal Cord Injury
    Authors: A Takeoka, S Arber
    Cell Rep, 2019-04-02;27(1):71-85.e3.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  27. PRDM12 Is Required for Initiation of the Nociceptive Neuron Lineage during Neurogenesis
    Authors: L Bartesaghi, Y Wang, P Fontanet, S Wanderoy, F Berger, H Wu, N Akkuratova, F Bouçanova, JJ Médard, C Petitpré, MA Landy, MD Zhang, P Harrer, C Stendel, R Stucka, M Dusl, ME Kastriti, L Croci, HC Lai, GG Consalez, A Pattyn, P Ernfors, J Senderek, I Adameyko, F Lallemend, S Hadjab, R Chrast
    Cell Rep, 2019-03-26;26(13):3484-3492.e4.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  28. Prdm12 Directs Nociceptive Sensory Neuron Development by Regulating the Expression of the NGF Receptor TrkA
    Authors: S Desiderio, S Vermeiren, C Van Campen, S Kricha, E Malki, S Richts, EV Fletcher, T Vanwelden, BZ Schmidt, KA Henningfel, T Pieler, CG Woods, V Nagy, C Verfaillie, EJ Bellefroid
    Cell Rep, 2019-03-26;26(13):3522-3536.e5.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  29. Mechanically Activated Piezo Channels Mediate Touch and Suppress Acute Mechanical Pain Response in Mice
    Authors: M Zhang, Y Wang, J Geng, S Zhou, B Xiao
    Cell Rep, 2019-02-05;26(6):1419-1431.e4.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  30. Characteristics of sensory neuronal groups in CGRP-cre-ER reporter mice: Comparison to Nav1.8-cre, TRPV1-cre and TRPV1-GFP mouse lines
    Authors: MJ Patil, AH Hovhannisy, AN Akopian
    PLoS ONE, 2018-06-04;13(6):e0198601.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  31. Optogenetic Activation of Non-Nociceptive A? Fibers Induces Neuropathic Pain-Like Sensory and Emotional Behaviors after Nerve Injury in Rats
    Authors: R Tashima, K Koga, M Sekine, K Kanehisa, Y Kohro, K Tominaga, K Matsushita, H Tozaki-Sai, Y Fukazawa, K Inoue, H Yawo, H Furue, M Tsuda
    eNeuro, 2018-02-15;5(1):.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC
  32. Phenotypic and Functional Characterization of Peripheral Sensory Neurons derived from Human Embryonic Stem Cells
    Authors: AJ Alshawaf, S Viventi, W Qiu, G D'Abaco, B Nayagam, M Erlichster, G Chana, I Everall, J Ivanusic, E Skafidas, M Dottori
    Sci Rep, 2018-01-12;8(1):603.
    Species: Human
    Sample Types: Whole Cells
    Applications: ICC
  33. Genetic Tracing of Cav3.2 T-Type Calcium Channel Expression in the Peripheral Nervous System
    Authors: YA Bernal Sie, J Haseleu, A Kozlenkov, V Bégay, GR Lewin
    Front Mol Neurosci, 2017-03-15;10(0):70.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  34. Development of a pharmacodynamic biomarker to measure target engagement from inhibition of the NGF-TrkA pathway
    Authors: EA Price, A Krasowska-, KK Nanda, SJ Stachel, DA Henze
    J. Neurosci. Methods, 2017-03-07;282(0):34-42.
    Species: Rat
    Sample Types: Tissue Homogenates
    Applications: ELISA Development (Capture)
  35. Genetic ablation of GINIP-expressing primary sensory neurons strongly impairs Formalin-evoked pain
    Authors: L Urien, S Gaillard, L Lo Re, P Malapert, M Bohic, A Reynders, A Moqrich
    Sci Rep, 2017-02-27;7(0):43493.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  36. Tropomyosin Receptor Kinase C Targeted Delivery of a Peptidomimetic Ligand-Photosensitizer Conjugate Induces Antitumor Immune Responses Following Photodynamic Therapy
    Sci Rep, 2016-11-17;6(0):37209.
    Species: Mouse
    Sample Types: In Vivo
    Applications: Neutralization
  37. Endogenous Modulation of Trkb Signaling by Treadmill Exercise After Peripheral Nerve Injury
    Authors: Ariadna Arbat-Plan
    Neuroscience, 2016-10-29;0(0):.
    Species: Rat
    Sample Types: Tissue Homogenates
    Applications: Western Blot
  38. Merkel Cell-Driven BDNF Signaling Specifies SAI Neuron Molecular and Electrophysiological Phenotypes
    Authors: EG Reed-Geagh, MC Wright, LA See, PC Adelman, KH Lee, HR Koerber, SM Maricich
    J Neurosci, 2016-04-13;36(15):4362-76.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  39. Distinct adhesion-independent functions of beta-catenin control stage-specific sensory neurogenesis and proliferation.
    Authors: Gay M, Valenta T, Herr P, Paratore-Hari L, Basler K, Sommer L
    BMC Biol, 2015-04-11;13(0):24.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  40. Egr3-dependent muscle spindle stretch receptor intrafusal muscle fiber differentiation and fusimotor innervation homeostasis.
    Authors: Oliveira Fernandes M, Tourtellotte W
    J Neurosci, 2015-04-08;35(14):5566-78.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  41. Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing.
    Authors: Usoskin D, Furlan A, Islam S, Abdo H, Lonnerberg P, Lou D, Hjerling-Leffler J, Haeggstrom J, Kharchenko O, Kharchenko P, Linnarsson S, Ernfors P
    Nat Neurosci, 2014-11-24;18(1):145-53.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  42. ADAM metalloproteases promote a developmental switch in responsiveness to the axonal repellant Sema3A.
    Authors: Romi E, Gokhman I, Wong E, Antonovsky N, Ludwig A, Sagi I, Saftig P, Tessier-Lavigne M, Yaron A
    Nat Commun, 2014-06-05;5(0):4058.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  43. Uncoupling of molecular maturation from peripheral target innervation in nociceptors expressing a chimeric TrkA/TrkC receptor.
    Authors: Gorokhova S, Gaillard S, Urien L, Malapert P, Legha W, Baronian G, Desvignes J, Alonso S, Moqrich A
    PLoS Genet, 2014-02-06;10(2):e1004081.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  44. Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling.
    Authors: Gatto G, Dudanova I, Suetterlin P, Davies A, Drescher U, Bixby J, Klein R
    J Neurosci, 2013-03-20;33(12):5399-410.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  45. Positional differences of axon growth rates between sensory neurons encoded by Runx3.
    EMBO J., 2012-08-17;31(18):3718-29.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  46. Npn-1 contributes to axon-axon interactions that differentially control sensory and motor innervation of the limb.
    Authors: Huettl RE, Soellner H, Bianchi E, Novitch BG, Huber AB
    PLoS Biol., 2011-02-22;9(2):e1001020.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  47. Reduced spiral ganglion neuronal loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis.
    Authors: Demel C, Hoegen T, Giese A
    J Neuroinflammation, 2011-01-24;8(1):7.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-P
  48. Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling.
    Authors: Vaegter CB, Jansen P, Fjorback AW
    Nat. Neurosci., 2010-11-21;14(1):54-61.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC-Fr
  49. Neurotrophin-3 production promotes human neuroblastoma cell survival by inhibiting TrkC-induced apoptosis.
    Authors: Bouzas-Rodriguez J, Cabrera JR, Delloye-Bourgeois C, Ichim G, Delcros JG, Raquin MA, Rousseau R, Combaret V, Benard J, Tauszig-Delamasure S, Mehlen P
    J. Clin. Invest., 2010-02-15;120(3):850-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Neutralization
  50. Runx3 is required for the specification of TrkC-expressing mechanoreceptive trigeminal ganglion neurons.
    Authors: Senzaki K, Ozaki S, Yoshikawa M, Ito Y, Shiga T
    Mol. Cell. Neurosci., 2009-12-23;43(3):296-307.
    Species: Mouse
    Sample Types: Whole Tissue
    Applications: IHC
  51. Immunohistochemical analysis of acid-sensing ion channel 2 expression in rat dorsal root ganglion and effects of axotomy.
    Authors: Kawamata T, Ninomiya T, Toriyabe M, Yamamoto J, Niiyama Y, Omote K, Namiki A
    Neuroscience, 2006-09-01;143(1):175-87.
    Species: Rat
    Sample Types: Whole Tissue
    Applications: IHC
  52. TRPV2, a capsaicin receptor homologue, is expressed predominantly in the neurotrophin-3-dependent subpopulation of primary sensory neurons.
    Authors: Tamura S, Morikawa Y, Senba E
    Neuroscience, 2005-01-01;130(1):223-8.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: ICC
  53. Conditional Deletion of Pten Leads to Defects in Nerve Innervation and Neuronal Survival in Inner Ear Development
    Authors: Hyung Jin Kim, Hae-Mi Woo, Jihee Ryu, Jinwoong Bok, Jin Woo Kim, Sang Back Choi et al.
    PLoS ONE
  54. Neuromuscular Junction Defects in Mice with Mutation of dynein heavy chain 1
    Authors: Stephanie L. Courchesne, Maria F. Pazyra-Murphy, Daniel J. Lee, Rosalind A. Segal
    PLoS ONE
  55. A Brainstem-Spinal Cord Inhibitory Circuit for Mechanical Pain Modulation by GABA and Enkephalins
    Authors: Amaury François, Sarah A. Low, Elizabeth I. Sypek, Amelia J. Christensen, Chaudy Sotoudeh, Kevin T. Beier et al.
    Neuron
  56. Genetic interplay between transcription factor Pou4f1/Brn3a and neurotrophin receptor Ret in retinal ganglion cell type specification
    Authors: Vladimir Vladimirovich Muzyka, Tudor Constantin Badea
    Neural Development
  57. A Local Source of FGF Initiates Development of the Unmyelinated Lineage of Sensory Neurons
    Authors: Saïda Hadjab, Marina C. M. Franck, Yiqiao Wang, Ulrich Sterzenbach, Anil Sharma, Patrik Ernfors et al.
    The Journal of Neuroscience
  58. Requirement for Dicer in Maintenance of Monosynaptic Sensory-Motor Circuits in the Spinal Cord
    Authors: Fumiyasu Imai, Xiaoting Chen, Matthew T. Weirauch, Yutaka Yoshida
    Cell Reports
  59. Nociceptor subtypes are born continuously over DRG development.
    Authors: Mark A. Landy, Megan Goyal, Helen C. Lai
    Developmental Biology
  60. Identification of Spinal Neurons Contributing to the Dorsal Column Projection Mediating Fine Touch and Corrective Motor Movements
    Authors: Sónia Paixão, Laura Loschek, Louise Gaitanos, Pilar Alcalà Alcalà Morales, Martyn Goulding, Rüdiger Klein
    Neuron
  61. Altering a Histone H3K4 Methylation Pathway in Glomerular Podocytes Promotes a Chronic Disease Phenotype
    Authors: Gaelle M. Lefevre, Sanjeevkumar R. Patel, Doyeob Kim, Lino Tessarollo, Gregory R. Dressler
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  62. Muscle-selective RUNX3 dependence of sensorimotor circuit development
    Authors: Yiqiao Wang, Haohao Wu, Pavel Zelenin, Paula Fontanet, Simone Wanderoy, Charles Petitpré et al.
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  63. A Functional Topographic Map for Spinal Sensorimotor Reflexes
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  64. Early ear neuronal development, but not olfactory or lens development, can proceed without SOX2
    Authors: Martina Dvorakova, Iva Macova, Romana Bohuslavova, Miroslava Anderova, Bernd Fritzsch, Gabriela Pavlinkova
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Mouse/Rat TrkC Antibody
By Anonymous on 07/13/2021
Application: WB Sample Tested: Adult brain Species: Mouse

Mouse/Rat TrkC Antibody
By Anonymous on 06/29/2021
Application: WB Sample Tested: brain lysate Species: Mouse